CA2205130A1 - Immunogenes pour stimuler l'immunite des muqueuses - Google Patents
Immunogenes pour stimuler l'immunite des muqueusesInfo
- Publication number
- CA2205130A1 CA2205130A1 CA002205130A CA2205130A CA2205130A1 CA 2205130 A1 CA2205130 A1 CA 2205130A1 CA 002205130 A CA002205130 A CA 002205130A CA 2205130 A CA2205130 A CA 2205130A CA 2205130 A1 CA2205130 A1 CA 2205130A1
- Authority
- CA
- Canada
- Prior art keywords
- antigen
- composition
- mucosal
- protein
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000008439 repair process Effects 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- 101150102864 rpoD gene Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 244000000033 sexually transmitted pathogen Species 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 101150117326 sigA gene Proteins 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
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- 230000007501 viral attachment Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
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- 239000011719 vitamin A Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/295—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne des immunogènes pour stimuler l'immunité des muqueuses contre un pathogène capable d'infecter un hôte mammifère par contact avec les membranes muqueuses. En particulier, cette invention concerne certains polypeptides et produits de recombinaison génétique contenant un polypetide, se fixant aux membranes en étant liés physiquement à un peptide provenant d'un pathogène. On décrit en détail dans le descriptif et dans les revendications de cette demande de brevet, des procédés permettant d'administrer ces immunogènes à des mammifères pour stimuler la réponse immunitaire au niveau des muqueuses.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34224194A | 1994-11-17 | 1994-11-17 | |
| US08/342,241 | 1994-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2205130A1 true CA2205130A1 (fr) | 1996-05-30 |
Family
ID=23340968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002205130A Abandoned CA2205130A1 (fr) | 1994-11-17 | 1995-11-17 | Immunogenes pour stimuler l'immunite des muqueuses |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0792365A1 (fr) |
| JP (1) | JPH10509325A (fr) |
| CN (1) | CN1173204A (fr) |
| AU (1) | AU3876795A (fr) |
| CA (1) | CA2205130A1 (fr) |
| MX (1) | MX9703676A (fr) |
| WO (1) | WO1996016178A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9626864D0 (en) * | 1996-12-24 | 1997-02-12 | Smithkline Beecham Biolog | Vaccine |
| FR2766193B1 (fr) | 1997-07-18 | 2001-09-14 | Inst Curie | Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique |
| CA2333921C (fr) * | 1998-05-15 | 2014-04-22 | Allan M. Green | Sous-unite b de verotoxine destinee a une immunisation |
| ATE469222T1 (de) * | 1998-12-08 | 2010-06-15 | Corixa Corp | Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen |
| WO2000039304A2 (fr) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides codant pour des polypeptides antigeniques du type c du vih; polypeptides et leurs utilisations |
| US20030072764A1 (en) * | 2001-04-05 | 2003-04-17 | O'hagan Derek | Mucosal boosting following parenteral priming |
| JP5033303B2 (ja) | 2001-07-05 | 2012-09-26 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 抗原性ｃ型ｈｉｖポリペプチドをコードするポリヌクレオチド、ポリペプチドおよびそれらの使用 |
| WO2006125076A2 (fr) * | 2005-05-18 | 2006-11-23 | Trinity Biosystems, Inc. | Procedes et compositions permettant l'immunisation contre les infections a chlamydia |
| US8961987B2 (en) * | 2007-08-20 | 2015-02-24 | New York University | Immunogen comprising the HIV GP120 V3 loop in a conformation that induces broadly neutralizing antibodies |
| CN106543287B (zh) * | 2015-09-16 | 2021-04-06 | 上海亨臻实业有限公司 | 构象表位疫苗和应用 |
| CN113813398B (zh) * | 2021-04-23 | 2023-11-07 | 天津医科大学 | 一种向表面富含神经节苷脂的细胞递送重组蛋白质的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3650571T2 (de) * | 1985-01-14 | 1997-02-27 | Chiron Corp | Hauptprotein der Aussenmembran von Chlamydia |
| IL92578A0 (en) * | 1988-12-07 | 1990-08-31 | Univ Leicester | Heat-labile toxin b subunit fusion proteins and their preparation |
| JPH02181236A (ja) * | 1989-01-05 | 1990-07-16 | Nec Corp | デバッグ装置 |
| DE69005572T2 (de) * | 1989-09-08 | 1994-04-07 | Takeda Chemical Industries Ltd | Fusionsproteine und Herstellung davon. |
| IL96475A0 (en) * | 1989-11-29 | 1991-08-16 | Innovative Tech Center | Chimeric proteins |
| GB9112553D0 (en) * | 1991-06-11 | 1991-07-31 | Wellcome Found | Fusion proteins |
-
1995
- 1995-11-17 CA CA002205130A patent/CA2205130A1/fr not_active Abandoned
- 1995-11-17 WO PCT/GB1995/002708 patent/WO1996016178A1/fr not_active Application Discontinuation
- 1995-11-17 JP JP8516667A patent/JPH10509325A/ja not_active Expired - Lifetime
- 1995-11-17 MX MX9703676A patent/MX9703676A/es unknown
- 1995-11-17 EP EP95937948A patent/EP0792365A1/fr not_active Withdrawn
- 1995-11-17 AU AU38767/95A patent/AU3876795A/en not_active Abandoned
- 1995-11-17 CN CN95197373A patent/CN1173204A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996016178A1 (fr) | 1996-05-30 |
| EP0792365A1 (fr) | 1997-09-03 |
| JPH10509325A (ja) | 1998-09-14 |
| AU3876795A (en) | 1996-06-17 |
| CN1173204A (zh) | 1998-02-11 |
| MX9703676A (es) | 1998-03-31 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |