BRPI0812625A2 - processo para preparar um sal de cis-atracúrio - Google Patents

processo para preparar um sal de cis-atracúrio

Info

Publication number
BRPI0812625A2
BRPI0812625A2 BRPI0812625A BRPI0812625A BRPI0812625A2 BR PI0812625 A2 BRPI0812625 A2 BR PI0812625A2 BR PI0812625 A BRPI0812625 A BR PI0812625A BR PI0812625 A BRPI0812625 A BR PI0812625A BR PI0812625 A2 BRPI0812625 A2 BR PI0812625A2
Authority
BR
Brazil
Prior art keywords
cis
atracurium
preparing
salt
compounds
Prior art date
Application number
BRPI0812625A
Other languages
English (en)
Inventor
Klopfer Eyal
Arad Oded
Sharon Ofer
Saeed Shady
Naddaka Vladimir
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Publication of BRPI0812625A2 publication Critical patent/BRPI0812625A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"processo para preparar um sal de cis-atracúrio". a presente invenção provê um processo para produzir compostos de cis-atracúrio, por exemplo, besilato de cis-atracúrio, a partir de sais de isoquinolínio da formula estrutural (viia) na qual x- é um ânion e r é h ou alquila de c1-c6, ou uma forma ativada do ácido carboxílico com 1,5-pentanodiol para formar um sal de cis-atracúrio, opcionalmente via um composto intermediário (viii). os compostos de cis-atracúrio podem ser purificados usando técnicas simples para propiciar besilato de cis-atracúrio sem a necessidade de purificação por hplc.
BRPI0812625A 2007-07-09 2008-05-01 processo para preparar um sal de cis-atracúrio BRPI0812625A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94862107P 2007-07-09 2007-07-09
PCT/IL2008/000590 WO2009007946A1 (en) 2007-07-09 2008-05-01 Process for producing cisatracurium and associated intermediates

Publications (1)

Publication Number Publication Date
BRPI0812625A2 true BRPI0812625A2 (pt) 2019-02-19

Family

ID=39673234

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812625A BRPI0812625A2 (pt) 2007-07-09 2008-05-01 processo para preparar um sal de cis-atracúrio

Country Status (5)

Country Link
US (2) US20100256381A1 (pt)
EP (1) EP2176227A1 (pt)
BR (1) BRPI0812625A2 (pt)
CA (1) CA2692636A1 (pt)
WO (1) WO2009007946A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0808272A2 (pt) * 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
CA2681060A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
EP2155684B1 (en) * 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
WO2008132746A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
EP2132181A1 (en) * 2007-06-18 2009-12-16 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
EP2197848A1 (en) 2007-10-29 2010-06-23 Chemagis Ltd. Novel r,r'-atracurium salts
AU2009241211A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
WO2010128518A2 (en) * 2009-05-04 2010-11-11 Gland Pharma Limited Novel process for the preparation of cisatracurium besylate
CN104557703B (zh) * 2015-01-27 2018-01-16 江苏嘉逸医药有限公司 一种苯磺顺阿曲库铵精制方法
CN111777554A (zh) * 2019-04-04 2020-10-16 山东瑞安药业有限公司 一种合成苯磺顺阿曲库铵的方法
CN112047883B (zh) * 2019-06-06 2024-04-19 上海特化医药科技有限公司 顺苯磺酸阿曲库铵的制备方法
CN113372271A (zh) * 2020-12-24 2021-09-10 上海药坦药物研究开发有限公司 一种顺苯磺酸阿曲库铵的制备方法
WO2023086696A2 (en) * 2021-11-10 2023-05-19 ODH IP Corp. Apparatus and methods for continuous flow synthesis of cisatracurium
CN115947685A (zh) * 2023-02-07 2023-04-11 山东铂源药业股份有限公司 苯磺顺阿曲库铵手性异构体杂质的制备方法

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AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
JPS62265266A (ja) * 1986-05-13 1987-11-18 Takasago Corp Ｎ−アシル−テトラヒドロイソキノリン類の製造法
US4988815A (en) * 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
RS49869B (sr) * 1997-03-25 2008-08-07 Avera Pharmaceuticals Inc., Supstituisani izohinolini kao neuromuskularni blokatori ultrakratkog delovanja
CA2380920C (en) * 1999-08-13 2011-07-19 Akzo Nobel N.V. Use of chemical chelators as reversal agents for drug-induced neuromuscular block
EP1346214A2 (en) * 2000-12-29 2003-09-24 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
US20060009485A1 (en) * 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
WO2008070121A1 (en) * 2006-12-06 2008-06-12 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
BRPI0808272A2 (pt) * 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
WO2008132746A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
EP2155684B1 (en) * 2007-05-01 2014-04-09 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
EP2197848A1 (en) * 2007-10-29 2010-06-23 Chemagis Ltd. Novel r,r'-atracurium salts

Also Published As

Publication number Publication date
US20130041154A1 (en) 2013-02-14
CA2692636A1 (en) 2009-01-15
WO2009007946A1 (en) 2009-01-15
EP2176227A1 (en) 2010-04-21
US20100256381A1 (en) 2010-10-07

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2512 DE 26-02-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]