BRPI0615141A2 - inibidores pentacìclicos de quinase - Google Patents

inibidores pentacìclicos de quinase

Info

Publication number
BRPI0615141A2
BRPI0615141A2 BRPI0615141-8A BRPI0615141A BRPI0615141A2 BR PI0615141 A2 BRPI0615141 A2 BR PI0615141A2 BR PI0615141 A BRPI0615141 A BR PI0615141A BR PI0615141 A2 BRPI0615141 A2 BR PI0615141A2
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
pentacyclic
malignancies
compounds
useful
Prior art date
Application number
BRPI0615141-8A
Other languages
English (en)
Inventor
Aihe Zhou
Thomas E Rawson
Brian Safina
Jennafer Dotson
Ignacio Aliagas-Martin
Jason Halladay
Jun Liang
Frederick Brookfield
Michael Prime
Birong Zhang
Jun M Li
Matthias Rueth
Bing-Yan Zhu
Original Assignee
Genentech Inc
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Hoffmann La Roche filed Critical Genentech Inc
Publication of BRPI0615141A2 publication Critical patent/BRPI0615141A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

INIBIDORES PENTACìCLICOS DE QUINASE. A presente invenção refere-se a novos inibidores de quinase que são úteis como agentes terapêutiCOs, por exemplo, no tratamento de estados malignos, em que os comDos:zs apresentam a Fórmula geral (1) em que A, X, Y, Z, Ra, Rb, Rc, R2 12, R2 22, R2 32 e m são tais como definidos no presente documento.
BRPI0615141-8A 2005-08-12 2006-08-14 inibidores pentacìclicos de quinase BRPI0615141A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70790205P 2005-08-12 2005-08-12
PCT/US2006/031682 WO2007022102A2 (en) 2005-08-12 2006-08-14 Pentacyclic kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0615141A2 true BRPI0615141A2 (pt) 2009-07-14

Family

ID=37607426

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0615141-8A BRPI0615141A2 (pt) 2005-08-12 2006-08-14 inibidores pentacìclicos de quinase

Country Status (14)

Country Link
US (1) US7749994B2 (pt)
EP (1) EP1919920B1 (pt)
JP (1) JP2009504680A (pt)
KR (1) KR20080035691A (pt)
CN (1) CN101287737A (pt)
AT (1) ATE509933T1 (pt)
AU (1) AU2006279659A1 (pt)
BR (1) BRPI0615141A2 (pt)
CA (1) CA2619276A1 (pt)
IL (1) IL189296A0 (pt)
NO (1) NO20081292L (pt)
RU (1) RU2008108903A (pt)
WO (1) WO2007022102A2 (pt)
ZA (1) ZA200801332B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5501251B2 (ja) 2008-01-11 2014-05-21 アルバニー モレキュラー リサーチ， インコーポレイテッド Ｍｃｈ拮抗薬としての（１−アジノン）置換ピリドインドール類
US8629158B2 (en) * 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
EP2448585B1 (en) * 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
JP6653573B2 (ja) 2012-05-22 2020-02-26 トラスティーズ・オブ・ダートマウス・カレッジ シクロアルカニル［ｂ］インドール、シクロアルカニル［ｂ］ベンゾフラン、シクロアルカニル［ｂ］ベンゾチオフェンを合成するための方法、化合物および使用の方法
WO2017162661A1 (en) 2016-03-22 2017-09-28 Bayer Pharma Aktiengesellschaft 1h-benzo[de]isoquinoline-1,3(2h)-diones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032869A1 (en) 2003-07-08 2005-02-10 Pharmacia Italia S.P.A. Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2006133885A1 (en) * 2005-06-15 2006-12-21 F. Hoffmann-La Roche Ag Tricyclic fused indole derivatives and their use as aurora kinase inhibitors

Also Published As

Publication number Publication date
EP1919920A2 (en) 2008-05-14
EP1919920B1 (en) 2011-05-18
WO2007022102A2 (en) 2007-02-22
IL189296A0 (en) 2008-06-05
US20070037791A1 (en) 2007-02-15
US7749994B2 (en) 2010-07-06
KR20080035691A (ko) 2008-04-23
CN101287737A (zh) 2008-10-15
ZA200801332B (en) 2009-10-28
WO2007022102A3 (en) 2007-05-10
CA2619276A1 (en) 2007-02-22
RU2008108903A (ru) 2009-09-20
JP2009504680A (ja) 2009-02-05
AU2006279659A1 (en) 2007-02-22
ATE509933T1 (de) 2011-06-15
NO20081292L (no) 2008-05-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2215 DE 18/06/2013.