BRPI0415657A - derivados de alcanamina de diidrobenzofuranila como agonistas de 5ht2c - Google Patents

derivados de alcanamina de diidrobenzofuranila como agonistas de 5ht2c

Info

Publication number
BRPI0415657A
BRPI0415657A BRPI0415657-9A BRPI0415657A BRPI0415657A BR PI0415657 A BRPI0415657 A BR PI0415657A BR PI0415657 A BRPI0415657 A BR PI0415657A BR PI0415657 A BRPI0415657 A BR PI0415657A
Authority
BR
Brazil
Prior art keywords
agonists
compounds
5ht2c agonists
alkanamine derivatives
derivatives
Prior art date
Application number
BRPI0415657-9A
Other languages
English (en)
Inventor
Jonathan Laird Gross
Marla Jean Williams
Gary Paul Stack
Hong Gao
Dahui Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34576747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0415657(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0415657A publication Critical patent/BRPI0415657A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

"DERIVADOS DE ALCANAMINA DE DIIDROBENZOFURANILA COMO AGONISTAS DE 5HT2C". Compostos de Fórmula (I) ou sal farmaceuticamente aceitável deste são fornecidos: Fórmula (I) que são agonistas ou agonistas parciais do subtipo 2C de receptores de serotonina cerebral. Os compostos e composições contendo os compostos, podem ser empregados para tratar uma variedade de distúrbios do sistema nervoso central, tal como esquizofrenia.
BRPI0415657-9A 2003-10-24 2004-10-22 derivados de alcanamina de diidrobenzofuranila como agonistas de 5ht2c BRPI0415657A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51445403P 2003-10-24 2003-10-24
US10/970,714 US7435837B2 (en) 2003-10-24 2004-10-21 Dihydrobenzofuranyl alkanamine derivatives and methods for using same
PCT/US2004/035280 WO2005044812A1 (en) 2003-10-24 2004-10-22 Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists

Publications (1)

Publication Number Publication Date
BRPI0415657A true BRPI0415657A (pt) 2006-12-19

Family

ID=34576747

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415657-9A BRPI0415657A (pt) 2003-10-24 2004-10-22 derivados de alcanamina de diidrobenzofuranila como agonistas de 5ht2c

Country Status (20)

Country Link
US (2) US7435837B2 (pt)
EP (1) EP1675840A1 (pt)
JP (1) JP2007509174A (pt)
KR (1) KR20060092257A (pt)
CN (1) CN1997635A (pt)
AR (1) AR046309A1 (pt)
AU (1) AU2004287809A1 (pt)
BR (1) BRPI0415657A (pt)
CA (1) CA2542878A1 (pt)
CR (1) CR8349A (pt)
EC (1) ECSP066520A (pt)
IL (1) IL174953A0 (pt)
MX (1) MXPA06004409A (pt)
NO (1) NO20062139L (pt)
PA (1) PA8615701A1 (pt)
PE (1) PE20050482A1 (pt)
RU (1) RU2006117789A (pt)
TW (1) TW200526615A (pt)
WO (1) WO2005044812A1 (pt)
ZA (1) ZA200603233B (pt)

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GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
CA2605587A1 (en) * 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
EP1879875A1 (en) * 2005-04-22 2008-01-23 Wyeth Crystal forms opf {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
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AU2006239942A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
EP1871358A1 (en) * 2005-04-22 2008-01-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
CN101198323A (zh) * 2005-04-22 2008-06-11 惠氏公司 用于治疗或预防精神障碍的治疗组合
GT200600164A (es) * 2005-04-22 2007-03-14 Derivados de dihidrobenzofuranos y usos de los mismos
AU2006239910A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
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CN103261138B (zh) 2010-12-21 2015-08-12 高露洁-棕榄公司 作为抗菌剂的卤代联苯酚
CN103242273B (zh) * 2012-02-09 2015-06-03 中国科学院上海药物研究所 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途
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US10407381B2 (en) 2015-01-29 2019-09-10 The Board Of Trustees Of The University Of Illinois Cyclopropylmethanamines as selective 5-HT(2C) receptor agonists
CN108084125B (zh) * 2016-11-23 2020-08-18 华东理工大学 苯并杂环烷基胺类化合物及其用途
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ZA200603233B (en) 2008-11-26
CN1997635A (zh) 2007-07-11
TW200526615A (en) 2005-08-16
PE20050482A1 (es) 2005-10-13
CR8349A (es) 2007-06-06
WO2005044812A1 (en) 2005-05-19
MXPA06004409A (es) 2007-01-26
KR20060092257A (ko) 2006-08-22
AU2004287809A1 (en) 2005-05-19
NO20062139L (no) 2006-07-21
EP1675840A1 (en) 2006-07-05
US20090082434A1 (en) 2009-03-26
RU2006117789A (ru) 2007-11-27
AR046309A1 (es) 2005-11-30
IL174953A0 (en) 2006-08-20
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US20050143452A1 (en) 2005-06-30
US7435837B2 (en) 2008-10-14

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