BR9914645A - Proteìna tensoativa d (sp-d) para a prevenção e diagnose de enfisema pulmonar - Google Patents

Proteìna tensoativa d (sp-d) para a prevenção e diagnose de enfisema pulmonar

Info

Publication number
BR9914645A
BR9914645A BR9914645-2A BR9914645A BR9914645A BR 9914645 A BR9914645 A BR 9914645A BR 9914645 A BR9914645 A BR 9914645A BR 9914645 A BR9914645 A BR 9914645A
Authority
BR
Brazil
Prior art keywords
emphysema
diagnosis
protein
surfactant protein
prevention
Prior art date
Application number
BR9914645-2A
Other languages
English (en)
Inventor
Jeffrey A Whitsett
Original Assignee
Childrens Hosp Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hosp Medical Center filed Critical Childrens Hosp Medical Center
Publication of BR9914645A publication Critical patent/BR9914645A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"PROTEìNA TENSOATIVA D (SP-D) PARA A PREVENçãO E DIAGNOSE DE ENFISEMA PULMONAR". A proteína tensoativa D (SP-D) é um elemento 43-kDa da família colecitina de proteínas contendo domínio de lecitina de colágeno que é expressada em células epiteliais do pulmão. O gene SP-D foi alvejado por recombinação homóloga em células tronco de embrião que foram usadas para produzir camundongos SP-D(-/-). A deficiência SP-D (-/-) causou inflamação, produção oxidante aumentada por macrófagos alveolares isolados, níveis e estrutura tensoativa anormais, e expressão SP-A diminuída. Portanto, descreveu-se o camundongo SP-D (-/-) como um excelente modelo para enfisema. Também foram incluídos modelos para testes de terapias de enfisema no modelo de camundongo, métodos para se usar a proteína SP-D ou DNA como um tratamento para infecções pulmonares e enfisema, e diagnose.
BR9914645-2A 1998-10-20 1999-10-20 Proteìna tensoativa d (sp-d) para a prevenção e diagnose de enfisema pulmonar BR9914645A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10494198P 1998-10-20 1998-10-20
PCT/US1999/024675 WO2000023569A1 (en) 1998-10-20 1999-10-20 Surfactant protein d for the prevention and diagnosis of pulmonary emphysema

Publications (1)

Publication Number Publication Date
BR9914645A true BR9914645A (pt) 2002-02-05

Family

ID=22303258

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914645-2A BR9914645A (pt) 1998-10-20 1999-10-20 Proteìna tensoativa d (sp-d) para a prevenção e diagnose de enfisema pulmonar

Country Status (11)

Country Link
EP (2) EP1123383B1 (pt)
JP (1) JP4807902B2 (pt)
AT (1) ATE402255T1 (pt)
AU (1) AU767774B2 (pt)
BR (1) BR9914645A (pt)
CA (2) CA2347248C (pt)
DE (1) DE69939179D1 (pt)
DK (1) DK1995315T3 (pt)
ES (2) ES2311307T3 (pt)
IL (2) IL142639A0 (pt)
WO (1) WO2000023569A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933032B2 (en) 1998-10-20 2015-01-13 Children's Hospital Medical Center Surfactant protein D for the treatment of disorders associated with lung injury
US20030221199A1 (en) * 1998-10-20 2003-11-27 Whitsett Jeffrey A. Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
US6838428B2 (en) * 1998-10-20 2005-01-04 Children's Hospital Medical Center Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
JP2005522988A (ja) 2001-10-25 2005-08-04 メディカル リサーチ カウンシル 分子
IL164078A0 (en) * 2002-04-01 2005-12-18 Gtc Biotherapeutics Inc Treatment of lung disorder
SE0203591D0 (sv) * 2002-12-04 2002-12-04 Siemens Elema Ab Förfarande för beredning av ett mediakament och en medicinsk anordning
JP5048678B2 (ja) * 2005-11-03 2012-10-17 チルドレンズ ホスピタル メディカル センター 肺感染症および敗血症を防止および処置するための表面活性タンパク質−ｄ
US8883730B2 (en) * 2006-09-29 2014-11-11 Council Of Scientific And Industrial Research Human lung surfactant protein, SP-D, modulates eosinophil activation and survival and enhances phagocytosis of apoptotic bosinophils
GB201402909D0 (en) 2014-02-19 2014-04-02 Univ Southampton Treating infection
US10682396B2 (en) 2015-06-09 2020-06-16 B.G. Negev Technologies And Applications Ltd Controlled release system for pulmonary delivery of surfactant protein D

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991000871A1 (en) * 1989-07-11 1991-01-24 Genentech, Inc. Surfactant compositions and methods
WO1994023582A1 (en) * 1993-04-08 1994-10-27 Genetic Therapy, Inc. Adenoviral vectors including dna encoding lung surfactant protein

Also Published As

Publication number Publication date
CA2749553C (en) 2015-09-15
EP1123383B1 (en) 2008-07-23
DE69939179D1 (de) 2008-09-04
WO2000023569A8 (en) 2003-11-06
DK1995315T3 (da) 2014-07-28
WO2000023569A9 (en) 2002-08-29
EP1123383A1 (en) 2001-08-16
JP4807902B2 (ja) 2011-11-02
ES2311307T3 (es) 2009-02-01
CA2347248A1 (en) 2000-04-27
AU767774B2 (en) 2003-11-27
ATE402255T1 (de) 2008-08-15
EP1123383A4 (en) 2002-07-17
EP1995315B1 (en) 2014-05-14
EP1995315A3 (en) 2010-06-23
ES2488692T3 (es) 2014-08-28
WO2000023569A1 (en) 2000-04-27
CA2749553A1 (en) 2000-04-27
EP1995315A2 (en) 2008-11-26
JP2002527102A (ja) 2002-08-27
AU1598000A (en) 2000-05-08
CA2347248C (en) 2011-09-20
IL142639A (en) 2009-09-01
IL142639A0 (en) 2002-03-10

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART. 24, ART. 8O COMBINADO COM ART. 13 E ART. 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.