BR112022017148A2 - Métodos para produzir células que expressam receptor de antígeno quimérico - Google Patents

Métodos para produzir células que expressam receptor de antígeno quimérico

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Publication number
BR112022017148A2
BR112022017148A2 BR112022017148A BR112022017148A BR112022017148A2 BR 112022017148 A2 BR112022017148 A2 BR 112022017148A2 BR 112022017148 A BR112022017148 A BR 112022017148A BR 112022017148 A BR112022017148 A BR 112022017148A BR 112022017148 A2 BR112022017148 A2 BR 112022017148A2
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BR
Brazil
Prior art keywords
methods
antigen receptor
chimeric antigen
producing cells
express chimeric
Prior art date
Application number
BR112022017148A
Other languages
English (en)
Inventor
Brogdon Jennifer
Dranoff Glenn
R Greene Michael
Hack Anniesha
Kodrasi Olja
Dorothy Pratico Elizabeth
Price Andrew
Marc Stein Andrew
RAYO Amy
Yang Jennifer
Walter GRANDA Brian
Bondanza Attilio
ENGELS Boris
Lim Hyungwook
Sohoni Akash
Zhu Xu
Treanor Louise
Jayashankar Shyamali
Guimaraes Carla
Cebe Regis
Tharian Koshy Sandeep
Miller Sandra
Bardroff Michael
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112022017148A2 publication Critical patent/BR112022017148A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
    • A61K2239/29—Multispecific CARs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
    • A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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Abstract

MÉTODOS PARA PRODUZIR CÉLULAS QUE EXPRESSAM RECEPTOR DE ANTÍGENO QUIMÉRICO. A presente invenção fornece métodos para produzir células imunoefetoras (por exemplo, células T, células NK) que expressam um receptor de antígeno quimérico (CAR) e composições geradas por tais métodos.
BR112022017148A 2020-02-27 2021-02-26 Métodos para produzir células que expressam receptor de antígeno quimérico BR112022017148A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062982665P 2020-02-27 2020-02-27
PCT/US2021/019889 WO2021173985A2 (en) 2020-02-27 2021-02-26 Methods of making chimeric antigen receptor-expressing cells

Publications (1)

Publication Number Publication Date
BR112022017148A2 true BR112022017148A2 (pt) 2022-11-08

Family

ID=74885109

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022017148A BR112022017148A2 (pt) 2020-02-27 2021-02-26 Métodos para produzir células que expressam receptor de antígeno quimérico

Country Status (14)

Country Link
US (1) US20230256017A1 (pt)
EP (1) EP4110376A2 (pt)
JP (1) JP2023516008A (pt)
KR (1) KR20220146530A (pt)
CN (1) CN115175695A (pt)
AR (1) AR121461A1 (pt)
AU (1) AU2021228708A1 (pt)
BR (1) BR112022017148A2 (pt)
CA (1) CA3173394A1 (pt)
CL (2) CL2022002327A1 (pt)
IL (1) IL295604A (pt)
MX (1) MX2022010604A (pt)
TW (1) TW202146441A (pt)
WO (1) WO2021173985A2 (pt)

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