BR112015023557A2 - proteínas de ligações dual específicas direcionadas contra tnfa - Google Patents
proteínas de ligações dual específicas direcionadas contra tnfaInfo
- Publication number
- BR112015023557A2 BR112015023557A2 BR112015023557A BR112015023557A BR112015023557A2 BR 112015023557 A2 BR112015023557 A2 BR 112015023557A2 BR 112015023557 A BR112015023557 A BR 112015023557A BR 112015023557 A BR112015023557 A BR 112015023557A BR 112015023557 A2 BR112015023557 A2 BR 112015023557A2
- Authority
- BR
- Brazil
- Prior art keywords
- binding proteins
- directed against
- specific dual
- dual binding
- proteins directed
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
resumo proteínas de ligações dual específicas direcionadas contra tnfa proteínas de ligação construídas multivalentes e multiespecíficas que que ligam tnfa, il-13, pge2 e/ou ngf são fornecidas, juntamente com métodos de produção e uso para a prevenção, diagnóstico, e/ou tratamento de doenças.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361794964P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/028646 WO2014144299A2 (en) | 2013-03-15 | 2014-03-14 | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST TNFα |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015023557A2 true BR112015023557A2 (pt) | 2017-10-24 |
Family
ID=50639981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015023557A BR112015023557A2 (pt) | 2013-03-15 | 2014-03-14 | proteínas de ligações dual específicas direcionadas contra tnfa |
Country Status (22)
Country | Link |
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US (1) | US20140271457A1 (pt) |
EP (1) | EP2970457A2 (pt) |
JP (1) | JP2016517277A (pt) |
KR (1) | KR20150131360A (pt) |
CN (1) | CN105209491A (pt) |
AR (1) | AR095588A1 (pt) |
AU (1) | AU2014227664A1 (pt) |
BR (1) | BR112015023557A2 (pt) |
CA (1) | CA2904407A1 (pt) |
CL (1) | CL2015002743A1 (pt) |
CR (1) | CR20150522A (pt) |
EC (1) | ECSP15040888A (pt) |
IL (1) | IL240915A0 (pt) |
MX (1) | MX2015013170A (pt) |
PE (1) | PE20151670A1 (pt) |
PH (1) | PH12015502007A1 (pt) |
RU (1) | RU2015143833A (pt) |
SG (1) | SG11201507423YA (pt) |
TW (1) | TW201446800A (pt) |
UY (1) | UY35479A (pt) |
WO (1) | WO2014144299A2 (pt) |
ZA (1) | ZA201506582B (pt) |
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TW201211252A (en) | 2010-08-26 | 2012-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
IN2014CN03936A (pt) | 2011-10-24 | 2015-09-04 | Abbvie Inc | |
WO2013102042A2 (en) | 2011-12-30 | 2013-07-04 | Abbvie Inc. | Dual specific binding proteins directed against il-13 and/or il-17 |
JP6109952B2 (ja) | 2012-11-01 | 2017-04-05 | アッヴィ・インコーポレイテッド | 抗vegf/dll4二重可変ドメイン免疫グロブリンおよびこれらの使用 |
CN105324396A (zh) | 2013-03-15 | 2016-02-10 | 艾伯维公司 | 针对IL-1β和/或IL-17的双重特异性结合蛋白 |
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EP3653207A1 (en) | 2014-02-10 | 2020-05-20 | Respivant Sciences GmbH | Mast cell stabilizers treatment for systemic disorders |
US20160367520A1 (en) | 2014-02-10 | 2016-12-22 | Patara Pharma, LLC | Mast cell stabilizers for lung disease treatment |
KR102523914B1 (ko) | 2014-09-03 | 2023-04-19 | 베링거잉겔하임인터내쇼날유한회사 | Il-23a 및 tnf-알파를 표적으로 하는 화합물 및 이의 용도 |
WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
US10265296B2 (en) | 2015-08-07 | 2019-04-23 | Respivant Sciences Gmbh | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
PL3365366T3 (pl) | 2015-10-25 | 2022-01-31 | Sanofi | Trójspecyficzne i/lub trójwalentne białka wiążące do zapobiegania lub leczenia zakażenia HIV |
GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
IL262241B2 (en) | 2016-04-13 | 2024-05-01 | Sanofi Sa | Trispecific and/or trivalent binding proteins with an arm that has a cross-linking dual variable domain and a traditional FAB antibody arm, the pharmaceutical composition that includes said binding proteins and their uses in the prevention and/or treatment of cancer or inflammatory diseases |
RS64771B1 (sr) | 2016-04-13 | 2023-11-30 | Sanofi Sa | Trispecifični i/ili trovalentni vezujući proteini |
LT3448391T (lt) | 2016-04-27 | 2024-06-25 | AbbVie Manufacturing Management Unlimited Company | Ligų, kurių atveju il-13 aktyvumas yra žalingas, gydymo būdas, panaudojant anti-il-13 antikūnus |
WO2018044942A1 (en) | 2016-08-31 | 2018-03-08 | Patara Pharma, LLC | Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis |
AU2017339366A1 (en) | 2016-10-07 | 2019-04-11 | Respivant Sciences Gmbh | Cromolyn compositions for treatment of pulmonary fibrosis |
CN107375904B (zh) * | 2017-08-01 | 2020-11-27 | 无锡市人民医院 | β-arrestin1在防治色素障碍性皮肤病中的应用 |
BR112020007002A2 (pt) | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
BR112021006558A2 (pt) | 2018-10-09 | 2021-07-13 | Sanofi | proteínas de ligação triespecíficas anti-cd38, anti-cd28 e anti-cd3 e métodos de uso para o tratamento de infecção viral |
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-
2014
- 2014-03-14 PE PE2015001934A patent/PE20151670A1/es not_active Application Discontinuation
- 2014-03-14 EP EP14721652.7A patent/EP2970457A2/en not_active Withdrawn
- 2014-03-14 MX MX2015013170A patent/MX2015013170A/es unknown
- 2014-03-14 SG SG11201507423YA patent/SG11201507423YA/en unknown
- 2014-03-14 CA CA2904407A patent/CA2904407A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/028646 patent/WO2014144299A2/en active Application Filing
- 2014-03-14 BR BR112015023557A patent/BR112015023557A2/pt not_active IP Right Cessation
- 2014-03-14 CN CN201480026314.7A patent/CN105209491A/zh active Pending
- 2014-03-14 AU AU2014227664A patent/AU2014227664A1/en not_active Abandoned
- 2014-03-14 US US14/211,596 patent/US20140271457A1/en not_active Abandoned
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- 2014-03-14 KR KR1020157029888A patent/KR20150131360A/ko not_active Application Discontinuation
- 2014-03-14 TW TW103109732A patent/TW201446800A/zh unknown
- 2014-03-14 JP JP2016502858A patent/JP2016517277A/ja active Pending
- 2014-03-17 AR ARP140101213A patent/AR095588A1/es unknown
- 2014-03-17 UY UY0001035479A patent/UY35479A/es not_active Application Discontinuation
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2015
- 2015-08-30 IL IL240915A patent/IL240915A0/en unknown
- 2015-09-07 ZA ZA2015/06582A patent/ZA201506582B/en unknown
- 2015-09-08 PH PH12015502007A patent/PH12015502007A1/en unknown
- 2015-09-15 CL CL2015002743A patent/CL2015002743A1/es unknown
- 2015-09-23 EC ECIEPI201540888A patent/ECSP15040888A/es unknown
- 2015-10-08 CR CR20150522A patent/CR20150522A/es unknown
Also Published As
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CN105209491A (zh) | 2015-12-30 |
CA2904407A1 (en) | 2014-09-18 |
WO2014144299A2 (en) | 2014-09-18 |
KR20150131360A (ko) | 2015-11-24 |
ECSP15040888A (es) | 2015-11-30 |
SG11201507423YA (en) | 2015-10-29 |
US20140271457A1 (en) | 2014-09-18 |
UY35479A (es) | 2014-09-30 |
WO2014144299A3 (en) | 2014-12-18 |
EP2970457A2 (en) | 2016-01-20 |
PH12015502007A1 (en) | 2016-01-11 |
CL2015002743A1 (es) | 2016-03-18 |
AU2014227664A8 (en) | 2015-10-15 |
TW201446800A (zh) | 2014-12-16 |
AU2014227664A1 (en) | 2015-09-24 |
JP2016517277A (ja) | 2016-06-16 |
MX2015013170A (es) | 2016-07-26 |
AR095588A1 (es) | 2015-10-28 |
PE20151670A1 (es) | 2015-12-12 |
RU2015143833A (ru) | 2017-04-21 |
IL240915A0 (en) | 2015-10-29 |
CR20150522A (es) | 2016-01-12 |
ZA201506582B (en) | 2017-01-25 |
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