BR112015023417A2 - compostos heterocíclicos e seus usos - Google Patents

compostos heterocíclicos e seus usos

Info

Publication number
BR112015023417A2
BR112015023417A2 BR112015023417A BR112015023417A BR112015023417A2 BR 112015023417 A2 BR112015023417 A2 BR 112015023417A2 BR 112015023417 A BR112015023417 A BR 112015023417A BR 112015023417 A BR112015023417 A BR 112015023417A BR 112015023417 A2 BR112015023417 A2 BR 112015023417A2
Authority
BR
Brazil
Prior art keywords
heterocyclic compounds
preparation
methods
pharmaceutical formulations
uses certain
Prior art date
Application number
BR112015023417A
Other languages
English (en)
Other versions
BR112015023417B1 (pt
Inventor
Bi Mingda
Kuehl Robert
Original Assignee
Amgen Inc
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50549466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015023417(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc, Cytokinetics Inc filed Critical Amgen Inc
Publication of BR112015023417A2 publication Critical patent/BR112015023417A2/pt
Publication of BR112015023417B1 publication Critical patent/BR112015023417B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1/1 resumo compostos heterocíclicos e seus usos são fornecidas certas formulações farmacêuticas de omecamtiv mecarbil e métodos para a sua preparação e utilização.
BR112015023417-8A 2013-03-14 2014-03-14 Formulação farmacêutica oral compreendendo hidrato de dicloridrato de omecamtiv mecarbil BR112015023417B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361785763P 2013-03-14 2013-03-14
US61/785,763 2013-03-14
PCT/US2014/027104 WO2014152236A1 (en) 2013-03-14 2014-03-14 Heterocyclic compounds and their uses

Publications (2)

Publication Number Publication Date
BR112015023417A2 true BR112015023417A2 (pt) 2017-07-18
BR112015023417B1 BR112015023417B1 (pt) 2023-10-17

Family

ID=50549466

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112015023417-8A BR112015023417B1 (pt) 2013-03-14 2014-03-14 Formulação farmacêutica oral compreendendo hidrato de dicloridrato de omecamtiv mecarbil
BR112015022857-7A BR112015022857B1 (pt) 2013-03-14 2014-03-14 Sal de omecamtiv mecarbil e processo para preparar sal

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112015022857-7A BR112015022857B1 (pt) 2013-03-14 2014-03-14 Sal de omecamtiv mecarbil e processo para preparar sal

Country Status (41)

Country Link
US (14) US9951015B2 (pt)
EP (3) EP2968173B1 (pt)
JP (5) JP6498658B2 (pt)
KR (2) KR102374159B1 (pt)
CN (3) CN108785265B (pt)
AP (1) AP2015008789A0 (pt)
AR (2) AR095542A1 (pt)
AU (2) AU2014239995B2 (pt)
BR (2) BR112015023417B1 (pt)
CA (3) CA3147180C (pt)
CL (1) CL2015002708A1 (pt)
CR (1) CR20150549A (pt)
CY (2) CY1122695T1 (pt)
DK (2) DK2968173T3 (pt)
EA (1) EA031185B1 (pt)
ES (2) ES2837038T3 (pt)
HK (4) HK1218080A1 (pt)
HR (2) HRP20191728T1 (pt)
HU (2) HUE046285T2 (pt)
IL (2) IL240788B (pt)
JO (1) JOP20140114B1 (pt)
LT (2) LT2970123T (pt)
MA (2) MA38399B2 (pt)
ME (1) ME03566B (pt)
MX (3) MX363347B (pt)
MY (1) MY186048A (pt)
NZ (1) NZ711225A (pt)
PE (1) PE20151786A1 (pt)
PH (2) PH12015501998B1 (pt)
PL (2) PL2968173T3 (pt)
PT (2) PT2968173T (pt)
RS (2) RS59536B1 (pt)
RU (1) RU2663663C2 (pt)
SA (1) SA515361088B1 (pt)
SG (2) SG10201706656RA (pt)
SI (2) SI2968173T1 (pt)
TN (1) TN2015000380A1 (pt)
TW (1) TWI667026B (pt)
UA (1) UA117011C2 (pt)
UY (1) UY35449A (pt)
WO (2) WO2014152270A1 (pt)

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US11608318B2 (en) * 2018-07-12 2023-03-21 Assia Chemical Industries Ltd. Solid state forms of Omecamtiv mecarbil and Omecamtiv mecarbil diHCl
EP3837009A1 (en) 2018-08-17 2021-06-23 Amgen, Inc Salts and crystal forms of omecamtiv mecarbil
US20220185790A1 (en) * 2019-03-12 2022-06-16 Amgen Inc. Polymorphs and cocrystals of a cardiac troponin activator
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WO2021053189A1 (en) 2019-09-19 2021-03-25 Synthon B.V. Salts of omecamtiv mecarbil and solid forms thereof
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WO2021070123A1 (en) * 2019-10-09 2021-04-15 Dr. Reddy’S Laboratories Limited Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof
US20230090391A1 (en) * 2020-02-10 2023-03-23 Amgen Inc. Omecamtiv mecarbil tablet
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JP2020526483A (ja) 2017-06-30 2020-08-31 アムジエン・インコーポレーテツド 心筋節活性化剤で心不全を治療する方法
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TW202233189A (zh) 2020-11-12 2022-09-01 美商安進公司 藉由投與奧美卡替莫卡必爾治療心臟衰竭之方法
WO2022177927A1 (en) 2021-02-16 2022-08-25 Assia Chemical Industries Ltd Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
BR112023018095A2 (pt) 2021-03-10 2023-12-12 Amgen Inc Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo

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CA2902646C (en) 2022-08-16
JP2022023891A (ja) 2022-02-08
TW201524507A (zh) 2015-07-01
US20200277261A1 (en) 2020-09-03
US20230044617A1 (en) 2023-02-09
JP6689942B2 (ja) 2020-04-28
AU2014239995A1 (en) 2015-09-10
AR095542A1 (es) 2015-10-21
MX2021001231A (es) 2021-04-12
US20140309235A1 (en) 2014-10-16
US20200331859A1 (en) 2020-10-22
WO2014152236A1 (en) 2014-09-25
CA2902646A1 (en) 2014-09-25
BR112015022857B1 (pt) 2022-10-25
AP2015008789A0 (en) 2015-10-31
SI2970123T1 (sl) 2019-12-31
MX2015012414A (es) 2016-04-25
MY186048A (en) 2021-06-17
DK2968173T3 (da) 2020-12-21
SI2968173T1 (sl) 2021-04-30
EA031185B1 (ru) 2018-11-30
CN108785265A (zh) 2018-11-13
EA201591728A1 (ru) 2016-01-29
US11384053B2 (en) 2022-07-12
EP2970123A1 (en) 2016-01-20
SA515361088B1 (ar) 2018-07-22
SG11201507258PA (en) 2015-10-29
HK1218080A1 (zh) 2017-02-03
KR20220045014A (ko) 2022-04-12
TWI667026B (zh) 2019-08-01
PH12015501998A1 (en) 2016-01-11
PT2968173T (pt) 2020-12-18
PT2970123T (pt) 2019-10-28
PL2968173T3 (pl) 2021-03-08
HUE046285T2 (hu) 2020-02-28
UA117011C2 (uk) 2018-06-11
KR102374159B1 (ko) 2022-03-15
RU2015143643A (ru) 2017-04-18
HRP20191728T1 (hr) 2019-12-13
RS61215B1 (sr) 2021-01-29
NZ750950A (en) 2020-09-25
JOP20140114B1 (ar) 2021-08-17
EP2970123B1 (en) 2019-08-14
JP6966590B2 (ja) 2021-11-17
PL2970123T3 (pl) 2020-03-31
ME03566B (me) 2020-07-20
MA38399A1 (fr) 2017-01-31
US20200399221A1 (en) 2020-12-24
TN2015000380A1 (en) 2017-01-03
US20200079736A1 (en) 2020-03-12
ES2837038T3 (es) 2021-06-29
EP2968173B1 (en) 2020-10-14
CN105120844A (zh) 2015-12-02
BR112015022857A2 (pt) 2017-07-18
NZ711225A (en) 2020-06-26
CA3147180C (en) 2024-04-23
AU2014240049A1 (en) 2015-09-10
HK1219484A1 (zh) 2017-04-07
US20220298114A1 (en) 2022-09-22
MA44637B1 (fr) 2021-04-30
MX363347B (es) 2019-03-20
EP3821882A1 (en) 2021-05-19
SG10201706656RA (en) 2017-09-28
CA3147180A1 (en) 2014-09-25
HK1218544A1 (zh) 2017-02-24
HUE052355T2 (hu) 2021-04-28
HK1218512A1 (zh) 2017-02-24
RU2663663C2 (ru) 2018-08-08
KR102474467B1 (ko) 2022-12-05
MX2015012429A (es) 2016-04-07
JP6498658B2 (ja) 2019-04-10
JP2016519071A (ja) 2016-06-30
IL240788B (en) 2020-09-30
CY1123633T1 (el) 2022-03-24
MA44637A1 (fr) 2019-08-30
US20180273479A1 (en) 2018-09-27
AU2014239995B2 (en) 2018-07-26
CY1122695T1 (el) 2021-03-12
IL241089B (en) 2019-10-31
US11472773B2 (en) 2022-10-18
CA2902436A1 (en) 2014-09-25
UY35449A (es) 2014-09-30
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AU2014240049C1 (en) 2019-03-07
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CN105209437B (zh) 2018-09-18
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WO2014152270A1 (en) 2014-09-25
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US20160016906A1 (en) 2016-01-21
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US20240217933A1 (en) 2024-07-04
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US20240317687A1 (en) 2024-09-26
IL240788A0 (en) 2015-10-29
BR112015023417B1 (pt) 2023-10-17
JP2020125307A (ja) 2020-08-20
CN105209437A (zh) 2015-12-30
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