BR112014032037A2 - formulações para a preparação de comprimidos de liberação imediata para uso oral contendo uma baixa dosagem de mifepristona para o tratamento de endometriose, comprimidos desse modo obtidos e seu processo de preparação - Google Patents

formulações para a preparação de comprimidos de liberação imediata para uso oral contendo uma baixa dosagem de mifepristona para o tratamento de endometriose, comprimidos desse modo obtidos e seu processo de preparação

Info

Publication number
BR112014032037A2
BR112014032037A2 BR112014032037A BR112014032037A BR112014032037A2 BR 112014032037 A2 BR112014032037 A2 BR 112014032037A2 BR 112014032037 A BR112014032037 A BR 112014032037A BR 112014032037 A BR112014032037 A BR 112014032037A BR 112014032037 A2 BR112014032037 A2 BR 112014032037A2
Authority
BR
Brazil
Prior art keywords
preparation
mifepristone
endometriosis
formulations
treatment
Prior art date
Application number
BR112014032037A
Other languages
English (en)
Inventor
Valducci Roberto
Avanessian Serozh
Original Assignee
Valpharma Int S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valpharma Int S P A filed Critical Valpharma Int S P A
Publication of BR112014032037A2 publication Critical patent/BR112014032037A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Inorganic Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ÿþr
BR112014032037A 2012-06-21 2013-06-21 formulações para a preparação de comprimidos de liberação imediata para uso oral contendo uma baixa dosagem de mifepristona para o tratamento de endometriose, comprimidos desse modo obtidos e seu processo de preparação BR112014032037A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000128A ITFI20120128A1 (it) 2012-06-21 2012-06-21 Formulazioni per la preparazione di compresse per uso orale a rilascio immediato contenenti mifepristone a basso dosaggio per il trattamento di endometriosi, compresse così ottenute e loro processo di preparazione.
PCT/EP2013/063011 WO2013190098A1 (en) 2012-06-21 2013-06-21 Formulations for the preparation of immediate-release tablets for oral use containing low-dose mifepristone for the treatment of endometriosis, tablets thus obtained and their preparation process

Publications (1)

Publication Number Publication Date
BR112014032037A2 true BR112014032037A2 (pt) 2017-06-27

Family

ID=46690573

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014032037A BR112014032037A2 (pt) 2012-06-21 2013-06-21 formulações para a preparação de comprimidos de liberação imediata para uso oral contendo uma baixa dosagem de mifepristona para o tratamento de endometriose, comprimidos desse modo obtidos e seu processo de preparação

Country Status (11)

Country Link
US (1) US20150164917A1 (pt)
EP (1) EP2863899B8 (pt)
JP (1) JP2015520207A (pt)
KR (1) KR20150036005A (pt)
CN (1) CN104540497A (pt)
BR (1) BR112014032037A2 (pt)
CA (1) CA2876939A1 (pt)
IT (1) ITFI20120128A1 (pt)
RU (1) RU2015101725A (pt)
WO (1) WO2013190098A1 (pt)
ZA (1) ZA201500410B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12083227B2 (en) * 2017-08-18 2024-09-10 Abbvie Inc. Solid pharmaceutical formulations for treating endometriosis, uterine fibroids, polycystic ovary syndrome or adenomyosis
EA202090461A1 (ru) 2017-08-18 2020-06-29 Эббви Инк. Фармацевтические препараты для лечения эндометриоза, миомы матки, синдрома поликистоза яичников или аденомиоза
EP4406539A1 (en) * 2023-01-24 2024-07-31 Laboratorios Litaphar, S.L. Low-dose mifepristone for the treatment of endometriosis associated pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1255107C (zh) * 2002-09-05 2006-05-10 上海医药工业研究院 米非司酮半固体骨架制剂的组合物
EP1987814A1 (en) * 2007-04-30 2008-11-05 Exelgyn Mifepristone pharmaceutical compositions and their methods of preparation
CN101455671A (zh) * 2009-01-08 2009-06-17 湖北葛店人福药业有限责任公司 米非司酮药物制剂和制备方法
EP2210585A1 (en) * 2009-01-16 2010-07-28 Exelgyn SPRM pharmaceutical compositions methods of treatment using them

Also Published As

Publication number Publication date
EP2863899A1 (en) 2015-04-29
RU2015101725A (ru) 2016-08-10
WO2013190098A1 (en) 2013-12-27
EP2863899B1 (en) 2016-11-02
ITFI20120128A1 (it) 2013-12-22
JP2015520207A (ja) 2015-07-16
KR20150036005A (ko) 2015-04-07
CA2876939A1 (en) 2013-12-27
US20150164917A1 (en) 2015-06-18
ZA201500410B (en) 2016-01-27
CN104540497A (zh) 2015-04-22
EP2863899B8 (en) 2017-05-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]