BR112014010574A2 - formas cristalinas e não cristalinas de inibidores sglt2 - Google Patents

formas cristalinas e não cristalinas de inibidores sglt2

Info

Publication number
BR112014010574A2
BR112014010574A2 BR112014010574A BR112014010574A BR112014010574A2 BR 112014010574 A2 BR112014010574 A2 BR 112014010574A2 BR 112014010574 A BR112014010574 A BR 112014010574A BR 112014010574 A BR112014010574 A BR 112014010574A BR 112014010574 A2 BR112014010574 A2 BR 112014010574A2
Authority
BR
Brazil
Prior art keywords
crystalline
forms
sglt2 inhibitors
crystalline forms
sglt2
Prior art date
Application number
BR112014010574A
Other languages
English (en)
Inventor
P Henschke Julian
Ho Meng-Fen
Chen Shu-Ping
Chen Yung-Fa
Original Assignee
Scinopharm Taiwan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scinopharm Taiwan Ltd filed Critical Scinopharm Taiwan Ltd
Publication of BR112014010574A2 publication Critical patent/BR112014010574A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

resumo formas cristalinas e não cristalinas de inibidores sglt2 a presente invenção fornece formas amorfas e complexos cristalinos de inibidores sglt2 como um material novo, em particular, em forma farmaceuticamente aceitável. as formas cristalinas do inibidor sglt2 canagliflozin são designadas como formas cs1, cs2, cs3, cs4 e cs5.
BR112014010574A 2011-10-31 2012-10-30 formas cristalinas e não cristalinas de inibidores sglt2 BR112014010574A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161553776P 2011-10-31 2011-10-31
PCT/IB2012/002852 WO2013064909A2 (en) 2011-10-31 2012-10-30 Crystalline and non-crystalline forms of sglt2 inhibitors

Publications (1)

Publication Number Publication Date
BR112014010574A2 true BR112014010574A2 (pt) 2017-05-02

Family

ID=48192943

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014010574A BR112014010574A2 (pt) 2011-10-31 2012-10-30 formas cristalinas e não cristalinas de inibidores sglt2

Country Status (12)

Country Link
US (1) US8999941B2 (pt)
EP (1) EP2773359A4 (pt)
JP (1) JP2014532639A (pt)
KR (1) KR20140097258A (pt)
CN (1) CN103889429B (pt)
AU (1) AU2012330818B2 (pt)
BR (1) BR112014010574A2 (pt)
CA (1) CA2852000A1 (pt)
IL (1) IL231946A0 (pt)
IN (1) IN2014DN03237A (pt)
TW (1) TWI495472B (pt)
WO (1) WO2013064909A2 (pt)

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Also Published As

Publication number Publication date
CN103889429A (zh) 2014-06-25
JP2014532639A (ja) 2014-12-08
KR20140097258A (ko) 2014-08-06
CA2852000A1 (en) 2013-05-10
TW201328698A (zh) 2013-07-16
CN103889429B (zh) 2016-10-19
AU2012330818A1 (en) 2014-04-24
EP2773359A4 (en) 2015-10-21
WO2013064909A2 (en) 2013-05-10
IL231946A0 (en) 2014-05-28
IN2014DN03237A (pt) 2015-05-22
US20130237487A1 (en) 2013-09-12
WO2013064909A3 (en) 2013-08-22
AU2012330818B2 (en) 2015-09-17
TWI495472B (zh) 2015-08-11
EP2773359A2 (en) 2014-09-10
US8999941B2 (en) 2015-04-07

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