BR0312560A - Novas espiropiperidinas ou espiropirrolidinas tricìclicas - Google Patents

Novas espiropiperidinas ou espiropirrolidinas tricìclicas

Info

Publication number
BR0312560A
BR0312560A BR0312560-2A BR0312560A BR0312560A BR 0312560 A BR0312560 A BR 0312560A BR 0312560 A BR0312560 A BR 0312560A BR 0312560 A BR0312560 A BR 0312560A
Authority
BR
Brazil
Prior art keywords
spiropyrrolidines
spiropiperidines
new tricyclic
tricyclic
new
Prior art date
Application number
BR0312560-2A
Other languages
English (en)
Inventor
Nafizal Hossain
Svetlana Ivanova
Marguerite Mensonides-Harsema
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0312560A publication Critical patent/BR0312560A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

"NOVAS ESPIROPIPERIDINAS OU ESPIROPIRROLIDINAS TRICìCLICAS". A invenção provê composto de fórmula (I) em que m, R^ 1^, n, R^ 2^, q, X, Y, Z, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, t e R^ 9^ são como definidos no relatório descritivo, a processos para sua preparação, a composições farmacêuticas os contendo e a seu uso em terapia.
BR0312560-2A 2002-07-08 2003-07-07 Novas espiropiperidinas ou espiropirrolidinas tricìclicas BR0312560A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0202133A SE0202133D0 (sv) 2002-07-08 2002-07-08 Novel compounds
PCT/SE2003/001185 WO2004005295A1 (en) 2002-07-08 2003-07-07 Novel tricyclic spiropiperidines or spiropyrrolidines

Publications (1)

Publication Number Publication Date
BR0312560A true BR0312560A (pt) 2005-05-10

Family

ID=20288470

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312560-2A BR0312560A (pt) 2002-07-08 2003-07-07 Novas espiropiperidinas ou espiropirrolidinas tricìclicas

Country Status (26)

Country Link
US (2) US7449475B2 (pt)
EP (1) EP1521757B1 (pt)
JP (1) JP2005537255A (pt)
CN (2) CN1974574A (pt)
AR (1) AR040475A1 (pt)
AT (1) ATE385235T1 (pt)
AU (1) AU2003243122B2 (pt)
BR (1) BR0312560A (pt)
CA (1) CA2492122A1 (pt)
CY (1) CY1107915T1 (pt)
DE (1) DE60318948T2 (pt)
DK (1) DK1521757T3 (pt)
ES (1) ES2298575T3 (pt)
HK (1) HK1074622A1 (pt)
IS (1) IS7662A (pt)
MX (1) MXPA05000278A (pt)
NO (1) NO20050635L (pt)
NZ (1) NZ537259A (pt)
PL (1) PL374877A1 (pt)
PT (1) PT1521757E (pt)
RU (1) RU2320664C2 (pt)
SE (1) SE0202133D0 (pt)
TW (1) TW200413386A (pt)
UA (1) UA77809C2 (pt)
WO (1) WO2004005295A1 (pt)
ZA (1) ZA200500024B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
US7732442B2 (en) 2003-09-05 2010-06-08 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonist and medical use thereof
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
US20070021498A1 (en) * 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0302811D0 (sv) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) * 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303280D0 (sv) * 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) * 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
AU2005267289A1 (en) 2004-06-24 2006-02-02 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
RU2458919C2 (ru) 2005-04-13 2012-08-20 Астекс Терапьютикс Лимитед ПРОИЗВОДНЫЕ ГИДРОКСИБЕНЗАМИДА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Hsp90
EP1943250A1 (en) 2005-09-09 2008-07-16 Euro-Celtique S.A. Fused and spirocycle compounds and the use thereof
JP5315590B2 (ja) * 2006-02-14 2013-10-16 Jnc株式会社 液晶化合物、液晶組成物および液晶表示素子
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
AU2007275931B2 (en) * 2006-07-19 2011-06-16 Astrazeneca Ab Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity
US8277807B2 (en) 2006-10-12 2012-10-02 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
EP2073804B1 (en) 2006-10-12 2017-09-13 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain
WO2008044027A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
ES2627221T3 (es) 2006-12-28 2017-07-27 Rigel Pharmaceuticals, Inc. Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
WO2008103126A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2008103125A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2008121066A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors
UY31162A1 (es) * 2007-06-20 2008-11-28 Glaxo Group Ltd Espiroindolinas como moduladores de receptores de quimioquinas
WO2009011655A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Splropiperidine compounds, a process of their preparation, pharmaceutical compositions containing them, and their use in the treatment of airway diseases, inflammatory diseases, copd or asthma
WO2009011654A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Process for the preparation of cyclic spiropiperidines
US8536198B2 (en) * 2007-07-24 2013-09-17 Bristol-Myers Squibb Company Piperidine derivatives as modulators of chemokine receptor activity
WO2009023754A1 (en) * 2007-08-14 2009-02-19 Glaxo Group Limited Spiroindenes and spiroindanes as modulators of chemokine receptors
WO2009061881A1 (en) * 2007-11-07 2009-05-14 Glaxo Group Limited Spirodihydrobenzofurans as modulators of chemokine receptors
ES2390004T3 (es) * 2008-01-30 2012-11-05 Cephalon, Inc. Derivados sustituidos de piperidina espirocíclica como ligandos del receptor de la histamina 3(H3)
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
EP2145891A1 (en) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
AR078948A1 (es) * 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
WO2019034697A1 (en) 2017-08-15 2019-02-21 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010201A (en) 1974-04-12 1977-03-01 The Upjohn Company Organic compounds
US4166120A (en) 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166119A (en) 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4263317A (en) 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US5366986A (en) 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
DE3930262A1 (de) 1989-09-11 1991-03-21 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
HUT72076A (en) * 1992-12-11 1996-03-28 Merck & Co Inc Process for preparing spiro piperidines and homologs which promote release of growth hormone and pharmaceutical compositions containing them
ES2119174T3 (es) * 1993-01-28 1998-10-01 Merck & Co Inc Azaciclos espiro-sustituidos como antagonistas de los receptores de las taquiquininas.
WO1995028397A1 (en) * 1994-04-14 1995-10-26 Merck & Co., Inc. Alpha1c adrenergic receptor antagonists
US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
CA2221357A1 (en) 1995-05-18 1996-11-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenyl dihydrobenzofuranes
US5931917A (en) * 1996-09-26 1999-08-03 Verifone, Inc. System, method and article of manufacture for a gateway system architecture with system administration information accessible from a browser
AU5803398A (en) * 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US5962462A (en) 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
EP1003743A4 (en) 1997-01-21 2001-04-11 Merck & Co Inc 3,3-DISBSTITUED PIPERIDINE LIKE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
EP1061076B1 (en) 1998-02-04 2004-12-08 Banyu Pharmaceutical Co., Ltd. N-acyl cyclic amine derivatives
US6151675A (en) * 1998-07-23 2000-11-21 Tumbleweed Software Corporation Method and apparatus for effecting secure document format conversion
US6288083B1 (en) * 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6212640B1 (en) * 1999-03-25 2001-04-03 Sun Microsystems, Inc. Resources sharing on the internet via the HTTP
US6226752B1 (en) * 1999-05-11 2001-05-01 Sun Microsystems, Inc. Method and apparatus for authenticating users
JP2003514777A (ja) 1999-10-27 2003-04-22 シーオーアール セラピューティクス インコーポレイテッド フィブリノゲン依存性血小板凝集の阻害剤としてのピリジル含有スピロ環化合物
WO2001064213A1 (en) 2000-03-02 2001-09-07 Smithkline Beecham Corporation Compounds and methods
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
US7017175B2 (en) * 2001-02-02 2006-03-21 Opentv, Inc. Digital television application protocol for interactive television
WO2002102387A1 (en) 2001-06-18 2002-12-27 H. Lundbeck A/S Treatment of neuropathic pain
AU2002363236A1 (en) 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
JP2006511500A (ja) 2002-10-30 2006-04-06 メルク エンド カムパニー インコーポレーテッド γ−アミノアミド系のケモカイン受容体活性調節剤
EP2431357A3 (en) 2002-11-27 2012-08-22 Incyte Corporation 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors
WO2004051453A1 (en) * 2002-12-04 2004-06-17 Entriq Inc. Multiple content provider user interface
US7966418B2 (en) * 2003-02-21 2011-06-21 Axeda Corporation Establishing a virtual tunnel between two computer programs
SE0302755D0 (sv) 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
US20070021498A1 (en) 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0302811D0 (sv) 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303280D0 (sv) 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
CA2563164A1 (en) 2004-03-29 2005-10-06 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists

Also Published As

Publication number Publication date
TW200413386A (en) 2004-08-01
RU2320664C2 (ru) 2008-03-27
PL374877A1 (en) 2005-11-14
CN1675218A (zh) 2005-09-28
US20090062322A1 (en) 2009-03-05
PT1521757E (pt) 2008-04-03
CN1326858C (zh) 2007-07-18
DE60318948T2 (de) 2009-05-20
AU2003243122B2 (en) 2006-09-28
UA77809C2 (en) 2007-01-15
AR040475A1 (es) 2005-04-06
DE60318948D1 (de) 2008-03-20
IS7662A (is) 2005-01-24
NZ537259A (en) 2006-08-31
DK1521757T3 (da) 2008-05-05
US20050245741A1 (en) 2005-11-03
SE0202133D0 (sv) 2002-07-08
AU2003243122A1 (en) 2004-01-23
MXPA05000278A (es) 2005-03-31
WO2004005295A1 (en) 2004-01-15
HK1074622A1 (en) 2005-11-18
CA2492122A1 (en) 2004-01-15
ATE385235T1 (de) 2008-02-15
US7449475B2 (en) 2008-11-11
CN1974574A (zh) 2007-06-06
EP1521757A1 (en) 2005-04-13
CY1107915T1 (el) 2013-09-04
ES2298575T3 (es) 2008-05-16
EP1521757B1 (en) 2008-01-30
JP2005537255A (ja) 2005-12-08
RU2004137278A (ru) 2005-09-10
NO20050635L (no) 2005-03-31
ZA200500024B (en) 2006-02-22

Similar Documents

Publication Publication Date Title
BR0312560A (pt) Novas espiropiperidinas ou espiropirrolidinas tricìclicas
BR0111667A (pt) Novos compostos
BR0108678A (pt) Novos compostos
SE0104140D0 (sv) Novel Compounds
BRPI0413094A (pt) derivados de quinolina e seu uso em terapia
BRPI0415613A (pt) novos compostos de diazaspiroalcanos e seu uso no tratamento de doenças mediadas por ccr8
SE9904505D0 (sv) Novel compounds
SE0301700D0 (sv) Novel compounds
UY27604A1 (es) Compuestos químicos.
BR0310077A (pt) Novos compostos e sua utilização
ATE365740T1 (de) Substituierte pyrazolopyrimidine
BR0016396A (pt) Novos antagonistas do receptor p2x7 para uso no tratamento de doenças inflamatórias, imunes ou cardiovasculares
UY27571A1 (es) 2-tio-3, 5-diciano-4-fenil-6-aminopiridinas sustituidas y su uso
SE0202539D0 (sv) Compounds
ATE332301T1 (de) Antivirale pyrazolopyridin verbindungen
SE0303541D0 (sv) New compounds
BRPI0414948A (pt) derivados de pirazolo-e-imidazo pirimidina
SE9902765D0 (sv) Novel compounds
DE60301339D1 (de) Pyrazolopyrimidin- und pyrazolotriazinderivate und diese enthaltende pharmazeutische zubereitungen
SE0101038D0 (sv) Novel compounds
SE0102716D0 (sv) Novel compounds
BRPI0416745A (pt) novos compostos
BR0111669A (pt) Novos compostos
BRPI0512986A (pt) novos derivados de hidantoìna
SE9902551D0 (sv) Novel compounds

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 8A ANUIDADE.