BR0312560A - Novas espiropiperidinas ou espiropirrolidinas tricìclicas - Google Patents
Novas espiropiperidinas ou espiropirrolidinas tricìclicasInfo
- Publication number
- BR0312560A BR0312560A BR0312560-2A BR0312560A BR0312560A BR 0312560 A BR0312560 A BR 0312560A BR 0312560 A BR0312560 A BR 0312560A BR 0312560 A BR0312560 A BR 0312560A
- Authority
- BR
- Brazil
- Prior art keywords
- spiropyrrolidines
- spiropiperidines
- new tricyclic
- tricyclic
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
"NOVAS ESPIROPIPERIDINAS OU ESPIROPIRROLIDINAS TRICìCLICAS". A invenção provê composto de fórmula (I) em que m, R^ 1^, n, R^ 2^, q, X, Y, Z, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, t e R^ 9^ são como definidos no relatório descritivo, a processos para sua preparação, a composições farmacêuticas os contendo e a seu uso em terapia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0202133A SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Novel compounds |
PCT/SE2003/001185 WO2004005295A1 (en) | 2002-07-08 | 2003-07-07 | Novel tricyclic spiropiperidines or spiropyrrolidines |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312560A true BR0312560A (pt) | 2005-05-10 |
Family
ID=20288470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0312560-2A BR0312560A (pt) | 2002-07-08 | 2003-07-07 | Novas espiropiperidinas ou espiropirrolidinas tricìclicas |
Country Status (26)
Country | Link |
---|---|
US (2) | US7449475B2 (pt) |
EP (1) | EP1521757B1 (pt) |
JP (1) | JP2005537255A (pt) |
CN (2) | CN1974574A (pt) |
AR (1) | AR040475A1 (pt) |
AT (1) | ATE385235T1 (pt) |
AU (1) | AU2003243122B2 (pt) |
BR (1) | BR0312560A (pt) |
CA (1) | CA2492122A1 (pt) |
CY (1) | CY1107915T1 (pt) |
DE (1) | DE60318948T2 (pt) |
DK (1) | DK1521757T3 (pt) |
ES (1) | ES2298575T3 (pt) |
HK (1) | HK1074622A1 (pt) |
IS (1) | IS7662A (pt) |
MX (1) | MXPA05000278A (pt) |
NO (1) | NO20050635L (pt) |
NZ (1) | NZ537259A (pt) |
PL (1) | PL374877A1 (pt) |
PT (1) | PT1521757E (pt) |
RU (1) | RU2320664C2 (pt) |
SE (1) | SE0202133D0 (pt) |
TW (1) | TW200413386A (pt) |
UA (1) | UA77809C2 (pt) |
WO (1) | WO2004005295A1 (pt) |
ZA (1) | ZA200500024B (pt) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
US7732442B2 (en) | 2003-09-05 | 2010-06-08 | Ono Pharmaceutical Co., Ltd. | Chemokine receptor antagonist and medical use thereof |
SE0302755D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel compounds |
US20070021498A1 (en) * | 2004-10-14 | 2007-01-25 | Nafizal Hossain | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity |
SE0302811D0 (sv) * | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
SE0303090D0 (sv) * | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
SE0303280D0 (sv) * | 2003-12-05 | 2003-12-05 | Astrazeneca Ab | Novel compounds |
SE0303541D0 (sv) * | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
AU2005267289A1 (en) | 2004-06-24 | 2006-02-02 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
RU2458919C2 (ru) | 2005-04-13 | 2012-08-20 | Астекс Терапьютикс Лимитед | ПРОИЗВОДНЫЕ ГИДРОКСИБЕНЗАМИДА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Hsp90 |
EP1943250A1 (en) | 2005-09-09 | 2008-07-16 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
JP5315590B2 (ja) * | 2006-02-14 | 2013-10-16 | Jnc株式会社 | 液晶化合物、液晶組成物および液晶表示素子 |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
AU2007275931B2 (en) * | 2006-07-19 | 2011-06-16 | Astrazeneca Ab | Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity |
US8277807B2 (en) | 2006-10-12 | 2012-10-02 | Astex Therapeutics Limited | Pharmaceutical combinations |
US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
EP2073804B1 (en) | 2006-10-12 | 2017-09-13 | Astex Therapeutics Limited | Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain |
WO2008044027A2 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical compounds having hsp90 inhibitory or modulating activity |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
ES2627221T3 (es) | 2006-12-28 | 2017-07-27 | Rigel Pharmaceuticals, Inc. | Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso |
WO2008103126A1 (en) * | 2007-02-23 | 2008-08-28 | Astrazeneca Ab | Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma |
WO2008103125A1 (en) * | 2007-02-23 | 2008-08-28 | Astrazeneca Ab | Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma |
WO2008121066A1 (en) * | 2007-03-30 | 2008-10-09 | Astrazeneca Ab | Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors |
UY31162A1 (es) * | 2007-06-20 | 2008-11-28 | Glaxo Group Ltd | Espiroindolinas como moduladores de receptores de quimioquinas |
WO2009011655A1 (en) * | 2007-07-17 | 2009-01-22 | Astrazeneca Ab | Splropiperidine compounds, a process of their preparation, pharmaceutical compositions containing them, and their use in the treatment of airway diseases, inflammatory diseases, copd or asthma |
WO2009011654A1 (en) * | 2007-07-17 | 2009-01-22 | Astrazeneca Ab | Process for the preparation of cyclic spiropiperidines |
US8536198B2 (en) * | 2007-07-24 | 2013-09-17 | Bristol-Myers Squibb Company | Piperidine derivatives as modulators of chemokine receptor activity |
WO2009023754A1 (en) * | 2007-08-14 | 2009-02-19 | Glaxo Group Limited | Spiroindenes and spiroindanes as modulators of chemokine receptors |
WO2009061881A1 (en) * | 2007-11-07 | 2009-05-14 | Glaxo Group Limited | Spirodihydrobenzofurans as modulators of chemokine receptors |
ES2390004T3 (es) * | 2008-01-30 | 2012-11-05 | Cephalon, Inc. | Derivados sustituidos de piperidina espirocíclica como ligandos del receptor de la histamina 3(H3) |
FR2928150A1 (fr) | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
EP2145891A1 (en) | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials |
AR078948A1 (es) * | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
WO2019034697A1 (en) | 2017-08-15 | 2019-02-21 | Inflazome Limited | NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS |
Family Cites Families (38)
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US4010201A (en) | 1974-04-12 | 1977-03-01 | The Upjohn Company | Organic compounds |
US4166120A (en) | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines |
US4166119A (en) | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines |
US4263317A (en) | 1979-09-06 | 1981-04-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s |
US5366986A (en) | 1988-04-15 | 1994-11-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
DE3930262A1 (de) | 1989-09-11 | 1991-03-21 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
HUT72076A (en) * | 1992-12-11 | 1996-03-28 | Merck & Co Inc | Process for preparing spiro piperidines and homologs which promote release of growth hormone and pharmaceutical compositions containing them |
ES2119174T3 (es) * | 1993-01-28 | 1998-10-01 | Merck & Co Inc | Azaciclos espiro-sustituidos como antagonistas de los receptores de las taquiquininas. |
WO1995028397A1 (en) * | 1994-04-14 | 1995-10-26 | Merck & Co., Inc. | Alpha1c adrenergic receptor antagonists |
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CA2221357A1 (en) | 1995-05-18 | 1996-11-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenyl dihydrobenzofuranes |
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AU5803398A (en) * | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
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EP1003743A4 (en) | 1997-01-21 | 2001-04-11 | Merck & Co Inc | 3,3-DISBSTITUED PIPERIDINE LIKE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
EP1061076B1 (en) | 1998-02-04 | 2004-12-08 | Banyu Pharmaceutical Co., Ltd. | N-acyl cyclic amine derivatives |
US6151675A (en) * | 1998-07-23 | 2000-11-21 | Tumbleweed Software Corporation | Method and apparatus for effecting secure document format conversion |
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WO2001064213A1 (en) | 2000-03-02 | 2001-09-07 | Smithkline Beecham Corporation | Compounds and methods |
AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
US7017175B2 (en) * | 2001-02-02 | 2006-03-21 | Opentv, Inc. | Digital television application protocol for interactive television |
WO2002102387A1 (en) | 2001-06-18 | 2002-12-27 | H. Lundbeck A/S | Treatment of neuropathic pain |
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SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
JP2006511500A (ja) | 2002-10-30 | 2006-04-06 | メルク エンド カムパニー インコーポレーテッド | γ−アミノアミド系のケモカイン受容体活性調節剤 |
EP2431357A3 (en) | 2002-11-27 | 2012-08-22 | Incyte Corporation | 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors |
WO2004051453A1 (en) * | 2002-12-04 | 2004-06-17 | Entriq Inc. | Multiple content provider user interface |
US7966418B2 (en) * | 2003-02-21 | 2011-06-21 | Axeda Corporation | Establishing a virtual tunnel between two computer programs |
SE0302755D0 (sv) | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel compounds |
US20070021498A1 (en) | 2004-10-14 | 2007-01-25 | Nafizal Hossain | Novel tricyclic spiroderivatives as modulators of chemokine receptor activity |
SE0302811D0 (sv) | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
SE0303090D0 (sv) | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
SE0303280D0 (sv) | 2003-12-05 | 2003-12-05 | Astrazeneca Ab | Novel compounds |
SE0303541D0 (sv) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
CA2563164A1 (en) | 2004-03-29 | 2005-10-06 | Pfizer Inc. | Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists |
-
2002
- 2002-07-08 SE SE0202133A patent/SE0202133D0/xx unknown
-
2003
- 2003-07-03 TW TW092118200A patent/TW200413386A/zh unknown
- 2003-07-07 CN CNA2006101435561A patent/CN1974574A/zh active Pending
- 2003-07-07 JP JP2004519472A patent/JP2005537255A/ja active Pending
- 2003-07-07 EP EP03762957A patent/EP1521757B1/en not_active Expired - Lifetime
- 2003-07-07 PT PT03762957T patent/PT1521757E/pt unknown
- 2003-07-07 DK DK03762957T patent/DK1521757T3/da active
- 2003-07-07 PL PL03374877A patent/PL374877A1/xx not_active Application Discontinuation
- 2003-07-07 MX MXPA05000278A patent/MXPA05000278A/es active IP Right Grant
- 2003-07-07 US US10/520,699 patent/US7449475B2/en not_active Expired - Fee Related
- 2003-07-07 BR BR0312560-2A patent/BR0312560A/pt not_active IP Right Cessation
- 2003-07-07 DE DE60318948T patent/DE60318948T2/de not_active Expired - Fee Related
- 2003-07-07 NZ NZ537259A patent/NZ537259A/en unknown
- 2003-07-07 AU AU2003243122A patent/AU2003243122B2/en not_active Ceased
- 2003-07-07 AT AT03762957T patent/ATE385235T1/de not_active IP Right Cessation
- 2003-07-07 CA CA002492122A patent/CA2492122A1/en not_active Abandoned
- 2003-07-07 RU RU2004137278/04A patent/RU2320664C2/ru not_active IP Right Cessation
- 2003-07-07 ES ES03762957T patent/ES2298575T3/es not_active Expired - Lifetime
- 2003-07-07 UA UA20041210166A patent/UA77809C2/uk unknown
- 2003-07-07 WO PCT/SE2003/001185 patent/WO2004005295A1/en active IP Right Grant
- 2003-07-07 CN CNB038191466A patent/CN1326858C/zh not_active Expired - Fee Related
- 2003-07-08 AR AR20030102463A patent/AR040475A1/es not_active Application Discontinuation
-
2005
- 2005-01-03 ZA ZA200500024A patent/ZA200500024B/xx unknown
- 2005-01-24 IS IS7662A patent/IS7662A/is unknown
- 2005-02-04 NO NO20050635A patent/NO20050635L/no not_active Application Discontinuation
- 2005-08-09 HK HK05106846A patent/HK1074622A1/xx not_active IP Right Cessation
-
2008
- 2008-04-03 CY CY20081100375T patent/CY1107915T1/el unknown
- 2008-11-05 US US12/265,251 patent/US20090062322A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200413386A (en) | 2004-08-01 |
RU2320664C2 (ru) | 2008-03-27 |
PL374877A1 (en) | 2005-11-14 |
CN1675218A (zh) | 2005-09-28 |
US20090062322A1 (en) | 2009-03-05 |
PT1521757E (pt) | 2008-04-03 |
CN1326858C (zh) | 2007-07-18 |
DE60318948T2 (de) | 2009-05-20 |
AU2003243122B2 (en) | 2006-09-28 |
UA77809C2 (en) | 2007-01-15 |
AR040475A1 (es) | 2005-04-06 |
DE60318948D1 (de) | 2008-03-20 |
IS7662A (is) | 2005-01-24 |
NZ537259A (en) | 2006-08-31 |
DK1521757T3 (da) | 2008-05-05 |
US20050245741A1 (en) | 2005-11-03 |
SE0202133D0 (sv) | 2002-07-08 |
AU2003243122A1 (en) | 2004-01-23 |
MXPA05000278A (es) | 2005-03-31 |
WO2004005295A1 (en) | 2004-01-15 |
HK1074622A1 (en) | 2005-11-18 |
CA2492122A1 (en) | 2004-01-15 |
ATE385235T1 (de) | 2008-02-15 |
US7449475B2 (en) | 2008-11-11 |
CN1974574A (zh) | 2007-06-06 |
EP1521757A1 (en) | 2005-04-13 |
CY1107915T1 (el) | 2013-09-04 |
ES2298575T3 (es) | 2008-05-16 |
EP1521757B1 (en) | 2008-01-30 |
JP2005537255A (ja) | 2005-12-08 |
RU2004137278A (ru) | 2005-09-10 |
NO20050635L (no) | 2005-03-31 |
ZA200500024B (en) | 2006-02-22 |
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