BR0214188A - Anticorpos monoclonais contra vìrus da hepatite e ou seus fragmentos com atividade de ligação e uso dos mesmos - Google Patents

Anticorpos monoclonais contra vìrus da hepatite e ou seus fragmentos com atividade de ligação e uso dos mesmos

Info

Publication number
BR0214188A
BR0214188A BR0214188-4A BR0214188A BR0214188A BR 0214188 A BR0214188 A BR 0214188A BR 0214188 A BR0214188 A BR 0214188A BR 0214188 A BR0214188 A BR 0214188A
Authority
BR
Brazil
Prior art keywords
hepatitis
virus
polypeptide
prophylaxis
virus infection
Prior art date
Application number
BR0214188-4A
Other languages
English (en)
Other versions
BRPI0214188B1 (pt
BRPI0214188B8 (pt
Inventor
Ningshao Xia
Jun Zhang
Ying Gu
Shaowei Li
Shengxiang Ge
Zhiqiang He
Original Assignee
Yang Sheng Tang Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4672637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0214188(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yang Sheng Tang Co Ltd filed Critical Yang Sheng Tang Co Ltd
Priority to BR122015016384A priority Critical patent/BR122015016384B8/pt
Publication of BR0214188A publication Critical patent/BR0214188A/pt
Publication of BRPI0214188B1 publication Critical patent/BRPI0214188B1/pt
Publication of BRPI0214188B8 publication Critical patent/BRPI0214188B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/28011—Hepeviridae
    • C12N2770/28111—Hepevirus, e.g. hepatitis E virus
    • C12N2770/28134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)

Abstract

"ANTICORPOS MONOCLONAIS CONTRA O VìRUS DA HEPATITE E OU SEUS FRAGMENTOS COM ATIVIDADE DE LIGAçãO E USO DOS MESMOS". A presente invenção refere-se ao anticorpo monoclonal especificamente ligado ao(s) polipeptídio(s) compreendendo a seq³ência de aminoácidos como representado na SEQ.ID.NO:1, da ORF2 do vírus da hepatite E ou suas variantes conservadas ou seus fragmentos ativos, ou outros anticorpos monoclonais contra a ORF2 que pode ter reação cruzada com o referido anticorpo monoclonal da presente invenção, e sua seq³ência de nucleotídeos ou sua seq³ência degradadas; para o determinante antigênico na ORF2 do vírus da hepatite E; para um método para classificação do polipeptídio isolado ou recombinado ou análogo do peptídeo, o qual tem a mesma propriedade de se ligar especificamente ao referido anticorpo monoclonal 8C11 e/ou 8H3 como o referido determinante antigênico 1) ou 3) da ORF2 do vírus da hepatite E; para polipeptídio ou análogo de peptídeo classificado pelo método acima e sua seq³ência de nucleotídeo ou sua seq³ência degenerada; para um uso do referido polipeptídio ou análogo de polipeptídio na preparação de um medicamento para o diagnóstico e/ou precaução da infecção do vírus da hepatite E; para um kit de diagnóstico para a infecção do vírus da hepatite E e uma composição de vacina para profilaxia da infecção do vírus da hepatite E; para usar os referidos anticorpos monoclonais ou seus fragmentos ativos ou variantes conservadas na preparação de um medicamento para diagnóstico, profilaxia e/ou tratamento da infecção do vírus da hepatite E; para composição farmacêutica para profilaxia e/ou tratamento da infecção do vírus da hepatite E e um método para profilaxia e/ou tratamento da infecção do vírus da hepatite E; para um vetor de expressão recombinante compreendendo a referida molécula de nucleotídeo na presente invenção e uma célula hospedeira transformada com o referido vetor de expressão recombinante que é capaz de expressar o anticorpo monoclonal e suas variantes conservadas ou fragmentos ativos ou polipeptídios ou análogos de polipeptídio.
BRPI0214188A 2001-11-08 2002-11-08 anticorpo ou fragmento do mesmo, molécula de ácido nucléico, uso do anticorpo monoclonal ou fragmento do mesmo, kit de diagnóstico, composição farmacêutica, vetor de expressão recombinante, célula hospedeira transformada com o vetor de expressão recombinante e método para detectar o antígeno do vírus da hepatite e ou o anticorpo contra o vírus da hepatite e em uma amostra BRPI0214188B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122015016384A BR122015016384B8 (pt) 2001-11-08 2002-11-08 polipeptídio recombinante ou isolado, molécula de ácido nucléico, kit de diagnóstico para detectar a infecção pelo vírus da hepatite e, composição de vacina, composição farmacêutica, vetor de expressão recombinante, célula hospedeira transformada e uso do polipeptídeo recombinante ou isolado

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN01134643 2001-11-08
PCT/CN2002/000797 WO2003040187A1 (fr) 2001-11-08 2002-11-08 Anticorps monoclonaux du virus de l'hepatite e ou fragments liants en provenant et utilisation correspondante

Publications (3)

Publication Number Publication Date
BR0214188A true BR0214188A (pt) 2004-09-14
BRPI0214188B1 BRPI0214188B1 (pt) 2016-08-02
BRPI0214188B8 BRPI0214188B8 (pt) 2021-05-25

Family

ID=4672637

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0214188A BRPI0214188B8 (pt) 2001-11-08 2002-11-08 anticorpo ou fragmento do mesmo, molécula de ácido nucléico, uso do anticorpo monoclonal ou fragmento do mesmo, kit de diagnóstico, composição farmacêutica, vetor de expressão recombinante, célula hospedeira transformada com o vetor de expressão recombinante e método para detectar o antígeno do vírus da hepatite e ou o anticorpo contra o vírus da hepatite e em uma amostra
BR122015016384A BR122015016384B8 (pt) 2001-11-08 2002-11-08 polipeptídio recombinante ou isolado, molécula de ácido nucléico, kit de diagnóstico para detectar a infecção pelo vírus da hepatite e, composição de vacina, composição farmacêutica, vetor de expressão recombinante, célula hospedeira transformada e uso do polipeptídeo recombinante ou isolado

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122015016384A BR122015016384B8 (pt) 2001-11-08 2002-11-08 polipeptídio recombinante ou isolado, molécula de ácido nucléico, kit de diagnóstico para detectar a infecção pelo vírus da hepatite e, composição de vacina, composição farmacêutica, vetor de expressão recombinante, célula hospedeira transformada e uso do polipeptídeo recombinante ou isolado

Country Status (9)

Country Link
US (2) US7786264B2 (pt)
EP (2) EP1452541B2 (pt)
JP (3) JP2005524386A (pt)
KR (1) KR101020256B1 (pt)
CN (1) CN100339395C (pt)
AU (1) AU2002349727B2 (pt)
BR (2) BRPI0214188B8 (pt)
MX (1) MXPA04004321A (pt)
WO (1) WO2003040187A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101020256B1 (ko) 2001-11-08 2011-03-08 베이징 완타이 바이오로지컬 파마시 엔터프라이즈 코포레이션 리미티드 Ｅ형 간염 바이러스 단클론 항체 또는 그의 결합 단편, 및이들의 용도
CN1850855B (zh) * 2006-05-26 2012-08-29 厦门大学 用于免疫或制备单克隆抗体的方法和组合物
JP5033195B2 (ja) * 2006-12-14 2012-09-26 浙江我武生物科技股▲分▼有限公司 アレルゲンの効力を測定するための標準化血清混合物の調製方法およびその使用
AR070141A1 (es) * 2008-01-23 2010-03-17 Glenmark Pharmaceuticals Sa Anticuerpos humanizados especificos para el factor von willebrand
JP5297734B2 (ja) * 2008-09-17 2013-09-25 株式会社Ｎｂｃメッシュテック スギ花粉アレルゲンへの結合能を有するペプチド
US8362203B2 (en) * 2009-02-10 2013-01-29 Wayne State University Non-natural peptides as models for the development of antibiotics
SI2544719T1 (sl) 2010-03-12 2019-11-29 Debiopharm Int Sa CD37-povezovalne molekule in njihovi imunokonjugati
US9447189B2 (en) * 2011-04-01 2016-09-20 Immunogen, Inc. CD37-binding molecules and immunoconjugates thereof
BR112013030963B1 (pt) * 2011-06-01 2020-12-01 Xiamen University proteína de fusão, polinucleotídio, constructo, vetor, célula hospedeira, composição farmacêutica ou vacina, uso da proteína de fusão, método para modificar uma proteína alvo para melhorar sua imunogenicidade e uso do fragmento de crm197 ou um fragmento do mesmo
US10183967B2 (en) 2013-02-12 2019-01-22 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
CN105445463A (zh) * 2014-09-25 2016-03-30 苏州新波生物技术有限公司 一种戊肝IgG抗体检测试剂盒及其制备方法和应用
CN108472361B (zh) 2015-06-08 2022-12-27 德彪发姆国际有限公司 抗cd37免疫缀合物及抗cd20抗体组合物
BR112018003147A2 (pt) 2015-08-28 2018-09-18 Debiopharm International S.A. anticorpos e testes para detecção de cd37
JP2020510608A (ja) 2016-11-02 2020-04-09 デビオファーム インターナショナル， エス． アー． 抗ｃｄ３７イムノコンジュゲート療法を改善するための方法
KR101940806B1 (ko) * 2017-04-21 2019-01-21 (주)웅비식품 포장김 절단기
CN110412267B (zh) * 2018-04-28 2023-04-11 洛阳普泰生物技术有限公司 犬副流感病毒单克隆抗体及其应用
CN112399972B (zh) * 2018-07-10 2024-02-06 国家医疗保健研究所 戊型肝炎病毒orf2i蛋白的表位
JP7455108B2 (ja) * 2018-07-10 2024-03-25 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｅ型肝炎ウイルスのＯＲＦ２ｉタンパク質に対する特異性を有する抗体及び診断目的のためのその使用
CN109913424B (zh) * 2019-03-28 2020-10-27 浙江大学 一种包含戊型肝炎病毒复制子的人肝癌细胞系、应用及构建方法
GB201904328D0 (en) * 2019-03-28 2019-05-15 Immunocore Ltd Specific binding molecules
CN117730255A (zh) * 2021-07-06 2024-03-19 株式会社先端生命科学研究所 E型肝炎病毒感染的检测方法、e型肝炎病毒感染检测用抗原多肽和试剂盒
WO2023174976A1 (en) 2022-03-16 2023-09-21 Universität Zu Lübeck Broadly neutralizing antibodies against hepatitis e virus
CN114957411B (zh) * 2022-05-25 2023-08-18 徐州医科大学 一种正戊型肝病毒属基因c1型病毒orf2重组蛋白及其制备方法和应用
CN116298305B (zh) * 2023-01-03 2024-05-28 郑州大学 一种抗nt5c1a自身抗体检测方法及体外诊断试剂盒

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470925A (en) 1982-05-05 1984-09-11 E. I. Du Pont De Nemours And Company Immunoglobulin half-molecules and process for producing hybrid antibodies
US4474493A (en) 1982-09-09 1984-10-02 Modular Systems, Inc. Dowel fastener and joints including same
US6291641B1 (en) * 1988-06-17 2001-09-18 Genelabs Technologies, Inc. Hepatitis E virus antigens and uses therefor
US5885768A (en) 1988-06-17 1999-03-23 The United States Of America As Represented By The Department Of Health And Human Services Hepatitis E virus peptide antigen and antibodies
US5686239A (en) 1988-06-17 1997-11-11 Genelabs Technologies, Inc. Hepatitis E virus peptides and methods
US5741490A (en) 1988-06-17 1998-04-21 Genelabs Technologies, Inc. Hepatitis E virus vaccine and method
US5219990A (en) * 1991-01-28 1993-06-15 Biogen, Inc. Papillomavirus e2 trans-activation repressors
JP2908107B2 (ja) 1992-03-19 1999-06-21 株式会社日立製作所 放射性廃棄物用固化材及び放射性廃棄物の処理方法
CA2144855C (en) * 1992-09-18 2008-09-09 Sergei A. Tsarev Recombinant proteins of a pakistani strain of hepatitis e and their use in diagnostic methods and vaccines
US5736315A (en) 1992-10-21 1998-04-07 National Institute Of Health Methods and compositions for detecting anti-hepatitis E virus activity
JP3919830B2 (ja) * 1992-11-28 2007-05-30 財団法人化学及血清療法研究所 抗ネコヘルペスウイルス−１組換え抗体および該抗体をコードする遺伝子断片
DE69435059D1 (de) * 1993-09-24 2008-02-14 Macfarlane Burnet Inst For Med Immunoreaktive antigene des hepatitis e viruses
JP3504963B2 (ja) * 1993-10-22 2004-03-08 智靖 羅 抗ヒト高親和性ＩｇＥ受容体モノクローナル抗体に係るアミノ酸配列をコードするＤＮＡ断片
US5830636A (en) * 1993-12-22 1998-11-03 Abbott Laboratories HEV orf-2 monoclonal antibodies and methods for using same
EP0736087A1 (en) * 1993-12-22 1996-10-09 Abbott Laboratories Monoclonal antibodies against hev orf-2 and methods for using same
EP0736088A1 (en) * 1993-12-22 1996-10-09 Abbott Laboratories Monoclonal antibodies to hepatitis e virus and methods for using same
US5830635A (en) * 1995-03-31 1998-11-03 Agnello; Vincent Method of detecting hepatitis C virus in tissues
ATE364631T1 (de) 1999-12-01 2007-07-15 Us Gov Health & Human Serv Hauptneutralisationsort des hepatitis e virus und verwendung dieses neutralisationsort in impfungverfahren und in verfahren zum screening nach neutralisationsantikörper
EP1274725B1 (en) * 2000-04-07 2006-06-07 The Government of the United States of America, as represented by The Secretary, Department of Health and Human Services Use of hev polypeptides
CN1345775A (zh) * 2000-09-30 2002-04-24 养生堂有限公司 用于预防、诊断及治疗戊型肝炎病毒的多肽,及它们作为诊断试剂和疫苗
KR101020256B1 (ko) 2001-11-08 2011-03-08 베이징 완타이 바이오로지컬 파마시 엔터프라이즈 코포레이션 리미티드 Ｅ형 간염 바이러스 단클론 항체 또는 그의 결합 단편, 및이들의 용도
JP2010053113A (ja) 2008-08-26 2010-03-11 Sadanao Namiki 薬物輸送に利用できる自己会合型磁性脂質ナノ粒子、及びその製造方法
JP5264792B2 (ja) 2010-01-25 2013-08-14 三菱電機株式会社 プレート式熱交換器

Also Published As

Publication number Publication date
EP1452541A1 (en) 2004-09-01
EP2322625B1 (en) 2016-01-06
BR122015016384B8 (pt) 2021-07-27
JP2010213693A (ja) 2010-09-30
JP5341799B2 (ja) 2013-11-13
BRPI0214188B1 (pt) 2016-08-02
US7786264B2 (en) 2010-08-31
US20060233822A1 (en) 2006-10-19
MXPA04004321A (es) 2004-08-11
CN100339395C (zh) 2007-09-26
JP2005524386A (ja) 2005-08-18
JP6016699B2 (ja) 2016-10-26
WO2003040187A1 (fr) 2003-05-15
KR20050044384A (ko) 2005-05-12
EP1452541A4 (en) 2005-07-20
EP1452541B1 (en) 2012-06-20
US20100003281A1 (en) 2010-01-07
EP2322625B8 (en) 2016-02-24
JP2013226136A (ja) 2013-11-07
EP2322625A1 (en) 2011-05-18
BR122015016384B1 (pt) 2017-02-07
CN1610697A (zh) 2005-04-27
BRPI0214188B8 (pt) 2021-05-25
KR101020256B1 (ko) 2011-03-08
EP1452541B2 (en) 2015-06-17
US9428554B2 (en) 2016-08-30
AU2002349727B2 (en) 2008-10-16

Similar Documents

Publication Publication Date Title
BR0214188A (pt) Anticorpos monoclonais contra vìrus da hepatite e ou seus fragmentos com atividade de ligação e uso dos mesmos
CN1609617B (zh) 诊断与预防严重急性呼吸道综合症（sars）的组合物和方法
CA2662715C (en) Method of treating peripheral nerve disorders
BR0114510A (pt) Fragmentos de polipeptìdeos do vìrus da hepatite e, composição de vacina e kits de diagnóstico compreendendo o mesmo e uso destes
US20170260239A1 (en) Modified vp1-capsid protein of parvovirus b19
CN116059336A (zh) 针对rsv的疫苗
EP2170365B1 (en) Influenza inhibiting compositions and methods
CA2377957C (fr) Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
US20230330238A1 (en) Chimeric conjugates for degradation of viral and host proteins and methods of use
AU2017200760A1 (en) Methods for treating immune-mediated dengue fever infections and antibody-dependent enhancement of dengue fever infections, including dengue hemorrhagic fever and dengue shock syndrome
BR0012919A (pt) Vacina para uso na profilaxia e/ou no tratamento da sìndrome de ponto branco (white spot syndrome) em crustáceos, proteìna estrutural derivada do vìrus da sìndrome de ponto branco, sequência de ácido nucléico, uso de uma proteìna estrutural, composição farmacêutica, anticorpos, vacina ou formulação farmacêutica, e, kit diagnóstico para detecção de wssv
US20070185027A1 (en) Antiviral agents for the treatment, control and prevention of infections by coronaviruses
EP1615610A2 (en) Inhibitors of coronavirus
EP3892298A1 (en) Epitopes having sequence homology to coronavirus spike protein subunit and uses thereof
US20110082073A1 (en) Modified Cpn10 and PRR signalling
Ishino et al. Comparison of NSP4 protein between group A and B human rotaviruses: detection of novel diarrhea-causing sequences in group B NSP4
KR102006869B1 (ko) 에볼라 바이러스의 핵단백질의 n-말단 도메인 단편, c-말단 도메인 단편 및 nc 융합 단백질, 및 이를 이용한 에볼라 바이러스 감염 진단용 키트
BERGSTRAND Encephalitogenic activity of the N‐terminal part of bovine myelin basic protein in rabbits
CN118684738A (zh) 靶向人呼吸道合胞病毒融合糖蛋白的多肽拮抗剂
WO2011097688A1 (en) Protein domains and uses therefor
US20040002581A1 (en) Peptides and use thereof in therapeutic agents against HIV infection

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: BEIJING WANTAI BIOLOGICAL PHARMACY ENTERPRISE CO.,

Free format text: TRANSFERIDO DE: YANG SHENG TANG COMPANY LIMITED

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/08/2016, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/11/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 08/11/2022