BG86132A - Производни на пиридазинамин - Google Patents

Производни на пиридазинамин

Info

Publication number
BG86132A
BG86132A BG086132A BG8613288A BG86132A BG 86132 A BG86132 A BG 86132A BG 086132 A BG086132 A BG 086132A BG 8613288 A BG8613288 A BG 8613288A BG 86132 A BG86132 A BG 86132A
Authority
BG
Bulgaria
Prior art keywords
diseases
pyridazinamine
pyridazinamine derivatives
alkylation
hepatitis
Prior art date
Application number
BG086132A
Other languages
English (en)
Other versions
BG60676B1 (bg
Inventor
Raymond Stockbroekx
Marcel Gerebernus Luyckx
Marcel Jozef Maria Van Aa
Gilbert Arthur Grauwels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BG86132A publication Critical patent/BG86132A/bg
Publication of BG60676B1 publication Critical patent/BG60676B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Изобретението се отнася до производните на пиридазинамин, получени при n-алкилиране на амин със съответно заместен пиридазин, до техните фармацевтично приемливи кисели адитивни соли и стереохимично изомерни форми, имащи значителна антивирусна активност, и до фармацевтични състави, съдържащи тези съединения. Те намират приложение в медицината при лечението на всички видове вирусни инфекции като респираторни заболявания, заболявания на централната нервна система и на стомашно-чревния тракт, хепатит, сърдечни, очни и кожни заболявания и други. 12 претенции
BG86132A 1987-11-23 1988-11-21 Производни на пиридазинамин BG60676B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12453087A 1987-11-23 1987-11-23

Publications (2)

Publication Number Publication Date
BG86132A true BG86132A (bg) 1993-12-24
BG60676B1 BG60676B1 (bg) 1995-12-29

Family

ID=22415413

Family Applications (1)

Application Number Title Priority Date Filing Date
BG86132A BG60676B1 (bg) 1987-11-23 1988-11-21 Производни на пиридазинамин

Country Status (26)

Country Link
EP (1) EP0320032B1 (bg)
JP (1) JPH0629255B2 (bg)
KR (1) KR0125280B1 (bg)
CN (1) CN1021328C (bg)
AT (1) ATE117296T1 (bg)
AU (1) AU611504B2 (bg)
BG (1) BG60676B1 (bg)
CA (1) CA1327573C (bg)
DE (1) DE3852816T2 (bg)
DK (1) DK651288A (bg)
ES (1) ES2070126T3 (bg)
FI (1) FI92584C (bg)
GR (1) GR3015816T3 (bg)
HU (1) HU200762B (bg)
IE (1) IE65768B1 (bg)
IL (1) IL88429A (bg)
JO (1) JO1552B1 (bg)
MA (1) MA21446A1 (bg)
MY (1) MY104343A (bg)
NO (1) NO171980C (bg)
NZ (1) NZ226920A (bg)
PH (1) PH26670A (bg)
PT (1) PT89047B (bg)
SU (1) SU1724013A3 (bg)
TN (1) TNSN88128A1 (bg)
ZA (1) ZA888744B (bg)

Families Citing this family (49)

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US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
JO1645B1 (en) * 1989-12-26 1991-11-27 شركة جانسين فارماسوتيكا ان. في Pyridazine compounds are antibacterial viruses
US5169855A (en) * 1990-03-28 1992-12-08 Du Pont Merck Pharmaceutical Company Piperidine ether derivatives as psychotropic drugs or plant fungicides
MX9100513A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
FR2668151A1 (fr) * 1990-10-23 1992-04-24 Rhone Poulenc Agrochimie Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant.
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5242924A (en) * 1992-07-02 1993-09-07 Sterling Winthrop Inc. Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents
CA2099630A1 (en) * 1992-07-02 1994-01-03 Guy Dominic Diana Heterocyclyl-phenoxyalkyl-piperidinylpyridazines as antiviral agents
US5364865A (en) * 1992-12-30 1994-11-15 Sterling Winthrop Inc. Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
JP3088016B2 (ja) * 1993-03-29 2000-09-18 ゼネカ・リミテッド 血小板凝集抑制剤としての複素環式化合物
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
KR100607838B1 (ko) * 1997-10-27 2006-08-04 뉴로서치 에이/에스 니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
BR9909369A (pt) 1998-02-19 2000-11-28 Eisai Co Ltd Compostos de ftalazina e agentes terapêuticos para disfunção eréctil
US6316500B1 (en) * 1999-01-05 2001-11-13 Isp Investments Inc. Aliphatically unsaturated hydroxy benzoates and preservative compositions thereof
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
KR100957516B1 (ko) 2001-08-15 2010-05-14 이코스 코포레이션 2ｈ-프탈라진-1-온 및 이것의 사용 방법
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US7494987B2 (en) * 2002-11-25 2009-02-24 Mochida Pharmaceutical Co., Ltd. Agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient
EP2316826A1 (en) * 2003-07-30 2011-05-04 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutics agents
KR100934554B1 (ko) 2003-07-30 2009-12-29 제논 파마슈티칼스 인크. 피리다진 유도체 및 그의 치료제로서의 용도
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
EP1771175B1 (en) * 2004-06-30 2015-12-23 Janssen Pharmaceutica NV Phthalazine derivatives as parp inhibitors
WO2006101521A2 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
TW200626592A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
JP4958786B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体および治療薬としてのそれらの使用
BRPI0515478A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase
BRPI0515489A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
EP2316458A1 (en) 2004-09-20 2011-05-04 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
EP2029138A1 (en) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
NZ564759A (en) * 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
CN1887875B (zh) * 2005-06-30 2011-04-06 深圳市东阳光实业发展有限公司 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途
EP1902028A2 (en) 2005-07-04 2008-03-26 Novo Nordisk A/S Histamine h3 receptor antagonists
AU2007267197B2 (en) 2006-05-29 2011-12-01 High Point Pharmaceuticals, Llc 3- (1, 3-Benzodioxol-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
CN101864003B (zh) * 2010-06-11 2012-05-02 漆又毛 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法
CN102344416B (zh) * 2010-08-02 2015-09-16 中国人民解放军军事医学科学院毒物药物研究所 哒嗪衍生物及其作为抗小rna病毒感染药物的用途
CN102485717B (zh) * 2010-12-06 2015-12-02 中国人民解放军军事医学科学院毒物药物研究所 噻唑胺衍生物及其作为抗小rna病毒感染药物的用途
TW201329025A (zh) 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
CN118047485B (zh) * 2024-04-08 2024-06-25 西安文理学院 一种污水治理的复合微生物菌剂及其制备方法和应用

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* Cited by examiner, † Cited by third party
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ES8802151A1 (es) * 1985-07-31 1988-04-01 Janssen Pharmaceutica Nv Un procedimiento para la preparacion de nuevos piridazinaminas.

Also Published As

Publication number Publication date
JPH01207278A (ja) 1989-08-21
KR0125280B1 (ko) 1997-12-05
EP0320032A1 (en) 1989-06-14
DE3852816T2 (de) 1995-06-08
NO171980B (no) 1993-02-15
MY104343A (en) 1994-03-31
PH26670A (en) 1992-09-15
AU611504B2 (en) 1991-06-13
BG60676B1 (bg) 1995-12-29
HU200762B (en) 1990-08-28
FI885409A (fi) 1989-05-24
ZA888744B (en) 1990-07-25
NO171980C (no) 1993-05-26
EP0320032B1 (en) 1995-01-18
JPH0629255B2 (ja) 1994-04-20
FI92584C (fi) 1994-12-12
PT89047B (pt) 1993-03-31
ATE117296T1 (de) 1995-02-15
FI92584B (fi) 1994-08-31
JO1552B1 (en) 1989-12-16
DK651288A (da) 1989-05-24
TNSN88128A1 (fr) 1990-07-10
DE3852816D1 (de) 1995-03-02
MA21446A1 (fr) 1989-07-01
NZ226920A (en) 1990-06-26
PT89047A (pt) 1988-12-01
IL88429A (en) 1993-05-13
AU2575188A (en) 1989-05-25
NO885190L (no) 1989-05-24
NO885190D0 (no) 1988-11-22
ES2070126T3 (es) 1995-06-01
KR890008126A (ko) 1989-07-08
CN1021328C (zh) 1993-06-23
SU1724013A3 (ru) 1992-03-30
HUT48617A (en) 1989-06-28
FI885409A0 (fi) 1988-11-22
IL88429A0 (en) 1989-06-30
CN1033274A (zh) 1989-06-07
CA1327573C (en) 1994-03-08
IE883486L (en) 1989-05-23
DK651288D0 (da) 1988-11-22
GR3015816T3 (en) 1995-07-31
IE65768B1 (en) 1995-11-15

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