BG17795A3 - Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер - Google Patents

Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер

Info

Publication number
BG17795A3
BG17795A3 BG017051A BG1705170A BG17795A3 BG 17795 A3 BG17795 A3 BG 17795A3 BG 017051 A BG017051 A BG 017051A BG 1705170 A BG1705170 A BG 1705170A BG 17795 A3 BG17795 A3 BG 17795A3
Authority
BG
Bulgaria
Prior art keywords
uracylythiocter
uracylethers
aminouracyls
arylpiperazinylalkyl
substituted
Prior art date
Application number
BG017051A
Other languages
English (en)
Inventor
Wolfgang Pruesse
Kurt Klemm
Wolfgang Schoetensack
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of BG17795A3 publication Critical patent/BG17795A3/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60Three or more oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Communication Cables (AREA)
BG017051A 1969-08-20 1970-08-19 Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер BG17795A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1942405A DE1942405C3 (de) 1969-08-20 1969-08-20 Arylsubstituierte Piperazinylpropylenaminouracile

Publications (1)

Publication Number Publication Date
BG17795A3 true BG17795A3 (bg) 1973-12-25

Family

ID=5743321

Family Applications (3)

Application Number Title Priority Date Filing Date
BG017052A BG17796A3 (bg) 1969-08-20 1970-08-15 Метод за получаване на субституирани с арилпиперазинилалкиламино- урацили,-урацилетер и урацилитиотер
BG017051A BG17795A3 (bg) 1969-08-20 1970-08-19 Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер
BG015509A BG17585A3 (bg) 1969-08-20 1970-08-19 Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG017052A BG17796A3 (bg) 1969-08-20 1970-08-15 Метод за получаване на субституирани с арилпиперазинилалкиламино- урацили,-урацилетер и урацилитиотер

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG015509A BG17585A3 (bg) 1969-08-20 1970-08-19 Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер

Country Status (24)

Country Link
US (2) US3957786A (bg)
AT (2) AT302359B (bg)
BE (1) BE755015A (bg)
BG (3) BG17796A3 (bg)
BR (1) BR6915466D0 (bg)
CA (1) CA956944A (bg)
CH (2) CH551990A (bg)
DE (1) DE1942405C3 (bg)
DK (1) DK124031B (bg)
ES (1) ES382842A1 (bg)
FI (1) FI54479C (bg)
FR (1) FR2073300B1 (bg)
GB (1) GB1309324A (bg)
HK (1) HK23678A (bg)
HU (1) HU163664B (bg)
IE (1) IE35177B1 (bg)
IL (1) IL35121A (bg)
LU (1) LU61527A1 (bg)
NL (1) NL155014B (bg)
NO (1) NO129148B (bg)
SE (1) SE386448B (bg)
SU (1) SU399130A3 (bg)
YU (2) YU36509B (bg)
ZA (1) ZA705729B (bg)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2329399A1 (de) * 1973-06-08 1975-01-02 Wuelfing J A Fa 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
LU74319A1 (bg) * 1976-02-09 1977-08-19
DE3326118A1 (de) 1982-08-02 1984-02-09 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Pyridopyrimidintrione, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
JPH078795B2 (ja) * 1989-09-06 1995-02-01 日立化成工業株式会社 排尿障害治療剤
EP0513058A1 (de) 1990-02-01 1992-11-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Verwendung von bekannte uracile zur herstellung von arzneimittel für die verhütungen und behandlung von krankheitszusännden, die auf proliferativen prozessen beruhen.
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
JPH10510253A (ja) * 1994-12-07 1998-10-06 ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング ウラシル誘導体
NZ510685A (en) 1998-09-30 2003-10-31 Takeda Chemical Industries Ltd Drugs for improving vesical excretory strength
EP1341777B1 (en) * 2000-11-29 2007-09-26 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatement of incontinence
WO2003000664A1 (de) * 2001-06-22 2003-01-03 Bayer Aktiengesellschaft Uracilderivative und ihre verwendung bei der behandlung bakterieller erkrankungen
JP5165242B2 (ja) 2003-09-12 2013-03-21 アラーガン、インコーポレイテッド 疼痛およびα2アドレナリン受容体が関与する他の状態の処置のための方法および組成物
US20050059744A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20050058696A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20060264442A1 (en) * 2005-05-18 2006-11-23 Allergan, Inc. Methods for the treatment of ocular and neurodegenerative conditions in a mammal
CN101200451B (zh) * 2006-12-15 2010-12-15 重庆药友制药有限责任公司 一种盐酸乌拉地尔的制备方法
CN102295607B (zh) * 2011-06-16 2013-04-17 郑州大学 乌拉地尔的逆相转移催化制备方法
CN116082250A (zh) * 2021-11-05 2023-05-09 江苏润安制药有限公司 一种新的制备盐酸乌拉地尔的方法
KR102638538B1 (ko) 2021-12-28 2024-02-20 주식회사 한서켐 우라피딜 제조 중간체의 제조방법
CN115477616A (zh) * 2022-09-27 2022-12-16 河北广祥制药有限公司 一种乌拉地尔杂质的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2567651A (en) * 1951-09-11 J-dialkyl-g-amino-l

Also Published As

Publication number Publication date
US4067982A (en) 1978-01-10
IE35177L (en) 1971-02-20
YU36509B (en) 1984-02-29
AT302359B (de) 1972-10-10
GB1309324A (en) 1973-03-07
FI54479C (fi) 1978-12-11
NL7012364A (bg) 1971-02-23
ES382842A1 (es) 1973-02-16
LU61527A1 (bg) 1971-06-22
SU363248A3 (bg) 1972-12-30
FR2073300B1 (bg) 1974-02-01
FI54479B (fi) 1978-08-31
BR6915466D0 (pt) 1973-05-15
SE386448B (sv) 1976-08-09
DE1942405B2 (de) 1973-10-31
FR2073300A1 (bg) 1971-10-01
NL155014B (nl) 1977-11-15
YU207670A (en) 1982-02-25
IE35177B1 (en) 1975-12-10
BG17796A3 (bg) 1973-12-25
HU163664B (bg) 1973-10-27
IL35121A (en) 1974-03-14
SU399130A3 (bg) 1973-09-27
NO129148B (bg) 1974-03-04
DE1942405C3 (de) 1974-05-30
CH551990A (de) 1974-07-31
BE755015A (fr) 1971-02-01
US3957786A (en) 1976-05-18
CH582173A5 (bg) 1976-11-30
ZA705729B (en) 1972-03-29
AT318651B (de) 1974-11-11
YU203979A (en) 1982-02-25
YU36518B (en) 1984-02-29
DE1942405A1 (de) 1971-09-16
HK23678A (en) 1978-05-12
CA956944A (en) 1974-10-29
BG17585A3 (bg) 1973-11-10
IL35121A0 (en) 1970-10-30
DK124031B (da) 1972-09-04

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