BG106971A - Method for the preparation of 5-cyanophthalide - Google Patents

Method for the preparation of 5-cyanophthalide

Info

Publication number
BG106971A
BG106971A BG106971A BG10697102A BG106971A BG 106971 A BG106971 A BG 106971A BG 106971 A BG106971 A BG 106971A BG 10697102 A BG10697102 A BG 10697102A BG 106971 A BG106971 A BG 106971A
Authority
BG
Bulgaria
Prior art keywords
cyanophthalide
preparation
alkyl
hydrogen
ring
Prior art date
Application number
BG106971A
Other languages
Bulgarian (bg)
Other versions
BG65516B1 (en
Inventor
Hans Petersen
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Priority to BG106971A priority Critical patent/BG65516B1/en
Publication of BG106971A publication Critical patent/BG106971A/en
Publication of BG65516B1 publication Critical patent/BG65516B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A method for the preparation of 5-cyanophthalide comprising treatment of a compound of formula wherein X is O or S, R1-R2 are each independently selected from hydrogen and C1-6 alkyl, or R1 and R2 together form a C2-5 alkylene chain thereby forming a spiro-ring; R3 is selected from hydrogen and C1-6 alkyl, R4 is selected from hydrogen, C1-6 alkyl, a carboxy group or a precursor group therefore, or R3 and R4 together form a C2-5 alkylene chain thereby forming a spiro ring: with a dehydration agent or alternatively where X is S, thermally cleavage of the thiazonine ring or treatment with a radical initiator, such as peroxide or with light, to form 5-cyanophthalide, which is an important intermediate used in the preparation of the antidepressant drug citalopram. 10 claims
BG106971A 2002-07-31 2002-07-31 Method for the preparation of citalopram BG65516B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG106971A BG65516B1 (en) 2002-07-31 2002-07-31 Method for the preparation of citalopram

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG106971A BG65516B1 (en) 2002-07-31 2002-07-31 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
BG106971A true BG106971A (en) 2003-05-30
BG65516B1 BG65516B1 (en) 2008-10-31

Family

ID=40328096

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106971A BG65516B1 (en) 2002-07-31 2002-07-31 Method for the preparation of citalopram

Country Status (1)

Country Link
BG (1) BG65516B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US493590A (en) * 1893-03-14 James h
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method

Also Published As

Publication number Publication date
BG65516B1 (en) 2008-10-31

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