BE905784A - CARBAMOYLOXYMETHYLALCOYLCARBAPENEMES. - Google Patents

CARBAMOYLOXYMETHYLALCOYLCARBAPENEMES.

Info

Publication number
BE905784A
BE905784A BE0/217435A BE217435A BE905784A BE 905784 A BE905784 A BE 905784A BE 0/217435 A BE0/217435 A BE 0/217435A BE 217435 A BE217435 A BE 217435A BE 905784 A BE905784 A BE 905784A
Authority
BE
Belgium
Prior art keywords
hydrogen atom
radical
lower alkyl
alkyl radical
carbamoyloxymethylalcoylcarbapenemes
Prior art date
Application number
BE0/217435A
Other languages
French (fr)
Inventor
Uyeo S
S Uyeo
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of BE905784A publication Critical patent/BE905784A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Acide (1S,5R,6S) -6- ((1R)-1-hydroxyéthyl) -2-carbamoyloxyméthyl- (éventuellement alcoylé) -1-alcoyl-1-carbapén -2- ème-3-carboxylique et ses dérivés de formule: (où R1 représente un atome d'hydrogène ou radical protecteur de la fonction hydroxyle; R2 représente un radical alxoyle inférieur; R3 représente un atome d'hydrogène ou radical alcoyle inférieur, et R4 représente un atome d'hydrogène ou radical formant sel ou ester).(1S, 5R, 6S) -6- ((1R) -1-hydroxyethyl) -2-carbamoyloxymethyl- (optionally alkylated) -1-alkoyl-1-carbapen -2- th-3-carboxylic acid and its derivatives of formula : (where R1 represents a hydrogen atom or radical protecting the hydroxyl function; R2 represents a lower alkyl radical; R3 represents a hydrogen atom or lower alkyl radical, and R4 represents a hydrogen atom or salt-forming radical or ester).

BE0/217435A 1985-11-19 1986-11-19 CARBAMOYLOXYMETHYLALCOYLCARBAPENEMES. BE905784A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26073185 1985-11-19

Publications (1)

Publication Number Publication Date
BE905784A true BE905784A (en) 1987-03-16

Family

ID=17351968

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/217435A BE905784A (en) 1985-11-19 1986-11-19 CARBAMOYLOXYMETHYLALCOYLCARBAPENEMES.

Country Status (10)

Country Link
JP (1) JPS62201889A (en)
KR (1) KR870004984A (en)
AU (1) AU6534786A (en)
BE (1) BE905784A (en)
CA (1) CA1283416C (en)
CH (1) CH671580A5 (en)
DE (1) DE3639542C2 (en)
FR (1) FR2590256B1 (en)
GB (1) GB2183236B (en)
IT (1) IT1195842B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292191A1 (en) * 1987-05-21 1988-11-23 Merck & Co. Inc. 2-(Substituted methyl)-1-alkylcarbapenem derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2201527T3 (en) * 1997-08-27 2004-03-16 MERCK & CO., INC. PREPARATION OF BETAMETILCARBAPENEM INTERMEDIARIES.
US6143885A (en) * 1997-08-27 2000-11-07 Merck & Co., Inc. Preparation of beta-methyl carbapenem intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
EP0184844A1 (en) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Methylcarbapenems having a 2-position substituent joined through an alkylenethio bridge

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292191A1 (en) * 1987-05-21 1988-11-23 Merck & Co. Inc. 2-(Substituted methyl)-1-alkylcarbapenem derivatives

Also Published As

Publication number Publication date
GB2183236B (en) 1989-04-12
JPS62201889A (en) 1987-09-05
FR2590256B1 (en) 1989-12-22
GB2183236A (en) 1987-06-03
GB8627656D0 (en) 1986-12-17
DE3639542A1 (en) 1987-05-21
KR870004984A (en) 1987-06-04
AU6534786A (en) 1987-05-21
FR2590256A1 (en) 1987-05-22
DE3639542C2 (en) 1995-07-13
IT8667861A0 (en) 1986-11-19
IT1195842B (en) 1988-10-27
CA1283416C (en) 1991-04-23
CH671580A5 (en) 1989-09-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SHIONOGI & CO LTD

Effective date: 19951130