BE2010C031I2 - - Google Patents
Download PDFInfo
- Publication number
- BE2010C031I2 BE2010C031I2 BE2010C031C BE2010C031C BE2010C031I2 BE 2010C031 I2 BE2010C031 I2 BE 2010C031I2 BE 2010C031 C BE2010C031 C BE 2010C031C BE 2010C031 C BE2010C031 C BE 2010C031C BE 2010C031 I2 BE2010C031 I2 BE 2010C031I2
- Authority
- BE
- Belgium
- Prior art keywords
- conjugate
- meningococcal serogroup
- buffer
- aluminium
- provides
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 abstract 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 abstract 1
- 229940001007 aluminium phosphate Drugs 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/04—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from fish or other sea animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09F—NATURAL RESINS; FRENCH POLISH; DRYING-OILS; OIL DRYING AGENTS, i.e. SICCATIVES; TURPENTINE
- C09F1/00—Obtaining purification, or chemical modification of natural resins, e.g. oleo-resins
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09G—POLISHING COMPOSITIONS; SKI WAXES
- C09G1/00—Polishing compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Formation And Processing Of Food Products (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0115176.0A GB0115176D0 (en) | 2001-06-20 | 2001-06-20 | Capular polysaccharide solubilisation and combination vaccines |
PCT/IB2002/003191 WO2003007985A2 (fr) | 2001-06-20 | 2002-06-20 | Solubilisation de polysaccharides capsulaires et vaccins de combinaison |
Publications (1)
Publication Number | Publication Date |
---|---|
BE2010C031I2 true BE2010C031I2 (fr) | 2021-07-19 |
Family
ID=9917070
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2010C031C BE2010C031I2 (fr) | 2001-06-20 | 2010-09-13 | |
BE2010C033C BE2010C033I2 (fr) | 2001-06-20 | 2010-09-13 | |
BE2010C032C BE2010C032I2 (fr) | 2001-06-20 | 2010-09-13 | |
BE2011C001C BE2011C001I2 (fr) | 2001-06-20 | 2011-01-13 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2010C033C BE2010C033I2 (fr) | 2001-06-20 | 2010-09-13 | |
BE2010C032C BE2010C032I2 (fr) | 2001-06-20 | 2010-09-13 | |
BE2011C001C BE2011C001I2 (fr) | 2001-06-20 | 2011-01-13 |
Country Status (23)
Country | Link |
---|---|
US (9) | US8753651B2 (fr) |
EP (10) | EP1401489B2 (fr) |
JP (4) | JP5075317B2 (fr) |
CN (4) | CN100482273C (fr) |
AT (3) | ATE474594T1 (fr) |
AU (3) | AU2002321716B2 (fr) |
BE (4) | BE2010C031I2 (fr) |
BR (2) | BRPI0210590B8 (fr) |
CA (3) | CA2450203C (fr) |
CY (6) | CY1110820T1 (fr) |
DE (6) | DE122011000003I1 (fr) |
DK (6) | DK2263688T4 (fr) |
ES (9) | ES2603275T3 (fr) |
FR (4) | FR10C0044I1 (fr) |
GB (1) | GB0115176D0 (fr) |
LU (4) | LU91734I2 (fr) |
MX (1) | MXPA03011462A (fr) |
NL (3) | NL300458I2 (fr) |
NZ (2) | NZ529881A (fr) |
PT (6) | PT1401489E (fr) |
RU (2) | RU2381814C2 (fr) |
TR (2) | TR201808026T4 (fr) |
WO (1) | WO2003007985A2 (fr) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
AP1897A (en) | 2001-01-23 | 2008-10-10 | Aventis Pasteur | Multivalent Meningococcal polysaccharide-Protein Conjugate Vaccine. |
GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
ES2318117T3 (es) * | 2002-03-26 | 2009-05-01 | Novartis Vaccines And Diagnostics S.R.L. | Sacaridos modificados que tienen una estabilidad mejorada en agua. |
GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
DE60328481D1 (de) | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
AU2003250204B8 (en) * | 2002-08-02 | 2008-07-10 | Glaxosmithkline Biologicals S.A. | Neisserial vaccine compositions comprising a combination of antigens |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
PT2353608T (pt) * | 2002-10-11 | 2020-03-11 | Novartis Vaccines And Diagnostics S R L | Vacinas de polipéptidos para protecção alargada contra linhagens meningocócicas hipervirulentas |
EP1562982B1 (fr) | 2002-11-15 | 2010-05-05 | Novartis Vaccines and Diagnostics S.r.l. | Proteines de surface inattendues du neisseria meningitidis |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
US10272147B2 (en) * | 2003-01-30 | 2019-04-30 | Glaxosmithkline Biologicals S.A. | Injectable vaccines against multiple meningococcal serogroups |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
AU2004251734B2 (en) * | 2003-06-23 | 2010-11-04 | Baxalta GmbH | Vaccines against group Y neisseria meningitidis and meningococcal combinations thereof |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
PT1961426E (pt) * | 2003-10-02 | 2011-06-28 | Novartis Vaccines & Diagnostic | Vacinas combinadas contra a meningite |
GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0408978D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Meningococcal fermentation for preparing conjugate vaccines |
GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
PL1740217T3 (pl) | 2004-04-30 | 2012-03-30 | Novartis Ag | Szczepienie koniugatem meningokokowym |
GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
GB0410866D0 (en) | 2004-05-14 | 2004-06-16 | Chiron Srl | Haemophilius influenzae |
GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
GB0413868D0 (en) * | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
AU2005279821A1 (en) * | 2004-08-30 | 2006-03-09 | Sanofi Pasteur, Inc. | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
KR20070095868A (ko) * | 2004-09-21 | 2007-10-01 | 사노피 파스퇴르 인크 | 다가 수막구균 유도체화된 다당류-단백질 접합체 및 백신 |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
GB0502096D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
DK2351772T3 (en) | 2005-02-18 | 2016-09-05 | Glaxosmithkline Biologicals Sa | Proteins and nucleic acids from meningitis / sepsis-associated Escherichia coli |
US8062644B2 (en) | 2005-02-18 | 2011-11-22 | Novartis Vaccines & Diagnostics Srl. | Immunogens from uropathogenic Escherichia coli |
GB0505518D0 (en) | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
EP2425856A1 (fr) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Composition conjuguée polysaccharide-protéine pneumococcique polyvalente |
EP2329843A3 (fr) | 2005-04-18 | 2011-09-14 | Novartis Vaccines and Diagnostics, Inc. | Expression de l'antigène de virus de l'hépatite B pour la préparation d'un vaccin |
GB0513071D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
GB0513069D0 (en) * | 2005-06-27 | 2005-08-03 | Glaxosmithkline Biolog Sa | Immunogenic composition |
ATE536884T1 (de) * | 2005-06-27 | 2011-12-15 | Glaxosmithkline Biolog Sa | Immunogene zusammensetzung |
WO2007026249A2 (fr) | 2005-09-01 | 2007-03-08 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Vaccination multiple comprenant des meningocoques du serogroupe c |
JP5047969B2 (ja) * | 2005-09-05 | 2012-10-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌特異的抗血清に対する血清殺菌アッセイ |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
KR20130135399A (ko) | 2006-03-17 | 2013-12-10 | 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 | 복합 다가 면역원성 콘쥬게이트의 제조 방법 |
EP2357001B1 (fr) | 2006-03-22 | 2018-03-07 | GlaxoSmithKline Biologicals S.A. | Schema posologique pour une immunisation avec des conjugues de meningocoques |
US10828361B2 (en) * | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
CN101081296B (zh) * | 2006-05-29 | 2010-08-04 | 北京民海生物科技有限公司 | 一种b型流感嗜血杆菌荚膜多糖制备方法及其联合疫苗 |
US7491517B2 (en) | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
CA2659552A1 (fr) | 2006-08-16 | 2008-02-21 | Novartis Ag | Immunogenes pour escherichia coli uropathogene |
CL2007002909A1 (es) * | 2006-10-10 | 2008-04-18 | Wyeth Corp | Metodo para reduccion o extraccion de impurezas de proteinas a partir de lisado celular de streptoccocus pneumoniae que comprende calentar dicho lisado, separar a los precipitantes a partir de dicho lisado produciendo un lisado que contiene polisacar |
GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
PL2436700T3 (pl) * | 2007-03-23 | 2018-12-31 | Wyeth Llc | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
US8398985B2 (en) * | 2007-04-23 | 2013-03-19 | Serum Institute Of India Ltd. | Antigenic polysaccharides and process for their preparation |
BRPI0811979A2 (pt) * | 2007-06-04 | 2014-10-21 | Novartis Ag | Formulação para vacinas de meningite |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
ES2528648T3 (es) * | 2007-09-11 | 2015-02-11 | University Of Guelph | Inmunógenos polisacáridos de la Clostridium Difficile |
ATE553774T1 (de) | 2007-10-19 | 2012-05-15 | Novartis Ag | Meningokokkenimpfstoffformulierungen |
US9579372B2 (en) | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
CN101724085B (zh) * | 2008-10-22 | 2011-09-21 | 上海生物制品研究所 | 一种荚膜多糖纯化方法 |
SI2349520T1 (sl) | 2008-10-27 | 2016-08-31 | Glaxosmithkline Biologicals S.A. | Postopek čiščenja za ogljikohidrat iz Streptococcus skupine A |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
EP2470204B1 (fr) | 2009-08-27 | 2015-12-16 | GlaxoSmithKline Biologicals SA | Polypeptides hybrides contenant des séquences fhbp à méningocoques |
BR112012009014B8 (pt) | 2009-09-30 | 2022-10-04 | Novartis Ag | Processo para preparar conjugado de polissacarídeo capsular de s. aureus tipo 5 ou tipo 8 e molécula de transporte crm197, conjugado e composição imunogênica |
WO2011051893A1 (fr) | 2009-10-27 | 2011-05-05 | Novartis Ag | Polypeptides fhbp méningococciques modifiés |
WO2011051917A1 (fr) | 2009-10-30 | 2011-05-05 | Novartis Ag | Purification de saccharides capsulaires de staphylococcus aureus de type 5 et de type 8 |
WO2012020326A1 (fr) | 2010-03-18 | 2012-02-16 | Novartis Ag | Vaccins adjuvantés contre le méningocoque de sérogroupe b |
HRP20240965T1 (hr) | 2010-08-23 | 2024-10-25 | Wyeth Llc | Stabilne formulacije antigena rlp2086 iz bakterije neisseria meningitidis |
ES2744471T3 (es) | 2010-09-04 | 2020-02-25 | Glaxosmithkline Biologicals Sa | Ensayos de anticuerpos bactericidas para evaluar la inmunogenia y la potencia de vacunas de sacárido capsular meningocócico |
PE20140173A1 (es) | 2010-09-10 | 2014-02-20 | Wyeth Llc | Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis |
GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
WO2012085668A2 (fr) | 2010-12-24 | 2012-06-28 | Novartis Ag | Composés |
CN103533954B (zh) | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | 含较低剂量的抗原和/或佐剂的联合疫苗 |
CN103764171B (zh) | 2011-07-08 | 2016-08-17 | 诺华股份有限公司 | 酪氨酸连接方法 |
CU20110202A7 (es) | 2011-11-02 | 2013-12-27 | Inst Finlay Ct De Investigación Producción De Sueros Y Vacunas | Composición inmunogénica de polisacáridos planos adyuvados y las formulaciones resultantes |
WO2013068949A1 (fr) | 2011-11-07 | 2013-05-16 | Novartis Ag | Molécule porteuse comprenant un antigène spr0096 et un antigène spr2021 |
CA2863178C (fr) * | 2012-01-30 | 2021-04-06 | Serum Institute Of India Ltd. | Composition immunogene |
CN104159603A (zh) | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | 带有tlr4激动剂的联合疫苗 |
SG10201602558UA (en) | 2012-03-09 | 2016-05-30 | Pfizer | Neisseria meningitidis compositions and methods thereof |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
SG11201407440WA (en) | 2012-05-22 | 2014-12-30 | Novartis Ag | Meningococcus serogroup x conjugate |
WO2014009971A2 (fr) * | 2012-07-07 | 2014-01-16 | Bharat Biotech International Limited | Compositions vaccinales sans alcool excluant toute origine animale et leur procédé de préparation |
CN103623404B (zh) * | 2012-08-28 | 2016-08-03 | 天士力制药集团股份有限公司 | 一种b型流感嗜血杆菌多糖结合疫苗的制备方法 |
RU2015106930A (ru) | 2012-09-06 | 2016-10-20 | Новартис Аг | Комбинированные вакцины с менингококком серогруппы в и к/д/с |
CN104936615B (zh) | 2012-11-21 | 2017-03-29 | 印度血清研究所私人有限公司 | 高产量的细菌多糖的制备 |
CN105007935A (zh) | 2012-12-18 | 2015-10-28 | 葛兰素史密丝克莱恩生物有限公司 | 用于保护免于白喉和/或破伤风的缀合物 |
US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
KR20160040556A (ko) | 2013-07-11 | 2016-04-14 | 노파르티스 아게 | 미생물 트랜스글루타미나제를 사용한 리신-특이적 화학효소적 단백질 변형 |
JP2016529885A (ja) | 2013-07-12 | 2016-09-29 | イー・エム・デイー・ミリポア・コーポレイシヨン | 活性炭を使用して標的タンパク質を含む試料からのウイルス除去を決定する方法 |
WO2015033251A2 (fr) | 2013-09-08 | 2015-03-12 | Pfizer Inc. | Compositions utilisables contre neisseria meningitidis et procédés associés |
SI3110442T1 (sl) | 2014-02-28 | 2021-01-29 | Glaxosmithkline Biologicals S.A. | Modificirani meningokokni fHbp polipeptidi |
EP3148577B1 (fr) | 2014-05-24 | 2021-01-20 | Biological E Limited | Nouveau vaccin conjugué méningococcique semi-synthétique |
CN104548090B (zh) * | 2015-01-27 | 2016-11-30 | 中国科学院过程工程研究所 | 一种β-葡聚糖修饰的脑膜炎多糖结合疫苗及其制备方法 |
MX2017010705A (es) | 2015-02-19 | 2017-12-04 | Pfizer | Composiciones de neisseria meningitidis y metodos de la misma. |
CN105037579A (zh) * | 2015-08-31 | 2015-11-11 | 成都欧林生物科技股份有限公司 | A群脑膜炎球菌细菌荚膜粗多糖的制备工艺 |
WO2017175082A1 (fr) | 2016-04-05 | 2017-10-12 | Gsk Vaccines S.R.L. | Compositions immunogènes |
JP7104027B2 (ja) | 2016-09-02 | 2022-07-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 淋菌に対するワクチン |
CN118236477A (zh) | 2016-09-02 | 2024-06-25 | 赛诺菲巴斯德股份有限公司 | 脑膜炎奈瑟氏菌疫苗 |
MX2019007910A (es) | 2016-12-30 | 2019-12-05 | Sutrovax Inc | Conjugados de polipeptido-antigeno con aminoacidos no naturales. |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
CA3052621A1 (fr) | 2017-02-03 | 2018-08-09 | Schadeck, Eva Barbara | Compositions de conjugue saccharide d'haemophilus influenzae-excipient et leurs utilisations |
EP3585427A4 (fr) * | 2017-02-24 | 2020-12-30 | Merck Sharp & Dohme Corp. | Procédés d'amélioration de la filtrabilité de réactions de polysaccharide conjugué à une protéine |
US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
EA201992636A1 (ru) * | 2017-05-05 | 2020-04-17 | Серум Инститьют Оф Индия Прайват Лимитед | Способ удаления примесей из препаратов на основе бактериальных капсулярных полисахаридов |
RU2019140392A (ru) * | 2017-05-17 | 2021-06-17 | Мсд Веллком Траст Хиллеман Лабораторис Пвт. Лтд. | Очистка бактериальных полисахаридов |
CN111050794A (zh) * | 2017-09-07 | 2020-04-21 | 默沙东公司 | 将肺炎球菌多糖与载体蛋白缀合的配制方法 |
WO2019175900A1 (fr) * | 2018-03-16 | 2019-09-19 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | Purification de polysaccharides de neisseria meningitidis |
BR112021017239A2 (pt) * | 2019-03-08 | 2021-11-09 | Glaxosmithkline Biologicals Sa | Derivados carbocíclicos e derivados conjugados dos mesmos, e seu uso em vacinas |
CA3139257A1 (fr) | 2019-05-10 | 2020-11-19 | Glaxosmithkline Biologicals Sa | Production de conjugues |
US20220387614A1 (en) | 2019-11-22 | 2022-12-08 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
GB202013262D0 (en) | 2020-08-25 | 2020-10-07 | Glaxosmithkline Biologicals Sa | Vaccine Composition |
CN115721709A (zh) * | 2021-08-27 | 2023-03-03 | 康希诺生物股份公司 | 一种肺炎球菌结合疫苗制备方法 |
GB202115151D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Methods |
GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
Family Cites Families (146)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB207117A (en) | 1923-04-05 | 1923-11-22 | Fernand Prosper Constant Lebru | Improvements in otter boards |
US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4123520A (en) * | 1977-08-01 | 1978-10-31 | Merck & Co., Inc. | Method for preparing high molecular weight meningococcal Group C vaccine |
US4134214A (en) | 1977-08-05 | 1979-01-16 | Merck & Co., Inc. | Freeze-drying process for the preparation of meningococcus vaccine without degradation of potency |
DE2748132A1 (de) | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
US4220717A (en) | 1977-12-22 | 1980-09-02 | American Cyanamid Company | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
US4351762A (en) | 1981-03-10 | 1982-09-28 | Bioresearch, Inc. | Rapid, quantitative peptide synthesis using mixed anhydrides |
US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
BE889979A (fr) * | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4902506A (en) | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
US4451446A (en) * | 1982-03-04 | 1984-05-29 | Smithkline-Rit | Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them |
US4496538A (en) | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
JPS59176214A (ja) * | 1982-11-23 | 1984-10-05 | ザ・ウエルカム・フアウンデ−シヨン・リミテツド | 抗原性組成物 |
EP0109688A3 (fr) | 1982-11-23 | 1986-12-03 | The Wellcome Foundation Limited | Complexes, procédés pour leur obtention et formulations contenant de tels complexes |
US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
US4663160A (en) | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
US4761283A (en) | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
US4762713A (en) | 1983-07-05 | 1988-08-09 | The University Of Rochester | Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers |
EP0145359B1 (fr) * | 1983-11-21 | 1991-01-16 | The Wellcome Foundation Limited | Complexes, leur procédé de préparation et formulations les contenant |
US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
US4882317A (en) | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
US4814276A (en) | 1986-04-25 | 1989-03-21 | Becton, Dickinson And Company | Selective medium for growth of neisseria |
US4877613A (en) | 1987-08-05 | 1989-10-31 | Biotech Connections, Inc. | Process for preparing veterinary acellular vaccines against gram-negative nonenteric pathogenic bacilli |
US4761713A (en) * | 1987-11-06 | 1988-08-02 | North American Philips Corp. | Glycol based mid-volt capacitor |
GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
NL8802046A (nl) | 1988-08-18 | 1990-03-16 | Gen Electric | Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen. |
DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
WO1990006696A2 (fr) | 1988-12-19 | 1990-06-28 | Praxis Biologics, Inc. | Vaccin meningocoque de la proteine de la membrane externe de la classe 1 |
ES2055785T3 (es) | 1989-01-17 | 1994-09-01 | Eniricerche Spa | Peptidos sinteticos y su uso como vehiculos universales para la preparacion de conjugados inmunogenos aptos para el desarrollo de vacunas sinteticas. |
US4963534A (en) | 1989-05-19 | 1990-10-16 | Merck & Co., Inc. | Process for solubilizing polyanoinic bacterial polysaccharides in aprotic solvents |
CA2017507C (fr) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant constitue d'une emulsion de gouttelettes submicron d'huile |
US5334379A (en) | 1989-07-14 | 1994-08-02 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
HU9201966D0 (en) * | 1989-12-14 | 1992-10-28 | Ca Nat Research Council | An improved vaccine of meningococcus-polysaccharide conjunction |
DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
US5256294A (en) * | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
CA2059693C (fr) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Antigenes polysaccharides de streptococcus pneumoniae |
CA2059692C (fr) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Vaccin conjugue de polysaccharide contre les pneumocoques |
JP2631035B2 (ja) | 1991-03-12 | 1997-07-16 | アメリカ合衆国 | 多糖類−タンパク質複合体 |
US5314811A (en) | 1992-07-13 | 1994-05-24 | Merck & Co., Inc. | Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide |
WO1993004183A1 (fr) * | 1991-08-16 | 1993-03-04 | Merck & Co., Inc. | Procede de conversion d'un polysaccharide capsulaire bacterien contenant des lipides en polysaccharide sans lipide |
FR2682388B1 (fr) | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
DE69333110T2 (de) | 1992-03-02 | 2004-05-06 | Chiron S.P.A. | Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose |
IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
DE69334297D1 (de) | 1992-05-23 | 2009-11-12 | Glaxosmithkline Biolog Sa | Kombinierte Impfstoffe, die Hepatitis B oberfläche Antigen und andere Antigenen enthalten |
ATE188613T1 (de) | 1992-06-25 | 2000-01-15 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
US5776468A (en) | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
ATE254475T1 (de) * | 1993-09-22 | 2003-12-15 | Jackson H M Found Military Med | Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
AU696941B2 (en) | 1994-07-01 | 1998-09-24 | Rican Limited | Helicobacter pylori antigenic protein preparation and immunoassays |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
ATE328890T1 (de) | 1994-07-15 | 2006-06-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
GB9422096D0 (en) | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
US6696065B1 (en) * | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
PT1090642E (pt) | 1995-06-07 | 2008-09-09 | Glaxosmithkline Biolog Sa | Vacinas compreendendo um conjugado de antigénio polissacarídico - proteína veículo e proteína veículo livre |
US5811102A (en) | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
US20030157129A1 (en) | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
SI0833662T2 (sl) * | 1995-06-23 | 2011-06-30 | Smithkline Beecham Biolog | Cepivni sestavek, ki vsebuje polisaharidni konjugirani antigen haemophilus influenzae b adsorbiran na aluminijevem fosfatu |
US20020054884A1 (en) | 1995-06-23 | 2002-05-09 | Smithkline Beecham Biologicals, Sa | Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
DE69737413T2 (de) | 1996-01-04 | 2007-10-31 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Bakterioferritin aus helicobacter pylori |
JP2001508758A (ja) | 1996-02-01 | 2001-07-03 | ノース・アメリカン・バクシーン・インコーポレイテッド | グループbナイセリア・メニンギチジス外膜(mb3)タンパク質の酵母からの発現およびワクチン |
EP0897427B1 (fr) † | 1996-02-14 | 2004-10-27 | Merck & Co., Inc. | Procede de precipitation de polysaccharides |
DE19630390A1 (de) | 1996-07-26 | 1998-01-29 | Chiron Behring Gmbh & Co | Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung |
CA2264735C (fr) * | 1996-08-27 | 2008-01-29 | Chiron Corporation | Glycoconjugues du groupe serologique b de neisseria meningitidis et leurs procedes d'utilisation |
EP0930893B1 (fr) | 1996-10-11 | 2005-04-13 | The Regents of The University of California | Conjugues polynucleotide immunostimulateur/molecule immunomodulatrice |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US6248334B1 (en) | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
AU722315B2 (en) | 1997-01-21 | 2000-07-27 | Pasteur Merieux Serums Et Vaccins | Polysaccharide-peptide conjugates |
DE59812033D1 (de) * | 1997-01-24 | 2004-11-04 | Schweiz Serum & Impfinst | Neues verfahren zur isolierung von polysacchariden |
EP1039935A4 (fr) | 1997-02-28 | 2005-04-27 | Univ Iowa Res Found | UTILISATION D'ACIDES NUCLEIQUES CONTENANT DES DINUCLEOTIDES CpG NON METHYLES DANS LE TRAITEMENT DES TROUBLES ASSOCIES AUX LIPOPOLYSACCHARIDES |
WO1998040100A1 (fr) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | UTILISATION D'ACIDES NUCLEIQUES CONTENANT UN DINUCLEOTIDE CpG NON METHYLE EN TANT QU'ADJUVANT |
US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
US6403306B1 (en) | 1997-04-09 | 2002-06-11 | Emory University | Serogroup-specific nucleotide sequences in the molecular typing of bacterial isolates and the preparation of vaccines thereto |
JP2002504096A (ja) | 1997-04-24 | 2002-02-05 | ヘンリー エム.ジャクソン ファウンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン | タンパク質−多糖ワクチンの調製のための未修飾タンパク質とハロアシルまたはジハロアシル誘導体化された多糖との結合 |
WO1998052581A1 (fr) | 1997-05-20 | 1998-11-26 | Ottawa Civic Hospital Loeb Research Institute | Vecteurs et procedes destines a l'immunisation et a des protocoles therapeutiques |
JP4173560B2 (ja) | 1997-05-28 | 2008-10-29 | カイロン ソチエタ ア レスポンサビリタ リミタータ | アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 |
DE69840850D1 (de) | 1997-06-06 | 2009-07-09 | Dynavax Tech Corp | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
US6413520B1 (en) | 1997-06-24 | 2002-07-02 | Chiron Corporation | Methods of immunizing adults using anti-meningococcal vaccine compositions |
US6030619A (en) * | 1997-08-27 | 2000-02-29 | Chiron Corporation | Molecular mimetics of meningococcal B epitopes |
DE69815692T2 (de) | 1997-09-05 | 2004-04-29 | Glaxosmithkline Biologicals S.A. | Öl in wasser emulsionen mit saponinen |
US5965714A (en) | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
ATE476508T1 (de) | 1997-11-06 | 2010-08-15 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
WO1999027105A2 (fr) | 1997-11-21 | 1999-06-03 | Genset | Sequence genomique et polypeptides de chlamydia pneumoniae, leurs fragments et leurs utilisations, en particulier pour le diagnostic, la prevention ou le traitement d'une infection |
GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
CA2309228A1 (fr) | 1997-11-28 | 1999-06-10 | Genset S.A. | Sequence genomique et polypeptides de chlamydia trachomatis, leurs fragments et leurs utilisations, en particulier, pour le diagnostic, la prevention et le traitement de l'infection |
DE69841676D1 (de) | 1997-12-23 | 2010-07-01 | Baxter Healthcare Sa | Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine |
BR9906927A (pt) | 1998-01-14 | 2001-11-20 | Chiron Spa | Proteìnas de neisseria meningitidis |
US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
GB9806456D0 (en) * | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
IL138000A0 (en) | 1998-04-09 | 2001-10-31 | Smithkline Beecham Biolog | Adjuvant compositions |
BR9910089A (pt) | 1998-05-01 | 2004-06-08 | Chiron Corp | Composições e antìgenos de neisseria meningitidis |
US8007815B1 (en) † | 1998-05-29 | 2011-08-30 | Novartis Ag | Combination meningitidis B/C vaccines |
GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
KR100704826B1 (ko) | 1998-08-19 | 2007-04-09 | 박스터 헬쓰케어 에스.에이. | N-아크릴로일화된 폴리사카라이드를 사용하여 제조된백신으로서 사용하기에 적합한 면역원성β-프로피온아미도-결합 폴리사카라이드 단백질 컨쥬게이트 |
US6128656A (en) * | 1998-09-10 | 2000-10-03 | Cisco Technology, Inc. | System for updating selected part of configuration information stored in a memory of a network element depending on status of received state variable |
MXPA01003557A (es) | 1998-10-09 | 2004-04-05 | Chiron Corp | Secuencias genomicas de neisseria y metodos para su uso. |
CN100558401C (zh) | 1998-10-16 | 2009-11-11 | 史密丝克莱恩比彻姆生物有限公司 | 佐剂系统及疫苗 |
EP1133572A4 (fr) | 1998-11-12 | 2005-06-15 | Univ California | Sequence genomique de chlamydia pneumoniae |
GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
JP4846906B2 (ja) * | 1999-03-19 | 2011-12-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
FR2791895B1 (fr) | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | Utilisation de trehalose pour stabiliser un vaccin liquide |
WO2000061761A2 (fr) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Support proteique recombinant de la toxine a pour vaccins conjugues polysaccharides |
IL145982A0 (en) | 1999-04-19 | 2002-07-25 | Smithkline Beecham Biolog | Vaccines |
WO2000071725A2 (fr) | 1999-05-19 | 2000-11-30 | Chiron S.P.A. | Compositions a base de combinaisons de neisseria |
GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
US6531131B1 (en) | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
BR0014285A (pt) | 1999-09-24 | 2002-05-21 | Smithkline Beecham Biolog | Adjuvantes compreendendo um éster ou éter de alquila de polioxietileno e pelo menos um tensoativo não-iÈnico |
CZ20021043A3 (cs) | 1999-09-24 | 2002-08-14 | Smithkline Beecham Biologicals S. A. | Pouľití kombinace polyoxyethylensorbitanového esteru a oktoxynolu pro výrobu pomocného prostředku |
GB9925559D0 (en) | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
DE60039450D1 (de) * | 1999-12-02 | 2008-08-21 | Novartis Vaccines & Diagnostic | Zusammensetzungen und methoden zur stabilisierung von biologischen molekülen nach lyophilisierung |
DK1248647T3 (da) | 2000-01-17 | 2010-09-27 | Novartis Vaccines & Diagnostic | Ydre membranvesikel (OMV) vaccine omfattende N. meningitidis serogruppe B ydre membranproteiner |
RU2299906C2 (ru) | 2000-02-28 | 2007-05-27 | Новартис Вэксинс Энд Диагностикс С.Р.Л. | Гетерологичная экспрессия белков neisseria |
US6800455B2 (en) | 2000-03-31 | 2004-10-05 | Scios Inc. | Secreted factors |
ES2385100T3 (es) | 2000-06-29 | 2012-07-18 | Smithkline Beecham Biologicals S.A. | Composición de vacuna multivalente con dosis reducida de Haemophilus influenzae de tipo B |
GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
ATE440861T1 (de) | 2000-07-03 | 2009-09-15 | Novartis Vaccines & Diagnostic | Immunisierung gegen chlamydia pneumoniae |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
US6753015B2 (en) * | 2000-09-28 | 2004-06-22 | Chiron Corporation | Microparticle compositions and methods for the manufacture thereof |
AU1412702A (en) | 2000-10-27 | 2002-05-06 | Chiron Spa | Nucleic acids and proteins from streptococcus groups a and b |
AP1897A (en) | 2001-01-23 | 2008-10-10 | Aventis Pasteur | Multivalent Meningococcal polysaccharide-Protein Conjugate Vaccine. |
CA2439111A1 (fr) * | 2001-04-05 | 2002-10-17 | Chiron Corporation | Augmentation de l'immunite des muqueuses a la suite d'un amorcage parenteral |
GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
WO2003028661A2 (fr) | 2001-10-03 | 2003-04-10 | Chiron Corporation | Compositions de meningocoque assorties d'un adjuvant |
ES2318117T3 (es) | 2002-03-26 | 2009-05-01 | Novartis Vaccines And Diagnostics S.R.L. | Sacaridos modificados que tienen una estabilidad mejorada en agua. |
GB0302218D0 (en) | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
MXPA04011248A (es) | 2002-05-14 | 2005-02-17 | Chiron Srl | Vacunas mucosales en combinacion para la meningitis bacteriana. |
GB0220198D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
PT2353608T (pt) | 2002-10-11 | 2020-03-11 | Novartis Vaccines And Diagnostics S R L | Vacinas de polipéptidos para protecção alargada contra linhagens meningocócicas hipervirulentas |
US10272147B2 (en) | 2003-01-30 | 2019-04-30 | Glaxosmithkline Biologicals S.A. | Injectable vaccines against multiple meningococcal serogroups |
GB0409745D0 (en) * | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
EP2357001B1 (fr) | 2006-03-22 | 2018-03-07 | GlaxoSmithKline Biologicals S.A. | Schema posologique pour une immunisation avec des conjugues de meningocoques |
GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
GB2495341B (en) * | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
-
2001
- 2001-06-20 GB GBGB0115176.0A patent/GB0115176D0/en not_active Ceased
-
2002
- 2002-06-20 CA CA2450203A patent/CA2450203C/fr not_active Expired - Lifetime
- 2002-06-20 EP EP02755452.6A patent/EP1401489B2/fr not_active Expired - Lifetime
- 2002-06-20 ES ES09075005.0T patent/ES2603275T3/es not_active Expired - Lifetime
- 2002-06-20 DE DE122011000003C patent/DE122011000003I1/de active Pending
- 2002-06-20 JP JP2003513590A patent/JP5075317B2/ja not_active Expired - Lifetime
- 2002-06-20 DE DE122010000040C patent/DE122010000040I1/de active Pending
- 2002-06-20 ES ES09075009.2T patent/ES2670196T3/es not_active Expired - Lifetime
- 2002-06-20 DK DK10007477.2T patent/DK2263688T4/da active
- 2002-06-20 ES ES06075175T patent/ES2347458T3/es not_active Expired - Lifetime
- 2002-06-20 CN CNB028124448A patent/CN100482273C/zh not_active Expired - Lifetime
- 2002-06-20 ES ES02755452T patent/ES2261705T5/es not_active Expired - Lifetime
- 2002-06-20 EP EP10179806.4A patent/EP2277537B1/fr not_active Expired - Lifetime
- 2002-06-20 PT PT02755452T patent/PT1401489E/pt unknown
- 2002-06-20 AU AU2002321716A patent/AU2002321716B2/en not_active Expired
- 2002-06-20 PT PT101798064T patent/PT2277537E/pt unknown
- 2002-06-20 DE DE122010000042C patent/DE122010000042I1/de active Pending
- 2002-06-20 CN CNA2009101281393A patent/CN101524533A/zh active Pending
- 2002-06-20 DE DE60210456T patent/DE60210456T3/de not_active Expired - Lifetime
- 2002-06-20 DK DK09075005.0T patent/DK2184071T3/en active
- 2002-06-20 EP EP09075009.2A patent/EP2216044B1/fr not_active Expired - Lifetime
- 2002-06-20 NZ NZ529881A patent/NZ529881A/xx not_active IP Right Cessation
- 2002-06-20 ES ES09075006.8T patent/ES2573259T3/es not_active Expired - Lifetime
- 2002-06-20 EP EP10179797.5A patent/EP2277536B1/fr not_active Expired - Lifetime
- 2002-06-20 EP EP10180707A patent/EP2277539A3/fr not_active Ceased
- 2002-06-20 RU RU2004101284/13A patent/RU2381814C2/ru not_active Application Discontinuation
- 2002-06-20 CN CN200910128140.6A patent/CN101524534B/zh not_active Expired - Lifetime
- 2002-06-20 PT PT101797975T patent/PT2277536T/pt unknown
- 2002-06-20 DE DE122010000041C patent/DE122010000041I1/de active Pending
- 2002-06-20 EP EP06075175A patent/EP1741442B1/fr not_active Expired - Lifetime
- 2002-06-20 WO PCT/IB2002/003191 patent/WO2003007985A2/fr active IP Right Grant
- 2002-06-20 TR TR2018/08026T patent/TR201808026T4/tr unknown
- 2002-06-20 US US10/481,457 patent/US8753651B2/en active Active
- 2002-06-20 AT AT06075175T patent/ATE474594T1/de active
- 2002-06-20 DK DK02755452.6T patent/DK1401489T4/da active
- 2002-06-20 PT PT10007477T patent/PT2263688E/pt unknown
- 2002-06-20 CN CN200910128141.0A patent/CN101524535B/zh not_active Expired - Lifetime
- 2002-06-20 ES ES10007477T patent/ES2387592T5/es not_active Expired - Lifetime
- 2002-06-20 DK DK09075006.8T patent/DK2189165T3/en active
- 2002-06-20 MX MXPA03011462A patent/MXPA03011462A/es active IP Right Grant
- 2002-06-20 DK DK10179797.5T patent/DK2277536T3/en active
- 2002-06-20 EP EP09075006.8A patent/EP2189165B1/fr not_active Expired - Lifetime
- 2002-06-20 AT AT02755452T patent/ATE322287T1/de active
- 2002-06-20 ES ES10179797.5T patent/ES2662015T3/es not_active Expired - Lifetime
- 2002-06-20 EP EP10007477.2A patent/EP2263688B2/fr not_active Expired - Lifetime
- 2002-06-20 DK DK06075175.7T patent/DK1741442T3/da active
- 2002-06-20 AT AT10007477T patent/ATE556718T1/de active
- 2002-06-20 EP EP09075005.0A patent/EP2184071B1/fr not_active Expired - Lifetime
- 2002-06-20 EP EP09075010.0A patent/EP2229954B1/fr not_active Expired - Lifetime
- 2002-06-20 ES ES09075010.0T patent/ES2670219T3/es not_active Expired - Lifetime
- 2002-06-20 BR BRPI0210590-0 patent/BRPI0210590B8/pt not_active IP Right Cessation
- 2002-06-20 BR BR122019009186A patent/BR122019009186B8/pt not_active IP Right Cessation
- 2002-06-20 TR TR2018/08055T patent/TR201808055T4/tr unknown
- 2002-06-20 CA CA2730856A patent/CA2730856C/fr not_active Expired - Lifetime
- 2002-06-20 NZ NZ544332A patent/NZ544332A/en not_active IP Right Cessation
- 2002-06-20 CA CA2641585A patent/CA2641585C/fr not_active Expired - Lifetime
- 2002-06-20 PT PT06075175T patent/PT1741442E/pt unknown
- 2002-06-20 ES ES10179806.4T patent/ES2539134T3/es not_active Expired - Lifetime
- 2002-06-20 DE DE60237123T patent/DE60237123D1/de not_active Expired - Lifetime
- 2002-06-20 PT PT90750050T patent/PT2184071T/pt unknown
-
2007
- 2007-07-24 AU AU2007203442A patent/AU2007203442B2/en not_active Expired
-
2009
- 2009-01-09 US US12/351,281 patent/US8889152B2/en not_active Expired - Lifetime
- 2009-01-14 US US12/353,409 patent/US8852606B2/en active Active
- 2009-01-20 US US12/321,464 patent/US9358278B2/en not_active Expired - Fee Related
- 2009-01-20 US US12/321,434 patent/US9782467B2/en not_active Expired - Lifetime
- 2009-01-20 US US12/321,417 patent/US9452207B2/en not_active Expired - Fee Related
- 2009-01-20 US US12/321,420 patent/US20090130147A1/en not_active Abandoned
- 2009-01-20 US US12/321,418 patent/US9782466B2/en not_active Expired - Lifetime
- 2009-02-26 JP JP2009044925A patent/JP5380111B2/ja not_active Expired - Lifetime
- 2009-02-26 JP JP2009044924A patent/JP5220658B2/ja not_active Expired - Lifetime
- 2009-03-11 RU RU2009108660/10A patent/RU2528066C2/ru active
-
2010
- 2010-09-13 FR FR10C0044C patent/FR10C0044I1/fr active Active
- 2010-09-13 NL NL300458C patent/NL300458I2/nl unknown
- 2010-09-13 BE BE2010C031C patent/BE2010C031I2/fr unknown
- 2010-09-13 BE BE2010C033C patent/BE2010C033I2/fr unknown
- 2010-09-13 BE BE2010C032C patent/BE2010C032I2/fr unknown
- 2010-09-13 NL NL300459C patent/NL300459I2/nl unknown
- 2010-09-13 FR FR10C0043C patent/FR10C0043I1/fr active Active
- 2010-09-13 NL NL300460C patent/NL300460I2/nl unknown
- 2010-09-13 FR FR10C0042C patent/FR10C0042I1/fr active Active
- 2010-09-14 LU LU91734C patent/LU91734I2/fr unknown
- 2010-09-14 LU LU91733C patent/LU91733I2/fr unknown
- 2010-09-14 LU LU91732C patent/LU91732I2/fr unknown
- 2010-10-11 CY CY20101100902T patent/CY1110820T1/el unknown
- 2010-11-19 AU AU2010246331A patent/AU2010246331B2/en not_active Expired
-
2011
- 2011-01-13 BE BE2011C001C patent/BE2011C001I2/fr unknown
- 2011-01-13 LU LU91778C patent/LU91778I2/fr unknown
- 2011-01-14 FR FR11C0001C patent/FR11C0001I2/fr active Active
- 2011-01-18 CY CY2011001C patent/CY2011001I2/el unknown
-
2012
- 2012-08-03 CY CY20121100693T patent/CY1113020T1/el unknown
- 2012-10-05 JP JP2012222942A patent/JP2013007057A/ja not_active Withdrawn
-
2016
- 2016-05-18 CY CY20161100432T patent/CY1117528T1/el unknown
- 2016-10-21 CY CY20161101065T patent/CY1118130T1/el unknown
- 2016-10-31 US US15/339,741 patent/US10716841B2/en not_active Expired - Fee Related
-
2018
- 2018-03-30 CY CY20181100356T patent/CY1120499T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR11C0001I1 (fr) | ||
ZA200306176B (en) | Multivalent meningococcal polysaccharide-protein conjugate vaccine. | |
AU2002309706A1 (en) | Novel meningitis conjugate vaccine | |
BR9814483A (pt) | "vacina" | |
AU2002353417A1 (en) | Adjuvanted antigenic meningococcal compositions | |
WO2000025814A3 (fr) | Constituant pour un vaccin | |
AU2002342949A1 (en) | Vaccine composition comprising at least two valences, one with enhanced adjuvant and not the other | |
AU2002315309A1 (en) | Vaccine against tuberculosis | |
AU2001281828A1 (en) | Disubstituted 1,7-guanines | |
AU2002321781A1 (en) | Igf-1 as feline vaccine adjuvant, in particular against feline retroviruses |