BE2008C047I2 - - Google Patents

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Publication number
BE2008C047I2
BE2008C047I2 BE2008C047C BE2008C047C BE2008C047I2 BE 2008C047 I2 BE2008C047 I2 BE 2008C047I2 BE 2008C047 C BE2008C047 C BE 2008C047C BE 2008C047 C BE2008C047 C BE 2008C047C BE 2008C047 I2 BE2008C047 I2 BE 2008C047I2
Authority
BE
Belgium
Application number
BE2008C047C
Other languages
French (fr)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8241767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2008C047(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of BE2008C047I2 publication Critical patent/BE2008C047I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BE2008C047C 1999-11-29 2008-12-10 BE2008C047I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99309558 1999-11-29
PCT/EP2000/011789 WO2001040316A1 (en) 1999-11-29 2000-11-23 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block

Publications (1)

Publication Number Publication Date
BE2008C047I2 true BE2008C047I2 (en) 2019-12-11

Family

ID=8241767

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2008C047C BE2008C047I2 (en) 1999-11-29 2008-12-10

Country Status (34)

Country Link
US (3) USRE44733E1 (en)
EP (1) EP1259550B1 (en)
JP (2) JP3880041B2 (en)
KR (1) KR100716524B1 (en)
CN (1) CN1188428C (en)
AR (1) AR026605A1 (en)
AT (1) ATE288450T1 (en)
AU (1) AU776536B2 (en)
BE (1) BE2008C047I2 (en)
BR (1) BRPI0015947B8 (en)
CA (1) CA2390463C (en)
CO (1) CO5251450A1 (en)
CY (1) CY2008018I1 (en)
CZ (1) CZ298206B6 (en)
DE (2) DE60017947T2 (en)
DK (1) DK1259550T3 (en)
ES (1) ES2237496T3 (en)
FR (1) FR08C0052I2 (en)
HK (1) HK1049489A1 (en)
HU (1) HU227451B1 (en)
IL (1) IL149423A0 (en)
LU (1) LU91501I2 (en)
MX (1) MXPA02004940A (en)
NL (1) NL300356I2 (en)
NO (2) NO328790B1 (en)
NZ (1) NZ518752A (en)
PE (1) PE20010902A1 (en)
PL (1) PL203012B1 (en)
PT (1) PT1259550E (en)
RU (1) RU2260013C2 (en)
SK (1) SK286282B6 (en)
TW (1) TWI242015B (en)
WO (1) WO2001040316A1 (en)
ZA (1) ZA200203538B (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6744471B1 (en) * 1997-12-05 2004-06-01 Olympus Optical Co., Ltd Electronic camera that synthesizes two images taken under different exposures
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
ATE337790T1 (en) * 2000-11-02 2006-09-15 Akzo Nobel Nv USE OF CORTISOL SEQUESTRING AGENTS TO TREAT HYPERCORTISOLAEMIA-RELATED DISEASES
BRPI0415637A (en) 2003-10-31 2006-12-12 Univ Kansas sulfoalkyl ether-alkyl ether cyclodextrin derivatives
EP1735326A4 (en) 2004-01-29 2011-04-20 Pinnacle Pharmaceuticals Beta-cyclodextrin derivatives and their use against anthrax lethal toxin
SI2708225T1 (en) 2004-04-23 2019-05-31 Cydex Pharmaceuticals, Inc. DPI Formulation Containing Sulfoalkyl Ether Cyclodextrin
JP2008528761A (en) 2005-01-28 2008-07-31 ピナクル ファーマシューティカルズ，インク． Β-cyclodextrin derivatives as antibacterial agents
EP2581078B1 (en) 2005-10-26 2014-12-10 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US20090069412A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched sugammadex
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
US7938283B2 (en) * 2008-06-20 2011-05-10 Grainpro, Inc. System and method for hermetic storage of agricultural commodities during shipping
WO2010053487A1 (en) 2008-11-07 2010-05-14 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
CN101591402B (en) * 2009-05-05 2011-11-30 杭州奥默医药技术有限公司 6-deoxy-sulfones cyclodextrin derivatives and preparation method thereof
US8492538B1 (en) 2009-06-04 2013-07-23 Jose R. Matos Cyclodextrin derivative salts
DE102010012281A1 (en) 2010-03-22 2011-09-22 Fresenius Medical Care Deutschland Gmbh Pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrin
CN101864003B (en) * 2010-06-11 2012-05-02 漆又毛 Synthesis method of 6-deoxy thioether amino acid cyclodextrin derivative
US9120876B2 (en) * 2010-08-25 2015-09-01 Ramamohan Rao Davuluri Process for preparation of Sugammadex
CN102060941B (en) * 2010-11-26 2012-12-26 漆又毛 6-deoxy alpha-amino acid derivative cyclodextrin, preparation and application thereof
PT3702374T (en) 2012-02-15 2022-06-23 Cydex Pharmaceuticals Inc Manufacturing process for cyclodextrin derivatives
RU2747757C2 (en) 2012-02-28 2021-05-13 Сидекс Фармасьютикалс, Инк. Compositions of alkylated cyclodextrin and methods of their preparation and application
JP5892847B2 (en) * 2012-04-27 2016-03-23 Ｄｏｗａホールディングス株式会社 Composite material of cyclodextrin and silica-containing substance, method for producing the same, and gas adsorbent
GB201211153D0 (en) * 2012-06-22 2012-08-08 Farmhispania Pharmaceutical compositions
EA032006B1 (en) 2012-10-22 2019-03-29 Сидекс Фармасьютикалс, Инк. Alkylated cyclodextrin compositions and processes for preparing and using the same
WO2014125501A1 (en) 2013-02-14 2014-08-21 Neuland Laboratories Limited An improved process for preparation of sugammadex sodium
US10662260B2 (en) 2014-05-29 2020-05-26 Uti Limited Partnership Cyclodextrin-based polyanionic and non-ionic dendrimers
SG11201609790SA (en) 2014-06-26 2017-01-27 Maruishi Pharma Rocuronium preparation with improved stability
CN105348412B (en) * 2014-08-22 2018-06-05 江苏恩华药业股份有限公司 A kind of purification process for the more glucose sodium that relaxes
JP6914188B2 (en) 2014-08-22 2021-08-04 サイデックス・ファーマシューティカルズ・インコーポレイテッド Fractional Alkylated Cyclodextrin Composition and Method for Preparation and Use thereof
CA2980170A1 (en) 2015-03-19 2016-09-22 Cydex Pharmaceuticals, Inc. Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same
CN104844732B (en) * 2015-03-27 2017-05-03 山东滨州智源生物科技有限公司 Preparation method for sugammadex sodium
US20180296679A1 (en) * 2015-04-08 2018-10-18 Chang-Chun Ling Pharmaceutical compositions of polyanionic and non-ionic cyclodextrin-based dendrimers and uses thereof
US10494450B2 (en) * 2015-05-29 2019-12-03 Lakshmi Prasad ALAPARTHI Processes for preparation of Sugammadex and intermediates thereof
CN104922693A (en) * 2015-06-19 2015-09-23 南开大学 Anionic-type cyclodextrin and anti-cancer drug clathrate compound and preparation method
AU2016334062A1 (en) * 2015-10-07 2018-05-10 Uti Limited Partnership Multifunctional polyanionic cyclodextrin dendrimers
EP3741779A1 (en) 2015-11-25 2020-11-25 Fresenius Kabi iPSUM S.r.l. An improved process for the preparation of sugammadex and its intermediates
ES2812226T5 (en) 2015-11-25 2024-04-29 Fresenius Kabi Ipsum S R L Crystalline forms of perchloro-gamma-cyclodextrins
WO2017163165A1 (en) 2016-03-22 2017-09-28 Fresenius Kabi Anti-Infectives S.r.l. An improved process for the preparation of sugammadex
CA3022455C (en) * 2016-04-29 2021-08-03 Stichting Sanquin Bloedvoorziening Cyclodextrins as procoagulants
ES2915423T3 (en) 2016-06-23 2022-06-22 Synthon Bv Sugammadex preparation process
US10526422B2 (en) 2016-06-29 2020-01-07 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Process for preparation and purification of Sugammades sodium
JP6692941B2 (en) * 2016-06-29 2020-05-27 北京叡創康泰医薬研究院有限公司Ｂｅｉｊｉｎｇ Ｃｒｅａｔｒｏｎ Ｉｎｓｔｉｔｕｔｅ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏ．， Ｌｔｄ． Method for manufacturing and purifying sugammadex
CN107778383B (en) 2016-08-24 2020-03-10 王炳永 Refining method of sugammadex sodium
US10385142B2 (en) 2017-01-23 2019-08-20 Scinopharm Taiwan, Ltd. Method for preparing sugammadex sodium
WO2018204535A1 (en) 2017-05-03 2018-11-08 Cydex Pharmaceuticals, Inc. Composition containing cyclodextrin and busulfan
CN109021148B (en) * 2017-06-08 2020-11-10 天津科伦药物研究有限公司 Method for preparing sugammadex sodium
US10442871B2 (en) * 2017-06-22 2019-10-15 Lawrence Livermore National Security, Llc Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof
ES2761899T3 (en) 2017-06-30 2020-05-21 Synthon Bv Process to prepare Sugammadex
TWI703163B (en) * 2017-08-23 2020-09-01 台耀化學股份有限公司 Method for preparing sugammadex sodium and crystalline form thereof
US10233263B1 (en) * 2017-08-23 2019-03-19 Formosa Laboratories, Inc. Method for preparation of sugammadex sodium
US11104746B2 (en) 2017-11-27 2021-08-31 Medichem, S.A. Process for the synthesis of a cyclodextrin derivative
CN107892727B (en) * 2017-11-27 2019-12-24 合肥博思科创医药科技有限公司 Method for purifying sugammadex sodium
US11225565B2 (en) 2018-04-06 2022-01-18 Synthon B.V. Purification of sugammadex
KR102054228B1 (en) 2018-05-28 2019-12-10 연성정밀화학(주) Process for Preparing Sugammadex Sodium
WO2019236436A1 (en) * 2018-06-07 2019-12-12 Merck Sharp & Dohme Corp. Processes for the preparation of sugammadex
CN110615860A (en) * 2018-06-20 2019-12-27 江苏恒瑞医药股份有限公司 Method for purifying sugammadex sodium
WO2020028448A1 (en) 2018-08-02 2020-02-06 Pliva Hrvatska D.O.O. Solid state forms of sugammadex sodium
US11845811B2 (en) 2018-09-20 2023-12-19 Natco Pharma Limited Process for the preparation of Sugammadex sodium and its novel polymorphic form
EP3856791A1 (en) 2018-09-27 2021-08-04 Werthenstein Biopharma GmbH Novel crystalline forms of sugammadex
JP6950966B2 (en) * 2018-11-01 2021-10-13 丸石製薬株式会社 Sugamadex or its pharmacologically acceptable salt-containing liquid and its production method
CN109438591B (en) * 2018-12-29 2021-02-09 博瑞生物医药（苏州）股份有限公司 Preparation process of sugammadex sodium
CN109824800A (en) * 2018-12-29 2019-05-31 鼎元(天津)生物医药科技有限公司 A kind of preparation method of the easypro more glucose sodium of selectivity flesh pine antagonistic
WO2020201930A1 (en) 2019-03-29 2020-10-08 Hospira, Inc. An improved process for preparation of sugammadex acid and sugammadex sodium
CN111978435B (en) 2019-05-22 2021-05-25 合肥博思科创医药科技有限公司 Preparation method of high-purity sugammadex sodium
US11324692B2 (en) 2019-07-03 2022-05-10 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions of suggamadex
EP4023292A4 (en) 2019-08-30 2023-09-06 TERUMO Kabushiki Kaisha Injection formulation
RU2724900C1 (en) * 2019-10-24 2020-06-26 Маруиси Фармасьютикал Ко., Лтд. Rocuronium preparation with improved stability
CN111019016B (en) * 2019-12-27 2022-02-18 武汉嘉诺康医药技术有限公司 Synthesis method of sugammadex impurity
CN115348974B (en) 2020-02-28 2024-03-08 摩迪康公司 Method for drying sugammadex
CN111714459B (en) * 2020-06-18 2022-06-14 广州瑞尔医药科技有限公司 Shugeng sodium gluconate powder injection and preparation method thereof
US11097023B1 (en) 2020-07-02 2021-08-24 Par Pharmaceutical, Inc. Pre-filled syringe containing sugammadex
ES2949710T1 (en) 2020-07-03 2023-10-02 Galenicum Health S L U Method for preparing pharmaceutical compositions
US11446325B2 (en) * 2020-09-30 2022-09-20 Cyclolab Cyclodextrin Research And Development Laboratory Ltd. Cyclodextrin derivatives in the treatment or prevention of lysosomal neurodegenerative diseases
US11945788B2 (en) 2021-06-07 2024-04-02 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
CN113637097A (en) * 2021-08-10 2021-11-12 北京恒创星远医药科技有限公司 6-full-deoxidation-6-full-iodo-gamma-cyclodextrin crystal and preparation method and application thereof
CN115708777A (en) * 2021-08-19 2023-02-24 北京费森尤斯卡比医药有限公司 Packaged pharmaceutical product comprising mercaptocyclodextrin derivative or pharmaceutically acceptable salt thereof and method of preservation

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929813A (en) 1973-12-26 1975-12-30 Interx Research Corp Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same
JPS52108027A (en) 1976-03-09 1977-09-10 Rikagaku Kenkyusho Anticarcinogen
US4816462A (en) 1982-05-18 1989-03-28 Nowicky Wassili Method for diagnosing and for the therapeutic treatment of tumors and/or infectious diseases of different types with alkaloid-compounds
HU194858B (en) 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
IT1196033B (en) 1984-02-22 1988-11-10 Chiesi Farma Spa COMPOUND WITH ANTI-INFLAMMATORY ACTIVITY OBTAINED BY COMPLEXATION WITH BETA-CYCLODEXTRINE AND RELATED PHARMACEUTICAL FORMULATIONS
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (en) 1986-12-26 1996-02-28 日清製粉株式会社 Sustained-release pharmaceutical preparation
HU201783B (en) 1987-10-13 1990-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing partially methylized carboxy-acyl-beta-cyclodextrines and salts
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5017566A (en) 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
ATE166884T1 (en) 1989-04-03 1998-06-15 Janssen Pharmaceutica Nv REGIOSELECTIVE SUBSTITUTIONS OF CYCLODEXTRINS
US5173481A (en) 1989-04-03 1992-12-22 The United States Of America As Represented By The Department Of Health And Human Services Preparation of specifically substituted cyclodextrins
EP0447171B1 (en) * 1990-03-15 1994-11-02 Tanabe Seiyaku Co., Ltd. Polysulfate of cyclodextrin derivative and process for preparing the same
US5180716A (en) 1990-08-01 1993-01-19 The Regents Of The University Of California Cyclodextrin complexes for neuraxial administration of drugs
JP2556236B2 (en) 1991-08-29 1996-11-20 田辺製薬株式会社 Polysulfate of β-cyclodextrin derivative and process for producing the same
US5840881A (en) 1992-11-27 1998-11-24 Takeda Chemical Industries, Ltd. Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
US5767112A (en) 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
AU708107B2 (en) 1994-11-04 1999-07-29 Commonwealth Scientific And Industrial Research Organisation Method for treating animals
GB2307176A (en) * 1995-11-15 1997-05-21 Todd Selwyn Everest Anti-inflammatory clathrating agents for topical use
US5935941A (en) 1997-10-24 1999-08-10 Pitha; Josef Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity
US5834446A (en) * 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
JP4249282B2 (en) 1998-02-27 2009-04-02 日本食品化工株式会社 Novel cyclodextrin derivative and process for producing the same
CA2330681C (en) 1998-05-29 2008-08-26 Andrea Giuffrida Control of pain with endogenous cannabinoids
JP4782334B2 (en) * 1999-08-13 2011-09-28 ナームローゼ・フエンノートチヤツプ・オルガノン Use of chemical chelators as antagonists for drug-induced neuromuscular blockade
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
US20020111377A1 (en) 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
WO2002064635A1 (en) 2001-02-14 2002-08-22 Akzo Nobel N.V. 2-alkylated-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
TW200402417A (en) 2002-06-21 2004-02-16 Akzo Nobel Nv 1-[(Indol-3-yl)carbonyl]piperazine derivatives

Also Published As

Publication number Publication date
AU5438001A (en) 2001-06-12
LU91501I9 (en) 2019-01-02
US6949527B2 (en) 2005-09-27
PL356097A1 (en) 2004-06-14
CZ298206B6 (en) 2007-07-18
CA2390463A1 (en) 2001-06-07
NO20022522D0 (en) 2002-05-28
NO2010019I1 (en) 2010-11-22
DE122008000068I2 (en) 2011-06-16
PT1259550E (en) 2005-05-31
LU91501I2 (en) 2009-01-26
NO20022522L (en) 2002-05-28
EP1259550A1 (en) 2002-11-27
WO2001040316A1 (en) 2001-06-07
NO2010019I2 (en) 2012-08-27
FR08C0052I1 (en) 2009-02-27
NZ518752A (en) 2003-03-28
FR08C0052I2 (en) 2009-12-18
KR100716524B1 (en) 2007-05-10
EP1259550B1 (en) 2005-02-02
CN1188428C (en) 2005-02-09
ATE288450T1 (en) 2005-02-15
CO5251450A1 (en) 2003-02-28
BRPI0015947B1 (en) 2012-02-07
TWI242015B (en) 2005-10-21
BRPI0015947A (en) 2002-08-20
ZA200203538B (en) 2003-08-04
PL203012B1 (en) 2009-08-31
NL300356I2 (en) 2009-04-01
CN1402737A (en) 2003-03-12
CA2390463C (en) 2009-02-03
DE122008000068I1 (en) 2009-04-23
CY2008018I2 (en) 2009-11-04
MXPA02004940A (en) 2003-05-23
IL149423A0 (en) 2002-11-10
DE60017947D1 (en) 2005-03-10
SK7262002A3 (en) 2002-11-06
HU227451B1 (en) 2011-06-28
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