AU8633082A - Paramagnetic complex salts and their use in nmr- diagnostics - Google Patents

Paramagnetic complex salts and their use in nmr- diagnostics

Info

Publication number
AU8633082A
AU8633082A AU86330/82A AU8633082A AU8633082A AU 8633082 A AU8633082 A AU 8633082A AU 86330/82 A AU86330/82 A AU 86330/82A AU 8633082 A AU8633082 A AU 8633082A AU 8633082 A AU8633082 A AU 8633082A
Authority
AU
Australia
Prior art keywords
numbers
see diagramm
diagnostics
nmr
paramagnetic complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU86330/82A
Other versions
AU566007B2 (en
Inventor
Heinz Gries
Douwe Rosenberg
Hans-Joachim Weinmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6137999&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU8633082(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Publication of AU8633082A publication Critical patent/AU8633082A/en
Application granted granted Critical
Publication of AU566007B2 publication Critical patent/AU566007B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. The use of at least one physiologically tolerable paramagnetic complex salt made from aminopolycarboxylic acids having the formulae I to IV see diagramm : EP0169299,P6,F1 N-hydroxyethyl-N,N',N'-ethylenediaminetriacetic acid (HEDTA), see diagramm : EP0169299,P6,F2 N,N,N',N",N"-diethylenetriaminepenta-acetic acid (DTPA), HOH2 C-CH2 N(CH2 COOH)2 N-hydroxyethylimino-diacetic acid, see diagramm : EP0169299,P6,F3 wherein m represents the numbers 1 to 4, n the numbers 0 to 2, R**1 a saturated or unsaturated hydrocarbon radical having from 4 to 12 hydrocarbon atoms or the group -CH2 -COOH, and from the ions of the lanthanide elements having the atomic numbers 57 to 70 or from the ions of the transition metals having the atomic numbers 21 to 29, 42 and 44 and, optionally from an inorganic base for the preparation of agents for NMR diagnostics.
AU86330/82A 1981-07-24 1982-07-22 Paramagnetic complex salts and their use in nmr- diagnostics Expired AU566007B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3129906A DE3129906C3 (en) 1981-07-24 1981-07-24 Paramagnetic complex salts, their preparation and agents for use in NMR diagnostics
DE31299067 1981-07-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU10186/88A Division AU601916B2 (en) 1981-07-24 1988-01-08 Paramagnetic complex salts, their preparation and their use in nmr-diagnostics

Publications (2)

Publication Number Publication Date
AU8633082A true AU8633082A (en) 1983-01-27
AU566007B2 AU566007B2 (en) 1987-10-08

Family

ID=6137999

Family Applications (2)

Application Number Title Priority Date Filing Date
AU86330/82A Expired AU566007B2 (en) 1981-07-24 1982-07-22 Paramagnetic complex salts and their use in nmr- diagnostics
AU10186/88A Expired AU601916B2 (en) 1981-07-24 1988-01-08 Paramagnetic complex salts, their preparation and their use in nmr-diagnostics

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU10186/88A Expired AU601916B2 (en) 1981-07-24 1988-01-08 Paramagnetic complex salts, their preparation and their use in nmr-diagnostics

Country Status (12)

Country Link
EP (2) EP0169299B1 (en)
JP (3) JPS5829718A (en)
AT (2) ATE52247T1 (en)
AU (2) AU566007B2 (en)
CA (2) CA1218597A (en)
DE (3) DE3129906C3 (en)
IE (1) IE53639B1 (en)
LU (1) LU88291I2 (en)
NL (1) NL930072I2 (en)
NO (2) NO164458C (en)
NZ (1) NZ201372A (en)
ZA (1) ZA825313B (en)

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WO1986001112A1 (en) * 1984-08-10 1986-02-27 Fox Chase Cancer Center Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging
WO1986002841A1 (en) * 1984-11-13 1986-05-22 New Salutar, Inc. Diamide-dtpa-paramagnetic contrast agents for mr imaging, apparatus and methods
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
WO1986006605A1 (en) * 1985-05-08 1986-11-20 The General Hospital Corporation Hepatobiliary nmr contrast agents
US4637929A (en) * 1985-01-04 1987-01-20 Salutar, Inc. Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
US4746507A (en) * 1985-04-02 1988-05-24 Salutar, Inc. EDHPA based contrast agents for MR imaging, apparatus and methods
US4749560A (en) * 1984-08-13 1988-06-07 Research Corporation Metal organo phosphorous compounds for NMR analysis
AU573611B2 (en) * 1983-08-12 1988-06-16 Du Pont Merck Pharmaceutical Company, The Nmr imaging utilizing chemical shift reagents
US4758422A (en) * 1985-01-04 1988-07-19 Salutar Inc. Ferrioxamine paramagnetic contrast agents for MR imaging
US4808541A (en) * 1983-03-15 1989-02-28 Lkb Produkter Ab Determination method utilizing reagents covalently labelled with essentially non-fluorescent lanthanide chelates in combination with time-resolved fluorescence spectroscopy and the reagents to be used in the method
AU583070B2 (en) * 1984-11-23 1989-04-20 Schering Aktiengesellschaft Magnetic particles for diagnostic purposes
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
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US4925652A (en) * 1983-08-03 1990-05-15 Schering Aktiengesellschaft Nitroxyl compounds, and diagnostic media based thereon useful for enhancing NmR imaging
US4972837A (en) * 1983-04-26 1990-11-27 Regents Of The University Of California Contrast agents for nuclear magnetic resonance imaging
US4985233A (en) * 1984-11-01 1991-01-15 Nycomed /As A diagnostic agent containing a non-radioactive paramagnetic metal species in a macromolecular carrier
US4986980A (en) * 1984-11-01 1991-01-22 Nycomed As Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents
US5010191A (en) * 1985-08-19 1991-04-23 The Regents Of The University Of California Imaging agents for in vivo magnetic resonance and scintigraphic imaging
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US5208324A (en) * 1988-01-26 1993-05-04 Nycomed Imaging As Paramagnetic compounds
US5474756A (en) * 1986-01-23 1995-12-12 Bracco International B.V. Method for imaging mammalian tissue using 1-substituted-1,4,7-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
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US5720939A (en) * 1985-08-15 1998-02-24 Nycomed Imaging As Method of contrast enhanced magnetic resonance imaging using magnetically responsive-particles
US6193950B1 (en) 1989-11-21 2001-02-27 Schering Ag Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
US6676929B2 (en) 1995-02-01 2004-01-13 Epix Medical, Inc. Diagnostic imaging contrast agents with extended blood retention
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DE3316703A1 (en) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen ORAL CONTRAST AGENT FOR MRI MRI AND THE PRODUCTION THEREOF
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US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
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US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
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LU88291I2 (en) 1994-05-04
IE53639B1 (en) 1989-01-04
CA1218597A (en) 1987-03-03
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JP2548436B2 (en) 1996-10-30
ZA825313B (en) 1983-05-25
DE3280157D1 (en) 1990-05-31
DE3129906C2 (en) 1990-05-17
AU1018688A (en) 1988-04-28
NO1994031I1 (en) 1994-12-30
NL930072I2 (en) 1994-01-17
NO164458C (en) 1992-11-23
EP0169299B1 (en) 1990-04-25
EP0169299A3 (en) 1986-12-03
ATE52247T1 (en) 1990-05-15
NO164458B (en) 1990-07-02
EP0071564B1 (en) 1986-03-26
JPS5829718A (en) 1983-02-22
JPH0339045B2 (en) 1991-06-12
DE3129906A1 (en) 1983-02-10
AU601916B2 (en) 1990-09-20
NZ201372A (en) 1986-08-08
AU566007B2 (en) 1987-10-08
IE821766L (en) 1983-01-24
DE3129906C3 (en) 1996-12-19
EP0169299A2 (en) 1986-01-29
EP0071564A1 (en) 1983-02-09
NL930072I1 (en) 1993-09-01
JPH03209389A (en) 1991-09-12

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