AU7230994A - Process for the synthesis of nucleic acids on a solid support and compounds which are useful in particular as solid supports in the said process - Google Patents

Process for the synthesis of nucleic acids on a solid support and compounds which are useful in particular as solid supports in the said process

Info

Publication number
AU7230994A
AU7230994A AU72309/94A AU7230994A AU7230994A AU 7230994 A AU7230994 A AU 7230994A AU 72309/94 A AU72309/94 A AU 72309/94A AU 7230994 A AU7230994 A AU 7230994A AU 7230994 A AU7230994 A AU 7230994A
Authority
AU
Australia
Prior art keywords
solid support
useful
nucleic acids
solid
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU72309/94A
Other versions
AU696421B2 (en
Inventor
Ludmilla Baranova
Francois Chatelain
Viktor Kumarev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Aldrich Co LLC
Original Assignee
Sigma Aldrich Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Aldrich Co LLC filed Critical Sigma Aldrich Co LLC
Publication of AU7230994A publication Critical patent/AU7230994A/en
Application granted granted Critical
Publication of AU696421B2 publication Critical patent/AU696421B2/en
Assigned to PROLIGO LLC reassignment PROLIGO LLC Alteration of Name(s) in Register under S187 Assignors: GENSET
Assigned to SIGMA-ALDRICH CO. LLC reassignment SIGMA-ALDRICH CO. LLC Request to Amend Deed and Register Assignors: PROLIGO LLC
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The object of the present invention is a process for synthesizing solid phase nucleic acids, characterized in that a mineral or organic polymer, bound by a bivalent hydrocarbon radical to an epoxy or glycol-type group, is used as a solid support, said epoxy or glycol-type group comprising two adjacent saturated carbon atoms on which an OH and a nucleophilic group are substituted. The present invention also pertains to compounds containing an epoxy or glycol-type group as defined above, useful for example as a solid support in a process for solid support nucleic acid synthesis.
AU72309/94A 1993-07-09 1994-07-07 Process for the synthesis of nucleic acids on a solid support and compounds which are useful in particular as solid supports in the said process Expired AU696421B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9308498 1993-07-09
FR9308498A FR2707296B1 (en) 1993-07-09 1993-07-09 Process for the synthesis of nucleic acids on a solid support and compounds useful in particular as a solid support in said process.
PCT/FR1994/000842 WO1995001987A1 (en) 1993-07-09 1994-07-07 Process for solid support nucleic acid synthesis and compounds useful as solid supports in said process

Publications (2)

Publication Number Publication Date
AU7230994A true AU7230994A (en) 1995-02-06
AU696421B2 AU696421B2 (en) 1998-09-10

Family

ID=9449129

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72309/94A Expired AU696421B2 (en) 1993-07-09 1994-07-07 Process for the synthesis of nucleic acids on a solid support and compounds which are useful in particular as solid supports in the said process

Country Status (14)

Country Link
EP (1) EP0707592B1 (en)
JP (1) JPH08512306A (en)
KR (1) KR960703937A (en)
AT (1) ATE157668T1 (en)
AU (1) AU696421B2 (en)
CA (1) CA2166765A1 (en)
DE (1) DE69405396T2 (en)
DK (1) DK0707592T3 (en)
ES (1) ES2109005T3 (en)
FR (1) FR2707296B1 (en)
GR (1) GR3025420T3 (en)
HK (1) HK1002731A1 (en)
TW (1) TW397839B (en)
WO (1) WO1995001987A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714061B1 (en) * 1993-12-16 1996-03-08 Genset Sa Process for the preparation of polynucleotides on solid support and apparatus allowing its implementation.
US5869696A (en) * 1996-04-22 1999-02-09 Beckman Instruments, Inc. Universal solid supports and methods for their use
US6590092B1 (en) 1998-05-19 2003-07-08 Nam Q. Ngo Process for preparing a “universal support” and the reagents used for generating such support
EP1006121B1 (en) * 1998-12-02 2003-05-02 Council of Scientific and Industrial Research A universal polymer support for the synthesis of oligonucleotides
WO2000047771A2 (en) 1999-02-12 2000-08-17 Genset Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
WO2000053578A1 (en) * 1999-03-11 2000-09-14 Kuraray Co., Ltd. Vitamin d derivatives and process for the preparation thereof
DK1132739T3 (en) * 2000-05-16 2002-01-28 Biochip Technologies Gmbh Linker system for activating surfaces for bioconjugation and methods for using them
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
EP1458754B1 (en) 2001-12-18 2009-12-09 Endocube SAS Novel death associated proteins of the thap family and related par4 pathways involved in apoptosis control
US7858297B2 (en) 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
US20060235200A1 (en) 2002-03-13 2006-10-19 Marie-Clair Grosjean-Cournoyer Mutagenesis of aspergillus fungi and identification of genes essential for growth
FR2900415B1 (en) 2006-04-28 2010-08-13 Agronomique Inst Nat Rech GENETIC SYSTEM FOR CONTROLLING THE DEVELOPMENT OF THE FLORAL TYPE OF A DICOTYLEDONE PLANT, AND IMPLEMENTATION IN DETECTION AND SELECTION PROCESSES
FR2954349A1 (en) 2009-12-22 2011-06-24 Agronomique Inst Nat Rech SULFATASE SELECTIVELY MODIFYING GLYCOSAMINOGLYCANS
US10865445B2 (en) 2010-08-18 2020-12-15 Fred Hutchinson Cancer Research Center Methods for alleviating facioscapulohumeral dystrophy (FSHD) by N siRNA molecule inhibiting the expression of DUX4-FL
EP3484908A4 (en) 2016-07-15 2020-04-08 AM Chemicals Llc Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2548112B2 (en) * 1983-09-02 1996-10-30 シンジェン，インコーポレイテッド Carrier and oligonucleotide synthesis
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
WO1991000868A1 (en) * 1989-07-07 1991-01-24 National Research Development Corporation Immobilised polynucleotides
DE69030672T2 (en) * 1989-12-04 1997-11-13 Microprobe Corp STRENGTHENED TARGET NUCLEIC ACIDS BY USE OF OLIGONUCLEOTIDES COVERED TO POLYMERS
WO1992007864A1 (en) * 1990-10-26 1992-05-14 Genta Incorporated Improved process for the synthesis of oligomers
NZ240354A (en) * 1990-10-26 1995-03-28 Genta Inc Polymeric reagent containing nucleoside moiety bound through a linking group suitable for solid phase synthesis of nucleotide oligomers

Also Published As

Publication number Publication date
DE69405396T2 (en) 1998-03-26
GR3025420T3 (en) 1998-02-27
EP0707592A1 (en) 1996-04-24
AU696421B2 (en) 1998-09-10
ES2109005T3 (en) 1998-01-01
HK1002731A1 (en) 1998-09-11
CA2166765A1 (en) 1995-01-19
FR2707296A1 (en) 1995-01-13
ATE157668T1 (en) 1997-09-15
DK0707592T3 (en) 1998-03-30
FR2707296B1 (en) 1995-09-29
WO1995001987A1 (en) 1995-01-19
DE69405396D1 (en) 1997-10-09
EP0707592B1 (en) 1997-09-03
TW397839B (en) 2000-07-11
KR960703937A (en) 1996-08-31
JPH08512306A (en) 1996-12-24

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