AU2986295A - N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors - Google Patents

N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors

Info

Publication number
AU2986295A
AU2986295A AU29862/95A AU2986295A AU2986295A AU 2986295 A AU2986295 A AU 2986295A AU 29862/95 A AU29862/95 A AU 29862/95A AU 2986295 A AU2986295 A AU 2986295A AU 2986295 A AU2986295 A AU 2986295A
Authority
AU
Australia
Prior art keywords
amide derivatives
substituted succinic
amino acid
metalloproteinase inhibitors
succinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU29862/95A
Inventor
Paul Raymond Beckett
Fionna Mitchell Martin
Andrew Miller
Mark Whittaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of AU2986295A publication Critical patent/AU2986295A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU29862/95A 1995-07-19 1995-07-19 N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors Abandoned AU2986295A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB1995/001698 WO1997003966A1 (en) 1995-07-19 1995-07-19 N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
AU2986295A true AU2986295A (en) 1997-02-18

Family

ID=10768743

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29862/95A Abandoned AU2986295A (en) 1995-07-19 1995-07-19 N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors

Country Status (2)

Country Link
AU (1) AU2986295A (en)
WO (1) WO1997003966A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
FR2762315B1 (en) * 1997-04-22 1999-05-28 Logeais Labor Jacques AMINO ACID DERIVATIVES INHIBITOR OF EXTRACELLULAR MATRIX METALLOPROTEASES AND TNF ALPHA RELEASE
HUP0002811A3 (en) * 1997-11-13 2002-11-28 British Biotech Pharm Succinamide derivative as metalloproteinase inhibitors and pharmaceutical compositions containing it
CN1125050C (en) * 1997-11-13 2003-10-22 英国生物技术药物有限公司 Metalloproteinase inhibitors
US9902943B2 (en) 2012-12-21 2018-02-27 Codexis, Inc. Engineered biocatalysts and methods for synthesizing chiral amines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
DE69412469T2 (en) * 1993-03-16 1999-02-04 British Biotech Pharmaceuticals Ltd., Cowley, Oxford HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS
EP0740655B1 (en) * 1994-01-22 1999-10-20 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors

Also Published As

Publication number Publication date
WO1997003966A1 (en) 1997-02-06

Similar Documents

Publication Publication Date Title
AU5687396A (en) N-aroylamino acid amides as endothelin inhibitors
AU4153197A (en) Phosphinic acid amides as matrix metalloprotease inhibitors
NZ304689A (en) Lactam-containing hydroxamic acid derivatives and use as matrix metalloprotease (mmp) inhibitors
AU5462696A (en) Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents
AU5475396A (en) Substituted N-(indole-2-carbonyl)-beta-alanimamides and derivatives as antidiabetic agents
AU4608696A (en) N-substituted glycine derivatives as inhibitors of factor xa
PL330482A1 (en) Novel amino acid derivatives and their application as thrombosin inhibitors
AU4024295A (en) Amino acid derivatives of paclitaxel
HUP0001383A3 (en) N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use
ZA964830B (en) Amino acid amides of 5-amino-1, 3, 4-thiadizone-2-thiols
AU2351895A (en) N-(3-pyrrolidinyl)benzamide derivative
AU6257594A (en) Indole derivatives as antagonists of excitatory amino acids
AU1517895A (en) N-(4-pyrimidinyl)amide pesticides
AU753513C (en) Process for producing acidic N-(long-chain acyl)amino acid
KR950702832A (en) Amino acid derivatives (AMINO ACID DERIVATIVE)
PL339211A1 (en) Basic salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartil]-l-phenylamine 1-methyl ester
AU1308400A (en) Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors
PL339207A1 (en) Acid salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartil]-l-phenylamine 1-methyl ester
AU1592697A (en) Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors
AU5825194A (en) Novel amino acid derivatives
AU7665694A (en) N-(3-pyrrolidinyl)benzamide derivative
AU2986295A (en) N-(amino acid) substituted succinic acid amide derivatives as metalloproteinase inhibitors
AU1684099A (en) Amino acid derivatives
AU3230895A (en) Amino acid derivative having nitrogen monoxide synthetase inhibitor activity
AU4485296A (en) Amino acid amide derivatives and their use as pesticides