AU2003283152A1 - Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine - Google Patents

Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine

Info

Publication number
AU2003283152A1
AU2003283152A1 AU2003283152A AU2003283152A AU2003283152A1 AU 2003283152 A1 AU2003283152 A1 AU 2003283152A1 AU 2003283152 A AU2003283152 A AU 2003283152A AU 2003283152 A AU2003283152 A AU 2003283152A AU 2003283152 A1 AU2003283152 A1 AU 2003283152A1
Authority
AU
Australia
Prior art keywords
benzyloxycarbonyl
polymerisation
glutamate
alanine
tyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003283152A
Other versions
AU2003283152A8 (en
Inventor
Elena Bejan
Stephen E. Horne
Gamini Weeratunga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Brantford Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002411786A external-priority patent/CA2411786C/en
Application filed by Brantford Chemicals Inc filed Critical Brantford Chemicals Inc
Publication of AU2003283152A8 publication Critical patent/AU2003283152A8/en
Publication of AU2003283152A1 publication Critical patent/AU2003283152A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
AU2003283152A 2002-11-13 2003-11-13 Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine Abandoned AU2003283152A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CA002411786A CA2411786C (en) 2002-11-13 2002-11-13 A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids
CA2,411,786 2002-11-13
US10/326,994 US7049399B2 (en) 2002-11-13 2002-12-24 Process for the preparation of polypeptide 1
US10/326,994 2002-12-24
PCT/CA2003/001744 WO2004043995A2 (en) 2002-11-13 2003-11-13 Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine

Publications (2)

Publication Number Publication Date
AU2003283152A8 AU2003283152A8 (en) 2004-06-03
AU2003283152A1 true AU2003283152A1 (en) 2004-06-03

Family

ID=32313425

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003283152A Abandoned AU2003283152A1 (en) 2002-11-13 2003-11-13 Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine

Country Status (3)

Country Link
EP (1) EP1565486A2 (en)
AU (1) AU2003283152A1 (en)
WO (1) WO2004043995A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162127A0 (en) 2001-12-04 2005-11-20 Teva Pharma Process for the measurement of the potency of glatiramer acetate
PL1797109T3 (en) * 2004-09-09 2016-11-30 Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof
BRPI0515033B1 (en) * 2004-09-09 2021-05-25 Teva Pharmaceutical Industries, Ltd PROCESS FOR OBTAINING A MIXTURE OF TRIFLUOROACETYL POLYPEPTIDES, MIXTURE OF TRIFLUOROACETYL POLYPEPTIDES, AND PROCESSES FOR OBTAINING A PHARMACEUTICAL COMPOSITION AND FOR THE PRODUCTION OF GLATIRAMER ACETATE
DE602005016292D1 (en) * 2004-10-29 2009-10-08 Sandoz Ag PROCESS FOR THE PRODUCTION OF GLATIRAMER
NZ556156A (en) * 2005-02-02 2010-03-26 Teva Pharma Process for producing acetate salts of polypeptides using hydrogenolysis
AU2007269140A1 (en) * 2006-07-05 2008-01-10 Momenta Pharmaceuticals, Inc. Improved process for the preparation of copolymer-1
WO2008157697A2 (en) 2007-06-21 2008-12-24 Momenta Pharmaceuticals, Inc. Copolymer assay
WO2009016643A1 (en) 2007-07-31 2009-02-05 Natco Pharma Limited Process for the preparation glatiramer acetate (copolymer-1)
EP2277050B2 (en) 2008-04-16 2022-09-28 Momenta Pharmaceuticals, Inc. Analysis of amino acid copolymer compositions
PL2949335T3 (en) 2009-08-20 2017-07-31 Yeda Research & Development Company, Ltd. Low frequency glatiramer acetate therapy
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
BR112013008573A2 (en) 2010-10-11 2016-07-12 Teva Pharma biomarker cytokines as indicators of clinical response to glatiramer acetate.
WO2013009885A2 (en) 2011-07-11 2013-01-17 Momenta Pharmaceuticals, Inc. Evaluation of copolymer diethylamide
AU2012323345A1 (en) 2011-10-10 2014-05-22 Teva Pharmaceutical Industries Ltd. Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
MX2019010174A (en) 2017-03-26 2019-10-15 Mapi Pharma Ltd Glatiramer depot systems for treating progressive forms of multiple sclerosis.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36670A (en) * 1971-04-21 1974-09-10 Sela M Therapeutic basic copolymers of amino acids

Also Published As

Publication number Publication date
AU2003283152A8 (en) 2004-06-03
EP1565486A2 (en) 2005-08-24
WO2004043995A3 (en) 2004-10-07
WO2004043995A2 (en) 2004-05-27

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase