AU2001278673A1 - Rapidly disintegrating sustained release cefuroxime axetil composition - Google Patents

Rapidly disintegrating sustained release cefuroxime axetil composition

Info

Publication number
AU2001278673A1
AU2001278673A1 AU2001278673A AU7867301A AU2001278673A1 AU 2001278673 A1 AU2001278673 A1 AU 2001278673A1 AU 2001278673 A AU2001278673 A AU 2001278673A AU 7867301 A AU7867301 A AU 7867301A AU 2001278673 A1 AU2001278673 A1 AU 2001278673A1
Authority
AU
Australia
Prior art keywords
cefuroxime axetil
composition
sustained release
rapidly disintegrating
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001278673A
Inventor
Rajesh S. Kshirsagar
Anupa Menjoge
Himadri Sen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lupin Ltd
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of AU2001278673A1 publication Critical patent/AU2001278673A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A fast disintegrating controlled release oral composition comprising a core material containing cefuroxime axetil present as controlled release form, the cefuroxime axetil being provided with an outer coating of a copolymer selected from aqueous dispersions of enteric methacrylic acid and methacrylic acid esters anionic copolymers having carboxyl group as the functional group or mixtures thereof and an inner coating of a sustained-release copolymer selected from aqueous dispersions of acrylate and methacrylate pH independent copolymers having quaternary ammonium group as a functional group or mixtures thereof, and optionally probenecid. Additionally, the coating composition may contain plasticizers. The composition is suitable for once daily administration.
AU2001278673A 2000-10-30 2001-08-03 Rapidly disintegrating sustained release cefuroxime axetil composition Abandoned AU2001278673A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70204200A 2000-10-30 2000-10-30
US09702042 2000-10-30
PCT/IN2001/000141 WO2002036126A1 (en) 2000-10-30 2001-08-03 Rapidly disintegrating sustained release cefuroxime axetil composition

Publications (1)

Publication Number Publication Date
AU2001278673A1 true AU2001278673A1 (en) 2002-05-15

Family

ID=24819640

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001278673A Abandoned AU2001278673A1 (en) 2000-10-30 2001-08-03 Rapidly disintegrating sustained release cefuroxime axetil composition

Country Status (7)

Country Link
US (1) US6932981B2 (en)
EP (1) EP1330250B1 (en)
AT (1) ATE266407T1 (en)
AU (1) AU2001278673A1 (en)
DE (1) DE60103299T2 (en)
ES (1) ES2220789T3 (en)
WO (1) WO2002036126A1 (en)

Families Citing this family (34)

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US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US7527807B2 (en) * 2000-06-21 2009-05-05 Cubist Pharmaceuticals, Inc. Compositions and methods for increasing the oral absorption of antimicrobials
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
WO2002089808A1 (en) * 2001-05-09 2002-11-14 Bayer Healthcare Ag Novel use of 2-phenyl-substituted imidazotriazinones
US8158106B2 (en) 2001-10-05 2012-04-17 Surmodics, Inc. Particle immobilized coatings and uses thereof
DE10232113A1 (en) * 2002-07-16 2004-01-29 Bayer Ag Medicinal products containing vardenafil hydrochloride trihydrate
SE0203778D0 (en) * 2002-12-09 2002-12-09 Astrazeneca Ab A new oral immediate release dosage form
GB0400971D0 (en) * 2004-01-16 2004-02-18 Sandoz Ag Pharmaceutical compositions
EP1727524B1 (en) * 2004-03-19 2009-10-21 Zentiva Kimyasal Ürünler Sanayi ve Ticaret A.S. Preparation of lipid coated cefuroxime axetil
DE102004023069A1 (en) * 2004-05-11 2005-12-08 Bayer Healthcare Ag New dosage forms of the PDE 5 inhibitor vardenafil
US7294347B2 (en) * 2004-06-21 2007-11-13 Council Of Scientific And Industrial Research Coating compositions for bitterness inhibition
US7378109B2 (en) * 2004-12-23 2008-05-27 Council Of Scientific And Industrial Research Pharmaceutical composition for improving palatability of drugs and process for preparation thereof
US8481565B2 (en) 2004-12-27 2013-07-09 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
DE102005001989A1 (en) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenous formulations of PDE inhibitors
DE102005009241A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with controlled bioavailability
DE102005009240A1 (en) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Dosage forms with improved pharmacokinetic properties
US20080069870A1 (en) * 2005-04-12 2008-03-20 Elan Corporation Pic Controlled Release Compositions Comprising a Cephalosporin for the Treatment of a Bacterial Infection
DE102005019458A1 (en) * 2005-04-25 2006-10-26 Grünenthal GmbH Composition, useful in the preparation of pellets and the multi-particular-presentation form, comprises cefuroximaxetil and carrageenan of the group of lambda carrageenan, tau carrageenan and kappa carrageenan
WO2006118948A2 (en) * 2005-04-29 2006-11-09 Cubist Pharmaceuticals, Inc. Therapeutic compositions
EP1931797A2 (en) * 2005-09-29 2008-06-18 Bayer HealthCare AG Pde inhibitors and combinations thereof for the treatment of urological disorders
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
WO2007063552A1 (en) * 2005-12-02 2007-06-07 Lupin Limited Stable taste masked formulations of cephalosporins
JP2010532319A (en) * 2007-06-13 2010-10-07 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト PDE inhibitors for the treatment of hearing impairment
IL187159A0 (en) * 2007-07-03 2009-02-11 Gur Megiddo Use of metadoxine in relief of alcohol intoxication
EP2448406B1 (en) 2009-02-26 2016-04-20 Relmada Therapeutics, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
CA2765033C (en) 2009-06-12 2020-07-14 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
CN104825483B (en) * 2015-05-26 2017-10-13 青岛海之星生物科技有限公司 A kind of probenecid sustained release tablets and preparation method
CN104856975A (en) * 2015-05-26 2015-08-26 青岛海之星生物科技有限公司 Probenecid slow release capsule and preparation method thereof
CN104940207A (en) * 2015-05-26 2015-09-30 青岛海之星生物科技有限公司 Cefalexin and probenecid compound sustained-release capsule and preparation method thereof
US11554112B2 (en) 2018-06-07 2023-01-17 Herum Therapeutics International Limited Combinations of β-lactam compounds and probenecid and uses thereof
CN112739330A (en) 2019-02-13 2021-04-30 伊泰伦治疗国际有限公司 Combination of beta-lactam compound and probenecid and use thereof
CN111704562A (en) * 2020-08-07 2020-09-25 安徽康正康仁药业有限公司 Freeze-drying process for disc-loaded sterile bulk pharmaceutical chemicals of probenecid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4325960A (en) * 1979-02-13 1982-04-20 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) 6-Amidinopenicillanic acid derivatives including the radical of a β-lactamase inhibitor
NZ223619A (en) * 1987-02-27 1990-10-26 Lilly Co Eli Sustained release tablet containing cefaclor, a hydrophilic polymer and an acrylic polymer
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
ATE217789T1 (en) * 1992-06-04 2002-06-15 Smithkline Beecham Corp PLEASANT TASTING PHARMACEUTICAL COMPOSITIONS
FR2772615B1 (en) * 1997-12-23 2002-06-14 Lipha MULTILAYER TABLET FOR INSTANT RELEASE THEN PROLONGED ACTIVE SUBSTANCES
DE69905452D1 (en) * 1998-03-03 2003-03-27 Daewoong Pharmaceutical Co MOISTURE-RESISTANT CEFUROXIM AXETIL-CONTAINING PHARMACEUTICAL COMPILATIONS
DE19835823A1 (en) * 1998-08-10 1999-10-07 Lindopharm Gmbh Antibiotic composition useful for preparing stable aqueous suspensions
CN1355692A (en) * 1999-06-11 2002-06-26 兰贝克赛实验室有限公司 Taste masked compositions

Also Published As

Publication number Publication date
DE60103299T2 (en) 2005-05-12
ATE266407T1 (en) 2004-05-15
EP1330250B1 (en) 2004-05-12
DE60103299D1 (en) 2004-06-17
US20020119195A1 (en) 2002-08-29
ES2220789T3 (en) 2004-12-16
US6932981B2 (en) 2005-08-23
EP1330250A1 (en) 2003-07-30
WO2002036126A1 (en) 2002-05-10

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