ATE486070T1 - Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors - Google Patents

Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors

Info

Publication number
ATE486070T1
ATE486070T1 AT07847833T AT07847833T ATE486070T1 AT E486070 T1 ATE486070 T1 AT E486070T1 AT 07847833 T AT07847833 T AT 07847833T AT 07847833 T AT07847833 T AT 07847833T AT E486070 T1 ATE486070 T1 AT E486070T1
Authority
AT
Austria
Prior art keywords
piperidinylaminopyridazine
dopamine
antagonists
receptor
rapid dissociation
Prior art date
Application number
AT07847833T
Other languages
English (en)
Inventor
Gregor James Macdonald
Jose Ignacio Andres-Gil
Den Keybus Frans Alfons Maria Van
Jose Manuel Bartolome-Nebreda
Gool Michiel Luc Maria Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37964744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE486070(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE486070T1 publication Critical patent/ATE486070T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07847833T 2006-12-08 2007-12-05 Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors ATE486070T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125685 2006-12-08
PCT/EP2007/063338 WO2008068277A1 (en) 2006-12-08 2007-12-05 Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE486070T1 true ATE486070T1 (de) 2010-11-15

Family

ID=37964744

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07847833T ATE486070T1 (de) 2006-12-08 2007-12-05 Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors

Country Status (29)

Country Link
US (1) US8466153B2 (de)
EP (1) EP2091938B1 (de)
JP (1) JP5255568B2 (de)
KR (1) KR101468384B1 (de)
CN (1) CN101547915B (de)
AR (1) AR064198A1 (de)
AT (1) ATE486070T1 (de)
AU (1) AU2007328897B2 (de)
BR (1) BRPI0720247A2 (de)
CA (1) CA2665924C (de)
CL (1) CL2007003556A1 (de)
CY (1) CY1112227T1 (de)
DE (1) DE602007010179D1 (de)
DK (1) DK2091938T3 (de)
EA (1) EA016654B1 (de)
ES (1) ES2354756T3 (de)
HK (1) HK1137434A1 (de)
IL (1) IL199076A (de)
JO (1) JO2642B1 (de)
MX (1) MX2009005983A (de)
MY (1) MY148772A (de)
NO (1) NO20092574L (de)
NZ (1) NZ576484A (de)
PL (1) PL2091938T3 (de)
PT (1) PT2091938E (de)
SI (1) SI2091938T1 (de)
TW (1) TWI433676B (de)
UA (1) UA98940C2 (de)
WO (1) WO2008068277A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
MX2009011414A (es) * 2007-04-23 2009-11-05 Janssen Pharmaceutica Nv Derivados de piridina como antagonistas del receptor de dopamina 2 de disociacion rapida.
CA2682671C (en) * 2007-04-23 2015-11-17 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
KR20100016620A (ko) * 2007-04-23 2010-02-12 얀센 파마슈티카 엔.브이. 속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체
EP2310374B1 (de) * 2008-07-03 2012-10-31 Janssen Pharmaceutica N.V. Substituierte 6-(1-piperazinyl)pyridazine als antagonisten am 5-ht6-rezeptor
WO2010012758A1 (en) * 2008-07-31 2010-02-04 Janssen Pharmaceutica Nv Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists

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NO147672C (no) 1975-09-23 1983-05-25 Janssen Pharmaceutica Nv Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider
US4197304A (en) * 1975-09-23 1980-04-08 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
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DE3218482A1 (de) 1982-05-15 1983-11-17 Bayer Ag, 5090 Leverkusen Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
MX173362B (es) 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
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AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
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KR100938369B1 (ko) 2001-10-09 2010-01-22 교린 세이야꾸 가부시키 가이샤 신규 4-(2-푸로일)아미노피페리딘, 그의 합성 중간체,그의 제조방법 및 의약으로서의 그의 용도
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EP1467981A1 (de) 2002-01-25 2004-10-20 Kylix Pharmaceuticals B.V. 4-(hetero)aryl-substituierte (thia-/oxa-/pyra)zole zur inhibierung von tie-2
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ATE551053T1 (de) * 2002-09-26 2012-04-15 Mandom Corp Antiseptische bakterizide, und kosmetika, arzneimittel und lebensmittel, die die antiseptischen bakterizide enthalten
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JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
WO2010012758A1 (en) * 2008-07-31 2010-02-04 Janssen Pharmaceutica Nv Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists

Also Published As

Publication number Publication date
TW200831098A (en) 2008-08-01
CN101547915A (zh) 2009-09-30
DK2091938T3 (da) 2011-02-07
NZ576484A (en) 2010-10-29
ES2354756T3 (es) 2011-03-17
DE602007010179D1 (de) 2010-12-09
MY148772A (en) 2013-05-31
BRPI0720247A2 (pt) 2013-12-31
WO2008068277A1 (en) 2008-06-12
CA2665924A1 (en) 2008-06-12
JP5255568B2 (ja) 2013-08-07
AR064198A1 (es) 2009-03-18
EA200970553A1 (ru) 2009-10-30
MX2009005983A (es) 2009-06-16
EP2091938A1 (de) 2009-08-26
NO20092574L (no) 2009-09-08
JO2642B1 (en) 2012-06-17
CL2007003556A1 (es) 2008-06-13
CN101547915B (zh) 2013-08-21
EP2091938B1 (de) 2010-10-27
KR101468384B1 (ko) 2014-12-03
CY1112227T1 (el) 2015-12-09
TWI433676B (zh) 2014-04-11
SI2091938T1 (sl) 2011-02-28
CA2665924C (en) 2014-08-12
US20100076187A1 (en) 2010-03-25
KR20090089858A (ko) 2009-08-24
PT2091938E (pt) 2011-01-20
AU2007328897A1 (en) 2008-06-12
HK1137434A1 (en) 2010-07-30
US8466153B2 (en) 2013-06-18
JP2010511673A (ja) 2010-04-15
IL199076A (en) 2012-12-31
EA016654B1 (ru) 2012-06-29
UA98940C2 (ru) 2012-07-10
AU2007328897B2 (en) 2013-01-10
PL2091938T3 (pl) 2011-04-29

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