ATE421575T1 - Verfahren zur kultivierung neuraler stammzellen unter verwendung des hepatozytenwachstumsfaktors - Google Patents

Verfahren zur kultivierung neuraler stammzellen unter verwendung des hepatozytenwachstumsfaktors

Info

Publication number
ATE421575T1
ATE421575T1 AT03812367T AT03812367T ATE421575T1 AT E421575 T1 ATE421575 T1 AT E421575T1 AT 03812367 T AT03812367 T AT 03812367T AT 03812367 T AT03812367 T AT 03812367T AT E421575 T1 ATE421575 T1 AT E421575T1
Authority
AT
Austria
Prior art keywords
stem cells
growth factor
neural stem
hepatocyte growth
cultivation
Prior art date
Application number
AT03812367T
Other languages
English (en)
Inventor
Jouji Kokuzawa
Shinichi Yoshimura
Hideomi Kitajima
Jun Shinoda
Yasuhiko Kaku
Toru Iwama
Ryuichi Morishita
Takahiro Kunisada
Noboru Sakai
Original Assignee
Anges Mg Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anges Mg Inc filed Critical Anges Mg Inc
Application granted granted Critical
Publication of ATE421575T1 publication Critical patent/ATE421575T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03812367T 2002-12-02 2003-12-02 Verfahren zur kultivierung neuraler stammzellen unter verwendung des hepatozytenwachstumsfaktors ATE421575T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43043102P 2002-12-02 2002-12-02

Publications (1)

Publication Number Publication Date
ATE421575T1 true ATE421575T1 (de) 2009-02-15

Family

ID=32469472

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03812367T ATE421575T1 (de) 2002-12-02 2003-12-02 Verfahren zur kultivierung neuraler stammzellen unter verwendung des hepatozytenwachstumsfaktors

Country Status (9)

Country Link
US (1) US20060134078A1 (de)
EP (1) EP1570052B1 (de)
JP (1) JP2006511214A (de)
CN (1) CN1745168A (de)
AT (1) ATE421575T1 (de)
AU (1) AU2003302707B2 (de)
CA (1) CA2507395A1 (de)
DE (1) DE60326003D1 (de)
WO (1) WO2004050865A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE388223T1 (de) * 2003-10-29 2008-03-15 Fcb Pharmicell Co Ltd Verfahren zur differenzierung einer mesenchym- stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit
DK1758986T3 (en) 2004-06-09 2016-01-18 Univ Edinburgh Neural stem cells
JP4868199B2 (ja) * 2004-09-10 2012-02-01 学校法人鈴鹿医療科学大学 サルビアノール酸ｂを有効成分とする神経幹細胞増殖剤
JP2009507081A (ja) * 2005-09-07 2009-02-19 ブレインセルス，インコーポレイティド ＨＤａｃ阻害による神経発生の調整
EP2176401A1 (de) * 2007-06-27 2010-04-21 Presidents and Fellows of Harvard College Neurale stammzellen
EP2379711B8 (de) 2008-12-23 2017-03-22 BOCO Silicon Valley, Inc. Zielpopulationen von oligodendrozyten-vorläuferzellen und verfahren zur herstellung und verwendung davon
KR101446711B1 (ko) 2011-05-23 2014-10-06 아주대학교산학협력단 간세포 성장인자 유전자 및 염기성 나선-고리-나선 계열의 신경형성 전사인자 유전자가 도입된 성체 줄기세포주 및 그의 용도
CN102399747B (zh) * 2011-11-24 2014-04-16 吉林省拓华生物科技有限公司 神经干细胞的传代分离方法
WO2017170180A1 (ja) * 2016-03-31 2017-10-05 味の素株式会社 神経分化能を亢進させる神経幹細胞用培地

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753505A (en) * 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6184035B1 (en) * 1998-11-18 2001-02-06 California Institute Of Technology Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
JP2002536423A (ja) * 1999-02-11 2002-10-29 ザ スキーペンズ アイ リサーチ インスティテュート インコーポレイテッド 未成熟及び成熟ジストロフィーレシピエントの神経組織内に移植された神経前駆細胞の統合
KR100449141B1 (ko) * 2001-04-19 2004-09-21 (주)라이프코드 간엽 간세포를 신경세포로 분화시키는 방법

Also Published As

Publication number Publication date
CN1745168A (zh) 2006-03-08
DE60326003D1 (de) 2009-03-12
CA2507395A1 (en) 2004-06-17
WO2004050865A1 (en) 2004-06-17
AU2003302707A1 (en) 2004-06-23
AU2003302707B2 (en) 2008-10-02
EP1570052A1 (de) 2005-09-07
JP2006511214A (ja) 2006-04-06
EP1570052B1 (de) 2009-01-21
US20060134078A1 (en) 2006-06-22

Similar Documents

Publication Publication Date Title
ATE406435T1 (de) Methoden zur züchtung von tierzellen
DK0960944T3 (da) Forbedret produktion af taxol og taxaner fra cellekulturer af taxus-arter
ATE288481T1 (de) Verwendung von collagenase in der zubereitung von neuralen stammzellkulturen
ATE513901T1 (de) Neurale vorläuferzellen
DE50108487D1 (de) Bioreaktor für die kultivierung von mikroorganismen sowie verfahren zur herstellung desselben
ATE443757T1 (de) L-aminosäure produzierender mikroorganismus und verfahren zur l-aminosäureproduktion
DE60313188D1 (de) Verfahren und medien zur kontrolle der sialysierung von proteinen, die von säugetierzellen produziert werden
ATE421575T1 (de) Verfahren zur kultivierung neuraler stammzellen unter verwendung des hepatozytenwachstumsfaktors
EA199700004A1 (ru) Усиленная аккумуляция трегалозы в растениях
ATE353953T1 (de) Wirtszelle, die reduzierte mengen einer metalloprotease exprimiert und methoden zur verwendung dieser wirtszelle zur proteinproduktion
ATE265802T1 (de) Verfahren zum erzeugen von metaboliten aus pflanzen in erdloser kultur
WO2003010304A3 (de) Verfahren zur herstellung isolierter zellkulturen, kulturmedium zur kultivierung von zellkulturen und zellkultur
ATE465264T1 (de) Pflanzen mit verbesserten wachstumseigenschaften und verfahren zur herstellung davon
TW200506058A (en) Method for culturing organic blue-green algae
ATE414760T1 (de) Verfahren zur herstellung einer epithelzellen enthaltenden zellzusammensetzung
DE60105435D1 (de) Verfahren zur herstellung von beta-karotin
ATE391787T1 (de) Verfahren zur herstellung von ubiquinon-10
ATE378397T1 (de) Verfahren zum kultivieren von mikroorganismen unter reduzierenden bedingungen mittels einer gasströmung
DE69520098D1 (de) Methode zur kontrolle der metallophosphatpraezipitation in fermentationen mit hoher zelldichte
ATE214736T1 (de) Verfahren zur fermentativen herstellung von l- aminosäuren unter verwendung coryneformer bakterien
ATE417919T1 (de) Mikrobiologisches verfahren zur herstellung von amiden
ATE310095T1 (de) Verfahren zur modulierung des niveaus von organischen schwefelverbindungen in pflanzen
DE502006005197D1 (de) Mikroorganismen burkholderia rhizoxina, neue endosymbionten aus rhizopus sp. und verfahren zur herstellung von rhizoxin und / oder rhizoxin-derivaten unter verwendung dieser mikroorganismen
DE69911284D1 (de) Pflanzenzuchtmittel aus Holzfasern und Verfahren zur Herstellung eines solchen Zuchtmittels
ATE486124T1 (de) Keratinozyten-kulturverfahren und verwendung davon

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties