ATE404541T1 - Xanthinoxidaseinhibitoren - Google Patents

Xanthinoxidaseinhibitoren

Info

Publication number
ATE404541T1
ATE404541T1 AT02780099T AT02780099T ATE404541T1 AT E404541 T1 ATE404541 T1 AT E404541T1 AT 02780099 T AT02780099 T AT 02780099T AT 02780099 T AT02780099 T AT 02780099T AT E404541 T1 ATE404541 T1 AT E404541T1
Authority
AT
Austria
Prior art keywords
xanthine
oxidasine
inhibitors
substituent
carboxyl
Prior art date
Application number
AT02780099T
Other languages
English (en)
Inventor
Shinichi Yoshida
Atsushi Tendo
Kunio Kobayashi
Nobutaka Mochiduki
Tomio Yamakawa
Yoriko Shinohara
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Application granted granted Critical
Publication of ATE404541T1 publication Critical patent/ATE404541T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02780099T 2001-11-16 2002-11-14 Xanthinoxidaseinhibitoren ATE404541T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001352340 2001-11-16

Publications (1)

Publication Number Publication Date
ATE404541T1 true ATE404541T1 (de) 2008-08-15

Family

ID=19164532

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02780099T ATE404541T1 (de) 2001-11-16 2002-11-14 Xanthinoxidaseinhibitoren

Country Status (11)

Country Link
US (2) US7253154B2 (de)
EP (1) EP1452528B1 (de)
JP (2) JP4634037B2 (de)
KR (1) KR100919147B1 (de)
CN (2) CN101092400A (de)
AT (1) ATE404541T1 (de)
DE (1) DE60228316D1 (de)
DK (1) DK1452528T3 (de)
ES (1) ES2309213T3 (de)
PT (1) PT1452528E (de)
WO (1) WO2003042185A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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ES2312857T3 (es) * 2002-12-19 2009-03-01 The Scripps Research Institute Composiciones y metodos para estabilizar la transtiretina e inhibir el mal replegamiento de la transtiretina.
WO2005105803A2 (en) * 2004-04-28 2005-11-10 Cv Therapeutics, Inc. Purine derivatives as a1 adenosine receptor antagonists
ES2367118T3 (es) * 2004-06-14 2011-10-28 Nippon Chemiphar Co., Ltd. Derivado de pirimidina condensado e inhibidor de xantina oxidasa.
KR101191071B1 (ko) 2004-06-14 2012-10-15 닛뽕 케미파 가부시키가이샤 축합 피리미딘 유도체 및 크산틴 옥시다제 저해제
WO2006012438A2 (en) * 2004-07-21 2006-02-02 University Of Florida Research Foundation, Inc. Compositions and methods for treatment and prevention of insulin resistance
US20090149452A1 (en) * 2005-07-01 2009-06-11 Nippon Chemiphar Co., Ltd. Xanthine oxidase inhibitor
KR20140037954A (ko) * 2006-06-22 2014-03-27 닛뽕 케미파 가부시키가이샤 항암제 내성 극복제
EP2074223A4 (de) * 2006-09-15 2010-03-10 Foldrx Pharmaceuticals Inc Testverfahren zum nachweis von proteinen im nativen zustand und zur identifizierung von die stabilität von proteinen im nativen zustand modulierenden verbindungen
US8227500B2 (en) * 2007-04-11 2012-07-24 Kissei Pharmaceutical Co., Ltd. 5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same
EP2165705A1 (de) 2008-09-18 2010-03-24 Centre National de la Recherche Scientifique (CNRS) Verwendung einer Verbindung mit der Fähigkeit zur Senkung des Harnsäureniveaus zur Prävention und/oder Behandlung von Lungenentzündung und -fibrose
JP5673008B2 (ja) 2010-08-11 2015-02-18 ソニー株式会社 画像処理装置、立体画像表示装置および立体画像表示システム、ならびに立体画像表示装置の視差ずれ検出方法および立体画像表示装置の製造方法
CN102095825B (zh) * 2010-12-08 2014-07-23 中国科学院长春应用化学研究所 超高效液相色谱和质谱联用筛选黄嘌呤氧化酶抑制剂的方法
MX2014003043A (es) 2011-09-16 2015-02-05 Pfizer Formas solidas de un inhibidor de disociacion transtiretina.
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151630A2 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
TN2016000253A1 (en) 2013-12-19 2017-10-06 Novartis Ag [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis.
JP2017048116A (ja) * 2014-01-10 2017-03-09 国立研究開発法人国立国際医療研究センター 肺高血圧症治療薬
EP3263109B1 (de) * 2015-02-24 2020-06-17 National University Corporation Tottori University Arzneimittel zur prävention und/oder behandlung von demenz
CN106146533B (zh) * 2016-07-14 2018-04-03 华润赛科药业有限责任公司 含硫杂环羧酸类衍生物、其制备方法和应用
WO2020009374A1 (ko) * 2018-07-04 2020-01-09 고려대학교 세종산학협력단 4-치환 옥사졸로퀴놀리논 유도체, 약학적으로 허용되는 이의 염인 화합물 및 이를 유효성분으로 포함하는 천식 또는 아토피 등의 알러지성 질환의 예방 또는 치료용 약학 조성물
CN110283137A (zh) * 2019-06-13 2019-09-27 爱斯特（成都）生物制药股份有限公司 一种2-(4-溴苯基)-1,3-苯并恶唑的制备方法
CN111620833A (zh) * 2020-06-05 2020-09-04 青岛伯川特聚科技有限公司 一种2-苯基苯并噁唑类化合物的制备方法
CN113004188B (zh) * 2021-03-16 2022-09-20 沈阳药科大学 一种吲哚衍生物及制备方法和应用

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DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
IL68495A0 (en) * 1982-05-03 1983-07-31 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
JPS62246581A (ja) * 1986-04-17 1987-10-27 Chugai Pharmaceut Co Ltd フロベンゾオキサゾ−ル誘導体
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
JPH03258770A (ja) * 1990-03-08 1991-11-19 Tanabe Seiyaku Co Ltd ベンズアゾール誘導体、その製法及びその合成中間体
JP3176073B2 (ja) * 1990-06-19 2001-06-11 キヤノン株式会社 液晶素子
US6858739B2 (en) * 2000-06-14 2005-02-22 Warner-Lambert Company Indole and benzimidazole 15-lipoxygenase inhibitors
MXPA02010763A (es) * 2000-06-14 2003-03-10 Warner Lambert Co Heterociclicos biciclos-6,5 fusionados.
GB0205256D0 (en) * 2002-03-06 2002-04-17 Oxford Glycosciences Uk Ltd Novel compounds

Also Published As

Publication number Publication date
CN101092400A (zh) 2007-12-26
US20050090472A1 (en) 2005-04-28
EP1452528A1 (de) 2004-09-01
WO2003042185A1 (fr) 2003-05-22
CN100338040C (zh) 2007-09-19
JP5297414B2 (ja) 2013-09-25
DE60228316D1 (en) 2008-09-25
KR20040065223A (ko) 2004-07-21
JPWO2003042185A1 (ja) 2005-03-10
EP1452528B1 (de) 2008-08-13
ES2309213T3 (es) 2008-12-16
US7253154B2 (en) 2007-08-07
EP1452528A4 (de) 2005-11-16
US20070265283A1 (en) 2007-11-15
PT1452528E (pt) 2008-10-14
JP2010180232A (ja) 2010-08-19
CN1615299A (zh) 2005-05-11
DK1452528T3 (da) 2008-11-10
JP4634037B2 (ja) 2011-02-16
KR100919147B1 (ko) 2009-09-25

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