ATE355300T1 - Gespannte, helixformende peptide und verfahren um sie herzustellen - Google Patents

Gespannte, helixformende peptide und verfahren um sie herzustellen

Info

Publication number
ATE355300T1
ATE355300T1 AT97948165T AT97948165T ATE355300T1 AT E355300 T1 ATE355300 T1 AT E355300T1 AT 97948165 T AT97948165 T AT 97948165T AT 97948165 T AT97948165 T AT 97948165T AT E355300 T1 ATE355300 T1 AT E355300T1
Authority
AT
Austria
Prior art keywords
strained
helix
processes
producing
peptides
Prior art date
Application number
AT97948165T
Other languages
English (en)
Inventor
Andrew Braisted
J Kevin Judice
Robert S Mcdowell
J Christopher Phelan
Melissa A Starovasnik
James A Wells
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE355300T1 publication Critical patent/ATE355300T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT97948165T 1996-11-06 1997-11-05 Gespannte, helixformende peptide und verfahren um sie herzustellen ATE355300T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74369896A 1996-11-06 1996-11-06
US87669897A 1997-06-16 1997-06-16

Publications (1)

Publication Number Publication Date
ATE355300T1 true ATE355300T1 (de) 2006-03-15

Family

ID=27114189

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97948165T ATE355300T1 (de) 1996-11-06 1997-11-05 Gespannte, helixformende peptide und verfahren um sie herzustellen

Country Status (8)

Country Link
EP (1) EP0938497B1 (de)
JP (1) JP2001503064A (de)
AT (1) ATE355300T1 (de)
AU (1) AU745101B2 (de)
CA (1) CA2270869A1 (de)
DE (1) DE69737415T2 (de)
IL (1) IL129772A0 (de)
WO (1) WO1998020036A1 (de)

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US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
EP1100890A2 (de) 1998-07-27 2001-05-23 Genentech, Inc. Verbesserung der transformationseffizienz in phagendisplay durch abänderung des hüllproteins
IL143866A0 (en) 1999-01-06 2002-04-21 Genentech Inc Insulin-like growth factor (igf) i mutant variants
ES2301547T3 (es) 2000-05-16 2008-07-01 Genentech, Inc. Tratamiento de trastornos del cartilago.
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
JP2004537534A (ja) 2001-06-20 2004-12-16 ジェネンテック・インコーポレーテッド 腫瘍の診断及び治療のための組成物及び方法
MXPA04002593A (es) 2001-09-18 2004-05-31 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumor.
KR100801388B1 (ko) 2002-01-02 2008-02-05 제넨테크, 인크. 종양의 진단 및 치료 방법 및 이를 위한 조성물
AU2003230874A1 (en) 2002-04-16 2003-11-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2004014951A2 (en) * 2002-08-06 2004-02-19 Aplagen Gmbh Binding molecules
DE50212514D1 (de) * 2002-08-06 2008-08-28 Aplagen Gmbh Synthetische Mimetika von physiologischen Bindungsmolekülen
EP1445614A1 (de) 2003-02-06 2004-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verfahren zur in vitro Überwachung der Entwicklung von HIV Virus eines Individuums
FR2851165A1 (fr) * 2003-02-19 2004-08-20 Aventis Pasteur Antigene derivant de l'helice c de la proteine gp41
SI2784084T2 (sl) 2003-07-08 2024-02-29 Novartis Pharma Ag Antagonistična protitelesa proti IL-17 A/F heterolognim polipeptidom
WO2005021574A2 (de) * 2003-08-26 2005-03-10 Brd, Vertreten Durch Das Bundesministerium Für Gesundheit Und Soziale Sicherung, Letztvertreten Durch Den Präsidenten Des Robert-Koch-Institutes Induktion antiviraler neutralisierender antikörper beim menschen und beim tier
US7329725B1 (en) 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
PL2161283T3 (pl) 2003-11-17 2014-11-28 Genentech Inc Kompozycja zawierająca przeciwciała przeciwko CD79b skoniugowane ze środkiem hamującym wzrost lub środkiem cytotoksycznym i sposoby leczenia guzów o pochodzeniu hematopoetycznym
WO2006098998A2 (en) 2005-03-10 2006-09-21 Genentech, Inc. Methods and compositions for modulating vascular integrity
EP2614839A3 (de) 2006-04-05 2015-01-28 Genentech, Inc. Verfahren zur Verwendung von BOC/CDO zur Modulation der Hedgehog-Signalisierung
JP5244103B2 (ja) 2006-08-09 2013-07-24 ホームステッド クリニカル コーポレイション 器官特異的蛋白質およびその使用方法
US20100297103A1 (en) 2006-09-14 2010-11-25 Medical & Biological Laboratories Co., Ltd. Antibody having enhanced adcc activity and method for production thereof
SI2140021T1 (sl) 2007-02-22 2012-04-30 Genentech Inc Postopki za detekcijo vnetne ÄŤrevesne bolezni
CA2713089C (en) 2008-01-23 2017-11-21 Dana Farber Cancer Institute Compositions and methods for the treatment of viral infections
US8575314B2 (en) 2008-06-20 2013-11-05 National University Corporation Okayama University Antibody against oxidized LDL/β2GPI complex and use of the same
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US9005631B2 (en) * 2008-08-04 2015-04-14 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Membrane proximal region of HIV gp41 anchored to the lipid layer of a virus-like particle vaccine
JP5908832B2 (ja) * 2009-06-18 2016-04-26 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド 構築されたウィルス性ペプチド組成物及び使用方法
RU2539772C2 (ru) 2009-10-22 2015-01-27 Дженентек, Инк. Способы и композиции для модуляции гепсином стимулирующего макрофаги белка
AU2010324686B2 (en) 2009-11-30 2016-05-19 Genentech, Inc. Antibodies for treating and diagnosing tumors expressing SLC34A2 (TAT211 = SEQID2 )
BR112012020373A8 (pt) 2010-02-23 2018-01-02 Genentech Inc anticorpo isolado, célula, ácido nucleico isolado, método de identificação, de inibição da proliferação de uma célula, de tratamento terapêutico, de determinação da presença de uma proteína tat419, de diagnóstico da presença de câncer e de distribuição de agente citotóxico
SG185027A1 (en) 2010-05-03 2012-11-29 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
CA2846083A1 (en) 2011-09-15 2013-03-21 Genentech, Inc. Methods of promoting differentiation
EP2766000A2 (de) 2011-10-15 2014-08-20 F.Hoffmann-La Roche Ag Scd1-antagonisten zur behandlung von krebs
CN104168920A (zh) 2012-01-18 2014-11-26 霍夫曼-拉罗奇有限公司 使用fgf19调控剂的方法
CN113398268A (zh) 2012-02-11 2021-09-17 霍夫曼-拉罗奇有限公司 R-spondin易位及其使用方法
US9139863B2 (en) 2012-03-16 2015-09-22 Genentech, Inc. Engineered conformationally-stabilized proteins
MX2014010943A (es) 2012-03-16 2014-11-26 Genentech Inc Proteinas estabilizadas conformacionalmente de ingenieria.
WO2013135745A1 (en) 2012-03-16 2013-09-19 F. Hoffmann-La Roche Ag Methods of treating melanoma with pak1 inhibitors
CN104583776B (zh) 2012-04-25 2016-09-07 比奥德赛公司 用于检测蛋白质的变构调节剂的方法
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
KR20230070054A (ko) 2013-03-15 2023-05-19 제넨테크, 인크. Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법
WO2015116902A1 (en) 2014-01-31 2015-08-06 Genentech, Inc. G-protein coupled receptors in hedgehog signaling
WO2015179835A2 (en) 2014-05-23 2015-11-26 Genentech, Inc. Mit biomarkers and methods using the same
US10562946B2 (en) 2014-06-20 2020-02-18 Genentech, Inc. Chagasin-based scaffold compositions, methods, and uses
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
AU2016252773B2 (en) 2015-04-24 2022-06-02 Genentech, Inc. Multispecific antigen-binding proteins
WO2017196891A1 (en) 2016-05-09 2017-11-16 Biodesy, Inc. Methods and devices for detection of peripheral membrane protein interactions using nonlinear optical techniques
EP3509616A1 (de) 2016-09-09 2019-07-17 H. Hoffnabb-La Roche Ag Selektive peptidinhibitoren des frizzled
WO2018152496A1 (en) 2017-02-17 2018-08-23 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Compositions and methods for the diagnosis and treatment of zika virus infection
EP4230649A3 (de) 2017-04-25 2023-10-25 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Antikörper und verfahren zur diagnose und behandlung von epstein barr-virusinfektion
US11827669B2 (en) 2017-07-19 2023-11-28 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Antibodies and methods for the diagnosis and treatment of hepatitis b virus infection
WO2020227554A1 (en) 2019-05-09 2020-11-12 Genentech, Inc. Methods of making antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0527789A1 (de) * 1990-04-03 1993-02-24 Genentech, Inc. Hiv-hüllpolypeptide
WO1992009625A1 (en) * 1990-11-29 1992-06-11 Smithkline Beecham Corporation Conformationally constrained peptides i
US6100377A (en) * 1994-06-10 2000-08-08 The Trustees Of The University Of Pennsylvania Constrained peptides

Also Published As

Publication number Publication date
CA2270869A1 (en) 1998-05-14
DE69737415T2 (de) 2007-10-31
AU5428798A (en) 1998-05-29
AU745101B2 (en) 2002-03-14
WO1998020036A1 (en) 1998-05-14
JP2001503064A (ja) 2001-03-06
IL129772A0 (en) 2000-02-29
DE69737415D1 (de) 2007-04-12
EP0938497B1 (de) 2007-02-28
EP0938497A1 (de) 1999-09-01

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