ATE292631T1 - Verfahren zu herstellung von 1,3-oxathiolane nukleosiden - Google Patents

Verfahren zu herstellung von 1,3-oxathiolane nukleosiden

Info

Publication number: ATE292631T1
Authority: AT; Austria
Prior art keywords: oxathiolane; producing; oxathiolane nucleosides; preparation; nucleosides
Prior art date: 1998-08-12

Application number

AT03077251T

Other languages

English (en)

Inventor

Darryl Cleary

Jose Soria

George R Painter

Dennis C Liotta

Merrick Almond

Marcos Luis Sznaidman

Original Assignee

Gilead Sciences Inc

Univ Emory

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-12

Filing date

1999-08-12

Publication date

2005-04-15

1999-08-12 Application filed by Gilead Sciences Inc, Univ Emory filed Critical Gilead Sciences Inc

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE292631T1 publication Critical patent/ATE292631T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT03077251T 1998-08-12 1999-08-12 Verfahren zu herstellung von 1,3-oxathiolane nukleosiden ATE292631T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9621498P	1998-08-12	1998-08-12
US12284199P	1999-03-04	1999-03-04

Publications (1)

Publication Number	Publication Date
ATE292631T1 true ATE292631T1 (de)	2005-04-15

Family

ID=26791450

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99943712T ATE282034T1 (de)	1998-08-12	1999-08-12	Verfahren zur herstellung von 1,3- oxathiolannukleoside
AT03077251T ATE292631T1 (de)	1998-08-12	1999-08-12	Verfahren zu herstellung von 1,3-oxathiolane nukleosiden

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT99943712T ATE282034T1 (de)	1998-08-12	1999-08-12	Verfahren zur herstellung von 1,3- oxathiolannukleoside

Country Status (17)

Country	Link
US (4)	US6215004B1 (de)
EP (4)	EP1535921A1 (de)
JP (4)	JP4249393B2 (de)
KR (3)	KR100856416B1 (de)
CN (1)	CN1141305C (de)
AT (2)	ATE282034T1 (de)
AU (2)	AU771779B2 (de)
BR (1)	BR9912951B1 (de)
CA (3)	CA2714085C (de)
DE (2)	DE69924651D1 (de)
ES (2)	ES2537540T3 (de)
HK (2)	HK1038921A1 (de)
IL (4)	IL141359A0 (de)
MX (1)	MXPA01001552A (de)
PT (2)	PT2322518E (de)
RU (2)	RU2244712C2 (de)
WO (1)	WO2000009494A1 (de)

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PT1632490E (pt) *	2001-06-15	2007-11-07	Shire Canada Inc	Método estereosselectivo de preparação de análogos de nucleósido
US6600044B2 (en)	2001-06-18	2003-07-29	Brantford Chemicals Inc.	Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
KR20040101991A (ko) *	2001-12-14	2004-12-03	파마셋, 리미티드	항바이러스성 뉴클레오사이드의 합성에 유용한 중간체의제조
BR0312802A (pt) *	2002-07-19	2005-04-19	Michael E Garst	Pró-drogas de inibidores de bombas de próton
ATE496054T1 (de)	2002-08-06	2011-02-15	Pharmasset Inc	Verfahren zur herstellung von 1,3-dioxolan- nucleosiden
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JPWO2005056870A1 (ja) *	2003-12-09	2007-12-13	旭硝子株式会社	可視光で光触媒活性を有するＴｉ酸化物膜およびその製造方法
WO2005074654A2 (en) *	2004-02-03	2005-08-18	Emory University	Methods to manufacture 1,3-dioxolane nucleosides
EP2086955A2 (de) *	2006-10-30	2009-08-12	Lupin Ltd.	Verbessertes verfahren zur herstellung von cis-(-)-lamivudin
ES2542154T3 (es) *	2007-09-28	2015-07-31	Avexa Limited	Un procedimiento para la resolución quiral de 1,3-oxatiolanos sustituidos en posición 2 y sustituidos en posición 4
EP2048151A1 (de) *	2007-10-10	2009-04-15	Cilag AG	Verfahren zur Herstellung von Nukleosiden durch direkte Glykosidation der Nukleosidbase
EP2050757A1 (de) *	2007-10-10	2009-04-22	Cilag AG	Verfahren zur Herstellung von 2' -deoxy-5-Azacytidin (Decitabin)
EP2350065A1 (de) *	2008-11-12	2011-08-03	Lupin Ltd.	Neues polymorph von emtricitabin und verfahren zu dessen herstellung
US20110282046A1 (en)	2009-01-19	2011-11-17	Rama Shankar	Process for preparation of cis-nucleoside derivative
EP2454244B1 (de)	2009-07-15	2013-06-26	Lupin Limited	Verbessertes verfahren zur herstellung von efavirenz
WO2011141805A2 (en)	2010-05-14	2011-11-17	Lupin Limited	An improved process for the manufacture of lamivudine
US20130296562A1 (en)	2011-08-05	2013-11-07	Lupin Limited	Stereoselective process for preparation of 1,3-oxathiolane nucleosides
CN106478618A (zh) *	2016-10-14	2017-03-08	上海礼泰医药科技有限公司	恩曲他滨氢卤酸盐的制备方法
CN109553610B (zh) *	2018-12-21	2020-10-27	江西富祥药业股份有限公司	一种恩曲他滨异构体的制备方法
CN115043823A (zh) *	2022-06-28	2022-09-13	江苏普信制药有限公司	一种恩曲他滨的合成方法

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GB9311709D0 (en)	1993-06-07	1993-07-21	Iaf Biochem Int	Stereoselective synthesis of nucleoside analogues using bicycle intermediate
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JP3390012B2 (ja)	1994-07-08	2003-03-24	三井化学株式会社	熱可塑性ポリエステル樹脂組成物
GB9506644D0 (en)	1995-03-31	1995-05-24	Wellcome Found	Preparation of nucleoside analogues
GB9525606D0 (en) *	1995-12-14	1996-02-14	Iaf Biochem Int	Method and compositions for the synthesis of dioxolane nucleosides with - configuration
TW318283B (en)	1996-12-09	1997-10-21	United Microelectronics Corp	Multi-level read only memory structure and manufacturing method thereof
AU771779B2 (en) *	1998-08-12	2004-04-01	Emory University	Method of manufacture of 1,3-oxathiolane nucleosides
US9308044B2 (en)	2002-04-08	2016-04-12	Medtronic Ardian Luxembourg S.A.R.L.	Methods for therapeutic renal neuromodulation
US9109124B2 (en)	2011-06-01	2015-08-18	Xerox Corporation	Solid ink compositions comprising semicrystalline oligomer resins
JP5800924B2 (ja)	2014-01-20	2015-10-28	ファナック株式会社	回転工具の回転振れ及び動バランス調整機構

1999
- 1999-08-12 AU AU56752/99A patent/AU771779B2/en not_active Expired
- 1999-08-12 RU RU2001106606/04A patent/RU2244712C2/ru active
- 1999-08-12 US US09/373,891 patent/US6215004B1/en not_active Expired - Lifetime
- 1999-08-12 WO PCT/US1999/018584 patent/WO2000009494A1/en active Application Filing
- 1999-08-12 PT PT101816783T patent/PT2322518E/pt unknown
- 1999-08-12 JP JP2000564946A patent/JP4249393B2/ja not_active Expired - Fee Related
- 1999-08-12 KR KR1020067007631A patent/KR100856416B1/ko not_active IP Right Cessation
- 1999-08-12 CN CNB998099929A patent/CN1141305C/zh not_active Expired - Lifetime
- 1999-08-12 DE DE69924651T patent/DE69924651D1/de not_active Expired - Lifetime
- 1999-08-12 KR KR1020077019476A patent/KR101208429B1/ko not_active IP Right Cessation
- 1999-08-12 PT PT99943712T patent/PT1104415E/pt unknown
- 1999-08-12 MX MXPA01001552A patent/MXPA01001552A/es not_active IP Right Cessation
- 1999-08-12 ES ES10181678.3T patent/ES2537540T3/es not_active Expired - Lifetime
- 1999-08-12 BR BRPI9912951-5A patent/BR9912951B1/pt not_active IP Right Cessation
- 1999-08-12 CA CA2714085A patent/CA2714085C/en not_active Expired - Lifetime
- 1999-08-12 IL IL14135999A patent/IL141359A0/xx active IP Right Grant
- 1999-08-12 CA CA2563022A patent/CA2563022C/en not_active Expired - Lifetime
- 1999-08-12 EP EP05075522A patent/EP1535921A1/de not_active Ceased
- 1999-08-12 DE DE69921829T patent/DE69921829T2/de not_active Expired - Lifetime
- 1999-08-12 EP EP10181678.3A patent/EP2322518B1/de not_active Expired - Lifetime
- 1999-08-12 AT AT99943712T patent/ATE282034T1/de active
- 1999-08-12 AT AT03077251T patent/ATE292631T1/de not_active IP Right Cessation
- 1999-08-12 KR KR1020017001827A patent/KR100687194B1/ko not_active IP Right Cessation
- 1999-08-12 CA CA002340214A patent/CA2340214C/en not_active Expired - Lifetime
- 1999-08-12 EP EP99943712A patent/EP1104415B1/de not_active Expired - Lifetime
- 1999-08-12 EP EP03077251A patent/EP1361223B1/de not_active Expired - Lifetime
- 1999-08-12 RU RU2004125183/04A patent/RU2439069C2/ru not_active Application Discontinuation
- 1999-08-12 ES ES99943712T patent/ES2232169T3/es not_active Expired - Lifetime
2000
- 2000-05-15 US US09/570,885 patent/US6518425B1/en not_active Expired - Lifetime
- 2000-09-26 US US09/669,806 patent/US6576776B1/en not_active Expired - Lifetime
2001
- 2001-02-09 IL IL141359A patent/IL141359A/en not_active IP Right Cessation
2002
- 2002-01-21 HK HK02100476A patent/HK1038921A1/xx not_active IP Right Cessation
2003
- 2003-02-11 US US10/361,980 patent/US6939965B2/en not_active Expired - Lifetime
2004
- 2004-06-30 AU AU2004202930A patent/AU2004202930C1/en not_active Expired
2006
- 2006-02-15 IL IL173745A patent/IL173745A/en not_active IP Right Cessation
2008
- 2008-11-13 JP JP2008291234A patent/JP5203897B2/ja not_active Expired - Fee Related
2009
- 2009-10-01 IL IL201293A patent/IL201293A/en not_active IP Right Cessation
2011
- 2011-10-11 HK HK11110762.2A patent/HK1156604A1/xx not_active IP Right Cessation
2012
- 2012-05-18 JP JP2012114415A patent/JP5547772B2/ja not_active Expired - Fee Related
2014
- 2014-03-25 JP JP2014061275A patent/JP5956492B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP2322518B1 (de)	2015-02-25
US6939965B2 (en)	2005-09-06
JP2009108080A (ja)	2009-05-21
RU2244712C2 (ru)	2005-01-20
IL173745A0 (en)	2006-07-05
JP2014132026A (ja)	2014-07-17
JP5547772B2 (ja)	2014-07-16
EP1361223A1 (de)	2003-11-12
DE69921829D1 (de)	2004-12-16
AU2004202930B2 (en)	2008-05-08
BR9912951B1 (pt)	2012-01-10
EP2322518A1 (de)	2011-05-18
MXPA01001552A (es)	2004-08-23
US6576776B1 (en)	2003-06-10
RU2004125183A (ru)	2006-01-27
ATE282034T1 (de)	2004-11-15
CA2714085C (en)	2013-02-05
AU2004202930C1 (en)	2008-11-13
US20030144532A1 (en)	2003-07-31
CA2563022C (en)	2010-11-23
DE69921829T2 (de)	2005-10-27
CA2563022A1 (en)	2000-02-24
EP1104415A1 (de)	2001-06-06
CA2340214A1 (en)	2000-02-24
JP5956492B2 (ja)	2016-07-27
US6215004B1 (en)	2001-04-10
CA2714085A1 (en)	2000-02-24
IL201293A0 (en)	2010-05-31
BR9912951A (pt)	2001-10-02
JP4249393B2 (ja)	2009-04-02
KR20070094667A (ko)	2007-09-20
KR100856416B1 (ko)	2008-09-04
US6518425B1 (en)	2003-02-11
IL141359A0 (en)	2002-03-10
AU2004202930A1 (en)	2004-07-29
IL173745A (en)	2010-05-31
HK1038921A1 (en)	2002-04-04
KR20060063991A (ko)	2006-06-12
PT2322518E (pt)	2015-06-08
KR101208429B1 (ko)	2012-12-05
CN1141305C (zh)	2004-03-10
EP1361223B1 (de)	2005-04-06
KR20010072428A (ko)	2001-07-31
CN1313858A (zh)	2001-09-19
CA2340214C (en)	2007-10-30
ES2537540T3 (es)	2015-06-09
KR100687194B1 (ko)	2007-02-27
JP5203897B2 (ja)	2013-06-05
EP1535921A1 (de)	2005-06-01
EP1104415B1 (de)	2004-11-10
HK1156604A1 (en)	2012-06-15
AU771779B2 (en)	2004-04-01
ES2232169T3 (es)	2005-05-16
IL141359A (en)	2006-07-05
PT1104415E (pt)	2005-03-31
IL201293A (en)	2011-02-28
RU2439069C2 (ru)	2012-01-10
AU5675299A (en)	2000-03-06
JP2012176974A (ja)	2012-09-13
WO2000009494A1 (en)	2000-02-24
JP2002522534A (ja)	2002-07-23
DE69924651D1 (de)	2005-05-12

Legal Events

Date	Code	Title	Description
2005-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE292631T1 (de)	2005-04-15	Verfahren zu herstellung von 1,3-oxathiolane nukleosiden
ATE277937T1 (de)	2004-10-15	Verfahren zur herstellung von 9-(2- (diethylphosphonomethoxy)ethyl)-adenin
DE3764602D1 (de)	1990-10-04	Verfahren zur herstellung von n,n-diaryl-harnstoffen.
ATE334136T1 (de)	2006-08-15	Verfahren zur herstellung von azithromycin
DE3750087D1 (de)	1994-07-21	Dekorblatt, sowie verfahren zur herstellung desselben.
DE3772590D1 (de)	1991-10-10	Verfahren zur herstellung von 1,4-dihydropyridin-derivaten.
DE59912242D1 (de)	2005-08-11	Verfahren zur herstellung von (s,s)-benzyl-2,8-diazabicyclo(4.3.0)nonan
DE68923171D1 (de)	1995-07-27	Aluminiumhydroxyd, verfahren zur herstellung und zusammensetzung.
DE59001006D1 (de)	1993-04-15	Verfahren zur herstellung von 1,1,1,2-tetrafluorethan.
DE59001106D1 (de)	1993-05-06	Verfahren zur herstellung von 1,1,1-trifluor-2-chlorethan.
DE69106370D1 (de)	1995-02-09	Verfahren zur herstellung von werkzeugen und matrizen.
DE3879843D1 (de)	1993-05-06	Verfahren zur herstellung von 3,5,5-trimethylcyclohexa-2-en-1,4-dion.
DE3778442D1 (de)	1992-05-27	Verfahren zur herstellung von metallfluoriden, verwendbar zur herstellung von fluorid-glaesern.
DK368587D0 (da)	1987-07-15	Fremgangsmaade til fremstilling af 5,6-substitueret-2,4-quinazolindiaminer samt mellemproduktforbindelser
DE3779247D1 (de)	1992-06-25	Verfahren zur herstellung von 2,3,5-trimethylhydrochinon.
ATE275563T1 (de)	2004-09-15	Verfahren zur herstellung von 1,3- disubstituierten-4-oxocyclischen harnstoffen
ATE209636T1 (de)	2001-12-15	Verbessertes verfahren zur herstellung von unsymmetrischen 4,6- bis(aryloxy)pyrimidinverbindungen
DE3871591D1 (de)	1992-07-09	Verfahren zur herstellung von 1-propargyl-2,4-dioxoimidazolidin.
DE3776860D1 (de)	1992-04-02	Verfahren zur herstellung von kleinsten, amorphen metallphosphat-partikeln.
DE69801454D1 (de)	2001-10-04	Verfahren zur Herstellung von 2-Methyl-1,4-Benzochinon
ATE241619T1 (de)	2003-06-15	Verfahren zur herstellung von nukleosid-analogen
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