ATE275134T1 - 4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittel - Google Patents
4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittelInfo
- Publication number
- ATE275134T1 ATE275134T1 AT99965907T AT99965907T ATE275134T1 AT E275134 T1 ATE275134 T1 AT E275134T1 AT 99965907 T AT99965907 T AT 99965907T AT 99965907 T AT99965907 T AT 99965907T AT E275134 T1 ATE275134 T1 AT E275134T1
- Authority
- AT
- Austria
- Prior art keywords
- antiviral agents
- quinolinecarboxamide
- dihydro
- oxo
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11511399P | 1999-01-08 | 1999-01-08 | |
US13839099P | 1999-06-09 | 1999-06-09 | |
US14061499P | 1999-06-23 | 1999-06-23 | |
PCT/US1999/027959 WO2000040563A1 (en) | 1999-01-08 | 1999-12-22 | 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE275134T1 true ATE275134T1 (de) | 2004-09-15 |
Family
ID=27381602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99965907T ATE275134T1 (de) | 1999-01-08 | 1999-12-22 | 4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittel |
Country Status (28)
Country | Link |
---|---|
US (1) | US6248736B1 (de) |
EP (1) | EP1140851B1 (de) |
JP (1) | JP2002534417A (de) |
KR (1) | KR20010101428A (de) |
CN (1) | CN1132818C (de) |
AT (1) | ATE275134T1 (de) |
AU (1) | AU2158300A (de) |
BR (1) | BR9916781A (de) |
CA (1) | CA2353634A1 (de) |
CO (1) | CO5150150A1 (de) |
CZ (1) | CZ20012458A3 (de) |
DE (1) | DE69919897T2 (de) |
EA (1) | EA004043B1 (de) |
ES (1) | ES2228162T3 (de) |
HK (1) | HK1041879A1 (de) |
HU (1) | HUP0105142A3 (de) |
ID (1) | ID29452A (de) |
IL (1) | IL144170A0 (de) |
MY (1) | MY118904A (de) |
NO (1) | NO320396B1 (de) |
NZ (1) | NZ512823A (de) |
PE (1) | PE20001337A1 (de) |
PL (1) | PL348769A1 (de) |
PT (1) | PT1140851E (de) |
SK (1) | SK8312001A3 (de) |
TR (1) | TR200101893T2 (de) |
TW (1) | TW593281B (de) |
WO (1) | WO2000040563A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6562822B2 (en) | 2000-07-12 | 2003-05-13 | Pharmacia & Upjohn Company | Heterocyle carboxamides as antiviral agents |
US6682892B2 (en) | 2000-07-13 | 2004-01-27 | Pharmacia & Upjohn Company | Method for treating herpes viruses |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
JP2004520424A (ja) | 2001-03-01 | 2004-07-08 | ファルマシア・アンド・アップジョン・カンパニー | 抗ウイルス剤としての置換型キノリンカルボキサミド |
WO2003020728A1 (en) | 2001-08-30 | 2003-03-13 | Pharmacia & Upjohn Company | 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS |
AR038118A1 (es) | 2002-01-14 | 2004-12-29 | Upjohn Co | Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales |
AR038117A1 (es) | 2002-01-14 | 2004-12-29 | Upjohn Co | Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida |
AR038294A1 (es) | 2002-01-14 | 2005-01-12 | Upjohn Co | Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales |
US20040176366A1 (en) * | 2002-08-30 | 2004-09-09 | Wathen Michael W | Method of preventing or treating atherosclerosis or restenosis |
WO2004019932A1 (en) * | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
CN100375742C (zh) * | 2002-11-20 | 2008-03-19 | 日本烟草产业株式会社 | 4-氧代喹啉化合物及其用途 |
TWI248928B (en) | 2002-11-20 | 2006-02-11 | Japan Tobacco Inc | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
CN100471842C (zh) | 2003-07-24 | 2009-03-25 | 安斯泰来制药有限公司 | 喹诺酮衍生物或其盐 |
MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
EP1758581A1 (de) | 2004-05-21 | 2007-03-07 | Japan Tobacco, Inc. | Kombinationen aus einem 4-isochinolon-derivat und anti-hiv-mitteln |
EP1773816B1 (de) | 2004-06-24 | 2015-01-07 | Vertex Pharmaceuticals Incorporated | Modulatoren von Transportern der ATP bindenden Kassette |
US20070032522A1 (en) * | 2005-07-01 | 2007-02-08 | Kumar Dange V | Antiviral agents |
LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
EP1978960A4 (de) * | 2006-02-01 | 2009-12-02 | Japan Tobacco Inc | Verwendung von 6-(3-chlor-2-fluorbenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl[-7-methoxy-4-oxo-1,4-dihydrochinolin-3-carboxylsäure oder einem salz daraus zur behandlung einer retrovireninfektion |
AU2007223260C1 (en) * | 2006-03-06 | 2011-02-03 | Japan Tobacco Inc. | Method for producing 4-oxoquinoline compound |
DE102008036099B4 (de) | 2008-08-04 | 2014-02-13 | Steag Power Saar Gmbh | Entstickungsanlage |
WO2010108162A1 (en) | 2009-03-20 | 2010-09-23 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
WO2011004389A2 (en) | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | An improved process for the preparation of elvitegravir |
MX342119B (es) * | 2010-08-27 | 2016-09-14 | Grünenthal Gmbh * | 2-oxi-quinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
EP2819670A1 (de) | 2012-02-27 | 2015-01-07 | Vertex Pharmaceuticals Incorporated | Pharmazeutische zusammensetzung und verabreichung davon |
CN104884448A (zh) | 2012-10-16 | 2015-09-02 | 詹森药业有限公司 | Rorγt的杂芳基连接的喹啉基调节剂 |
CN105209453B (zh) | 2012-10-16 | 2017-06-20 | 詹森药业有限公司 | ROR‑γ‑T的亚甲基连接的喹啉基调节剂 |
SG11201502935VA (en) | 2012-10-16 | 2015-09-29 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror-gamma-t |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
US9624225B2 (en) | 2013-10-15 | 2017-04-18 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORγt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
CA2926339A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of roryt |
CA2963945C (en) | 2014-10-07 | 2023-01-10 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
WO2020053654A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
AU2020353055B2 (en) | 2019-09-26 | 2024-03-07 | Gilead Sciences, Inc. | Antiviral pyrazolopyridinone compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2593810B1 (fr) * | 1986-01-24 | 1988-04-22 | Sanofi Sa | Derives de la quinoleine, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant |
US4786644A (en) * | 1987-11-27 | 1988-11-22 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-quinolinecarboxamide |
US4959363A (en) * | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
US5175151A (en) | 1990-09-07 | 1992-12-29 | Schering Corporation | Antiviral compounds and antihypertensive compounds |
JPH06502845A (ja) * | 1990-09-07 | 1994-03-31 | シェリング・コーポレーション | 抗ウイルス化合物および抗高血圧化合物 |
DE69115692T2 (de) | 1991-09-10 | 1996-08-01 | Agfa Gevaert Nv | Thermisch übertragbare fluoreszierende Verbindungen |
MX9800922A (es) * | 1995-08-02 | 1998-05-31 | Darwin Discovery Ltd | Quinolonas y su uso terapeutico. |
EP0876349B1 (de) | 1995-10-19 | 2002-09-11 | Takeda Chemical Industries, Ltd. | Chinolinderivate als gnrh antagonisten |
IL129344A0 (en) | 1996-11-27 | 2000-02-17 | Du Pont Pharm Co | Novel integrin receptor antagonists |
US6093732A (en) | 1997-12-22 | 2000-07-25 | Pharmacia & Upjohn Company | 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents |
-
1999
- 1999-12-17 US US09/465,670 patent/US6248736B1/en not_active Expired - Fee Related
- 1999-12-22 HU HU0105142A patent/HUP0105142A3/hu unknown
- 1999-12-22 AT AT99965907T patent/ATE275134T1/de not_active IP Right Cessation
- 1999-12-22 NZ NZ512823A patent/NZ512823A/en unknown
- 1999-12-22 KR KR1020017008641A patent/KR20010101428A/ko not_active Application Discontinuation
- 1999-12-22 TR TR2001/01893T patent/TR200101893T2/xx unknown
- 1999-12-22 PT PT99965907T patent/PT1140851E/pt unknown
- 1999-12-22 JP JP2000592271A patent/JP2002534417A/ja active Pending
- 1999-12-22 EA EA200100755A patent/EA004043B1/ru not_active IP Right Cessation
- 1999-12-22 AU AU21583/00A patent/AU2158300A/en not_active Abandoned
- 1999-12-22 IL IL14417099A patent/IL144170A0/xx unknown
- 1999-12-22 WO PCT/US1999/027959 patent/WO2000040563A1/en active Search and Examination
- 1999-12-22 EP EP99965907A patent/EP1140851B1/de not_active Expired - Lifetime
- 1999-12-22 ID IDW00200101463A patent/ID29452A/id unknown
- 1999-12-22 DE DE69919897T patent/DE69919897T2/de not_active Expired - Fee Related
- 1999-12-22 ES ES99965907T patent/ES2228162T3/es not_active Expired - Lifetime
- 1999-12-22 CN CN998151602A patent/CN1132818C/zh not_active Expired - Fee Related
- 1999-12-22 CA CA002353634A patent/CA2353634A1/en not_active Abandoned
- 1999-12-22 PL PL99348769A patent/PL348769A1/xx unknown
- 1999-12-22 CZ CZ20012458A patent/CZ20012458A3/cs unknown
- 1999-12-22 BR BR9916781-6A patent/BR9916781A/pt not_active Application Discontinuation
- 1999-12-22 SK SK831-2001A patent/SK8312001A3/sk unknown
- 1999-12-24 MY MYPI99005719A patent/MY118904A/en unknown
- 1999-12-28 PE PE1999001326A patent/PE20001337A1/es not_active Application Discontinuation
- 1999-12-29 CO CO99081336A patent/CO5150150A1/es unknown
-
2000
- 2000-01-07 TW TW089100222A patent/TW593281B/zh not_active IP Right Cessation
-
2001
- 2001-07-06 NO NO20013379A patent/NO320396B1/no unknown
-
2002
- 2002-05-07 HK HK02103436A patent/HK1041879A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20010101428A (ko) | 2001-11-14 |
JP2002534417A (ja) | 2002-10-15 |
MY118904A (en) | 2005-02-28 |
EA004043B1 (ru) | 2003-12-25 |
HUP0105142A2 (hu) | 2002-04-29 |
US6248736B1 (en) | 2001-06-19 |
BR9916781A (pt) | 2001-12-04 |
WO2000040563A1 (en) | 2000-07-13 |
NO320396B1 (no) | 2005-11-28 |
HK1041879A1 (en) | 2002-07-26 |
CA2353634A1 (en) | 2000-07-13 |
CN1332729A (zh) | 2002-01-23 |
NO20013379D0 (no) | 2001-07-06 |
NZ512823A (en) | 2003-10-31 |
SK8312001A3 (en) | 2001-12-03 |
CZ20012458A3 (cs) | 2001-12-12 |
NO20013379L (no) | 2001-07-06 |
CO5150150A1 (es) | 2002-04-29 |
DE69919897D1 (en) | 2004-10-07 |
TR200101893T2 (tr) | 2001-11-21 |
PE20001337A1 (es) | 2000-11-23 |
ES2228162T3 (es) | 2005-04-01 |
HUP0105142A3 (en) | 2002-05-28 |
CN1132818C (zh) | 2003-12-31 |
IL144170A0 (en) | 2002-05-23 |
PT1140851E (pt) | 2004-12-31 |
EA200100755A1 (ru) | 2001-12-24 |
ID29452A (id) | 2001-08-30 |
TW593281B (en) | 2004-06-21 |
EP1140851B1 (de) | 2004-09-01 |
PL348769A1 (en) | 2002-06-17 |
EP1140851A1 (de) | 2001-10-10 |
AU2158300A (en) | 2000-07-24 |
DE69919897T2 (de) | 2005-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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REN | Ceased due to non-payment of the annual fee |