ATE253050T1 - Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen - Google Patents

Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen

Info

Publication number
ATE253050T1
ATE253050T1 AT93906370T AT93906370T ATE253050T1 AT E253050 T1 ATE253050 T1 AT E253050T1 AT 93906370 T AT93906370 T AT 93906370T AT 93906370 T AT93906370 T AT 93906370T AT E253050 T1 ATE253050 T1 AT E253050T1
Authority
AT
Austria
Prior art keywords
oxo
hydroxy
amine derivatives
substituted hydrocarbons
enzymes
Prior art date
Application number
AT93906370T
Other languages
English (en)
Inventor
Damian Wojciech Grobelny
Original Assignee
Narhex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Narhex Ltd filed Critical Narhex Ltd
Priority claimed from PCT/AU1993/000103 external-priority patent/WO1993018006A1/en
Application granted granted Critical
Publication of ATE253050T1 publication Critical patent/ATE253050T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
AT93906370T 1992-03-11 1993-03-11 Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen ATE253050T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPL130492 1992-03-11
PCT/AU1993/000103 WO1993018006A1 (en) 1992-03-11 1993-03-11 Amine derivatives of oxo- and hydroxy-substitued hydrocarbons

Publications (1)

Publication Number Publication Date
ATE253050T1 true ATE253050T1 (de) 2003-11-15

Family

ID=29274649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93906370T ATE253050T1 (de) 1992-03-11 1993-03-11 Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen

Country Status (5)

Country Link
US (1) US6258806B1 (de)
KR (1) KR950700897A (de)
AT (1) ATE253050T1 (de)
DE (1) DE69333270T2 (de)
MX (1) MXPA93002392A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2410972A1 (en) * 2000-06-30 2002-01-10 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
MXPA03010733A (es) * 2001-05-22 2004-07-01 Upjohn Co Compuestos de etilamina aza-hidroxilados.
JP5001833B2 (ja) * 2004-04-23 2012-08-15 フォレスト，レナード・エドワード 椎間板の治療又は除去のための装置及び方法

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3330857A (en) 1963-07-01 1967-07-11 Pfizer & Co C N-carbazoylamino acid intermediates for polypeptides
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US5252477A (en) 1987-06-01 1993-10-12 The United States Of America As Represented By The United States Department Of Health And Human Services Human immunodeficiency virus specific proteolytic enzyme and a method for its synthesis and renaturation
EP0395664A1 (de) 1987-10-21 1990-11-07 The Upjohn Company Renin-inhibitoren, die einen (1-amino-2-hydroxy-2-heterocyclus)-ethyl-baustein enthalten
WO1989010920A1 (en) 1988-05-03 1989-11-16 The Upjohn Company Renin inhibitory peptides containing a substituted phenoxyacetyle group
IL90218A0 (en) 1988-05-13 1989-12-15 Abbott Lab Retroviral protease inhibitors
US5248667A (en) 1988-05-27 1993-09-28 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method of treating psoriasis using synthetic peptide compositions
CA1340748C (en) 1988-07-13 1999-09-14 Stephen Oroszlan Synthetic hiv protease gene and method for its expression
IL91307A0 (en) 1988-08-24 1990-03-19 Merck & Co Inc Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
EP0361341A3 (de) 1988-09-28 1991-07-03 Miles Inc. Therapeutika für AIDS auf der Basis von HIV-Protease-Inhibitoren
IL92011A0 (en) 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
DE3840452A1 (de) 1988-12-01 1990-06-07 Hoechst Ag (beta)-amino-boronsaeure-derivate
DE3841520A1 (de) 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US5215968A (en) 1988-12-10 1993-06-01 Hoechst Aktiengesellschaft Dipeptide derivatives having an enzyme inhibitory action
DE3842067A1 (de) 1988-12-14 1990-06-21 Hoechst Ag Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3842197A1 (de) 1988-12-15 1990-06-21 Hoechst Ag Rasch spaltbares substrat fuer die hiv-protease
EP0374098A3 (de) 1988-12-15 1991-05-02 Ciba-Geigy Ag Retrovirale Proteasehemmer
US5198426A (en) 1988-12-30 1993-03-30 Warner-Lambert Company Renin inhibitors containing c-terminal dihydroxy amides
CA2010531A1 (en) 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
US5086165A (en) 1989-03-08 1992-02-04 Washington University Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond
KR920700221A (ko) 1989-04-18 1992-02-19 원본미기재 극성 n-말단기들을 갖는 신규 리닌 억제인자 펩티드
DE3913272A1 (de) 1989-04-22 1990-10-25 Hoechst Ag Dipeptid-derivate mit enzym-inhibitorischer wirkung
US5256677A (en) 1989-05-23 1993-10-26 Abbott Laboratories Retroviral protease inhibiting compounds
US5151438A (en) 1989-05-23 1992-09-29 Abbott Laboratories Retroviral protease inhibiting compounds
US5126326A (en) 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives
US5212157A (en) 1989-06-06 1993-05-18 Bio-Mega, Inc. Enzyme inhibitors
JPH04506808A (ja) 1989-07-19 1992-11-26 ジ・アップジョン・カンパニー 転移状態擬態としてのジアミノグリコール類を含有するペプチド類
EP0421109A3 (en) 1989-09-11 1992-01-08 American Cyanamid Company Screening methods for protease inhibitors
EP0428849A3 (en) 1989-09-28 1991-07-31 Hoechst Aktiengesellschaft Retroviral protease inhibitors
DE4033062A1 (de) 1990-10-18 1992-04-23 Merck Patent Gmbh Aminosaeurederivate
JPH05501879A (ja) 1989-10-27 1993-04-08 ジ・アップジョン・カンパニー Ｈｉｖおよび他のレトロウイルスを処理する方法およびそれに有用な化合物
US5221665A (en) 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
AU638774B2 (en) 1989-11-20 1993-07-08 Eli Lilly And Company Methods of treating retroviral infection
US5254682A (en) 1989-12-08 1993-10-19 Merck & Co., Inc. Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs
US5194605A (en) 1989-12-08 1993-03-16 Merck & Co., Inc. Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs
GB8927915D0 (en) 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
DE3941235A1 (de) 1989-12-14 1991-06-20 Bayer Ag Neue peptide, ihre herstellung und ihre verwendung in arzneimitteln
DK0506769T3 (da) 1989-12-18 1994-11-28 Transgene Sa Farmaceutisk præparat til behandling eller forebyggelse af retrovirus-infektioner
CA2032259A1 (en) 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
US5164300A (en) 1989-12-28 1992-11-17 Washington University Method for determining activity of retroviral protease
US5011910A (en) 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease
DE4001236A1 (de) 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
US5221667A (en) 1990-01-22 1993-06-22 Warner-Lambert Company Renin inhibiting peptides having an α-heteroatom amino acid at the P3 position
CA2036398C (en) 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
CA2036397C (en) 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
CA2036413C (en) 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
GB9005829D0 (en) 1990-03-15 1990-05-09 Proteus Biotech Ltd Synthetic polypeptides
AU7732691A (en) 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
AU8205491A (en) 1990-06-01 1991-12-31 Du Pont Merck Pharmaceutical Company, The 1,4-diamino-2,3-dihydroxybutanes
EP0532693A1 (de) 1990-06-01 1993-03-24 The Du Pont Merck Pharmaceutical Company 1,4-diamino-2,3-dihydroxybutane
US5248606A (en) 1990-06-11 1993-09-28 Dowelanco Dna encoding inactive precursor and active forms of maize ribosome inactivating protein
US5141735A (en) 1990-06-18 1992-08-25 Hoffman-La Roche, Inc. Substituted amino-benzodiazepines having anitviral activity
US5223633A (en) 1990-06-30 1993-06-29 Bayer Aktiengesellschaft Preparation of sec. or tert. alcohols
DE4021007A1 (de) 1990-07-02 1992-01-09 Hoechst Ag Aminodiol-derivate
AU8320691A (en) 1990-07-06 1992-02-04 Smithkline Beecham Corporation Inhibitors of retroviral proteases
EP0538374A4 (en) 1990-07-06 1993-05-19 Smith-Kline Beecham Corporation Aspartic protease inhibitors
AU8231391A (en) 1990-07-06 1992-02-04 Smithkline Beecham Corporation Inhibitors of aspartic proteases
CA2086414A1 (en) 1990-07-06 1992-01-07 Geoffrey B. Dreyer Retroviral protease inhibitors
JPH06500561A (ja) 1990-08-24 1994-01-20 ジ・アップジョン・カンパニー 遷移状態模擬体としてのアミノポリオール含有ペプチド
EP0475231A1 (de) 1990-09-10 1992-03-18 F. Hoffmann-La Roche Ag Benzodiazepine
US5171662A (en) 1990-09-13 1992-12-15 The Upjohn Company Method of detecting HIV protease activity
US5183826A (en) 1990-09-25 1993-02-02 Merck & Co., Inc. Antiviral agent
EP0552247A1 (de) 1990-10-10 1993-07-28 The Upjohn Company Peptide mit substituierten 1,4-diaminen als übergangszustandeinschub
US5192668A (en) 1990-10-11 1993-03-09 Merck & Co., Inc. Synthesis of protease inhibitor
US5188950A (en) 1990-10-11 1993-02-23 Merck & Co., Inc. Method of preparing HIV protease inhibitors
US5187074A (en) 1990-10-11 1993-02-16 Merck & Co., Inc. Method of hydroxylation with ATCC 55086
US5137876A (en) 1990-10-12 1992-08-11 Merck & Co., Inc. Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same
EP0483403A1 (de) 1990-10-31 1992-05-06 Hoechst Aktiengesellschaft Aminsäurederivate mit renininhibierender Aktivität, Verfahren zu deren Herstellung und pharmazeutische Zubereitungen die sie enthalten
DK0813867T3 (da) 1990-11-19 2005-10-03 Monsanto Co Retrovirale proteaseinhibitorer
EP0735019B1 (de) 1990-11-19 2000-09-20 Monsanto Company Inhibitoren retroviraler Proteasen
EP0558673B1 (de) 1990-11-19 1996-04-17 Monsanto Company Retrovirale proteaseinhibitoren
ES2059289T3 (es) 1990-11-19 1997-10-16 Monsanto Co Inhibidores de la proteasa retroviral.
IE913840A1 (en) 1990-11-20 1992-05-20 Abbott Lab Retroviral protease inhibiting compounds
DE4037437A1 (de) 1990-11-24 1992-05-27 Hoechst Ag Aminodiol-derivate
US5438118A (en) 1990-11-30 1995-08-01 Smithkline Beechman Corp. HIV protease inhibitors
CA2056911C (en) 1990-12-11 1998-09-22 Yuuichi Nagano Hiv protease inhibitors
EP0491218A1 (de) 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinone
EP0492136A3 (en) 1990-12-20 1993-05-26 American Cyanamid Company Retroviral protease inhibitors derived from 3-chloro-2-chloromethyl-1-propene
AU649766B2 (en) 1991-01-02 1994-06-02 Aventis Inc. Anti-viral compounds
IE920414A1 (en) 1991-02-08 1992-08-12 Sankyo Co New beta-amino-alpha-hydroxycarboxylic acids and their use
CA2104602A1 (en) 1991-02-22 1992-08-23 Carl N. Hodge Substituted .alpha.-aminoaldehydes and derivatives
WO1992017490A1 (en) 1991-04-04 1992-10-15 The Upjohn Company Phosphorus containing compounds as inhibitors of retroviruses
US5430041A (en) 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
US5235039A (en) 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
PL294870A1 (de) 1991-06-21 1993-02-08 Hoechst Ag
PL294866A1 (en) 1991-06-21 1993-05-31 Hoechst Ag Method of obtaining novel rennin redtarding heterocyclic compounds
US5169952A (en) 1991-07-02 1992-12-08 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides
JPH07501786A (ja) 1991-07-02 1995-02-23 サンド・リミテッド ４−アミノ−３−ヒドロキシカルボン酸誘導体
US5753652A (en) 1991-07-03 1998-05-19 Novartis Corporation Antiretroviral hydrazine derivatives
EP0521827B1 (de) 1991-07-03 1996-09-25 Ciba-Geigy Ag Pharmakologisch wirksame Hydrazinderivate und Verfahren zu deren Herstellung
CN1071930A (zh) 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
IE922316A1 (en) 1991-07-17 1993-01-27 Smithkline Beecham Corp Retroviral protease inhibitors
US5554728A (en) 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
DE4126485A1 (de) 1991-08-10 1993-02-11 Bayer Ag Trifluormethyl-haltige pseudopeptide
US5516784A (en) 1991-08-13 1996-05-14 Schering Corporation Anti-HIV (AIDS) agents
DE4128790A1 (de) 1991-08-30 1993-03-04 Bayer Ag Neue substituierte 2,3-diaminosaeuren, verfahren zu ihrer herstellung und ihre verwendung als zwischenstufen fuer peptidische wirkstoffe
AU2642492A (en) 1991-09-11 1993-04-05 Smithkline Beecham Corporation Peptide isoters containing a heterocycle as h.i.v. inhibitors
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5250563A (en) 1991-09-25 1993-10-05 Merck & Co., Inc. Inhibitors of HIV protease
WO1993008184A1 (en) 1991-10-23 1993-04-29 Merck & Co., Inc. Hiv protease inhibitors
DE69224703T2 (de) 1991-11-08 1998-10-15 Merck & Co., Inc., Rahway, N.J. HIV-Protease-Inhibitoren verwendbar in der AIDS-Behandlung
FR2683723B1 (fr) 1991-11-14 1995-05-19 Mayoly Spindler Laboratoires Nouveaux medicaments antiviraux actifs sur le virus vih.
AU3497293A (en) 1992-02-26 1993-09-13 F. Hoffmann-La Roche Ag Benzodiazepinones and medicines containing them
US5294737A (en) 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
BR9306058A (pt) 1992-03-11 1997-11-18 Narhex Ltd Derivados de amina de hidrocarbonetos oxo- e hidroxi- substituidos
EP0560268B1 (de) 1992-03-13 1995-01-04 Bio-Mega/Boehringer Ingelheim Research Inc. Substituierte Pipecoline-Säurederivate als HIV-Protease-Hemmer
ZA931777B (en) 1992-03-13 1993-09-23 Bio Mega Boehringer Ingelheim Substituted pyrrolidine derivatives as HIV protease inhibitors.
TW217410B (de) 1992-04-01 1993-12-11 Ciba Geigy
US5231153A (en) 1992-04-06 1993-07-27 The Goodyear Tire & Rubber Company Anionic polymerization of conjugated dienes modified with alkyltetrahydrofurfuryl ethers
DE4215874A1 (de) 1992-05-14 1993-11-18 Bayer Ag Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp
US5296604A (en) 1992-05-15 1994-03-22 Miles Inc. Proline derivatives and compositions for their use as inhibitors of HIV protease
SI9300288A (sl) 1992-06-16 1993-12-31 Hoffmann La Roche Benzodiazepini
ES2152241T3 (es) 1992-06-19 2001-02-01 Lilly Co Eli Oxiranos 2,3-bis-carboxamidometil sustituidos como inhibidores de la proteasa del hiv y su uso para el tratamiento del sida.
US5559256A (en) 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
DE4232173A1 (de) 1992-09-25 1994-03-31 Bayer Ag 5-Oxo-dibenzo(a,d)cyclohepta-1,4-diene
TW372972B (en) 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds
ES2093394T3 (es) 1992-12-23 1996-12-16 Ciba Geigy Ag Derivados de hidrazina antiretrovirales.
DE4308096A1 (de) 1993-03-13 1994-09-15 Hoechst Ag Prodrug-Derivate von Enzyminhibitoren mit Hydroxylgruppen, Verfahren zu deren Herstellung und ihre Verwendung

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DE69333270T2 (de) 2004-08-05
KR950700897A (ko) 1995-02-20

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