ATE182889T1 - Bicyclische amidinderivate als no-synthetase inhibitoren - Google Patents

Bicyclische amidinderivate als no-synthetase inhibitoren

Info

Publication number
ATE182889T1
ATE182889T1 AT95918069T AT95918069T ATE182889T1 AT E182889 T1 ATE182889 T1 AT E182889T1 AT 95918069 T AT95918069 T AT 95918069T AT 95918069 T AT95918069 T AT 95918069T AT E182889 T1 ATE182889 T1 AT E182889T1
Authority
AT
Austria
Prior art keywords
synthetase inhibitors
amideine
bicyclic
derivatives
formula
Prior art date
Application number
AT95918069T
Other languages
English (en)
Inventor
James Edwin Macdonald
William Calvin Shakespeare
Robert John Murray
James Russell Matz
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9409201A external-priority patent/GB9409201D0/en
Priority claimed from GB9409462A external-priority patent/GB9409462D0/en
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of ATE182889T1 publication Critical patent/ATE182889T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
AT95918069T 1994-05-07 1995-05-09 Bicyclische amidinderivate als no-synthetase inhibitoren ATE182889T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9409201A GB9409201D0 (en) 1994-05-07 1994-05-07 Pharmaceutically active compounds
GB9409462A GB9409462D0 (en) 1994-05-12 1994-05-12 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
ATE182889T1 true ATE182889T1 (de) 1999-08-15

Family

ID=26304851

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918069T ATE182889T1 (de) 1994-05-07 1995-05-09 Bicyclische amidinderivate als no-synthetase inhibitoren

Country Status (15)

Country Link
US (2) US5807886A (de)
EP (1) EP0759027B1 (de)
JP (1) JPH10500138A (de)
AT (1) ATE182889T1 (de)
AU (1) AU682768B2 (de)
CA (1) CA2188680A1 (de)
DE (1) DE69511260T2 (de)
DK (1) DK0759027T3 (de)
ES (1) ES2137512T3 (de)
FI (1) FI964463A (de)
GR (1) GR3031693T3 (de)
HK (1) HK1009043A1 (de)
MX (1) MX9605366A (de)
NO (1) NO964698L (de)
WO (1) WO1996001817A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265441B1 (en) * 1994-05-11 2001-07-24 Jes Olesen Use of no scavengers, inhibitors of antagonists in the treatment of migraine
BR9509297A (pt) * 1995-08-10 1998-07-07 Astra Ab Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto
US6069162A (en) * 1996-05-27 2000-05-30 Fujisawa Pharmaceutical Co., Ltd. Indolyl and benzofuranyl carboxamides as inhibitors of nitric oxide production
US6335445B1 (en) 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
FR2764889B1 (fr) * 1997-06-20 2000-09-01 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2761066B1 (fr) * 1997-03-24 2000-11-24 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
SE9701682D0 (sv) * 1997-05-05 1997-05-05 Astra Ab Compounds
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
EP1075475B1 (de) * 1998-05-04 2003-06-18 Fujisawa Pharmaceutical Co., Ltd. Heterocyclische carbonsäureamid derivate als hemmstoffe der stickstoffmonoxid-produktion
CA2319495A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2784678B1 (fr) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
CA2408913A1 (en) 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
US7232822B2 (en) * 2001-10-12 2007-06-19 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
JP4542341B2 (ja) * 2002-03-13 2010-09-15 ザ ユニバーシティ オブ テネシー リサーチ ファウンデイション 置換テトラヒドロイソキノリン化合物、調製方法、およびその使用
CL2008000838A1 (es) * 2007-03-23 2008-10-10 Neuraxon Inc Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135043C (de) * 1963-10-11
GB1145278A (en) * 1964-07-07 1969-03-12 Wellcome Found Amidine derivatives, processes for their preparation, and compositions incorporating them
GB1180629A (en) * 1967-07-14 1970-02-04 Delalande Sa Di-Amidines derived from Aromatic Diamines and process for obtaining same
GB1188956A (en) * 1967-07-14 1970-04-22 Delalande Sa N-Substituted Aromatic Amidines and process for obtaining same
US3669974A (en) * 1971-03-25 1972-06-13 Usv Pharma Corp N,n1-disubstituted benzamidines
DE2321330A1 (de) * 1973-04-27 1974-11-07 Bayer Ag Azolyl-amidine, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide
JPS5246949B2 (de) * 1973-10-19 1977-11-29
US3903163A (en) * 1974-10-02 1975-09-02 Dow Chemical Co N,N-Disubstituted naphthaleneacetamidines
US4073639A (en) * 1975-01-06 1978-02-14 United Technologies Corporation Metallic filler material
IE62023B1 (en) * 1989-01-02 1994-12-14 Boots Co Plc Therapeutic agents
AU636713B2 (en) * 1990-02-26 1993-05-06 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
EP0551330A4 (en) * 1990-08-30 1994-07-06 Oregon State Substituted amidines having high binding to the sigma receptor and the use thereof
US5246971A (en) * 1991-12-16 1993-09-21 Washington University Method of inhibiting nitric oxide formation
CA2085399A1 (en) * 1991-12-16 1993-06-17 Joseph Robert Williamson Method for inhibiting nitric oxide formation
WO1993013066A1 (en) * 1991-12-20 1993-07-08 Syntex (U.S.A.) Inc. Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9200114D0 (en) * 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
US5362747A (en) * 1992-11-25 1994-11-08 Abbott Laboratories 2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase
WO1994012165A2 (en) * 1992-11-27 1994-06-09 The Wellcome Foundation Limited Enzyme inhibitors
EP0690851B1 (de) * 1993-03-23 1999-05-19 Astra Aktiebolag Guanidinderivate mit therapeutischer wirkung
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
SK16396A3 (en) * 1993-08-12 1996-09-04 Astra Ab Amidine derivatives with nitric oxide synthetase activities
EP0723438A1 (de) * 1993-10-04 1996-07-31 The Wellcome Foundation Limited Substitutierte harnstoff und isothioharnstoff derivate als no synthase inhibitoren
GB9320484D0 (en) * 1993-10-05 1993-11-24 Wellcome Found Pharmaceutical combinations
KR950703941A (ko) * 1993-10-13 1995-11-17 오오쓰까 아끼히꼬 일산화질소 합성 억제제(nitrogen monoxide synthesis inhibitor)
AU688811B2 (en) * 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
EP0724435B1 (de) * 1993-10-21 2002-08-14 G.D. Searle & Co. Amidino-derivate nützlich als no synthase-hemmer
US5629322A (en) * 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
NO964698D0 (no) 1996-11-06
FI964463A0 (fi) 1996-11-06
FI964463A (fi) 1996-11-06
DK0759027T3 (da) 2000-03-27
MX9605366A (es) 1997-12-31
DE69511260D1 (en) 1999-09-09
CA2188680A1 (en) 1996-01-25
GR3031693T3 (en) 2000-02-29
HK1009043A1 (en) 1999-05-21
AU682768B2 (en) 1997-10-16
US6117898A (en) 2000-09-12
NO964698L (no) 1996-11-06
WO1996001817A1 (en) 1996-01-25
JPH10500138A (ja) 1998-01-06
AU2413995A (en) 1996-02-09
EP0759027A1 (de) 1997-02-26
US5807886A (en) 1998-09-15
ES2137512T3 (es) 1999-12-16
DE69511260T2 (de) 2000-03-16
EP0759027B1 (de) 1999-08-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee