ATE182889T1 - Bicyclische amidinderivate als no-synthetase inhibitoren - Google Patents
Bicyclische amidinderivate als no-synthetase inhibitorenInfo
- Publication number
- ATE182889T1 ATE182889T1 AT95918069T AT95918069T ATE182889T1 AT E182889 T1 ATE182889 T1 AT E182889T1 AT 95918069 T AT95918069 T AT 95918069T AT 95918069 T AT95918069 T AT 95918069T AT E182889 T1 ATE182889 T1 AT E182889T1
- Authority
- AT
- Austria
- Prior art keywords
- synthetase inhibitors
- amideine
- bicyclic
- derivatives
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9409201A GB9409201D0 (en) | 1994-05-07 | 1994-05-07 | Pharmaceutically active compounds |
GB9409462A GB9409462D0 (en) | 1994-05-12 | 1994-05-12 | Pharmaceutically active compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE182889T1 true ATE182889T1 (de) | 1999-08-15 |
Family
ID=26304851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95918069T ATE182889T1 (de) | 1994-05-07 | 1995-05-09 | Bicyclische amidinderivate als no-synthetase inhibitoren |
Country Status (15)
Country | Link |
---|---|
US (2) | US5807886A (de) |
EP (1) | EP0759027B1 (de) |
JP (1) | JPH10500138A (de) |
AT (1) | ATE182889T1 (de) |
AU (1) | AU682768B2 (de) |
CA (1) | CA2188680A1 (de) |
DE (1) | DE69511260T2 (de) |
DK (1) | DK0759027T3 (de) |
ES (1) | ES2137512T3 (de) |
FI (1) | FI964463A (de) |
GR (1) | GR3031693T3 (de) |
HK (1) | HK1009043A1 (de) |
MX (1) | MX9605366A (de) |
NO (1) | NO964698L (de) |
WO (1) | WO1996001817A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995031195A1 (en) * | 1994-05-11 | 1995-11-23 | Jes Olesen | Use of no scavengers, inhibitors or antagonists in the treatment of migraine |
BR9509297A (pt) * | 1995-08-10 | 1998-07-07 | Astra Ab | Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto |
US6069162A (en) * | 1996-05-27 | 2000-05-30 | Fujisawa Pharmaceutical Co., Ltd. | Indolyl and benzofuranyl carboxamides as inhibitors of nitric oxide production |
US6335445B1 (en) | 1997-03-24 | 2002-01-01 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
FR2761066B1 (fr) * | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
FR2764889B1 (fr) * | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
US6166030A (en) * | 1997-05-05 | 2000-12-26 | Astra Aktiebolag | Compounds |
SE9701681D0 (sv) * | 1997-05-05 | 1997-05-05 | Astra Ab | New compounds |
ES2196798T3 (es) * | 1998-05-04 | 2003-12-16 | Fujisawa Pharmaceutical Co | Derivados heterociclicos de carboxamida como inhibidores de la produccion de oxido nitrico. |
EP1085846A2 (de) * | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Mehrfachbindende inhibitoren des microsomalen triglyceridtransferase-proteins |
FR2783519B1 (fr) | 1998-09-23 | 2003-01-24 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
FR2784678B1 (fr) * | 1998-09-23 | 2002-11-29 | Sod Conseils Rech Applic | Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
EP1283199A4 (de) * | 2000-05-16 | 2003-12-17 | Takeda Chemical Industries Ltd | Antagonisten des melanin-konzentrierenden hormons |
PE20020856A1 (es) | 2001-02-13 | 2002-11-11 | Aventis Pharma Gmbh | 1,2,3,4-tetrahidronaftil aminas aciladas |
US7232822B2 (en) * | 2001-10-12 | 2007-06-19 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
NZ535366A (en) * | 2002-03-13 | 2007-07-27 | Univ Tennessee Res Foundation | Substituted tetrahydroisoquinoline compounds, methods of making, and their use |
CL2008000838A1 (es) * | 2007-03-23 | 2008-10-10 | Neuraxon Inc | Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09504278A (ja) * | 1944-06-01 | 1997-04-28 | ザ、ウェルカム、ファンデーション、リミテッド | Noシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体 |
NL135043C (de) * | 1963-10-11 | |||
GB1145278A (en) * | 1964-07-07 | 1969-03-12 | Wellcome Found | Amidine derivatives, processes for their preparation, and compositions incorporating them |
GB1188956A (en) * | 1967-07-14 | 1970-04-22 | Delalande Sa | N-Substituted Aromatic Amidines and process for obtaining same |
GB1180629A (en) * | 1967-07-14 | 1970-02-04 | Delalande Sa | Di-Amidines derived from Aromatic Diamines and process for obtaining same |
US3669974A (en) * | 1971-03-25 | 1972-06-13 | Usv Pharma Corp | N,n1-disubstituted benzamidines |
DE2321330A1 (de) * | 1973-04-27 | 1974-11-07 | Bayer Ag | Azolyl-amidine, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
JPS5246949B2 (de) * | 1973-10-19 | 1977-11-29 | ||
US3903163A (en) * | 1974-10-02 | 1975-09-02 | Dow Chemical Co | N,N-Disubstituted naphthaleneacetamidines |
US4073639A (en) * | 1975-01-06 | 1978-02-14 | United Technologies Corporation | Metallic filler material |
IE62023B1 (en) * | 1989-01-02 | 1994-12-14 | Boots Co Plc | Therapeutic agents |
CA2036770C (en) * | 1990-02-26 | 2003-09-09 | Jeffrey P. Whitten | Inhibitors of nitric oxide biosynthesis |
AU671071B2 (en) * | 1990-08-30 | 1996-08-15 | State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon, Johnson Hall, | Substituted amidines having high binding to the sigma receptor and the use thereof |
DE69230928T2 (de) * | 1991-12-16 | 2001-01-11 | Washington University, St. Louis | Verwendung von Aminoguamidin zur Herstellung eines Arzneimittels zur Unterdrückung der Stickoxidbildung |
US5246971A (en) * | 1991-12-16 | 1993-09-21 | Washington University | Method of inhibiting nitric oxide formation |
AU3278293A (en) * | 1991-12-20 | 1993-07-28 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
GB9200114D0 (en) * | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
US5281627A (en) * | 1992-05-28 | 1994-01-25 | Cornell Research Foundation, Inc. | Substituted arginines and substituted homoarginines and use thereof |
US5362747A (en) * | 1992-11-25 | 1994-11-08 | Abbott Laboratories | 2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase |
AU5533094A (en) * | 1992-11-27 | 1994-06-22 | Wellcome Foundation Limited, The | Enzyme inhibitors |
ES2132393T3 (es) * | 1993-03-23 | 1999-08-16 | Astra Ab | Derivados de guanidina utiles en terapeutica. |
GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
RU2130017C1 (ru) * | 1993-08-12 | 1999-05-10 | Астра Актиенболаг | Производные амидина, способ их получения и лекарственное средство на их основе, обладающее свойством ингибировать активность синтетазы оксида азота (у) |
GB9320484D0 (en) * | 1993-10-05 | 1993-11-24 | Wellcome Found | Pharmaceutical combinations |
WO1995010266A1 (en) * | 1993-10-13 | 1995-04-20 | Otsuka Pharmaceutical Co., Ltd. | Nitrogen monoxide synthesis inhibitor |
JPH09504028A (ja) * | 1993-10-21 | 1997-04-22 | ジー.ディー.サール アンド カンパニー | 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体 |
EP0724435B1 (de) * | 1993-10-21 | 2002-08-14 | G.D. Searle & Co. | Amidino-derivate nützlich als no synthase-hemmer |
US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
-
1995
- 1995-05-09 WO PCT/GB1995/001041 patent/WO1996001817A1/en active IP Right Grant
- 1995-05-09 MX MX9605366A patent/MX9605366A/es unknown
- 1995-05-09 CA CA002188680A patent/CA2188680A1/en not_active Abandoned
- 1995-05-09 ES ES95918069T patent/ES2137512T3/es not_active Expired - Lifetime
- 1995-05-09 AU AU24139/95A patent/AU682768B2/en not_active Ceased
- 1995-05-09 US US08/737,286 patent/US5807886A/en not_active Expired - Fee Related
- 1995-05-09 AT AT95918069T patent/ATE182889T1/de not_active IP Right Cessation
- 1995-05-09 JP JP8501368A patent/JPH10500138A/ja not_active Ceased
- 1995-05-09 DE DE69511260T patent/DE69511260T2/de not_active Expired - Fee Related
- 1995-05-09 EP EP95918069A patent/EP0759027B1/de not_active Expired - Lifetime
- 1995-05-09 DK DK95918069T patent/DK0759027T3/da active
-
1996
- 1996-11-06 NO NO964698A patent/NO964698L/no not_active Application Discontinuation
- 1996-11-06 FI FI964463A patent/FI964463A/fi unknown
-
1998
- 1998-08-07 HK HK98109759A patent/HK1009043A1/xx not_active IP Right Cessation
-
1999
- 1999-07-22 US US09/358,427 patent/US6117898A/en not_active Expired - Fee Related
- 1999-10-29 GR GR990402784T patent/GR3031693T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HK1009043A1 (en) | 1999-05-21 |
MX9605366A (es) | 1997-12-31 |
FI964463A0 (fi) | 1996-11-06 |
US6117898A (en) | 2000-09-12 |
GR3031693T3 (en) | 2000-02-29 |
DE69511260T2 (de) | 2000-03-16 |
FI964463A (fi) | 1996-11-06 |
EP0759027A1 (de) | 1997-02-26 |
AU682768B2 (en) | 1997-10-16 |
ES2137512T3 (es) | 1999-12-16 |
NO964698D0 (no) | 1996-11-06 |
EP0759027B1 (de) | 1999-08-04 |
AU2413995A (en) | 1996-02-09 |
DE69511260D1 (en) | 1999-09-09 |
WO1996001817A1 (en) | 1996-01-25 |
DK0759027T3 (da) | 2000-03-27 |
US5807886A (en) | 1998-09-15 |
NO964698L (no) | 1996-11-06 |
CA2188680A1 (en) | 1996-01-25 |
JPH10500138A (ja) | 1998-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |