ATE176464T1 - Semisynthetisch taxal derivate mit antitumor wirkung - Google Patents

Semisynthetisch taxal derivate mit antitumor wirkung

Info

Publication number
ATE176464T1
ATE176464T1 AT95927699T AT95927699T ATE176464T1 AT E176464 T1 ATE176464 T1 AT E176464T1 AT 95927699 T AT95927699 T AT 95927699T AT 95927699 T AT95927699 T AT 95927699T AT E176464 T1 ATE176464 T1 AT E176464T1
Authority
AT
Austria
Prior art keywords
taxal
semisynthetic
derivatives
tumor effect
tumoural
Prior art date
Application number
AT95927699T
Other languages
English (en)
Inventor
Ezio Bombardelli
Bellis Paolo De
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI941592A external-priority patent/IT1274356B/it
Priority claimed from IT95RM000413A external-priority patent/IT1278108B1/it
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of ATE176464T1 publication Critical patent/ATE176464T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
AT95927699T 1994-07-26 1995-07-21 Semisynthetisch taxal derivate mit antitumor wirkung ATE176464T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI941592A IT1274356B (it) 1994-07-26 1994-07-26 Tassani semisintetici odtati di attivita' antitumorale
IT95RM000413A IT1278108B1 (it) 1995-06-19 1995-06-19 Secotassani dotati di attivita' antitumorale.

Publications (1)

Publication Number Publication Date
ATE176464T1 true ATE176464T1 (de) 1999-02-15

Family

ID=26331178

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95927699T ATE176464T1 (de) 1994-07-26 1995-07-21 Semisynthetisch taxal derivate mit antitumor wirkung

Country Status (24)

Country Link
US (1) US5756776A (de)
EP (1) EP0773938B1 (de)
JP (1) JP2986550B2 (de)
KR (1) KR100220490B1 (de)
CN (4) CN1073105C (de)
AT (1) ATE176464T1 (de)
AU (1) AU684218B2 (de)
BG (1) BG62851B1 (de)
CA (1) CA2195844C (de)
CZ (1) CZ293076B6 (de)
DE (1) DE69507702T2 (de)
DK (1) DK0773938T3 (de)
ES (1) ES2126919T3 (de)
FI (1) FI120398B (de)
GR (1) GR3029309T3 (de)
HK (1) HK1011687A1 (de)
HU (1) HU222496B1 (de)
NO (1) NO315116B1 (de)
PL (1) PL187579B1 (de)
RO (2) RO116549B1 (de)
RU (1) RU2134688C1 (de)
SI (1) SI9520078B (de)
SK (1) SK281526B6 (de)
WO (1) WO1996003394A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6395770B1 (en) * 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
FR2745814B1 (fr) * 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
EP0868422A1 (de) * 1996-09-24 1998-10-07 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) * 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
KR100615783B1 (ko) * 1997-05-27 2006-08-25 아이박스 리서치 인코포레이티드 탁산 치료를 받고 있는 인체를 제외한 포유동물의 과민증 또는 알러지 반응을 경감시키기 위한 방법 및 약학적 키트
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1317731B1 (it) * 2000-01-18 2003-07-15 Indena Spa Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
EP1129991A1 (de) * 2000-03-02 2001-09-05 Degussa AG Verfahren zur Herstellung eines titanhaltigen Zeolithen
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
MX2007009748A (es) * 2005-02-14 2007-09-26 Univ Florida State Res Found Composiciones de taxano sustituidas con esteres ciclopropilicos en c10.
ITMI20050415A1 (it) * 2005-03-15 2006-09-16 Indena Spa Derivati tassanici semi-sintetici ad attivita' antitumorale
ITMI20062479A1 (it) * 2006-12-21 2008-06-22 Indena Spa Processo per la preparazione di secotassani
KR20100047282A (ko) * 2007-08-22 2010-05-07 6570763 캐나다 인크. 9­디히드로­13­아세틸박카틴ⅲ을 도세탁셀 또는 파클리탁셀로 전환하는 방법
EP2276755A4 (de) * 2008-03-31 2011-05-04 Univ Florida State Res Found C(10)-ethylester- und c(10)-cyclopropylester-substituierte taxane
MX2011001583A (es) 2008-08-11 2011-04-04 Nektar Therapeutics Conjugados de alcanoato polimericos de multiples brazos.
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088433A1 (en) * 2010-12-22 2012-06-28 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
WO2012088391A1 (en) * 2010-12-22 2012-06-28 Nektar Therapeutics Non-ring hydroxy substituted taxanes and methods for synthesizing the same
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
CA2092705C (en) * 1991-07-17 1995-11-07 Koji Saito Compound having antitumor activity, nsc-lsc1, and process for producing the same
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
FR2688499B1 (fr) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol

Also Published As

Publication number Publication date
CN1073105C (zh) 2001-10-17
SK281526B6 (sk) 2001-04-09
HU222496B1 (hu) 2003-07-28
FI970271A0 (fi) 1997-01-23
SI9520078B (sl) 1998-12-31
EP0773938A1 (de) 1997-05-21
ES2126919T3 (es) 1999-04-01
CN1308073A (zh) 2001-08-15
RO116549B1 (ro) 2001-03-30
PL318289A1 (en) 1997-06-09
BG101165A (en) 1997-08-29
AU3164195A (en) 1996-02-22
CN1128795C (zh) 2003-11-26
RO115875B1 (ro) 2000-07-28
NO970296L (no) 1997-03-12
GR3029309T3 (en) 1999-05-28
CN1120161C (zh) 2003-09-03
CA2195844A1 (en) 1996-02-08
HK1011687A1 (en) 1999-07-16
DE69507702T2 (de) 1999-08-26
CN1130356C (zh) 2003-12-10
DK0773938T3 (da) 1999-09-20
BG62851B1 (bg) 2000-09-29
AU684218B2 (en) 1997-12-04
US5756776A (en) 1998-05-26
HUT76829A (en) 1997-11-28
FI120398B (fi) 2009-10-15
CN1332163A (zh) 2002-01-23
SI9520078A (en) 1997-06-30
JPH09512827A (ja) 1997-12-22
CZ19997A3 (en) 1997-07-16
JP2986550B2 (ja) 1999-12-06
SK10097A3 (en) 1997-08-06
CN1308072A (zh) 2001-08-15
CN1154109A (zh) 1997-07-09
DE69507702D1 (de) 1999-03-18
FI970271A (fi) 1997-03-19
EP0773938B1 (de) 1999-02-03
NO315116B1 (no) 2003-07-14
KR100220490B1 (ko) 1999-09-15
RU2134688C1 (ru) 1999-08-20
PL187579B1 (pl) 2004-08-31
NO970296D0 (no) 1997-01-23
CA2195844C (en) 2001-10-09
CZ293076B6 (cs) 2004-02-18
WO1996003394A1 (en) 1996-02-08

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UEP Publication of translation of european patent specification