AR095541A1 - Muteínas de interleucina-2 (il-2) para la expansión de células t reguladoras - Google Patents
Muteínas de interleucina-2 (il-2) para la expansión de células t reguladorasInfo
- Publication number
- AR095541A1 AR095541A1 ARP140101154A ARP140101154A AR095541A1 AR 095541 A1 AR095541 A1 AR 095541A1 AR P140101154 A ARP140101154 A AR P140101154A AR P140101154 A ARP140101154 A AR P140101154A AR 095541 A1 AR095541 A1 AR 095541A1
- Authority
- AR
- Argentina
- Prior art keywords
- mutein
- cells
- regulatory
- human
- interleucine
- Prior art date
Links
- 210000003289 regulatory T cell Anatomy 0.000 title abstract 4
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 abstract 4
- 108010002350 Interleukin-2 Proteins 0.000 abstract 3
- 102000000588 Interleukin-2 Human genes 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108091006020 Fc-tagged proteins Proteins 0.000 abstract 1
- 102000055277 human IL2 Human genes 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicación 1: Una muteína de interleucina-2 (IL-2) humana que comprende una sustitución V91K y una secuencia de aminoácidos al menos 90% idéntica a la secuencia de aminoácidos establecida en la SEQ ID Nº 1, donde dicha muteína de IL-2 estimula preferentemente las células T reguladoras. Reivindicación 6: Una proteína de fusión Fc que comprende una Fc y la muteína de la IL-2 humana de cualquiera de las reivindicaciones 1 - 5. Reivindicación 25: Un ácido nucleico aislado que codifica la muteína de la IL-2 humana de cualquiera de las reivindicaciones 1 - 5. Reivindicación 53: Un método para aumentar la relación de células T reguladoras (Treg) a células T no reguladoras dentro de una población de células T, que comprende poner en contacto la población de células T con una cantidad eficaz de una muteína de IL-2 humana de cualquiera de las reivindicaciones 1 - 5. Reivindicación 71: Un método para tratar un sujeto con una enfermedad inflamatoria o autoinmunitaria, dicho método comprende administrarle a dicho sujeto una cantidad terapéuticamente eficaz de una muteína de IL-2 de cualquiera de las reivindicaciones 1 - 5. Reivindicación 87: Un anticuerpo que comprende una región Fc de cualquiera de las reivindicaciones 77 - 86.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784669P | 2013-03-14 | 2013-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR095541A1 true AR095541A1 (es) | 2015-10-21 |
Family
ID=50680166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101154A AR095541A1 (es) | 2013-03-14 | 2014-03-14 | Muteínas de interleucina-2 (il-2) para la expansión de células t reguladoras |
Country Status (40)
| Country | Link |
|---|---|
| US (8) | US9546203B2 (es) |
| EP (2) | EP2970441B1 (es) |
| JP (5) | JP6450365B2 (es) |
| KR (4) | KR20220101009A (es) |
| CN (2) | CN105358570B (es) |
| AP (1) | AP2015008737A0 (es) |
| AR (1) | AR095541A1 (es) |
| AU (2) | AU2014236316B2 (es) |
| BR (1) | BR112015022440B1 (es) |
| CA (3) | CA2905141A1 (es) |
| CL (2) | CL2015002686A1 (es) |
| CR (2) | CR20200004A (es) |
| CY (2) | CY1121767T1 (es) |
| DK (2) | DK2970441T3 (es) |
| EA (2) | EA034326B1 (es) |
| ES (2) | ES2737598T3 (es) |
| HK (1) | HK1220695A1 (es) |
| HR (2) | HRP20190970T1 (es) |
| HU (2) | HUE043488T2 (es) |
| IL (2) | IL241349B (es) |
| JO (1) | JO3796B1 (es) |
| LT (2) | LT2970441T (es) |
| MA (2) | MA38477B1 (es) |
| ME (2) | ME03437B (es) |
| MX (2) | MX2015012890A (es) |
| MY (2) | MY202248A (es) |
| NZ (1) | NZ751148A (es) |
| PE (1) | PE20151763A1 (es) |
| PH (1) | PH12015502051B1 (es) |
| PL (2) | PL2970423T3 (es) |
| PT (2) | PT2970423T (es) |
| RS (2) | RS58854B1 (es) |
| SG (2) | SG11201507574VA (es) |
| SI (2) | SI2970441T1 (es) |
| TN (1) | TN2015000416A1 (es) |
| TR (2) | TR201908362T4 (es) |
| TW (3) | TWI687435B (es) |
| UA (1) | UA119140C2 (es) |
| UY (1) | UY35454A (es) |
| WO (2) | WO2014153063A1 (es) |
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