AR091858A1 - INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) - Google Patents

INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)

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Publication number
AR091858A1
AR091858A1 ARP130102599A ARP130102599A AR091858A1 AR 091858 A1 AR091858 A1 AR 091858A1 AR P130102599 A ARP130102599 A AR P130102599A AR P130102599 A ARP130102599 A AR P130102599A AR 091858 A1 AR091858 A1 AR 091858A1
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
cse
inhibitors
compounds
Prior art date
Application number
ARP130102599A
Other languages
English (en)
Inventor
G Duron Sergio
Chapman Justin
G Rao Srinivas
Stein Gregory
G Sydserff Simon
Original Assignee
Sova Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sova Pharmaceuticals Inc filed Critical Sova Pharmaceuticals Inc
Publication of AR091858A1 publication Critical patent/AR091858A1/es

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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Compuestos y composiciones farmacéuticas que los contienen que inhiben la cistationin-g-liasa (CSE). También se describen métodos para usar tales inhibidores de CSE, solos o en combinación con otros compuestos, para tratar el tratamiento de enfermedades o condiciones en las que resulta beneficiosa su inhibición. Reivindicación 1: Un compuesto, caracterizado porque es de fórmula (1), donde: A es un isóstero de ácido carboxílico; X es CR¹, o N; R¹ es H, alquilo sustituido o no sustituido, heteroalquilo sustituido o no sustituido, heterocicloalquilo sustituido o no sustituido, arilo sustituido o no sustituido, o heteroarilo sustituido o no sustituido; R² y R³ son en forma independiente entre sí H, alquilo sustituido o no sustituido, o heteroalquilo sustituido o no sustituido; o R² y R³ junto con el carbono al cual están unidos forman un anillo cicloalquilo o heterocicloalquilo; o una sal aceptable farmacéuticamente, solvato, o prodroga del mismo.
ARP130102599A 2012-07-25 2013-07-22 INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) AR091858A1 (es)

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