AR074127A1 - 2,4 diaminopirimidinas y uso para la preparacion de un medicamento para el tratamiento de cancer, infecciones y enfermedades inflamatorias y autoinmunes - Google Patents

2,4 diaminopirimidinas y uso para la preparacion de un medicamento para el tratamiento de cancer, infecciones y enfermedades inflamatorias y autoinmunes

Info

Publication number
AR074127A1
AR074127A1 ARP090104416A ARP090104416A AR074127A1 AR 074127 A1 AR074127 A1 AR 074127A1 AR P090104416 A ARP090104416 A AR P090104416A AR P090104416 A ARP090104416 A AR P090104416A AR 074127 A1 AR074127 A1 AR 074127A1
Authority
AR
Argentina
Prior art keywords
nrere
nrcrc
nrg
orc
ore
Prior art date
Application number
ARP090104416A
Other languages
English (en)
Inventor
Bodo Betzemeier
Heinz Stadtmueller
Ioannis Sapountzis
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR074127A1 publication Critical patent/AR074127A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos que son adecuados para el tratamiento de enfermedades que se caracterizan por una proliferacion excesiva o anomala de células, así como su uso para la produccion de un medicamento con las propiedades mencionadas precedentemente. Reivindicacion 1: Compuestos caracterizados por la formula general (1) en la que R1 es un radical seleccionado del grupo compuesto por Ra, Rb y Ra sustituido con uno o varios Rb y/o Rc iguales o diferentes; R2 y R3 es cada uno, de modo independiente, un radical seleccionado del grupo compuesto por halogeno, -Orc, y alquilo C1-4, cada Ra está seleccionado, de modo independiente entre sí, del grupo compuesto por alquilo C1-6, cicloalquilo C3-10, cicloalquilalquilo C4-16, arilo C6-10, arilalquilo C7-16, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilalquilo de 4-14 miembros, heteroarilo de 5-12 miembros y heteroarilalquilo de 6-18 miembros; cada Rb es un radical adecuado, y en cada caso independientemente uno de otro, se selecciona del grupo consistente en =O, -ORc, haloalcoxi C1-3, -OCF3, =S, -SRc, =NRc, =NORc, =NNRcRc, =NN(Rg)C(O)NRcRc, -NRcRc, -ONRcRc, -N(ORc)Rc, -N(Rg)NRcRc, halogeno, -CF3, -CN, -NC, -OCN, -SCN, -NO, -NO2, =N2, -N3, -S(O)Rc, -S(O)ORc, -S(O)2Rc, -S(O)2ORc, -S(O)NRcRc, -S(O)2NRcRc, -OS(O)Rc, -OS(O)2Rc, -OS(O)2ORc, -OS(O)NRcRc, -OS(O)2NRcRc, -C(O)Rc, -C(O)ORc, -C(O)SRc, -C(O)NRcRc, -C(O)N(Rg)NRcRc, -C(O)N(Rg)ORc, -C(NRg)NRcRc, -C(NOH)Rc, - C(NOH)NRcRc, -OC(O)Rc, -OC(O)ORc, -OC(O)SRc, -OC(O)NRcRc, -OC(NRg)NRcRc, -SC(O)Rc, -SC(O)ORc, -SC(O)NRcRc, -SC(NRg)NRcRc, -N(Rg)C(O)Rc, -N[C(O)Rc]2, -N(ORg)C(O)Rc, -N(Rg)C(NRg)Rc, -N(Rg)N(Rg)C(O)Rc, -N[C(O)Rc]NRcRc, -N(Rg)C(S)Rc, -N(Rg)S(O)Rc, -N(Rg)S(O)ORc, -N(Rg)S(O)2Rc, -N[S(O)2Rc]2, -N(Rg)S(O)2ORc, -N(Rg)S(O)2NRcRc, -N(Rg)[S(O)2]2Rc, -N(Rg)C(O)ORc, -N(Rg)C(O)SRc, -N(Rg)C(O)NRcRc, -N(Rg)C(O)NRgNRcRc, -N(Rg)N(Rg)C(O)NRcRc, -N(Rg)C(S)NRcRc, -[N(Rg)C(O)]2Rc, -N(Rg)[C(O)]2Rc, -N{[C(O)]2Rc}2, -N(Rg)[C(O)]2ORc, -N(Rg)[C(O)]2NRcRc, -N{[C(O)]2ORc}2, -N{[C(O)]2NRcRc}2, -[N(Rg)C(O)]2ORc, -N(Rg)C(NRg)ORc, -N(Rg)C(NOH)Rc, -N(Rg)C(NRg)SRc y -N(Rg)C(NRg)NRcRc, cada Rc es, de modo independiente entre sí, H o un radical eventualmente sustituido con uno o varios Rd y/o Re iguales o diferentes seleccionados del grupo compuesto por alquilo C1-6, cicloalquilo C3-10, cicloalquilalquilo C4-11, arilo C6-10, arilalquilo C7-16, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilo de 4-14 miembros, heteroarilo de 5-12 miembros o heteroarilalquilo de 6-18 miembros, cada Rd es un radical apropiado y está seleccionado en cada caso, de modo independiente entre sí, del grupo compuesto por =O, -ORe, haloalquil C1-3-oxi, -OCF3, =S, -SRe, =NRe, =NORe, =NNReRe, =NN(Rg)C(O)NReRe, -NReRe, -ONReRe, -N(Rg)NReRe, halogeno, -CF3, -CN, -NC, -OCN, -SCN, -NO, -NO2, =N2, -N3, -S(O)Re, -S(O)ORe, -S(O)2Re, -S(O)2ORe, -S(O)NReRe, -S(O)2NReRe, -OS(O)Re, -OS(O)2Re, -OS(O)2ORe, -OS(O)NReRe, -OS(O)2NReRe, -C(O)Re, -C(O)ORe, -C(O)SRe, -C(O)NReRe, -C(O)N(Rg)NReRe, -C(O)N(Rg)ORe, -C(NRg)NReRe, -C(NOH)Re, -C(NOH)NReRe, -OC(O)Re, -OC(O)ORe, -OC(O)SRe, -OC(O)NReRe, -OC(NRg)NReRe, -SC(O)Re, -SC(O)ORe, -SC(O)NReRe, -SC(NRg)NReRe, -N(Rg)C(O)Re, -N[C(O)Re]2, -N(ORg)C(O)Re, -N(Rg)C(NRg)Re, -N(Rg)N(Rg)C(O)Re, -N[C(O)Re]NReRe, -N(Rg)C(S)Re, -N(Rg)S(O)Re, -N(Rg)S(O)ORe, -N(Rg)S(O)2Re, -N[S(O)2Re]2, -N(Rg)S(O)2ORe, -N(Rg)S(O)2NReRe, -N(Rg)[S(O)2]2Re, -N(Rg)C(O)ORe, -N(Rg)C(O)SRe, -N(Rg)C(O)NReRe, -N(Rg)C(O)NRgNReRe, -N(Rg)N(Rg)C(O)NReRe, -N(Rg)C(S)NReRe, -[N(Rg)C(O)]2Re, -N(Rg)[C(O)]2Re, -N{[C(O)]2Re}2, -N(Rg)[C(O)]2ORe, -N(Rg)[C(O)]2NReRe, -N{[C(O)]2ORe}2, -N{[C(O)]2NReRe}2, -[N(Rg)C(O)]2ORe, -N(Rg)C(NRg)ORe, -N(Rg)C(NOH)Re, -N(Rg)C(NRg)SRe y -N(Rg)C(NRg)NReRe, cada Re es, de modo independiente entre sí, H o un radical eventualmente sustituido con uno o varios Rf y/o Rg iguales o diferentes seleccionado del grupo compuesto por alquilo C1-6, cicloalquilo C3-8, cicloalquilalquilo C4-11, arilo C6-10, arilalquilo C7-16, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilalquilo de 4-14 miembros, heteroarilo de 5-12 miembros o heteroarilalquilo de 6-18 miembros, cada Rf es un radical adecuado y en cada caso independientemente uno de otro, se selecciona del grupo consistente en halogeno y -CF3; y cada Rg es, de modo independiente entre sí, H, alquilo C1-6, cicloalquilo C3-8, cicloalquilalquilo C4-11, arilo C6-10, arilalquilo C7-16, heteroalquilo de 2-6 miembros, heterocicloalquilo de 3-8 miembros, heterocicloalquilo de 4-14 miembros, heteroarilo de 5-12 miembros o heteroarilalquilo de 6-18 miembros, y n puede ser igual a 1 o 2, en donde la cadena de alquilos que se produce está eventualmente ramificada; eventualmente en forma de sus tautomeros, sus racematos, sus enantiomeros, sus diastereoisomeros y sus mezclas, así como eventualmente sus sales por adicion de ácidos farmacologicamente inocuos.
ARP090104416A 2008-11-14 2009-11-13 2,4 diaminopirimidinas y uso para la preparacion de un medicamento para el tratamiento de cancer, infecciones y enfermedades inflamatorias y autoinmunes AR074127A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08169139 2008-11-14

Publications (1)

Publication Number Publication Date
AR074127A1 true AR074127A1 (es) 2010-12-22

Family

ID=40364424

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104416A AR074127A1 (es) 2008-11-14 2009-11-13 2,4 diaminopirimidinas y uso para la preparacion de un medicamento para el tratamiento de cancer, infecciones y enfermedades inflamatorias y autoinmunes

Country Status (8)

Country Link
US (1) US8377943B2 (es)
EP (1) EP2370416A1 (es)
JP (1) JP5619762B2 (es)
AR (1) AR074127A1 (es)
CA (1) CA2743073A1 (es)
TW (1) TW201022239A (es)
UY (1) UY32240A (es)
WO (1) WO2010055117A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729265B2 (en) 2009-08-14 2014-05-20 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
AU2011260323A1 (en) * 2010-06-04 2012-11-15 F. Hoffmann-La Roche Ag Aminopyrimidine derivatives as LRRK2 modulators
DE102010034699A1 (de) 2010-08-18 2012-02-23 Merck Patent Gmbh Pyrimidinderivate
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
LT3124483T (lt) 2010-11-10 2019-09-25 Genentech, Inc. Pirazolo aminopirimidino dariniai, kaip lrrk2 moduliatoriai
CA2827171C (en) 2011-02-17 2019-04-09 Cancer Therapeutics Crc Pty Limited Fak inhibitors
US9174946B2 (en) 2011-02-17 2015-11-03 Cancer Therapeutics Crc Pty Ltd Selective FAK inhibitors
DE102011111400A1 (de) 2011-08-23 2013-02-28 Merck Patent Gmbh Bicyclische heteroaromatische Verbindungen
WO2014027199A1 (en) * 2012-08-14 2014-02-20 Cancer Therapeutics Crc Pty Ltd Fak and flt3 inhibitors
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
KR101992621B1 (ko) 2017-12-07 2019-09-27 주식회사 온코빅스 암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
US11427542B2 (en) 2018-03-29 2022-08-30 Elex Biotech, Inc. Compounds for treatment of cardiac arrhythmias and heart failure
WO2020023851A1 (en) * 2018-07-26 2020-01-30 Yale University Bifunctional substitued pyrimidines as modulators of fak proteolyse
CN111892578B (zh) * 2020-08-03 2023-10-20 沈阳药科大学 一种靶向降解黏着斑激酶的化合物及应用
US20230295129A1 (en) * 2020-08-14 2023-09-21 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors of ack1/tnk2 tyrosine kinase
US20240010634A1 (en) * 2020-08-14 2024-01-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pyrimidinyl sulfonamides as inhibitors of ack1/tnk2 tyrosine kinase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092603A1 (en) 2001-05-14 2002-11-21 Novartis Ag Oxazolo-and furopyrimidines and their use in medicaments against tumors
MXPA03010810A (es) 2001-05-29 2004-03-22 Schering Ag Pirimidinas inhibidoras de cdk, su obtencion y su uso como medicamentos.
WO2003030909A1 (en) 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
US6960968B2 (en) 2002-06-26 2005-11-01 Koninklijke Philips Electronics N.V. Planar resonator for wireless power transfer
RS20050363A (en) 2002-11-28 2007-11-15 Schering Aktiengesellschaft, Chk-,pdk-and akt-inhibitory pyrimidines,their production an use as pharmaceutical agents
ES2593486T3 (es) * 2007-04-18 2016-12-09 Pfizer Products Inc. Derivados de sulfonil amida para el tratamiento del crecimiento celular anómalo

Also Published As

Publication number Publication date
WO2010055117A1 (en) 2010-05-20
JP2012508724A (ja) 2012-04-12
EP2370416A1 (en) 2011-10-05
US8377943B2 (en) 2013-02-19
US20110275633A1 (en) 2011-11-10
CA2743073A1 (en) 2010-05-20
JP5619762B2 (ja) 2014-11-05
TW201022239A (en) 2010-06-16
UY32240A (es) 2010-06-30

Similar Documents

Publication Publication Date Title
AR074127A1 (es) 2,4 diaminopirimidinas y uso para la preparacion de un medicamento para el tratamiento de cancer, infecciones y enfermedades inflamatorias y autoinmunes
AR074209A1 (es) Derivados de pirimidina utiles para el tratamiento del cancer
AR074210A1 (es) Derivados de pirimidina como inhibidores de ptk2-quinasa
AR076134A1 (es) Derivados de 2,4 diaminopirimidinas
AR076620A1 (es) 2,4 DIAMINOPIRIMIDINAS, COMPOSICIONES FARMACEUTICAS, PROCESOS DE PREPARACIoN Y SU USO COMO MEDICAMENTO.
AR078513A1 (es) Pirimidinas y composiciones farmaceuticas que las comprenden
AR072538A1 (es) Derivados de indolinonas, composiciones farmacéuticas y usos
AR066963A1 (es) Derivados de indolinona, preparaciones farmaceuticas que los contienen y usos de los mismos para el tratamiento y/o prevencion de cancer y enfermedades inflamatorias y autoinmunes.
CY1121744T1 (el) Παραγωγα c4-μονομεθυλο-τριτερπενοειδους και μεθοδοι χρησης αυτων
AR051743A1 (es) Tiazolil - dihidro- indazoles
AR072845A1 (es) 5-alquil-pirimidinas y su uso en el tratamiento de enfermedades mediadas por la actividad de quinasas.
CO2020005200A2 (es) Compuestos novedosos y composiciones farmaceuticas de los mismos para el tratamiento de trastornos inflamatorios
AR082850A1 (es) Aminopirazoloquinazolinas
ECSP14013231A (es) Imidazopiridazinas sustituidas con amino
CU20170085A7 (es) Derivados de imidazolidindiona para el tratamiento de la osteoartritis
MX2017001637A (es) 2-(morfolin-4-il)-1,7-naftiridinas.
ECSP15031579A (es) Lactamas Fusionadas de Arilo y Heteroarilo
CO7151542A2 (es) Anticuerpos biespecíficos anti-vegf/anti-ang-2 y su utilización en el tratamiento de enfermedades vasculares oculares
ECSP15045801A (es) Inhibidores de la phd de 6–(5–hidroxi–1h–pirazol–1–il)nicotinamida
EA201301181A1 (ru) Триазолопиридины
AR083100A1 (es) Monohidrato de derivados de aza-adamantano
PE20151653A1 (es) Compuesto
CU24608B1 (es) Compuestos de dihidrooxadiazinonas sustituidas útiles en el tratamiento de enfermedades hiperproliferativas y métodos para preparar dichos compuestos
AR070877A1 (es) Tiazolil-dihidro-indazoles, una preparacion farmaceutica en base al compuesto y uso del compuesto para preparar un medicamento
CO2018007278A2 (es) Derivados de ácido aminobenzoico metaazacíclico como antagonistas de la integrina pan

Legal Events

Date Code Title Description
FB Suspension of granting procedure