AR070558A1 - Derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino,proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de enfermedades dependientes de tirosinquinasas,tales como enfermedades proliferativas. - Google Patents
Derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino,proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de enfermedades dependientes de tirosinquinasas,tales como enfermedades proliferativas.Info
- Publication number
- AR070558A1 AR070558A1 ARP090100362A ARP090100362A AR070558A1 AR 070558 A1 AR070558 A1 AR 070558A1 AR P090100362 A ARP090100362 A AR P090100362A AR P090100362 A ARP090100362 A AR P090100362A AR 070558 A1 AR070558 A1 AR 070558A1
- Authority
- AR
- Argentina
- Prior art keywords
- halo
- cycloalkyl
- cycloalkyloxy
- lower alkyl
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula (1) en donde R1 representa heterociclilo insustituido o sustituido, arilo insustituido o sustituido, cicloalquilo insustituido o sustituido; R2 representa hidrogeno, halogeno, alquilo inferior, alquiloxilo inferior, halo-alquilo inferior, cicloalquilo, cicloalquiloxilo, halo-cicloalquilo, cicloalquiloxilo, halo-cicloalquiloxilo; R3 representa hidrogeno, halogeno, alquilo inferior, alquiloxilo inferior, halo-alquilo inferior, cicloalquilo, cicloalquiloxilo, halo-cicloalquilo, cicloalquiloxilo, halo-cicloalquiloxilo; o R2 y/o R3 se conectan con R5 o R7 para formar una fraccion cíclica fusionada con el anillo de fenilo con el que R2/R3 están unidos; R2a representa hidrogeno, halogeno, alquilo inferior, alquiloxilo inferior, halo-alquilo inferior, cicloalquilo, cicloalquiloxilo, halo-cicloalquilo, cicloalquiloxilo, halo-cicloalquiloxilo; R3a representa hidrogeno, halogeno, alquilo inferior, alquiloxilo inferior, halo-alquilo inferior, cicloalquilo, cicloalquiloxilo, halo-cicloalquilo, cicloalquiloxilo, halo-cicloalquiloxilo; R4 representa un grupo -A1-N(R6)(R7) en donde A1 representa uno de los grupoide formulas (2) en donde el átomo marcado con * es un enlace con el anillo de fenilo; o R4 representa uno de los grupos de formulas (3); R5 representa, independientemente de cada otro hidrogeno, alquilo inferior, halo-alquilo inferior, cicloalquilo, halocicloalquilo o forma, junto con el átomo de carbono con el que está unido, un cicloalquilo; R6 y R7 representan, junto con el átomo de nitrogeno con el que están unidos, un heterociclo opcionalmente sustituido; o R6 representa hidrogeno o alquilo opcionalmente sustituido; y R7 representa alquilo opcionalmente sustituido; R8 representa alquilo, hidroxilo, alquiloxilo inferior, halo-alquiloxilo inferior, cicloalquiloxilo, halo-cicloalquiloxilo, alquilo inferior-sulfonilo, halo-alquilo inferior-sulfonilo, cicloalquil-sulfonilo, halo-cicloalquil-sulfonilo, alquilo inferior-sulfinilo, halo-alquilo inferior-sulfinilo, cicloalquil-sulfinilo, halo-cicloalquil-sulfinilo; R9 representa H o alquilo inferior; R10 representa hidrogeno, alquilo inferior, halo-alquilo inferior, cicloalquilo, halo-cicloalquilo; n representa 0, 1 o 2; o sales de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08151137 | 2008-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070558A1 true AR070558A1 (es) | 2010-04-21 |
Family
ID=39739330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100362A AR070558A1 (es) | 2008-02-06 | 2009-02-04 | Derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino,proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de enfermedades dependientes de tirosinquinasas,tales como enfermedades proliferativas. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8420657B2 (es) |
| EP (1) | EP2247591A1 (es) |
| JP (1) | JP5323095B2 (es) |
| KR (2) | KR101277823B1 (es) |
| CN (1) | CN101981036B (es) |
| AR (1) | AR070558A1 (es) |
| AU (1) | AU2009211338B2 (es) |
| BR (1) | BRPI0908433A2 (es) |
| CA (1) | CA2714177A1 (es) |
| CL (1) | CL2009000255A1 (es) |
| CO (1) | CO6321262A2 (es) |
| CR (1) | CR11614A (es) |
| DO (1) | DOP2010000242A (es) |
| EA (1) | EA017952B1 (es) |
| EC (1) | ECSP10010463A (es) |
| IL (1) | IL207224A0 (es) |
| MA (1) | MA32134B1 (es) |
| MX (1) | MX2010008719A (es) |
| NI (1) | NI201000137A (es) |
| NZ (1) | NZ587271A (es) |
| PA (1) | PA8815201A1 (es) |
| PE (1) | PE20091485A1 (es) |
| SM (1) | SMP201000104B (es) |
| TW (1) | TW200938202A (es) |
| UY (1) | UY31631A1 (es) |
| WO (1) | WO2009098236A1 (es) |
| ZA (1) | ZA201005338B (es) |
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| JO3235B1 (ar) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
| JP4861772B2 (ja) * | 2006-08-28 | 2012-01-25 | 富士通株式会社 | 移動体標定プログラム、該プログラムを記録した記録媒体、移動体標定装置、および移動体標定方法 |
| CL2007002994A1 (es) | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| KR20090033605A (ko) * | 2007-10-01 | 2009-04-06 | 삼성전자주식회사 | 적층형 반도체 패키지, 그 형성방법 및 이를 구비하는전자장치 |
| WO2009070524A1 (en) | 2007-11-27 | 2009-06-04 | Wyeth | Pyrrolo[3,2-d]pyrimidine compounds and their use as pi3 kinase and mtor kinase inhibitors |
| CN101945867A (zh) | 2007-12-19 | 2011-01-12 | 安姆根有限公司 | 作为细胞周期抑制剂的稠合吡啶、嘧啶和三嗪化合物 |
| US20090192176A1 (en) * | 2008-01-30 | 2009-07-30 | Wyeth | 1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES |
-
2009
- 2009-02-04 WO PCT/EP2009/051281 patent/WO2009098236A1/en active Application Filing
- 2009-02-04 EP EP09708802A patent/EP2247591A1/en not_active Withdrawn
- 2009-02-04 KR KR1020107019690A patent/KR101277823B1/ko not_active IP Right Cessation
- 2009-02-04 NZ NZ587271A patent/NZ587271A/en not_active IP Right Cessation
- 2009-02-04 EA EA201001242A patent/EA017952B1/ru not_active IP Right Cessation
- 2009-02-04 MX MX2010008719A patent/MX2010008719A/es active IP Right Grant
- 2009-02-04 KR KR1020137011455A patent/KR20130066703A/ko not_active Application Discontinuation
- 2009-02-04 AU AU2009211338A patent/AU2009211338B2/en not_active Ceased
- 2009-02-04 JP JP2010545458A patent/JP5323095B2/ja not_active Expired - Fee Related
- 2009-02-04 UY UY031631A patent/UY31631A1/es not_active Application Discontinuation
- 2009-02-04 CN CN2009801117630A patent/CN101981036B/zh not_active Expired - Fee Related
- 2009-02-04 AR ARP090100362A patent/AR070558A1/es not_active Application Discontinuation
- 2009-02-04 PE PE2009000162A patent/PE20091485A1/es not_active Application Discontinuation
- 2009-02-04 BR BRPI0908433A patent/BRPI0908433A2/pt not_active IP Right Cessation
- 2009-02-04 CA CA2714177A patent/CA2714177A1/en not_active Abandoned
- 2009-02-05 CL CL2009000255A patent/CL2009000255A1/es unknown
- 2009-02-05 TW TW098103755A patent/TW200938202A/zh unknown
- 2009-02-05 US US12/366,218 patent/US8420657B2/en not_active Expired - Fee Related
- 2009-02-05 PA PA20098815201A patent/PA8815201A1/es unknown
-
2010
- 2010-07-26 IL IL207224A patent/IL207224A0/en unknown
- 2010-07-27 ZA ZA2010/05338A patent/ZA201005338B/en unknown
- 2010-07-29 CR CR11614A patent/CR11614A/es not_active Application Discontinuation
- 2010-08-04 DO DO2010000242A patent/DOP2010000242A/es unknown
- 2010-08-04 NI NI201000137A patent/NI201000137A/es unknown
- 2010-09-02 MA MA33139A patent/MA32134B1/fr unknown
- 2010-09-02 SM SM201000104T patent/SMP201000104B/it unknown
- 2010-09-06 CO CO10110021A patent/CO6321262A2/es not_active Application Discontinuation
- 2010-09-06 EC EC2010010463A patent/ECSP10010463A/es unknown
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