AR063988A1 - HETEROCICLIC DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
HETEROCICLIC DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- AR063988A1 AR063988A1 ARP070105256A ARP070105256A AR063988A1 AR 063988 A1 AR063988 A1 AR 063988A1 AR P070105256 A ARP070105256 A AR P070105256A AR P070105256 A ARP070105256 A AR P070105256A AR 063988 A1 AR063988 A1 AR 063988A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- linear
- alkyl
- substituted
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Abstract
Reivindicacion 1: Compuestos de formula (1) en la que R1 representa alquilo C1-6 lineal o ramificado sustituido con uno o varios grupos COOR3 o NR4R5, en los que R3 representa un átomo de H o alquilo C1-6 lineal o ramificado; R4 representa un grupo COOR'3 o alquilo C1-6 lineal o ramificado sustituido con un grupo COOR'3 en el que R'3 representa un átomo de H o alquilo C1-6 lineal o ramificado; R5 representa alquilo C1-6 lineal o ramificado sustituido con un grupo fenilo no sustituido o sustituido con 1 a 3 grupos alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, polihaloalquilo C1-6 lineal o ramificado o átomos de halogeno; R2 representa un grupo fenilo no sustituido o sustituido con uno o varios grupos alquilo C1- 6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, polihaloalquilo C1-6 lineal o ramificado o átomos de halogeno, n vale 0, 1, 2, 3, 4, 5, 6, 7 u 8, sus enantiomeros y diastereoisomeros así como sus sales de adicion a un ácido o a una base aceptables farmacéuticamente.Claim 1: Compounds of formula (1) wherein R1 represents linear or branched C1-6 alkyl substituted with one or more COOR3 or NR4R5 groups, wherein R3 represents a linear or branched C1-6 alkyl or H atom; R4 represents a linear or branched COOR'3 or C1-6 alkyl group substituted with a COOR'3 group in which R'3 represents a linear or branched C1-6 alkyl or H atom; R5 represents linear or branched C1-6 alkyl substituted with a phenyl group unsubstituted or substituted with 1 to 3 linear or branched C1-6 alkyl groups, linear or branched C1-6 alkoxy, linear or branched C1-6 polyhaloalkyl or halogen atoms ; R2 represents a phenyl group unsubstituted or substituted with one or more linear or branched C1-6 alkyl, linear or branched C1-6 alkoxy, linear or branched C1-6 polyhaloalkyl or halogen atoms groups, worth 0, 1, 2, 3, 4, 5, 6, 7 or 8, their enantiomers and diastereoisomers as well as their addition salts to a pharmaceutically acceptable acid or base.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0610458A FR2909379B1 (en) | 2006-11-30 | 2006-11-30 | NOVEL HETEROCYCLIC DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063988A1 true AR063988A1 (en) | 2009-03-04 |
Family
ID=38283326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105256A AR063988A1 (en) | 2006-11-30 | 2007-11-28 | HETEROCICLIC DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR063988A1 (en) |
| FR (1) | FR2909379B1 (en) |
| WO (1) | WO2008081096A2 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012522750A (en) | 2009-04-01 | 2012-09-27 | ビーエーエスエフ ソシエタス・ヨーロピア | Isoxazoline compounds for combating invertebrate pests |
| HUE035069T2 (en) | 2011-12-28 | 2018-05-02 | Global Blood Therapeutics Inc | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation |
| US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| CN105073728A (en) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | Compounds and uses thereof for the modulation of hemoglobin |
| PE20160078A1 (en) | 2013-03-15 | 2016-03-02 | Global Blood Therapeutics Inc | COMPOUNDS AND THEIR USES TO MODULATE HEMOGLOBIN |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CA2903022C (en) | 2013-03-15 | 2021-11-09 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (en) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION |
| AP2016009261A0 (en) | 2014-02-07 | 2016-06-30 | Global Blood Therapeutics Inc | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| MA41841A (en) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | ALDEHYDE COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, HYPOXIA, AND AUTOIMMUNE AND CONNECTIVE TISSUE DISEASES |
| MX2018006832A (en) | 2015-12-04 | 2018-11-09 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl) pyridin-3-yl)methoxy)benzaldehyde. |
| TWI752307B (en) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | Novel compound and method of preparing compound |
| TW202332423A (en) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4345083A (en) * | 1978-09-18 | 1982-08-17 | Mcneilab, Inc. | (1-Methyl-2-quinolinylidene) derivatives of guanidine |
| FR2869611B1 (en) * | 2004-05-03 | 2006-07-28 | Merck Sante Soc Par Actions Si | HEXENOIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND THERAPEUTIC APPLICATIONS |
| FR2869615B1 (en) * | 2004-05-03 | 2007-11-16 | Merck Sante Soc Par Actions Si | BUTANOIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THERAPEUTIC APPLICATIONS THEREOF |
| FR2881137B1 (en) * | 2005-01-27 | 2007-03-02 | Servier Lab | NOVEL HETEROCYCLIC OXIMIC DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
-
2006
- 2006-11-30 FR FR0610458A patent/FR2909379B1/en not_active Expired - Fee Related
-
2007
- 2007-11-28 AR ARP070105256A patent/AR063988A1/en unknown
- 2007-11-29 WO PCT/FR2007/001957 patent/WO2008081096A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008081096A2 (en) | 2008-07-10 |
| WO2008081096A3 (en) | 2008-08-21 |
| FR2909379A1 (en) | 2008-06-06 |
| FR2909379B1 (en) | 2009-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR063988A1 (en) | HETEROCICLIC DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR052568A1 (en) | DERIVATIVES OF PIRAZOLO-PYRIMIDINE AS ANGLOSTS OF MGLUR2 | |
| CR10643A (en) | DERIVATIVES OF 2-ARIL-6-FENIL-IMIDAZOL [1,2-a] PIRIDINAS, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS | |
| AR062677A1 (en) | DERIVATIVES OF BIARIL-SULFONAMIDE, PRODUCTION PROCESSES AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM | |
| AR060489A1 (en) | BENZOAZEPIN ACID DERIVATIVES - OXI- ACETIC AS A PPAR - DELTA AGONIST USED TO INCREASE HDL-C, REDUCE LDL-C AND REDUCE CHOLESTEROL | |
| NI201000022A (en) | NEW 6-TRIAZOLOPYRIDACINE-SULFANIL BENZOTHIAZOLE AND BENZHIMIDAZOLE DERIVATIVES, THEIR PREPARATION PROCEDURE, THEIR APPLICATION AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NEW USE MAINLY AS MET INHIBITORS. | |
| ECSP088731A (en) | DERIVATIVES OF 1,2,4,5-TETRAHIDRO-3H-BENZAZEPINAS, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| RS52978B (en) | Fused amino pyridine as hsp90 inhibitors | |
| AR061835A1 (en) | TETRACICLIC DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR086538A1 (en) | COMPOUNDS TO REDUCE THE PRODUCTION OF B-AMYLOID | |
| AR073136A1 (en) | PIRROL COMPOUNDS | |
| AR053554A1 (en) | PIRIMIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | |
| AR053453A1 (en) | SUBSTITUTED AMINOALQUIL- AND AMIDOALQUIL-BENZOPIRANO DERIVATIVES | |
| AR075892A1 (en) | DERIVATIVES OF BENZOTIADIAZEPINAS, ITS PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR074053A1 (en) | ANILINA-PYRIMIDINE DERIVATIVES REPLACED WITH SULFOXIMINE AS INHIBITORS OF CYCLINE-DEPENDENT KINASE (CDK), AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR073043A1 (en) | COMPOUNDS OF POLYSUSTITUTED AZETIDINS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, METHOD OF PREPARATION AND USE OF THE SAME IN THE TREATMENT OF RESPIRATORY, METABOLIC DISEASES AND OF THE CENTRAL NERVOUS SYSTEM, AMONG OTHERS. | |
| RS53389B (en) | Pharmaceutical compounds | |
| ECSP10010380A (en) | NEW DIHYDROINDOLONE DERIVATIVES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR064424A1 (en) | SUBSTITUTED DERIVATIVES OF 1-OXO-FTALAZINAS and 1-OXO-PIRIDO-PIRIDAZINAS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES TO PREVENT AND / OR TREAT INFLAMMATORY AND ALLERGIC DISEASES OF RESPIRATORY TRACT. | |
| AR069643A1 (en) | DIAZENIDIOLATE DERIVATIVES, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR063328A1 (en) | INDOLIC DERIVATIVES ITS PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR072103A1 (en) | DERIVATIVES OF (PIPERAZINILO WITH BRIDGE LINKS) -1- ALCANONA, ITS USE AS P75 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| AR054584A1 (en) | ISOTOPICALLY REPLACED PROTON PUMP INHIBITORS | |
| AR043186A1 (en) | INDOZOLAMIDS PROVIDED WITH ANALGESIC ACTIVITY, METHOD OF PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOUND THAT INCLUDES THEM | |
| AR072486A1 (en) | CYCLE-RENTED BENZOTIADIAZINE DERIVATIVES THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |