AR051387A1 - Analogos de anilino-pirimidina - Google Patents
Analogos de anilino-pirimidinaInfo
- Publication number
- AR051387A1 AR051387A1 ARP050104293A ARP050104293A AR051387A1 AR 051387 A1 AR051387 A1 AR 051387A1 AR P050104293 A ARP050104293 A AR P050104293A AR P050104293 A ARP050104293 A AR P050104293A AR 051387 A1 AR051387 A1 AR 051387A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- heteroatoms
- hydrogen
- group
- groups
- Prior art date
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
Proceso, composicion farmacéutica, intermediarios. Inhibidor de quinasa IKK. Reivindicacion 1: Un compuesto de la formula (1), en la que: R1 hidrogeno; R2 se selecciona del grupo formado por NR7R8, guanidinilo, ureido, imidazolilo opcionalmente sustituido, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, hidroxi, y alcoxi; R3 selecciona del grupo formado por hidrogeno; fenilo opcionalmente sustituido; un anillo heteroarilo de 5 o 6 miembros opcionalmente sustituido con 1 a 4 heteroátomos, siempre que el anillo heteroarilo no sea piridina, furano, isoxazol, pirazol, triazol, imidazol, o tiazol; un anillo de benceno fusionado a un anillo de 4 a 8 miembros que contiene de 0 a 4 heteroátomos, interrumpido por 0 a 2 de los grupos C=O, SO, o SO2, y opcionalmente sustituido; un anillo monocíclico o policíclico opcionalmente sustituido que contiene de 0 a 4 heteroátomos; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; -NR7R8; -COOR9; -CONR7R8; y -SO2R10; R4 es hidrogeno; R5 se selecciona del grupo formado por hidrogeno, metilo, alquilo, alquilcarbonilo, alcoxicarbonilo, alquilsulfonilo, hidroximetilo, y alquilaminometilo; R6 se selecciona del grupo formado por hidrogeno; halogeno; fenilo opcionalmente sustituido; un heteroarilo de 5 o 6 miembros opcionalmente sustituido con 1 a 4 heteroátomos; un anillo de benceno fusionado a un anillo de 4 a 8 miembros que contiene de 0 a 4 heteroátomos, interrumpido por 0 a 2 de los grupos C=O, SO, o SO2, y opcionalmente sustituido; un anillo monocíclico o policíclico opcionalmente sustituido que contiene de 0 a 4 heteroátomos; -NR7R8; -COOR9; -CONR7R8; -SO2R10; alquilo opcionalmente sustituido; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; hidroxi; alcoxi; OR7; y SR7; R7 y R8 se seleccionan independientemente del grupo formado por hidrogeno; alquilo opcionalmente sustituido; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; hidroxi; alcoxi; alquilamino; arilamino; heteroarilamino; -NCOR9; -COR9; -CONR7R8; SO2R10; aminas cíclicas de 3 a 10 miembros opcionalmente sustituidas que contienen de 0 a 3 heteroátomos; opcionalmente, R7 y R8 juntos forman un anillo monocíclico o bicíclico de 3 a 12 miembros opcionalmente sustituido que contiene de 0 a 4 heteroátomos; R9 se selecciona del grupo formado por hidrogeno, metilo, trifluormetilo, alquilo opcionalmente sustituido, arilo opcionalmente sustituido, y heteroarilo opcionalmente sustituido; R10 se selecciona del grupo formado por metilo, trifluormetilo, alquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, y NR7R8; y las sales, solvatos e hidratos de los mismos. Reivindicacion 67: Una guanidina de formula (2), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 68: Una amina de formula (3), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 69: Una sulfonamida halogenada de formula (4), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 70: Un cloruro de sulfonilo de formula (5), donde los grupos R son definidos como en la reivindicacion 1.
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US (1) | US7799915B2 (es) |
EP (1) | EP1799652A1 (es) |
JP (1) | JP2008515986A (es) |
KR (1) | KR20070084067A (es) |
CN (1) | CN101039919A (es) |
AR (1) | AR051387A1 (es) |
AU (1) | AU2005295788A1 (es) |
BR (1) | BRPI0516597A (es) |
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PA (1) | PA8649401A1 (es) |
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-
2005
- 2005-10-13 AU AU2005295788A patent/AU2005295788A1/en not_active Abandoned
- 2005-10-13 PA PA20058649401A patent/PA8649401A1/es unknown
- 2005-10-13 GT GT200500286A patent/GT200500286A/es unknown
- 2005-10-13 AR ARP050104293A patent/AR051387A1/es not_active Application Discontinuation
- 2005-10-13 RU RU2007114080/04A patent/RU2007114080A/ru not_active Application Discontinuation
- 2005-10-13 WO PCT/US2005/036674 patent/WO2006044457A1/en active Application Filing
- 2005-10-13 PE PE2005001207A patent/PE20060582A1/es not_active Application Discontinuation
- 2005-10-13 KR KR1020077010445A patent/KR20070084067A/ko not_active Application Discontinuation
- 2005-10-13 BR BRPI0516597-0A patent/BRPI0516597A/pt not_active IP Right Cessation
- 2005-10-13 TW TW094135620A patent/TW200626559A/zh unknown
- 2005-10-13 CN CNA2005800349350A patent/CN101039919A/zh not_active Withdrawn
- 2005-10-13 JP JP2007536838A patent/JP2008515986A/ja active Pending
- 2005-10-13 US US11/248,495 patent/US7799915B2/en not_active Expired - Fee Related
- 2005-10-13 CA CA002580913A patent/CA2580913A1/en not_active Abandoned
- 2005-10-13 MX MX2007004488A patent/MX2007004488A/es unknown
- 2005-10-13 EP EP05812654A patent/EP1799652A1/en not_active Withdrawn
-
2007
- 2007-03-28 NO NO20071642A patent/NO20071642L/no not_active Application Discontinuation
- 2007-03-29 IL IL182316A patent/IL182316A0/en unknown
- 2007-04-11 CR CR9048A patent/CR9048A/es unknown
- 2007-04-12 ZA ZA200703022A patent/ZA200703022B/xx unknown
Also Published As
Publication number | Publication date |
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JP2008515986A (ja) | 2008-05-15 |
MX2007004488A (es) | 2007-09-11 |
BRPI0516597A (pt) | 2008-09-16 |
EP1799652A1 (en) | 2007-06-27 |
GT200500286A (es) | 2006-06-13 |
ZA200703022B (en) | 2009-04-29 |
RU2007114080A (ru) | 2008-11-27 |
WO2006044457A1 (en) | 2006-04-27 |
CA2580913A1 (en) | 2006-04-27 |
CR9048A (es) | 2007-08-28 |
NO20071642L (no) | 2007-06-01 |
CN101039919A (zh) | 2007-09-19 |
US7799915B2 (en) | 2010-09-21 |
PE20060582A1 (es) | 2006-08-17 |
PA8649401A1 (es) | 2006-09-22 |
US20060079543A1 (en) | 2006-04-13 |
AU2005295788A1 (en) | 2006-04-27 |
IL182316A0 (en) | 2007-07-24 |
KR20070084067A (ko) | 2007-08-24 |
TW200626559A (en) | 2006-08-01 |
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