AR051387A1 - Analogos de anilino-pirimidina - Google Patents

Analogos de anilino-pirimidina

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Publication number
AR051387A1
AR051387A1 ARP050104293A ARP050104293A AR051387A1 AR 051387 A1 AR051387 A1 AR 051387A1 AR P050104293 A ARP050104293 A AR P050104293A AR P050104293 A ARP050104293 A AR P050104293A AR 051387 A1 AR051387 A1 AR 051387A1
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AR
Argentina
Prior art keywords
optionally substituted
heteroatoms
hydrogen
group
groups
Prior art date
Application number
ARP050104293A
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English (en)
Original Assignee
Wyeth Corp
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35945218&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR051387(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR051387A1 publication Critical patent/AR051387A1/es

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    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Proceso, composicion farmacéutica, intermediarios. Inhibidor de quinasa IKK. Reivindicacion 1: Un compuesto de la formula (1), en la que: R1 hidrogeno; R2 se selecciona del grupo formado por NR7R8, guanidinilo, ureido, imidazolilo opcionalmente sustituido, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, hidroxi, y alcoxi; R3 selecciona del grupo formado por hidrogeno; fenilo opcionalmente sustituido; un anillo heteroarilo de 5 o 6 miembros opcionalmente sustituido con 1 a 4 heteroátomos, siempre que el anillo heteroarilo no sea piridina, furano, isoxazol, pirazol, triazol, imidazol, o tiazol; un anillo de benceno fusionado a un anillo de 4 a 8 miembros que contiene de 0 a 4 heteroátomos, interrumpido por 0 a 2 de los grupos C=O, SO, o SO2, y opcionalmente sustituido; un anillo monocíclico o policíclico opcionalmente sustituido que contiene de 0 a 4 heteroátomos; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; -NR7R8; -COOR9; -CONR7R8; y -SO2R10; R4 es hidrogeno; R5 se selecciona del grupo formado por hidrogeno, metilo, alquilo, alquilcarbonilo, alcoxicarbonilo, alquilsulfonilo, hidroximetilo, y alquilaminometilo; R6 se selecciona del grupo formado por hidrogeno; halogeno; fenilo opcionalmente sustituido; un heteroarilo de 5 o 6 miembros opcionalmente sustituido con 1 a 4 heteroátomos; un anillo de benceno fusionado a un anillo de 4 a 8 miembros que contiene de 0 a 4 heteroátomos, interrumpido por 0 a 2 de los grupos C=O, SO, o SO2, y opcionalmente sustituido; un anillo monocíclico o policíclico opcionalmente sustituido que contiene de 0 a 4 heteroátomos; -NR7R8; -COOR9; -CONR7R8; -SO2R10; alquilo opcionalmente sustituido; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; hidroxi; alcoxi; OR7; y SR7; R7 y R8 se seleccionan independientemente del grupo formado por hidrogeno; alquilo opcionalmente sustituido; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; hidroxi; alcoxi; alquilamino; arilamino; heteroarilamino; -NCOR9; -COR9; -CONR7R8; SO2R10; aminas cíclicas de 3 a 10 miembros opcionalmente sustituidas que contienen de 0 a 3 heteroátomos; opcionalmente, R7 y R8 juntos forman un anillo monocíclico o bicíclico de 3 a 12 miembros opcionalmente sustituido que contiene de 0 a 4 heteroátomos; R9 se selecciona del grupo formado por hidrogeno, metilo, trifluormetilo, alquilo opcionalmente sustituido, arilo opcionalmente sustituido, y heteroarilo opcionalmente sustituido; R10 se selecciona del grupo formado por metilo, trifluormetilo, alquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, y NR7R8; y las sales, solvatos e hidratos de los mismos. Reivindicacion 67: Una guanidina de formula (2), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 68: Una amina de formula (3), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 69: Una sulfonamida halogenada de formula (4), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 70: Un cloruro de sulfonilo de formula (5), donde los grupos R son definidos como en la reivindicacion 1.
ARP050104293A 2004-10-13 2005-10-13 Analogos de anilino-pirimidina AR051387A1 (es)

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EP1799652A1 (en) 2007-06-27
GT200500286A (es) 2006-06-13
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RU2007114080A (ru) 2008-11-27
WO2006044457A1 (en) 2006-04-27
CA2580913A1 (en) 2006-04-27
CR9048A (es) 2007-08-28
NO20071642L (no) 2007-06-01
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US7799915B2 (en) 2010-09-21
PE20060582A1 (es) 2006-08-17
PA8649401A1 (es) 2006-09-22
US20060079543A1 (en) 2006-04-13
AU2005295788A1 (en) 2006-04-27
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KR20070084067A (ko) 2007-08-24
TW200626559A (en) 2006-08-01

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