AR051387A1 - Analogos de anilino-pirimidina - Google Patents

Analogos de anilino-pirimidina

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Publication number
AR051387A1
AR051387A1 ARP050104293A ARP050104293A AR051387A1 AR 051387 A1 AR051387 A1 AR 051387A1 AR P050104293 A ARP050104293 A AR P050104293A AR P050104293 A ARP050104293 A AR P050104293A AR 051387 A1 AR051387 A1 AR 051387A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
heteroatoms
hydrogen
group
groups
Prior art date
Application number
ARP050104293A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35945218&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR051387(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR051387A1 publication Critical patent/AR051387A1/es

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Abstract

Proceso, composicion farmacéutica, intermediarios. Inhibidor de quinasa IKK. Reivindicacion 1: Un compuesto de la formula (1), en la que: R1 hidrogeno; R2 se selecciona del grupo formado por NR7R8, guanidinilo, ureido, imidazolilo opcionalmente sustituido, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, hidroxi, y alcoxi; R3 selecciona del grupo formado por hidrogeno; fenilo opcionalmente sustituido; un anillo heteroarilo de 5 o 6 miembros opcionalmente sustituido con 1 a 4 heteroátomos, siempre que el anillo heteroarilo no sea piridina, furano, isoxazol, pirazol, triazol, imidazol, o tiazol; un anillo de benceno fusionado a un anillo de 4 a 8 miembros que contiene de 0 a 4 heteroátomos, interrumpido por 0 a 2 de los grupos C=O, SO, o SO2, y opcionalmente sustituido; un anillo monocíclico o policíclico opcionalmente sustituido que contiene de 0 a 4 heteroátomos; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; -NR7R8; -COOR9; -CONR7R8; y -SO2R10; R4 es hidrogeno; R5 se selecciona del grupo formado por hidrogeno, metilo, alquilo, alquilcarbonilo, alcoxicarbonilo, alquilsulfonilo, hidroximetilo, y alquilaminometilo; R6 se selecciona del grupo formado por hidrogeno; halogeno; fenilo opcionalmente sustituido; un heteroarilo de 5 o 6 miembros opcionalmente sustituido con 1 a 4 heteroátomos; un anillo de benceno fusionado a un anillo de 4 a 8 miembros que contiene de 0 a 4 heteroátomos, interrumpido por 0 a 2 de los grupos C=O, SO, o SO2, y opcionalmente sustituido; un anillo monocíclico o policíclico opcionalmente sustituido que contiene de 0 a 4 heteroátomos; -NR7R8; -COOR9; -CONR7R8; -SO2R10; alquilo opcionalmente sustituido; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; hidroxi; alcoxi; OR7; y SR7; R7 y R8 se seleccionan independientemente del grupo formado por hidrogeno; alquilo opcionalmente sustituido; alquenilo opcionalmente sustituido; alquinilo opcionalmente sustituido; arilo opcionalmente sustituido; heteroarilo opcionalmente sustituido; hidroxi; alcoxi; alquilamino; arilamino; heteroarilamino; -NCOR9; -COR9; -CONR7R8; SO2R10; aminas cíclicas de 3 a 10 miembros opcionalmente sustituidas que contienen de 0 a 3 heteroátomos; opcionalmente, R7 y R8 juntos forman un anillo monocíclico o bicíclico de 3 a 12 miembros opcionalmente sustituido que contiene de 0 a 4 heteroátomos; R9 se selecciona del grupo formado por hidrogeno, metilo, trifluormetilo, alquilo opcionalmente sustituido, arilo opcionalmente sustituido, y heteroarilo opcionalmente sustituido; R10 se selecciona del grupo formado por metilo, trifluormetilo, alquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, y NR7R8; y las sales, solvatos e hidratos de los mismos. Reivindicacion 67: Una guanidina de formula (2), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 68: Una amina de formula (3), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 69: Una sulfonamida halogenada de formula (4), donde los grupos R son definidos como en la reivindicacion 1. Reivindicacion 70: Un cloruro de sulfonilo de formula (5), donde los grupos R son definidos como en la reivindicacion 1.
ARP050104293A 2004-10-13 2005-10-13 Analogos de anilino-pirimidina AR051387A1 (es)

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Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7442697B2 (en) * 2002-03-09 2008-10-28 Astrazeneca Ab 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity
GB0205688D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205690D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0311276D0 (en) * 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
GB0311274D0 (en) * 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
TW200528101A (en) * 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
US7279288B2 (en) * 2004-09-03 2007-10-09 California Institute Of Technology I kappa B kinase complex as a target for the treatment of Huntington's disease
WO2006064251A1 (en) * 2004-12-17 2006-06-22 Astrazeneca Ab 4- (4- (imidazol-4-yl) pyrimidin-2-ylamino) benzamides as cdk inhibitors
WO2007015064A1 (en) * 2005-07-30 2007-02-08 Astrazeneca Ab Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders
US7745428B2 (en) * 2005-09-30 2010-06-29 Astrazeneca Ab Imidazo[1,2-A]pyridine having anti-cell-proliferation activity
GB0520955D0 (en) * 2005-10-14 2005-11-23 Cyclacel Ltd Compound
WO2007053776A1 (en) * 2005-11-03 2007-05-10 Sgx Pharmaceuticals, Inc. Pyrimidinyl-thiophene kinase modulators
WO2007120593A1 (en) * 2006-04-12 2007-10-25 Wyeth Anilino-pyrimidine phenyl and benzothiophene analogs
TW200811169A (en) * 2006-05-26 2008-03-01 Astrazeneca Ab Chemical compounds
EP2044061A2 (en) * 2006-07-20 2009-04-08 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
AR063946A1 (es) * 2006-09-11 2009-03-04 Cgi Pharmaceuticals Inc Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
US20110117121A1 (en) * 2006-10-27 2011-05-19 James Dao Compositions for treatment and inhibition of pain
FR2911139A1 (fr) * 2007-01-05 2008-07-11 Sanofi Aventis Sa Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911138B1 (fr) * 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
FR2911140B1 (fr) * 2007-01-05 2009-02-20 Sanofi Aventis Sa Nouveaux derives de 2-anilino 4-heteroaryle pyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk
RU2498983C2 (ru) 2007-03-12 2013-11-20 Юм Биосайнсес Аустралия Пти Лтд Соединения фениламинопиримидина и их применения
AU2013201306B2 (en) * 2007-03-12 2015-11-12 Glaxosmithkline Llc Phenyl Amino Pyrimidine Compounds and Uses Thereof
AU2016200866B2 (en) * 2007-03-12 2017-06-22 Glaxosmithkline Llc Phenyl amino pyrimidine compounds and uses thereof
ES2593486T3 (es) 2007-04-18 2016-12-09 Pfizer Products Inc. Derivados de sulfonil amida para el tratamiento del crecimiento celular anómalo
JP5160636B2 (ja) * 2007-05-04 2013-03-13 アイアールエム・リミテッド・ライアビリティ・カンパニー ｃ−ｋｉｔおよびＰＤＧＦＲキナーゼ阻害剤としてのピリミジン誘導体および組成物
EP2173743A2 (en) * 2007-07-13 2010-04-14 Icagen, Inc. Sodium channel inhibitors
US20090048282A1 (en) * 2007-08-14 2009-02-19 Wyeth Pyrimidine sulfonamide analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
ES2368876T3 (es) * 2007-08-22 2011-11-23 Irm Llc Derivados de 2-heteroarilaminopirimidina como inhibidores de cinasa.
WO2009026276A1 (en) 2007-08-22 2009-02-26 Irm Llc 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors
CA2698511C (en) * 2007-09-04 2016-10-11 The Scripps Research Institute Substituted pyrimidinyl-amines as protein kinase inhibitors
CN101888999B (zh) * 2007-12-05 2013-12-11 巴斯夫欧洲公司 吡啶基甲基磺酰胺化合物
CN101952275B (zh) * 2008-02-22 2014-06-18 弗·哈夫曼-拉罗切有限公司 β-淀粉样蛋白的调节剂
CN101970417A (zh) * 2008-03-14 2011-02-09 巴斯夫欧洲公司 作为杀真菌剂使用的取代的吡嗪基甲基磺酰胺
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
EA029131B1 (ru) 2008-05-21 2018-02-28 Ариад Фармасьютикалз, Инк. Фосфорсодержащие производные в качестве ингибиторов киназы
SG10201510696RA (en) 2008-06-27 2016-01-28 Celgene Avilomics Res Inc Heteroaryl compounds and uses thereof
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
WO2010068863A2 (en) 2008-12-12 2010-06-17 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
CA2760794C (en) 2009-05-05 2017-07-25 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
WO2010151747A1 (en) * 2009-06-26 2010-12-29 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimine compounds and methods of making and using same
CN101991553B (zh) * 2009-08-21 2015-02-25 北京以岭生物工程技术有限公司 一种依西美坦片及其制备方法
NZ599826A (en) * 2009-10-12 2014-08-29 Myrexis Inc Amino-pyrimidine compounds as inhibitors of ikk epsilon and/or tbk1
FR2954317B1 (fr) * 2009-12-23 2012-01-27 Galderma Res & Dev Nouveaux derives phenoliques, et leur utilisation pharmaceutique ou cosmetique
CA2788450A1 (en) * 2009-12-30 2011-07-07 Arqule, Inc. Substituted naphthalenyl-pyrimidine compounds
US8334292B1 (en) 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
GB201012105D0 (en) 2010-07-19 2010-09-01 Domainex Ltd Novel pyrimidine compounds
BR112013003388A2 (pt) 2010-08-10 2016-07-12 Celgene Avilomics Res Inc sal de besilato de um inibidor de btk
MY181898A (en) 2010-11-01 2021-01-12 Celgene Car Llc Heterocyclic compounds and uses thereof
JP5956999B2 (ja) 2010-11-01 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド ヘテロアリール化合物およびその使用
JP5957003B2 (ja) 2010-11-10 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド 変異体選択的ｅｇｆｒ阻害剤およびその使用
EP2704572B1 (en) 2011-05-04 2015-12-30 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
TW201325593A (zh) 2011-10-28 2013-07-01 Celgene Avilomics Res Inc 治療布魯頓（ｂｒｕｔｏｎ’ｓ）酪胺酸激酶疾病或病症之方法
US8629274B2 (en) 2011-12-21 2014-01-14 Novira Therapeutics, Inc. Hepatitis B antiviral agents
KR102090453B1 (ko) 2012-03-15 2020-03-19 셀젠 카르 엘엘씨 상피 성장 인자 수용체 키나제 억제제의 염
MY169233A (en) 2012-03-15 2019-03-19 Celgene Car Llc Solid forms of an epidermal growth factor receptor kinase inhibitor
US20150166591A1 (en) 2012-05-05 2015-06-18 Ariad Pharmaceuticals, Inc. Methods and compositions for raf kinase mediated diseases
US8809359B2 (en) 2012-06-29 2014-08-19 Ym Biosciences Australia Pty Ltd Phenyl amino pyrimidine bicyclic compounds and uses thereof
JP2015533782A (ja) 2012-08-28 2015-11-26 ヤンセン・サイエンシズ・アイルランド・ユーシー スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用
WO2014100748A1 (en) 2012-12-21 2014-06-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US20150368209A1 (en) * 2013-01-07 2015-12-24 École Polytechnique Fédérale De Lausanne (Epfl) 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections
US9145387B2 (en) 2013-02-08 2015-09-29 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof
EP2961732B1 (en) 2013-02-28 2017-04-12 Janssen Sciences Ireland UC Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
AU2014240026B2 (en) * 2013-03-15 2018-06-14 Discoverybiomed, Inc. Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders
CN105246887B (zh) 2013-03-15 2018-05-11 发现生物医药公司 香豆素衍生物以及用于治疗过度增生性疾病的方法
MX353412B (es) 2013-04-03 2018-01-10 Janssen Sciences Ireland Uc Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
AU2014267235B2 (en) 2013-05-17 2017-10-05 Janssen Sciences Ireland Uc Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US10450270B2 (en) 2013-07-25 2019-10-22 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
KR102290189B1 (ko) 2013-10-23 2021-08-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
AU2015214961B2 (en) 2014-02-06 2018-08-30 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
TWI681954B (zh) 2014-06-12 2020-01-11 美商西爾拉癌症醫學公司 Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺
DK3179858T3 (da) 2014-08-13 2019-07-22 Celgene Car Llc Forme og sammensætninger af en ERK-inhibitor
CN106188029B (zh) * 2015-05-05 2018-09-18 山东轩竹医药科技有限公司 二并环类间变性淋巴瘤激酶抑制剂
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
KR101767602B1 (ko) * 2016-04-04 2017-08-14 한국원자력의학원 N-페닐피리미딘-2-아민계 화합물, 이의 제조방법, 이를 포함하는 암 예방 및 치료용 약학 조성물 및 이를 이용한 암 예방 또는 암 치료 방법
CN109640980A (zh) 2016-04-15 2019-04-16 诺维拉治疗公司 包含壳体装配抑制剂的组合和方法
JP6936814B2 (ja) * 2016-06-30 2021-09-22 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としてのシアノインドリン誘導体
MA47301B1 (fr) * 2017-01-17 2023-02-28 Astrazeneca Ab 151 85 Soedertaelje Inhibiteurs sélectifs de jak1
CN106946888B (zh) * 2017-04-06 2018-06-01 福建拓路建设有限公司 一种磺酰胺基衍生物及其在制备抗肿瘤药物中的用途
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE
WO2019175657A1 (en) 2018-03-14 2019-09-19 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
CN109438365B (zh) * 2018-12-06 2022-04-05 华南师范大学 N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物
EP3911309A4 (en) * 2019-01-17 2023-01-25 Board Of Trustees Of Michigan State University COMPOSITIONS AND METHODS FOR IMMUNE MODULATION AND THE TREATMENT OF CANCER
KR20210130753A (ko) 2019-02-22 2021-11-01 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Hbv 감염 또는 hbv-유발성 질환의 치료에 유용한 아미드 유도체
CN109912584B (zh) * 2019-03-22 2021-08-13 中国药科大学 一种具有抗肿瘤活性的brd4蛋白抑制剂及其制备方法和应用
MX2021013594A (es) 2019-05-06 2021-12-10 Janssen Sciences Ireland Unlimited Co Derivados de amida utiles en el tratamiento de la infeccion por vhb o de enfermedades inducidas por vhb.
CN111574413B (zh) * 2020-06-08 2022-04-05 杭州尚合生物医药科技有限公司 一种2-氨甲基吡啶与dmf-dma作为胺源的磺酰脒的制备方法
CN114014847B (zh) * 2021-12-08 2023-11-03 滨州医学院 一种含苯并噻吩嘧啶衍生物及其制备方法和在制备抗肿瘤药物中的应用
MX2024009405A (es) * 2022-02-03 2024-08-14 Nexys Therapeutics Inc Agonistas del receptor aril-hidrocarburo y sus usos.

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR829926A (fr) * 1936-11-28 1938-07-11 Ig Farbenindustrie Ag Ortho et para-aminoarylsulfones et leur procêdé de préparation
CH210790A (de) * 1938-01-31 1940-07-31 Chem Ind Basel Verfahren zur Darstellung eines Benzolsulfamidderivates.
US3775168A (en) * 1972-02-28 1973-11-27 Cities Service Co Process for protecting a substrate with an n{11 -pyrimidylamino-arylsulfonamide intumercent agent
US4876252A (en) * 1986-01-13 1989-10-24 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
US4788195A (en) * 1986-01-13 1988-11-29 American Cyanamid Company 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
JPH0796543B2 (ja) * 1987-08-11 1995-10-18 サントリー株式会社 アシルアミノベンゼンスルホンアミド誘導体及びそれを有効成分として含有する除草剤
SK47096A3 (en) * 1993-10-12 1996-10-02 Du Pont Merck Pharma 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB2302021A (en) 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption
GB9622363D0 (en) * 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9705361D0 (en) * 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
US6670348B1 (en) * 1997-05-14 2003-12-30 Sloan-Kettering Institute For Cancer Research Methods and compositions for destruction of selected proteins
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
PL366110A1 (en) * 1999-08-13 2005-01-24 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
DE19942354A1 (de) * 1999-09-04 2001-03-08 Aventis Pharma Gmbh Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
GB0004888D0 (en) * 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
JP2004506732A (ja) * 2000-08-21 2004-03-04 アストラゼネカ　アクチボラグ キナゾリン誘導体
GB0021726D0 (en) * 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
PT1343782E (pt) * 2000-12-21 2009-06-29 Smithkline Beecham Corp Pirimidinoaminas como moduladores de angiogénese
US20020132823A1 (en) * 2001-01-17 2002-09-19 Jiahuai Han Assay method
GB0103926D0 (en) * 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
MXPA03007266A (es) * 2001-02-20 2003-12-04 Astrazeneca Ab 2-arilamino-pirimidinas para tratamiento de desordenes relacionados a glucogeno-sintasa cinasa-3(gsk3).
JP4160401B2 (ja) * 2001-03-29 2008-10-01 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃ−ｊｕｎｎ末端キナーゼ（ｊｎｋ）および他のタンパク質キナーゼのインヒビター
CA2443234A1 (en) 2001-04-10 2002-10-24 Vertex Pharmaceuticals Incorporated Isoxaxole derivatives as inhibitors of src and other protein kinases
AU2002338642A1 (en) * 2001-04-13 2002-10-28 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
EP1404669A2 (en) 2001-05-16 2004-04-07 Vertex Pharmaceuticals Incorporated Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases
MXPA03010810A (es) * 2001-05-29 2004-03-22 Schering Ag Pirimidinas inhibidoras de cdk, su obtencion y su uso como medicamentos.
ES2274035T3 (es) 2001-06-01 2007-05-16 Vertex Pharmaceuticals Incorporated Compuestos de tiazol utiles como inhibidores de proteina quinasas.
WO2002102800A1 (en) * 2001-06-15 2002-12-27 Vertex Pharmaceuticals Incorporated 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors
US6939874B2 (en) * 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
US6703414B2 (en) 2001-09-14 2004-03-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Device and method for treating restenosis
JP2005522438A (ja) * 2002-02-08 2005-07-28 スミスクライン ビーチャム コーポレーション ピリミジン化合物
EP1487824B1 (en) 2002-03-01 2007-06-20 SmithKline Beecham Corporation Diamino-pyrimidines and their use as angiogenesis inhibitors
US7442697B2 (en) 2002-03-09 2008-10-28 Astrazeneca Ab 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity
GB0215844D0 (en) * 2002-07-09 2002-08-14 Novartis Ag Organic compounds
DE60330895D1 (de) * 2002-11-01 2010-02-25 Vertex Pharma Verbindungen, die sich als inhibitoren vonjak und anderen proteinkinasen eignen
CA2507406A1 (en) * 2002-11-05 2004-05-21 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of jak and other protein kinases
GB0226582D0 (en) 2002-11-14 2002-12-18 Cyclacel Ltd Anti-viral compounds
GB0226583D0 (en) * 2002-11-14 2002-12-18 Cyclacel Ltd Compounds

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EP1799652A1 (en) 2007-06-27
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CR9048A (es) 2007-08-28
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US7799915B2 (en) 2010-09-21
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US20060079543A1 (en) 2006-04-13
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