Chemistry:Acetylfentanyl

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Short description: Opioid analgesic
Acetylfentanyl
Acetylfentanyl.svg
Acetylfentanyl 3D BS.png
Clinical data
Other namesAcetyl fentanyl
Routes of
administration		oral, iv, im, insuflation
ATC code
  • none
Legal status
Legal status
  • AU: Illegal
  • BR: F1
  • CA: Schedule I [1]
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • UK: Class A
  • US: Schedule I [2]
  • Illegal in China, Cyprus, Estonia, Finland, Ireland, Latvia, Lithuania, Norway, Poland, Sweden and Switzerland[3]
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC21H26N2O
Molar mass322.452 g·mol−1
3D model (JSmol)

Acetylfentanyl (acetyl fentanyl) is an opioid analgesic drug that is an analog of fentanyl.[4] Studies have estimated acetylfentanyl to be 15 times more potent than morphine,[5][6] which would mean that despite being somewhat weaker than fentanyl, it is nevertheless still several times stronger than pure heroin. It has never been licensed for medical use and instead has only been sold as a designer drug. Acetylfentanyl was discovered at the same time as fentanyl itself and had only rarely been encountered on the illicit market in the late 1980s. However, in 2013, Canadian police seized 3 kilograms of acetylfentanyl.[7] As a μ-opioid receptor agonist, acetylfentanyl may serve as a direct substitute for heroin or other opioids. Common side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[8][9][10]

Deaths

Europe

Acetylfentanyl has been analytically confirmed in 32 fatalities in four European member states between 2013 and August 2015, Germany (2), Poland (1), Sweden (27) and the United Kingdom (2).[3]

Russia

Twelve deaths have been associated with acetylfentanyl in Russia since 2012.[3][11]

United States

The Centers for Disease Control and Prevention (CDC) issued a health alert to report that between March 2013 and May 2013, 14 overdose deaths related to injected acetylfentanyl had occurred among intravenous drug users (ages between 19 and 57 years) in Rhode Island. After confirming five overdoses in one county, including a fatality, Pennsylvania asked coroners and medical examiners across the state to screen for acetylfentanyl. As a result of this investigation, Pennsylvania confirmed at least one acetylfentanyl overdose death and attributed at least 50 fatalities to either fentanyl or acetylfentanyl during the first half of 2013.[12][13] In July 2015, the DEA informed about 52 confirmed fatalities involving acetylfentanyl in the United States between 2013 and 2015.[14]

Japan

One fatal poisoning caused by intravenous injection of a "bath salt" product containing acetylfentanyl and 4'-Methoxy-α-pyrrolidinopentiophenone (or 4-MeO-α-PVP, a substituted cathinone) has been reported in 2016.[15]

Legal status

Canada

As an analog of fentanyl, acetylfentanyl is a Schedule I controlled drug.[1]

China

As of October 2015 acetylfentanyl is a controlled substance in China.[16]

United States

Acetylfentanyl is a Schedule I controlled substance as of May 2015.[17]

Switzerland

(As of March 2023), acetylfentanyl is a controlled substance in Switzerland.[18]

United Kingdom

Acetylfentanyl was made a class A drug as an analogue of fentanyl in 1986.[19]

Overdose

Acetylfentanyl overdosage has been reported to closely resemble heroin overdosage clinically. Additionally, while naloxone (Narcan) is effective in treating acetylfentanyl overdose, larger than normal doses of the antidote may be required.[5]

Detection in body fluids

Acetylfentanyl may be quantitated in blood, plasma or urine by liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. Postmortem peripheral blood acetylfentanyl concentrations have been in a range of 89–945 μg/L in victims of acute overdosage.[20][21]

See also

References

  1. ↑ 1.0 1.1 "Controlled Drugs and Substances Act". IsomerDesign. https://isomerdesign.com/Cdsa/schedule.php?schedule=1&section=16&structure=C. 
  2. ↑ "Two Charged With Witness Tampering in Joint Woonsocket Police, DEA Investigation". The United States Attorney's Office: District of Rhode Island. US Department of Justice. 6 June 2013. https://www.justice.gov/usao-ri/pr/two-charged-witness-tampering-joint-woonsocket-police-dea-investigation. 
  3. ↑ 3.0 3.1 3.2 European Monitoring Centre for Drugs Drug Addiction; European Police Office (June 2016). EMCDDA–Europol Joint Report on acetylfentanyl. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). doi:10.2810/890694. ISBN 9789291689163. https://www.emcdda.europa.eu/publications/joint-reports/acetylfentanyl. 
  4. ↑ "Intoxications involving the fentanyl analogs acetylfentanyl, 4-methoxybutyrfentanyl and furanylfentanyl: results from the Swedish STRIDA project". Clinical Toxicology 54 (4): 324–32. 20 April 2016. doi:10.3109/15563650.2016.1139715. PMID 26850293. 
  5. ↑ 5.0 5.1 "Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues". Forensic Toxicology 26 (1): 1–5. June 2008. doi:10.1007/s11419-007-0039-1. ISSN 1860-8965. 
  6. ↑ "Dependence studies on new compounds in the rhesus monkey, rat and mouse (1989)". NIDA Research Monograph 95: 578–631. 1989. PMID 2641054. https://archives.drugabuse.gov/pdf/monographs/81.pdf. Retrieved 2016-08-26. 
  7. ↑ "Extremely potent painkiller hits Montreal black market". CBS News. 13 May 2013. https://www.cbc.ca/news/canada/montreal/extremely-potent-painkiller-hits-montreal-black-market-1.1340808. 
  8. ↑ "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". The International Journal on Drug Policy 26 (7): 626–31. July 2015. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511. 
  9. ↑ "Detection of fentanyl and its analogs by enzyme-linked immunosorbent assay". Journal of Analytical Toxicology 14 (3): 160–4. May–June 1990. doi:10.1093/jat/14.3.160. PMID 2374405. 
  10. ↑ Kroll, David (29 August 2013). "CDC Issues Alert On Deadly New Designer Drug, Acetyl Fentanyl". https://www.forbes.com/sites/davidkroll/2013/08/29/cdc-issues-alert-on-deadly-new-designer-drug-acetyl-fentanyl/. 
  11. ↑ "Identification and analytical properties of acetyl fentanyl metabolites". Journal of Analytical Chemistry 70 (2): 240–248. February 2015. doi:10.1134/S1061934815020124. ISSN 1061-9348. 
  12. ↑ Centers for Disease Control Prevention (CDC) (August 2013). "Acetyl fentanyl overdose fatalities--Rhode Island, March-May 2013". MMWR. Morbidity and Mortality Weekly Report 62 (34): 703–4. PMID 23985500. PMC 4604997. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6234a5.htm. 
  13. ↑ "Acetyl Fentanyl, a Novel Fentanyl Analog, Causes 14 Overdose Deaths in Rhode Island, March-May 2013". Journal of Medical Toxicology 11 (2): 208–17. June 2015. doi:10.1007/s13181-015-0477-9. PMID 25934111. 
  14. ↑ Drug Enforcement Administration (July 2015). "Acetyl fentanyl". Drug Enforcement Administration Office of Diversion Control. https://www.deadiversion.usdoj.gov/drug_chem_info/acetylfentanyl.pdf. 
  15. ↑ "A fatal poisoning case by intravenous injection of "bath salts" containing acetyl fentanyl and 4-methoxy PV8". Forensic Science International 267: e6–e9. October 2016. doi:10.1016/j.forsciint.2016.08.025. PMID 27591912. 
  16. ↑ "Error: no |title= specified when using {{Cite web}}" (in zh). 29 September 2015. https://www.sfda.gov.cn/WS01/CL0056/130753.html. 
  17. ↑ "80 FR 29227 - Schedules of Controlled Substances: Temporary Placement of Acetyl Fentanyl into Schedule I". U.S. Government Publishing Office (GPO). 21 May 2015. https://www.gpo.gov/fdsys/granule/FR-2015-05-21/2015-12331. 
  18. ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in de). 30 May 2011. https://www.fedlex.admin.ch/eli/cc/2011/363/de. 
  19. ↑ "The Misuse of Drugs Act 1971 (Modification) Order 1986". UK Home Office. 16 December 1986. https://www.legislation.gov.uk/uksi/1986/2230/introduction/made. 
  20. ↑ "Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS". Analytical Chemistry 86 (3): 1760–6. February 2014. doi:10.1021/ac4036197. PMID 24354295. 
  21. ↑ Baselt, Randall C. (2017). "Acetylfentanyl". Disposition of toxic drugs and chemicals in man. Seal Beach, Ca.: Biomedical Publications. ISBN 978-0-692-77499-1. https://www.biomedicalpublications.com/acetylfentanyl.pdf. 

Further reading

  • "The potential threat of acetyl fentanyl: legal issues, contaminated heroin, and acetyl fentanyl "disguised" as other opioids". Annals of Emergency Medicine 64 (6): 637–9. December 2014. doi:10.1016/j.annemergmed.2014.07.017. PMID 25153008. 



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