Biology:Wolbachia

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Short description: Genus of bacteria in the Alphaproteobacteria class

Wolbachia
Wolbachia.png
Transmission electron micrograph of Wolbachia within an insect cell
Credit:Public Library of Science / Scott O'Neill
Scientific classification e
Domain: Bacteria
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Ehrlichiaceae
Genus: Wolbachia
Hertig 1936 (Approved Lists 1980)
Species
  • "Candidatus Wolbachia bourtzisii" Ramirez-Puebla et al. 2015
  • "Candidatus Wolbachia brugii" Ramirez-Puebla et al. 2015
  • "Candidatus Wolbachia collembolicola" Ramirez-Puebla et al. 2015
  • "Candidatus Wolbachia ivorensis" Ehounoud et al. 2016
  • Wolbachia melophagi (Nöller 1917) Philip 1956 (Approved Lists 1980)
  • "Candidatus Wolbachia multihospitum" Ramirez-Puebla et al. 2015
  • "Candidatus Wolbachia onchocercicola" Ramirez-Puebla et al. 2015
  • Wolbachia pipientis Hertig 1936 (Approved Lists 1980)

Wolbachia is a genus of gram-negative bacteria that can either infect many species of arthropod as an intracellular parasite, or act as a mutualistic microbe in filarial nematodes.[1][2] It is one of the most common parasitic microbes of arthropods, and is possibly the most common reproductive parasite in the biosphere.[3] Its interactions with its hosts are often complex. Some host species cannot reproduce, or even survive, without Wolbachia colonisation. One study concluded that more than 16% of neotropical insect species carry bacteria of this genus,[4] and as many as 25 to 70% of all insect species are estimated to be potential hosts.[5]

History

The genus was first identified in 1924 by Marshall Hertig and Simeon Burt Wolbach in the common house mosquito. They described it as "a somewhat pleomorphic, rodlike, Gram-negative, intracellular organism [that] apparently infects only the ovaries and testes".[6] Hertig formally described the species in 1936, and proposed both the generic and specific names: Wolbachia pipientis.[7] Research on Wolbachia intensified after 1971, when Janice Yen and A. Ralph Barr of UCLA discovered that Culex mosquito eggs were killed by a cytoplasmic incompatibility when the sperm of Wolbachia-infected males fertilized infection-free eggs.[8][9] The genus Wolbachia is of considerable interest today due to its ubiquitous distribution, its many different evolutionary interactions, and its potential use as a biocontrol agent.

Phylogenetic studies have shown that Wolbachia persica (now Francisella persica) was closely related to species in the genus Francisella[10][11][12][13] and that Wolbachia melophagi (now Bartonella melophagi) was closely related to species in the genus Bartonella,[14][15][16] leading to a transfer of these species to these respective genera. Furthermore, unlike true Wolbachia, which needs a host cell to multiply, F. persica and B. melophagi can be cultured on agar plates.[17][16]

Method of sexual differentiation in hosts

These bacteria can infect many different types of organs, but are most notable for the infections of the testes and ovaries of their hosts. Wolbachia species are ubiquitous in mature eggs, but not mature sperm. Only infected females, therefore, pass the infection on to their offspring. Wolbachia bacteria maximize their spread by significantly altering the reproductive capabilities of their hosts, with four different phenotypes:

  • Male killing occurs when infected males die during larval development, which increases the rate of born, infected females.[18]
  • Feminization results in infected males that develop as females or infertile pseudofemales. This is especially prevalent in Lepidoptera species such as the adzuki bean borer (Ostrinia scapulalis).[19]
  • Parthenogenesis is reproduction of infected females without males. Some scientists have suggested that parthenogenesis may always be attributable to the effects of Wolbachia,[20] though this is not the case for the marbled crayfish.[21] An example of parthenogenesis induced by presence of Wolbachia are some species within the Trichogramma parasitoid wasp genus,[22] which have evolved to procreate without males due to the presence of Wolbachia. Males are rare in this genus of wasp, possibly because many have been killed by that same strain of Wolbachia.[23]
  • Cytoplasmic incompatibility is the inability of Wolbachia-infected males to successfully reproduce with uninfected females or females infected with another Wolbachia strain. This reduces the reproductive success of those uninfected females and therefore promotes the infecting strain. In the cytoplasmic incompatibility mechanism, Wolbachia interferes with the parental chromosomes during the first mitotic divisions to the extent that they can no longer divide in synchrony.[24]

Effects of sexual differentiation in hosts

Several host species, such as those within the genus Trichogramma, are so dependent on sexual differentiation of Wolbachia that they are unable to reproduce effectively without the bacteria in their bodies, and some might even be unable to survive uninfected.[25]

One study on infected woodlice showed the broods of infected organisms had a higher proportion of females than their uninfected counterparts.[26]

Wolbachia, especially Wolbachia-caused cytoplasmic incompatibility, may be important in promoting speciation.[27][28][29] Wolbachia strains that distort the sex ratio may alter their host's pattern of sexual selection in nature,[30][31] and also engender strong selection to prevent their action, leading to some of the fastest examples of natural selection in natural populations.[32]

The male killing and feminization effects of Wolbachia infections can also lead to speciation in their hosts. For example, populations of the pill woodlouse, Armadillidium vulgare which are exposed to the feminizing effects of Wolbachia, have been known to lose their female-determining chromosome.[33] In these cases, only the presence of Wolbachia can cause an individual to develop into a female.[33] Cryptic species of ground wētā (Hemiandrus maculifrons complex) are host to different lineages of Wolbachia which might explain their speciation without ecological or geographical separation.[34][35]

Effect on aromatase

The enzyme aromatase is found to mediate sex-change in many species of fish. Wolbachia can affect the activity of aromatase in developing fish embryos.[36]

Fitness advantages by Wolbachia infections

Wolbachia infection has been linked to viral resistance in Drosophila melanogaster, Drosophila simulans, and mosquito species. Flies, including mosquitoes,[37] infected with the bacteria are more resistant to RNA viruses such as Drosophila C virus, norovirus, flock house virus, cricket paralysis virus, chikungunya virus, and West Nile virus.[38][39][40]

In the common house mosquito, higher levels of Wolbachia were correlated with more insecticide resistance.[41]

In leafminers of the species Phyllonorycter blancardella, Wolbachia bacteria help their hosts produce green islands on yellowing tree leaves, that is, small areas of leaf remaining fresh, allowing the hosts to continue feeding while growing to their adult forms. Larvae treated with tetracycline, which kills Wolbachia, lose this ability and subsequently only 13% emerge successfully as adult moths.[42]

Muscidifurax uniraptor, a parasitoid wasp, also benefits from hosting Wolbachia bacteria.[43]

In the parasitic filarial nematode species responsible for elephantiasis, such as Brugia malayi and Wuchereria bancrofti, Wolbachia has become an obligate endosymbiont and provides the host with chemicals necessary for its reproduction and survival.[44] Elimination of the Wolbachia symbionts through antibiotic treatment therefore prevents reproduction of the nematode, and eventually results in its premature death.

Some Wolbachia species that infect arthropods also provide some metabolic provisioning to their hosts. In Drosophila melanogaster, Wolbachia is found to mediate iron metabolism under nutritional stress[45] and in Cimex lectularius, the Wolbachia strain cCle helps the host to synthesize B vitamins.[46]

Some Wolbachia strains have increased their prevalence by increasing their hosts' fecundity. Wolbachia strains captured from 1988 in southern California still induce a fecundity deficit, but nowadays the fecundity deficit is replaced with a fecundity advantage such that infected Drosophila simulans produces more offspring than the uninfected ones.[47]

Life-history consequences of Wolbachia infection

Wolbachia often manipulates host reproduction and life-history in a way that favours its own propagation. In the Pharaoh ant, Wolbachia infection correlates with increased colony-level production of reproductives (i.e., greater reproductive investment), and earlier onset of reproductive production (i.e., shorter life-cycle). Infected colonies also seem to grow more rapidly.[48] There is substantial evidence that the presence of Wolbachia that induce parthenogenesis have put pressure on species to reproduce primarily or entirely this way.[49]

Additionally, Wolbachia has been seen to decrease the lifespan of Aedes aegypti, carriers of mosquito-borne diseases, and it decreases their efficacy of pathogen transmission because older mosquitoes are more likely to have become carriers of one of those diseases.[50] This has been exploited as a method for pest control.

Genomics

The first Wolbachia genome to be determined was that of strain wMel, which infects D. melanogaster fruit flies.[51] This genome was sequenced at The Institute for Genomic Research in a collaboration between Jonathan Eisen and Scott O'Neill. The second Wolbachia genome to be determined was of strain wBm, which infects Brugia malayi nematodes.[44] Genome sequencing projects for several other Wolbachia strains are in progress.

Horizontal gene transfer

Wolbachia species also harbor a bacteriophage called bacteriophage WO or phage WO.[52] Comparative sequence analyses of bacteriophage WO offer some of the most compelling examples of large-scale horizontal gene transfer between Wolbachia coinfections in the same host.[53] It is the first bacteriophage implicated in frequent lateral transfer between the genomes of bacterial endosymbionts. Gene transfer by bacteriophages could drive significant evolutionary change in the genomes of intracellular bacteria that were previously considered highly stable or prone to loss of genes over time.[53]

Wolbachia also transfers genes to the host. A nearly complete copy of the Wolbachia genome sequence was found within the genome sequence of the fruit fly Drosophila ananassae and large segments were found in seven other Drosophila species.[54]

In an application of DNA barcoding to the identification of species of Protocalliphora flies, several distinct morphospecies had identical cytochrome c oxidase I gene sequences, most likely through horizontal gene transfer (HGT) by Wolbachia species as they jump across host species.[55] As a result, Wolbachia can cause misleading results in molecular cladistical analyses.[56] It is estimated that between 20 and 50 percent of insect species have evidence of HGT from Wolbachia—passing from microbes to animal (i.e. insects).[57]

Small RNA

The small non-coding RNAs WsnRNA-46 and WsnRNA-59 in Wolbachia were detected in Aedes aegypti mosquitoes and Drosophila melanogaster. The small RNAs (sRNAs) may regulate bacterial and host genes.[58] Highly conserved intragenic region sRNA called ncrwmel02 was also identified in Wolbachia pipientis. It is expressed in four different strains in a regulated pattern that differs according to the sex of the host and the tissue localisation. This suggested that the sRNA may play important roles in the biology of Wolbachia.[59]

Relation to human-related infections

Role in parasites

Outside of insects, Wolbachia infects a variety of isopod species, spiders, mites, and many species of filarial nematodes (a type of parasitic worm), including those causing onchocerciasis (river blindness) and elephantiasis in humans, as well as heartworms in dogs. Not only are these disease-causing filarial worms infected with Wolbachia, but Wolbachia also seems to play an inordinate role in these diseases.

A large part of the pathogenicity of filarial nematodes is due to host immune response toward their Wolbachia. Elimination of Wolbachia from filarial nematodes generally results in either death or sterility of the nematode.[60] Consequently, current strategies for control of filarial nematode diseases include elimination of their symbiotic Wolbachia via the simple doxycycline antibiotic, rather than directly killing the nematode with often more toxic antinematode medications.[61]

Disease prevention

Further information: Biology:Biological pest control
Indonesian research minister Mohamad Nasir during a visit to a Wolbachia mosquito lab of the Eliminate Dengue Project.

Naturally existing strains of Wolbachia have been shown to be a route for vector control strategies because of their presence in arthropod populations, such as mosquitoes.[62][63] Due to the unique traits of Wolbachia that cause cytoplasmic incompatibility, some strains are useful to humans as a promoter of genetic drive within an insect population. Wolbachia-infected females are able to produce offspring with uninfected and infected males; however, uninfected females are only able to produce viable offspring with uninfected males. This gives infected females a reproductive advantage that is greater the higher the frequency of Wolbachia in the population. Computational models predict that introducing Wolbachia strains into natural populations will reduce pathogen transmission and reduce overall disease burden.[64] An example includes a life-shortening Wolbachia that can be used to control dengue virus and malaria by eliminating the older insects that contain more parasites. Promoting the survival and reproduction of younger insects lessens selection pressure for evolution of resistance.[65][66]

Adi Utarini, research lead of the Wolbachia trial in Yogyakarta, Indonesia

In addition, some Wolbachia strains are able to directly reduce viral replication inside the insect. For dengue they include wAllbB and wMelPop with Aedes aegypti, wMel with Aedes albopictus.[67] and Aedes aegypti.[68]

Wolbachia has also been identified to inhibit replication of chikungunya virus (CHIKV) in A. aegypti. The wMel strain of Wolbachia pipientis significantly reduced infection and dissemination rates of CHIKV in mosquitoes, compared to Wolbachia uninfected controls and the same phenomenon was observed in yellow fever virus infection converting this bacterium in an excellent promise for YFV and CHIKV suppression.[69]

Wolbachia also inhibits the secretion of West Nile virus (WNV) in cell line Aag2 derived from A. aegypti cells. The mechanism is somewhat novel, as the bacteria actually enhances the production of viral genomic RNA in the cell line Wolbachia. Also, the antiviral effect in intrathoracically infected mosquitoes depends on the strain of Wolbachia, and the replication of the virus in orally fed mosquitoes was completely inhibited in wMelPop strain of Wolbachia.[70]

The effect of Wolbachia infection on virus replication in insect hosts is complex and depends on the Wolbachia strain and virus species.[71] While several studies have indicated consistent refractory phenotypes of Wolbachia infection on positive-sense RNA viruses in Drosophila melanogaster,[72][73] the yellow fever mosquito Aedes aegypti[74] and the Asian tiger mosquito Aedes albopictus.[75][76] This effect is not seen in DNA virus infection[73] and in some cases Wolbachia infection has been associated or shown to increase single stranded DNA[77] and double-stranded DNA virus infection.[78] There is also currently no evidence that Wolbachia infection restricts any tested negative-sense RNA viruses[79][80][81][82] indicating Wolbachia would be unsuitable for restriction of negative-sense RNA arthropod borne viruses.

Wolbachia infection can also increase mosquito resistance to malaria, as shown in Anopheles stephensi where the wAlbB strain of Wolbachia hindered the lifecycle of Plasmodium falciparum.[83]

However, Wolbachia infections can also enhance pathogen transmission. Wolbachia has enhanced multiple arboviruses in Culex tarsalis mosquitoes.[84] In another study, West Nile Virus (WNV) infection rate was significantly higher in Wolbachia (strain wAlbB)-infected C. tarsalis compared to controls.[85]

Wolbachia may induce reactive oxygen species–dependent activation of the Toll (gene family) pathway, which is essential for activation of antimicrobial peptides, defensins, and cecropins that help to inhibit virus proliferation.[86] Conversely, certain strains actually dampen the pathway, leading to higher replication of viruses. One example is with strain wAlbB in Culex tarsalis, where infected mosquitoes actually carried the west nile virus (WNV) more frequently. This is because wAlbB inhibits REL1, an activator of the antiviral Toll immune pathway. As a result, careful studies of the Wolbachia strain and ecological consequences must be done before releasing artificially-infected mosquitoes in the environment.[85]

Techniques and deployments

Strain wMel, mixed-sex

The World Mosquito Program (WMP) uses Wolbachia strain wMel to infect Aedes mosquitos. The mixed-sex mosquitos are intended to infect the local population with wMel, giving them transmission resistance.[87]

In 2014, WMP released infected mosquitos in Townsville, an Australia city with 187,000 inhabitants plagued by dengue. For four years after introduction, no cases of dengue were reported.[88] Trials in much smaller areas had been carried out, but a larger area had not been tested. No environmental ill-effects were reported. The cost was A$15 per inhabitant, but it was hoped that it could be reduced to US$1 in poorer countries with lower labor costs.[89]

In 2016, WMP scientist Scott Ritchie proposed using wMel mosquitos to combat the spread of the Zika virus.[90] A study reported that Wolbachia wMel has the ability to block Zika in Brazil.[91] In October 2016, it was announced that US$18 million in funding was being allocated for the use of Wolbachia-infected mosquitoes to fight Zika and dengue viruses. Deployment is slated for early 2017 in Colombia and Brazil.[92]

Between 2016 and 2020, WMP conducted its first randomized controlled trial in Yogyakarta, an Indonesian city of about 400,000 inhabitants. In August 2020, the trial's Indonesian lead scientist Adi Utarini announced that the trial showed a 77% reduction in dengue cases compared to the control areas. This trial was the "strongest evidence yet" for the technique.[93][94]

In 2017–2019, WMP released mosquitos in Niterói, Brazil.[95]

In March 2023, Brazil's Oswaldo Cruz Foundation signed an agreement with WMP to provide funds for a large "mosquito factory" producing infected insects.[96]

Male incompatibility

Another method to use Wolbachia in mosquitos exploits the cytoplamic incompatibility between infected males and uninfected females. If an uninfected female mates with an infected male, her eggs become infertile. With enough infected males released, the mosquito population would be reduced temporarily.[97]

Verily, the life sciences arm of Google's parent company Alphabet Inc., uses this method. In July 2017, it announced a plan to release about 20 million Wolbachia-infected male Aedes aegypti mosquitoes in Fresno, California , in an attempt to combat the Zika virus.[97][98] Singapore's National Environment Agency has teamed up with Verily to come up with an advanced, more efficient way to release male Wolbachia mosquitoes for Phase 2 of its study to suppress the urban Aedes aegypti mosquito population and fight dengue.[99]

On November 3, 2017, the US Environmental Protection Agency (EPA) registered Mosquito Mate, Inc. to release Wolbachia strain "ZAP"-infected male mosquitoes in 20 US states and the District of Columbia.[100]

See also

References

  1. ↑ "Genome Sequence of the Intracellular Bacterium Wolbachia". PLOS Biology 2 (3): e76. March 2004. doi:10.1371/journal.pbio.0020076. 
  2. ↑ "Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes". Microbiology 164 (11): 1345–1347. November 2018. doi:10.1099/mic.0.000724. PMID 30311871. 
  3. ↑ "The diversity of reproductive parasites among arthropods: Wolbachia do not walk alone". BMC Biology 6 (1): 27. June 2008. doi:10.1186/1741-7007-6-27. PMID 18577218. 
  4. ↑ "Distribution of Wolbachia among neotropical arthropods". Proceedings of the Royal Society B 262 (1364): 197–204. 1995. doi:10.1098/rspb.1995.0196. Bibcode: 1995RSPSB.262..197W. 
  5. ↑ "The Discovery of Wolbachia in Arthropods and Nematodes – A Historical Perspective". Wolbachia: A Bug's Life in another Bug. Issues in Infectious Diseases. 5. 2007. pp. 1–14. doi:10.1159/000104228. ISBN 978-3-8055-8180-6. 
  6. ↑ "Studies on Rickettsia-Like Micro-Organisms in Insects". The Journal of Medical Research 44 (3): 329–374.7. March 1924. PMID 19972605. 
  7. ↑ "The Rickettsia, Wolbachia pipientis (gen. et sp. n.)". Parasitology 28 (4): 453–486. October 1936. doi:10.1017/S0031182000022666. 
  8. ↑ "New hypothesis of the cause of cytoplasmic incompatibility in Culex pipiens L". Nature 232 (5313): 657–658. August 1971. doi:10.1038/232657a0. PMID 4937405. Bibcode: 1971Natur.232..657Y. 
  9. ↑ Bourtzis, Kostas; Miller, Thomas A. (2003). "14: Insect pest control using Wolbachia and/or radiation". Insect Symbiosis. Taylor & Francis. p. 230. ISBN 9780849341946. https://books.google.com/books?id=Y9_HAm28SoYC&pg=PA230. 
  10. ↑ "Analysis of 16S ribosomal DNA sequences of Francisella strains and utilization for determination of the phylogeny of the genus and for identification of strains by PCR". International Journal of Systematic Bacteriology 44 (1): 38–46. January 1994. doi:10.1099/00207713-44-1-38. PMID 8123561. 
  11. ↑ "Endosymbionts of ticks and their relationship to Wolbachia spp. and tick-borne pathogens of humans and animals". Applied and Environmental Microbiology 63 (10): 3926–3932. October 1997. doi:10.1128/AEM.63.10.3926-3932.1997. PMID 9327557. Bibcode: 1997ApEnM..63.3926N. 
  12. ↑ "Characterization of an endosymbiont infecting wood ticks, Dermacentor andersoni, as a member of the genus Francisella". Applied and Environmental Microbiology 63 (10): 3933–3940. October 1997. doi:10.1128/AEM.63.10.3933-3940.1997. PMID 9327558. Bibcode: 1997ApEnM..63.3933N. 
  13. ↑ "Reclassification of Wolbachia persica as Francisella persica comb. nov. and emended description of the family Francisellaceae". International Journal of Systematic and Evolutionary Microbiology 66 (3): 1200–1205. March 2016. doi:10.1099/ijsem.0.000855. PMID 26747442. 
  14. ↑ "Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila". International Journal of Systematic and Evolutionary Microbiology 51 (Pt 6): 2145–2165. November 2001. doi:10.1099/00207713-51-6-2145. PMID 11760958. 
  15. ↑ "Taxonomic status of the intracellular bacterium Wolbachia pipientis". International Journal of Systematic and Evolutionary Microbiology 57 (Pt 3): 654–657. March 2007. doi:10.1099/ijs.0.64515-0. PMID 17329802. 
  16. ↑ 16.0 16.1 "Isolation of Candidatus Bartonella melophagi from human blood". Emerging Infectious Diseases 15 (1): 66–68. January 2009. doi:10.3201/eid1501.081080. PMID 19116054. 
  17. ↑ "Reorganized Genomic Taxonomy of Francisellaceae Enables Design of Robust Environmental PCR Assays for Detection of Francisella tularensis". Microorganisms 9 (1): 146. January 2021. doi:10.3390/microorganisms9010146. PMID 33440900. 
  18. ↑ "Cultivation of the Drosophila sex-ratio spiroplasma". Science 232 (4755): 1253–1255. June 1986. doi:10.1098/rspb.1999.0698. PMID 17810745. 
  19. ↑ "Transfection of Wolbachia in Lepidoptera: the feminizer of the adzuki bean borer Ostrinia scapulalis causes male killing in the Mediterranean flour moth Ephestia kuehniella". Proceedings. Biological Sciences 268 (1469): 855–859. April 2001. doi:10.1098/rspb.2001.1593. PMID 11345332. 
  20. ↑ Microbiology: an introduction. Pearson Benjamin Cummings. 2007. ISBN 978-0-8053-4790-6. https://archive.org/details/microbiologyintr0009tort. 
  21. ↑ Vogt, Günter; Tolley, Laura; Scholtz, Gerhard (September 2004). "Life stages and reproductive components of the Marmorkrebs (Marbled crayfish), the first parthenogenetic decapod crustacean". Journal of Morphology 261 (3): 286–311. doi:10.1002/jmor.10250. PMID 15281058. https://pubmed.ncbi.nlm.nih.gov/15281058/. 
  22. ↑ "Meet the Herod bug". Nature 412 (6842): 12–14. July 2001. doi:10.1038/35083744. PMID 11452274. Bibcode: 2001Natur.412...12K. 
  23. ↑ "Garden Friends & Foes: Trichogramma Wasps". Weeder's Digest (Washington State University Whatcom County Extension). https://whatcom.wsu.edu/ag/homehort/pest/trichogramma.htm. Retrieved 16 July 2009. 
  24. ↑ "Microorganisms associated with chromosome destruction and reproductive isolation between two insect species". Nature 346 (6284): 558–560. August 1990. doi:10.1038/346558a0. PMID 2377229. Bibcode: 1990Natur.346..558B. 
  25. ↑ "Invasion of the Gender Benders: by manipulating sex and reproduction in their hosts, many parasites improve their own odds of survival and may shape the evolution of sex itself". Natural History 112 (1): 58. February 2003. ISSN 0028-0712. OCLC 1759475. 
  26. ↑ "Wolbachia infection in the terrestrial isopod oniscus asellus: sex ratio distortion and effect on fecundity". Heredity 83 (# (Pt 4)): 469–475. October 1999. doi:10.1038/sj.hdy.6885990. PMID 10583549.  However, the broods also often consisted of fewer eggs than the broods of the uninfected Oniscus asellus.
  27. ↑ "Wolbachia-induced incompatibility precedes other hybrid incompatibilities in Nasonia". Nature 409 (6821): 707–710. February 2001. doi:10.1038/35055543. PMID 11217858. Bibcode: 2001Natur.409..707B. 
  28. ↑ "Wolbachia. A tale of sex and survival". Science 292 (5519): 1093–1095. May 2001. doi:10.1126/science.292.5519.1093. PMID 11352061. 
  29. ↑ "Wolbachia-induced unidirectional cytoplasmic incompatibility and speciation: mainland-island model". PLOS ONE 2 (8): e701. August 2007. doi:10.1371/journal.pone.0000701. PMID 17684548. Bibcode: 2007PLoSO...2..701T. 
  30. ↑ "Male-killing bacteria trigger a cycle of increasing male fatigue and female promiscuity". Current Biology 17 (3): 273–277. February 2007. doi:10.1016/j.cub.2006.11.068. PMID 17276921. 
  31. ↑ "Sex-ratio-distorting Wolbachia causes sex-role reversal in its butterfly host". Proceedings. Biological Sciences 267 (1438): 69–73. January 2000. doi:10.1098/rspb.2000.0968. PMID 10670955. 
  32. ↑ "Extraordinary flux in sex ratio". Science 317 (5835): 214. July 2007. doi:10.1126/science.1143369. PMID 17626876. Bibcode: 2007Sci...317..214C. 
  33. ↑ 33.0 33.1 "Evolutionary consequences of Wolbachia infections". Trends in Genetics 19 (4): 217–223. April 2003. doi:10.1016/S0168-9525(03)00024-6. PMID 12683975. 
  34. ↑ "First detection of Wolbachia in the New Zealand biota". PLOS ONE 13 (4): e0195517. 2018-04-25. doi:10.1371/journal.pone.0195517. PMID 29694414. Bibcode: 2018PLoSO..1395517B. 
  35. ↑ "Three new ground wētā species and a redescription of Hemiandrus maculifrons". New Zealand Journal of Zoology 43 (4): 363–383. October 2016. doi:10.1080/03014223.2016.1205109. ISSN 0301-4223. 
  36. ↑ "Fish are the sex-switching masters of the animal kingdom". Our Blue Planet. British Broadcasting System (BBC). 2014. https://ourblueplanet.bbcearth.com/blog/?article=incredible-sex-changing-fish-from-blue-planet. 
  37. ↑ "The Impact of Wolbachia on Virus Infection in Mosquitoes". Viruses 7 (11): 5705–5717. November 2015. doi:10.3390/v7112903. PMID 26556361. "In contrast [to natural infection], stable transinfection of Wolbachia into heterologous mosquito hosts clearly produces antiviral effects against arboviruses including DENV [dengue virus], WNV [West Nile virus], YFV [yellow fever virus] and CHIKV [Chikungunya virus]....as adaption occurs these effects may decrease". 
  38. ↑ "The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster". PLOS Biology 6 (12): e2. December 2008. doi:10.1371/journal.pbio.1000002. PMID 19222304. 
  39. ↑ "Wolbachia and virus protection in insects". Science 322 (5902): 702. October 2008. doi:10.1126/science.1162418. PMID 18974344. Bibcode: 2008Sci...322..702H. 
  40. ↑ "The native Wolbachia endosymbionts of Drosophila melanogaster and Culex quinquefasciatus increase host resistance to West Nile virus infection". PLOS ONE 5 (8): e11977. August 2010. doi:10.1371/journal.pone.0011977. PMID 20700535. Bibcode: 2010PLoSO...511977G. 
  41. ↑ "High Wolbachia density in insecticide-resistant mosquitoes". Proceedings. Biological Sciences 269 (1498): 1413–1416. July 2002. doi:10.1098/rspb.2002.2022. PMID 12079666. 
  42. ↑ "Plant green-island phenotype induced by leaf-miners is mediated by bacterial symbionts". Proceedings. Biological Sciences 277 (1692): 2311–2319. August 2010. doi:10.1098/rspb.2010.0214. PMID 20356892. 
  43. ↑ "Wolbachia density and host fitness components in Muscidifurax uniraptor (Hymenoptera: pteromalidae)". Journal of Invertebrate Pathology 75 (4): 267–272. May 2000. doi:10.1006/jipa.2000.4927. PMID 10843833. 
  44. ↑ 44.0 44.1 "The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode". PLOS Biology 3 (4): e121. April 2005. doi:10.1371/journal.pbio.0030121. PMID 15780005. 
  45. ↑ "Evidence for metabolic provisioning by a common invertebrate endosymbiont, Wolbachia pipientis, during periods of nutritional stress". PLOS Pathogens 5 (4): e1000368. April 2009. doi:10.1371/journal.ppat.1000368. PMID 19343208. 
  46. ↑ "Evolutionary origin of insect-Wolbachia nutritional mutualism". Proceedings of the National Academy of Sciences of the United States of America 111 (28): 10257–10262. July 2014. doi:10.1073/pnas.1409284111. PMID 24982177. Bibcode: 2014PNAS..11110257N. 
  47. ↑ "From parasite to mutualist: rapid evolution of Wolbachia in natural populations of Drosophila". PLOS Biology 5 (5): e114. May 2007. doi:10.1371/journal.pbio.0050114. PMID 17439303. 
  48. ↑ "Wolbachia-infected ant colonies have increased reproductive investment and an accelerated life cycle". The Journal of Experimental Biology 223 (Pt 9): jeb.220079. May 2020. doi:10.1242/jeb.220079. PMID 32253286. 
  49. ↑ "Irreversible thelytokous reproduction in Muscidifurax uniraptor". Entomologia Experimentalis et Applicata 100 (3): 271–278. 2001. doi:10.1046/j.1570-7458.2001.00874.x. ISSN 1570-7458. 
  50. ↑ "Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission". Nature 476 (7361): 454–457. August 2011. doi:10.1038/nature10356. PMID 21866160. Bibcode: 2011Natur.476..454H. 
  51. ↑ "Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements". PLOS Biology 2 (3): E69. March 2004. doi:10.1371/journal.pbio.0020069. PMID 15024419. 
  52. ↑ "Distribution and evolution of bacteriophage WO in Wolbachia, the endosymbiont causing sexual alterations in arthropods". Journal of Molecular Evolution 51 (5): 491–497. November 2000. doi:10.1007/s002390010112. PMID 11080372. Bibcode: 2000JMolE..51..491M. 
  53. ↑ 53.0 53.1 "Complete bacteriophage transfer in a bacterial endosymbiont (Wolbachia) determined by targeted genome capture". Genome Biology and Evolution 3: 209–218. 2011. doi:10.1093/gbe/evr007. PMID 21292630. 
  54. ↑ "Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes". Science 317 (5845): 1753–1756. September 2007. doi:10.1126/science.1142490. PMID 17761848. Bibcode: 2007Sci...317.1753H. 
  55. ↑ "DNA barcoding cannot reliably identify species of the blowfly genus Protocalliphora (Diptera: Calliphoridae)". Proceedings. Biological Sciences 274 (1619): 1731–1739. July 2007. doi:10.1098/rspb.2007.0062. PMID 17472911. 
  56. ↑ "Maternally inherited male-killing microorganisms may confound interpretation of mitochondrial DNA variability". Biological Journal of the Linnean Society 58 (4): 453–470. 1996. doi:10.1111/j.1095-8312.1996.tb01446.x. 
  57. ↑ I contain multitudes : the microbes within us and a grander view of life (First U.S. ed.). New York, NY. 2016-08-09. pp. 197. ISBN 9780062368591. OCLC 925497449. 
  58. ↑ "Wolbachia small noncoding RNAs and their role in cross-kingdom communications". Proceedings of the National Academy of Sciences of the United States of America 111 (52): 18721–18726. December 2014. doi:10.1073/pnas.1420131112. PMID 25512495. Bibcode: 2014PNAS..11118721M. 
  59. ↑ "Discovery of putative small non-coding RNAs from the obligate intracellular bacterium Wolbachia pipientis". PLOS ONE 10 (3): e0118595. 2015-01-01. doi:10.1371/journal.pone.0118595. PMID 25739023. Bibcode: 2015PLoSO..1018595W. 
  60. ↑ "Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production". Medical Microbiology and Immunology 192 (4): 211–216. November 2003. doi:10.1007/s00430-002-0174-6. PMID 12684759. 
  61. ↑ "Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial". Lancet 365 (9477): 2116–2121. 2005. doi:10.1016/S0140-6736(05)66591-9. PMID 15964448. 
  62. ↑ "Generation of a novel Wolbachia infection in Aedes albopictus (Asian tiger mosquito) via embryonic microinjection". Insect Biochemistry and Molecular Biology 35 (8): 903–910. August 2005. doi:10.1016/j.ibmb.2005.03.015. PMID 15944085. 
  63. ↑ "A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium". Cell 139 (7): 1268–1278. December 2009. doi:10.1016/j.cell.2009.11.042. PMID 20064373. 
  64. ↑ "Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases". PLOS Neglected Tropical Diseases 5 (4): e1024. April 2011. doi:10.1371/journal.pntd.0001024. PMID 21541357. 
  65. ↑ "Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti". Science 323 (5910): 141–144. January 2009. doi:10.1126/science.1165326. PMID 19119237. Bibcode: 2009Sci...323..141M. 
  66. ↑ "'Bug' could combat dengue fever". BBC News (British Broadcasting Corporation). 2 January 2009. https://news.bbc.co.uk/1/hi/health/7804326.stm. 
  67. ↑ "Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus". Proceedings of the National Academy of Sciences of the United States of America 109 (1): 255–260. January 2012. doi:10.1073/pnas.1112021108. PMID 22123944. Bibcode: 2012PNAS..109..255B. 
  68. ↑ "Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations". PLOS Neglected Tropical Diseases 8 (9): e3115. September 2014. doi:10.1371/journal.pntd.0003115. PMID 25211492. 
  69. ↑ "Impact of Wolbachia on infection with chikungunya and yellow fever viruses in the mosquito vector Aedes aegypti". PLOS Neglected Tropical Diseases 6 (11): e1892. 2012. doi:10.1371/journal.pntd.0001892. PMID 23133693. 
  70. ↑ "Effect of Wolbachia on replication of West Nile virus in a mosquito cell line and adult mosquitoes". Journal of Virology 87 (2): 851–858. January 2013. doi:10.1128/JVI.01837-12. PMID 23115298. 
  71. ↑ "The Impact of Wolbachia on Virus Infection in Mosquitoes". Viruses 7 (11): 5705–5717. November 2015. doi:10.3390/v7112903. PMID 26556361. 
  72. ↑ "Wolbachia and virus protection in insects". Science 322 (5902): 702. October 2008. doi:10.1126/science.1162418. PMID 18974344. Bibcode: 2008Sci...322..702H. 
  73. ↑ 73.0 73.1 "The bacterial symbiont Wolbachia induces resistance to RNA viral infections in Drosophila melanogaster". PLOS Biology 6 (12): e2. December 2008. doi:10.1371/journal.pbio.1000002. PMID 19222304. 
  74. ↑ "A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium". Cell 139 (7): 1268–1278. December 2009. doi:10.1016/j.cell.2009.11.042. PMID 20064373. 
  75. ↑ "Native Wolbachia from Aedes albopictus Blocks Chikungunya Virus Infection In Cellulo". PLOS ONE 10 (4): e0125066. 2015. doi:10.1371/journal.pone.0125066. PMID 25923352. Bibcode: 2015PLoSO..1025066R. 
  76. ↑ "Effect of Wolbachia wAlbB on a positive-sense RNA negev-like virus: a novel virus persistently infecting Aedes albopictus mosquitoes and cells". The Journal of General Virology 101 (2): 216–225. February 2020. doi:10.1099/jgv.0.001361. PMID 31846415. 
  77. ↑ "Density-dependent enhanced replication of a densovirus in Wolbachia-infected Aedes cells is associated with production of piRNAs and higher virus-derived siRNAs". Virology 528: 89–100. February 2019. doi:10.1016/j.virol.2018.12.006. PMID 30583288. 
  78. ↑ "Wolbachia in a major African crop pest increases susceptibility to viral disease rather than protects". Ecology Letters 15 (9): 993–1000. September 2012. doi:10.1111/j.1461-0248.2012.01820.x. PMID 22731846. https://gala.gre.ac.uk/id/eprint/8744/1/8744_GRZYWACZ_Wolbachia_in_a_Major_African_Crop_Pest_2012.pdf. 
  79. ↑ "Aedes Anphevirus: an Insect-Specific Virus Distributed Worldwide in Aedes aegypti Mosquitoes That Has Complex Interplays with Wolbachia and Dengue Virus Infection in Cells". Journal of Virology 92 (17). September 2018. doi:10.1128/JVI.00224-18. PMID 29950416. 
  80. ↑ "Wolbachia wStri Blocks Zika Virus Growth at Two Independent Stages of Viral Replication". mBio 9 (3). May 2018. doi:10.1128/mBio.00738-18. PMID 29789369. 
  81. ↑ "Wolbachia effects on Rift Valley fever virus infection in Culex tarsalis mosquitoes". PLOS Neglected Tropical Diseases 11 (10): e0006050. October 2017. doi:10.1371/journal.pntd.0006050. PMID 29084217. 
  82. ↑ "Persistent Spodoptera frugiperda rhabdovirus infection in Sf9 cells is not restricted by Wolbachia wMelPop-CLA and wAlbB strains and is targeted by the RNAi machinery". Virology 563: 82–87. November 2021. doi:10.1016/j.virol.2021.08.013. PMID 34492433. 
  83. ↑ "Wolbachia invades Anopheles stephensi populations and induces refractoriness to Plasmodium infection". Science 340 (6133): 748–751. May 2013. doi:10.1126/science.1236192. PMID 23661760. Bibcode: 2013Sci...340..748B. 
  84. ↑ "Wolbachia-induced enhancement of human arboviral pathogens". 2017. https://pennstate.pure.elsevier.com/en/projects/wolbachia-induced-enhancement-of-human-arboviral-pathogens. 
  85. ↑ 85.0 85.1 "Wolbachia enhances West Nile virus (WNV) infection in the mosquito Culex tarsalis". PLOS Neglected Tropical Diseases 8 (7): e2965. July 2014. doi:10.1371/journal.pntd.0002965. PMID 25010200. 
  86. ↑ "Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti". Proceedings of the National Academy of Sciences of the United States of America 109 (1): E23–E31. January 2012. doi:10.1073/pnas.1116932108. PMID 22123956. Bibcode: 2012PNAS..109E..23P. 
  87. ↑ "Our Wolbachia method" (in en). https://www.worldmosquitoprogram.org/en/work/wolbachia-method. 
  88. ↑ O'Neill, SL; Ryan, PA; Turley, AP; Wilson, G; Retzki, K; Iturbe-Ormaetxe, I; Dong, Y; Kenny, N et al. (2018). "Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses.". Gates Open Research 2: 36. doi:10.12688/gatesopenres.12844.3. PMID 30596205. 
  89. ↑ "Dengue fever outbreak halted by release of special mosquitoes". The Guardian. 1 August 2018. https://www.theguardian.com/society/2018/aug/01/dengue-fever-outbreak-halted-by-release-of-infected-mosquitoes. 
  90. ↑ "The Best Weapon for Fighting Zika? More Mosquitoes". Bloomberg.com. 4 February 2016. https://www.bloomberg.com/news/articles/2016-02-04/as-zika-virus-goes-global-scientists-breed-infected-mosquitoes. 
  91. ↑ "Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes". Cell Host & Microbe 19 (6): 771–774. June 2016. doi:10.1016/j.chom.2016.04.021. PMID 27156023. 
  92. ↑ "Wolbachia efforts ramp up to fight Zika in Brazil, Colombia". CIDRAP News. 26 October 2016. https://www.cidrap.umn.edu/news-perspective/2016/10/wolbachia-efforts-ramp-fight-zika-brazil-colombia. 
  93. ↑ "The mosquito strategy that could eliminate dengue". Nature. August 2020. doi:10.1038/d41586-020-02492-1. PMID 32855552. 
  94. ↑ "Nature's 10: ten people who helped shape science in 2020" (in en). 15 December 2020. https://www.nature.com/articles/d41586-020-03435-6. 
  95. ↑ Pinto, SB; Riback, TIS; Sylvestre, G; Costa, G; Peixoto, J; Dias, FBS; Tanamas, SK; Simmons, CP et al. (July 2021). "Effectiveness of Wolbachia-infected mosquito deployments in reducing the incidence of dengue and other Aedes-borne diseases in Niterói, Brazil: A quasi-experimental study.". PLOS Neglected Tropical Diseases 15 (7): e0009556. doi:10.1371/journal.pntd.0009556. PMID 34252106. 
  96. ↑ "Brazil to build mosquito factory to fight dengue, Zika, chikungunya" (in en). 31 March 2023. https://agenciabrasil.ebc.com.br/en/geral/noticia/2023-03/new-aedes-aegypti-factory-brazil-will-expand-fight-against-diseases. 
  97. ↑ 97.0 97.1 "Google's life sciences unit is releasing 20 million bacteria-infected mosquitoes in Fresno". Oath Inc.. 14 July 2017. https://techcrunch.com/2017/07/14/googles-life-sciences-unit-is-releasing-20-million-bacteria-infected-mosquitoes-in-fresno/. 
  98. ↑ "Verily Robot Will Raise 20 Million Sterile Mosquitoes for Release in California". https://www.technologyreview.com/s/608280/alphabet-has-built-a-robot-that-is-releasing-millions-of-sterile-mosquitoes-in-california/. 
  99. ↑ "NEA, Alphabet Inc's Verily team up to fight dengue with AI". 18 September 2018. https://www.channelnewsasia.com/news/singapore/nea-alphabet-inc-s-verily-team-up-to-fight-dengue-with-ai-10731556. 
  100. ↑ "EPA Registers the Wolbachia ZAP Strain in Live Male Asian Tiger Mosquitoes". U.S. Environmental Protection Agency (EPA). 7 November 2017. https://www.epa.gov/pesticides/epa-registers-wolbachia-zap-strain-live-male-asian-tiger-mosquitoes/. 

Further reading

External links

Wikidata ☰ Q283526 entry



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