Biology:E4F1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1][2][3]
Function
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]
Interactions
E4F1 has been shown to interact with:
References
- ↑ "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet 82 (1–2): 99–100. November 1998. doi:10.1159/000015075. PMID 9763670.
- ↑ "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res 6 (6): 525–537. December 1996. doi:10.1101/gr.6.6.525. PMID 8828041.
- ↑ 3.0 3.1 "Entrez Gene: E4F1 E4F transcription factor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1877.
- ↑ 4.0 4.1 "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–4989. February 2003. doi:10.1074/jbc.M210978200. PMID 12446718.
- ↑ "p53 is involved in the p120E4F-mediated growth arrest". Oncogene 19 (2): 188–199. January 2000. doi:10.1038/sj.onc.1203250. PMID 10644996.
- ↑ "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–7743. July 2000. doi:10.1073/pnas.130198397. PMID 10869426. Bibcode: 2000PNAS...97.7738F.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–174. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.". Mol. Cell. Biol. 17 (4): 1890–1903. 1997. doi:10.1128/mcb.17.4.1890. PMID 9121437.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–156. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.". Mamm. Genome 9 (4): 320–323. 1998. doi:10.1007/s003359900758. PMID 9530632.
- "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–37543. 2000. doi:10.1074/jbc.274.53.37538. PMID 10608806.
- "p53 is involved in the p120E4F-mediated growth arrest.". Oncogene 19 (2): 188–199. 2000. doi:10.1038/sj.onc.1203250. PMID 10644996.
- "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–7743. 2000. doi:10.1073/pnas.130198397. PMID 10869426. Bibcode: 2000PNAS...97.7738F.
- "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.". J. Biol. Chem. 278 (7): 4981–4989. 2003. doi:10.1074/jbc.M210978200. PMID 12446718.
- "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene.". Cancer Res. 64 (1): 102–107. 2004. doi:10.1158/0008-5472.CAN-03-2622. PMID 14729613.
- "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis.". Am. J. Pathol. 165 (6): 2019–2031. 2005. doi:10.1016/s0002-9440(10)63253-1. PMID 15579445.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–1178. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The LIM-only protein FHL2 is a negative regulator of E4F1.". Oncogene 25 (40): 5475–5484. 2006. doi:10.1038/sj.onc.1209567. PMID 16652157.
- "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.". Cell 127 (4): 775–788. 2006. doi:10.1016/j.cell.2006.09.031. PMID 17110336.
- "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.". EMBO Rep. 8 (7): 671–677. 2007. doi:10.1038/sj.embor.7400983. PMID 17557114.
External links
- E4F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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