Simulation of Nanopore Sequencing Signals Based on BiGRU

Oxford Nanopore sequencing is an important sequencing technology, which reads the nucleotide sequence by detecting the electrical current signal changes when DNA molecule is forced to pass through a biological nanopore. The research on signal simulation of nanopore sequencing is highly desirable for method developments of nanopore sequencing applications. To improve the simulation accuracy, we propose a novel signal simulation method based on Bi-directional Gated Recurrent Units (BiGRU). We named the proposed method NanosigSim.

git clone https://github.com/zpllx/NanosigSim.git
cd NanosigSim