QuIP is a web accessible toolset designed to support analysis, management, and exploration of whole slide tissue images for cancer research. The QuIP software consists of a set of docker containers, which provide analysis execution and data management backend services, and web applications to load and visualize whole slide tissue images (in OpenSlide supported formats), and visualize and explore the analysis results.

QuIP has several web applications to view whole slide tissue images, view and interact with analysis results, and edit and curate analysis results. caMicroscope, for example, facilitates the interactive exploration of whole slide tissue images and analysis results (overlaid on images as polygons or heatmaps).

1. docker and docker-compose. You should be able to run docker commands (e.g., pull, run).
2. git
3. Port 80 should be open to access and use the web applications remotely.

Clone this repository.

git clone https://github.com/SBU-BMI/quip_distro

2. Place yourself in quip_distro folder.
   
3. Copy config/httpd.conf.template to config/httpd.conf
   
4. Configure httpd.conf with your certificates to enable https.
   
5. Build with, "docker-compose -f quip-pathdb.yml build"
   
6. Run with, "docker-compose -f quip-pathdb.yml up -d"

We have developed a collection of deep learning methods for analysis of whole slide tissue images. The methods include deep learning models for predicting spatial distribution of tumor infiltrating lymphocytes, segmentation and classification of tumor regions, and segmentation of nuclei.

More information about the deep learning models and links to the code repositories can be found at https://github.com/SBU-BMI/histopathology_analysis

The image loader container is deployed when QuIP is installed.

Please see README at https://github.com/SBU-BMI/ImageLoader for user instructions to load images to QuIP.

Results from the tumor infiltrating lymphocyte analysis methods and the tumor segmentation methods are probability maps. The probability maps can be loaded to QuIP as heatmaps using the heatmap loader container, which is deployed when QuIP is installed.

Please see README at https://github.com/SBU-BMI/uploadHeatmaps for user instructions to load heatmaps to QuIP.

The segmentation results container is deployed, when QuIP is installed. Nucleus segmentation resuilts can be loaded to QuIP using this container.

Please see README at https://github.com/SBU-BMI/SegmentationLoader for user instructions to load segmentation results to QuIP.

Feel free to add any support inquiry as a github issue to this repository. Other feedback can be given via this form.