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A new perspective for mitigation of SARS-CoV-2 infection: priming the innate immune system for viral attack

Oren Kolodny, Michael Berger, Marcus W. Feldman, and Yoav Ram

Open Biology 2020

This repository contains a Jupyter notebook used to produce the Figure in the paper. The notebook contains the model implementation.

The following equation system describes the model:

with these variables and parameters (all rates are in 1/day):

  • S: susceptible
  • E: exposed
  • I1: infected without priming
  • I2: infected with priming
  • H: hospitalized
  • R: recovered
  • N: total population size (constant)
  • β (beta): transmission rate
  • δ (delta): incubation rate
  • α (alpha): fraction of population receiving priming
  • r: clearance rate infected
  • ρ (rho): increase in clearance rate due to priming
  • h: hospitalization rate of infected
  • γ (gamma): clearance rate of hospitalized

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CC-BY-SA 4.0

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