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This is a repo with the MATLAB files used to get the results for the project "A systems biology analysis of adrenergically stimulated adiponectin exocytosis in white adipocytes"

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A systems biology analysis of adrenergically stimulated adiponectin exocytosis in white adipocytes

These files are used to generate the results and the plots in the paper published with the same title. To run the scripts, MATLAB 2018b or newer is necessary (for the function sgtitle used when plotting), and the toolboxes global optimization toolbox and parallel computing toolbox are needed to run the parameter estimation scripts. Furthermore, a valid c compiler is necessary. Check if MATLAB has one available by running mex -setup

Below is a list of the scripts and what they do.

PlotFigures

Used to generate the figures in the paper. Some postprocessing was done manually in illustrator.

RunOptimization and RunOptimizationPred

A top level script used to run multiple parameter estimations in parallel.

runParallel and runParallelPred

Top level scripts used to run parameter estimation in parallel at the super computer center.

EstimateParameters and EstimateParametersPred

The scripts that runs the actual parameter estimations.

CostFunction and CostFunctionPred

Used to estimate the objective function value when either finding the optimal solution, or when finding the boundary of the predictions.

SimulateExperiments

A function used to simulate corresponding biological experiments.

SimulateSteadyState

A function use to simulate steady state before the experiment is started.

model_equations.txt

The file containing the model equations. Note that the model name (when compiled and used in the scripts) are adr_endo.

expData, fig5a-data, fig5e-data

MATLAB files containing the experimental data.

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This is a repo with the MATLAB files used to get the results for the project "A systems biology analysis of adrenergically stimulated adiponectin exocytosis in white adipocytes"

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