import pandas as pd
import numpy as np
import seaborn as sns
import matplotlib.pylab as plt
from matplotlib.pylab import rcParams
rcParams['figure.figsize'] = 20, 4
sns.set_style("darkgrid")

# for the sampling
from imblearn.over_sampling import RandomOverSampler, SMOTE, ADASYN
from imblearn.under_sampling import RandomUnderSampler
from imblearn.pipeline import Pipeline

# for the linear models that need scaled input data
from sklearn.preprocessing import MinMaxScaler, StandardScaler

# for general modeling
from sklearn import model_selection, pipeline, ensemble, metrics, linear_model, svm, neighbors
from sklearn.dummy import DummyClassifier

# for lda
from sklearn.discriminant_analysis import LinearDiscriminantAnalysis

# for tracking how long things take
import time

X = pd.read_csv('train_features.csv')
test = pd.read_csv('test_features.csv')
y = pd.read_csv('train_targets_scored.csv')
#y_notscored = pd.read_csv('train_ys_nonscored.csv')
#sample_submission = pd.read_csv('sample_submission.csv')
y.drop('sig_id',axis=1,inplace=True)

print("Null values present in X: {}".format(X.isnull().any().any()))
print("Null values present in X: {}".format(test.isnull().any().any()))

call_viability_columns = list(X.columns[X.columns.str.contains('c-')])

cell_data = X[call_viability_columns]

cell_data.info(verbose=False)

print("Min Cell Viability value: {}".format(cell_data.min().min()))
print("Max Cell Viability value: {}".format(cell_data.max().max()))

sns.boxplot(x='variable', y='value', data=pd.melt(cell_data.iloc[:,:10]))

sns.distplot(cell_data.iloc[:,:], kde=False)

# Those outliers! Let's double check.
((cell_data>=-10) & (cell_data<-9)).sum().sum()

sns.distplot(cell_data.mean(axis=1), kde=True)

print("Mean of our Cell Viability data: {}".format(cell_data.mean(axis=1).mean()))
print("Standard Deviation of our Cell Viability data: {}".format(cell_data.mean(axis=1).std()))

gene_columns = list(X.columns[X.columns.str.contains('g-')])

gene_data = X[gene_columns]

gene_data.info()

print("Min Gene Expression value: {}".format(gene_data.min().min()))
print("Max Gene Expression value: {}".format(gene_data.max().max()))

sns.boxplot(x='variable', y='value', data=pd.melt(gene_data.iloc[:,10:20]))

sns.distplot(gene_data.iloc[:,:], kde=False)

sns.distplot(gene_data.mean(axis=1), kde=True)

print("Mean of our Gene Expression data: {}".format(gene_data.mean(axis=1).mean()))
print("Standard Deviation of our Gene Expression data: {}".format(gene_data.mean(axis=1).std()))

compound_columns = ['cp_type', 'cp_time', 'cp_dose']

X_compound_data = X[compound_columns]

X_compound_data.info()

X_compound_data.apply(pd.Series.value_counts)

sns.violinplot(x="cp_dose", y="cp_time", hue="cp_type",data=X_compound_data, palette='Set2',inner="quartile")

from sklearn.preprocessing import OneHotEncoder, LabelEncoder

encoder = OneHotEncoder(sparse=False)

# and also transform the test data
X_compound_data_encoded = pd.DataFrame(encoder.fit_transform(X_compound_data))
X_compound_data_encoded.columns = encoder.get_feature_names()

X_encoded = pd.concat([X.drop(compound_columns,axis=1), X_compound_data_encoded ], axis=1)

# and also transform the test data
test_compound_data = test[compound_columns]
test_compound_data_encoded = pd.DataFrame(encoder.transform(test_compound_data))
test_compound_data_encoded.columns = encoder.get_feature_names()

test_encoded = pd.concat([test.drop(compound_columns,axis=1), test_compound_data_encoded ], axis=1)

y.shape

num_pos_classes = (y==1).sum().sum()
num_neg_classes = (y==0).sum().sum()
print("Only {:.2f}% of all the target values belong to the positive class.".format((num_pos_classes/(num_neg_classes+num_pos_classes))*100))

moa_class_ratios = (y.T.sum(axis=1)/y.shape[0]).rename('% of positive class')

plt.hist(moa_class_ratios)
plt.title('Class Ratios (for each drug type)')
plt.ylabel('Drug Count')
plt.show()

mlbl_count_data = y.sum(axis=1).value_counts()

sns.barplot(x=mlbl_count_data.index, y=mlbl_count_data.values/y.shape[0], palette='Set2')
plt.ylabel('% of Samples', fontsize=12)
plt.xlabel('# of multi-labels', fontsize=12)

mms = MinMaxScaler()
X_encoded_scaled = pd.DataFrame(mms.fit_transform(X_encoded.drop('sig_id',axis=1)), columns=X_encoded.drop('sig_id',axis=1).columns)

X_train_split, X_test_split, y_train_split, y_test_split = model_selection.train_test_split(X_encoded_scaled, y, 
                                                                                            shuffle=True, random_state=0, test_size=0.15)

# Courtesy of https://www.kaggle.com/lane203j
def pr_auc_score(clf, x, y):
    '''
        This function computes area under the precision-recall curve. 
    '''
      
    precisions, recalls,_ = metrics.precision_recall_curve(y, clf.predict_proba(x)[:,1], pos_label=1)
    
    return metrics.auc(recalls, precisions)

def avg_precision_wrapper(clf, x, y):
    y_prob = clf.predict_proba(x)
    return metrics.average_precision_score(y, y_prob,
                                          average='micro')

def udf_log_loss(clf, x, y):
    
    loss = metrics.log_loss(y, clf.predict_proba(x)[:,1])
    return loss

def imbalanced_cross_validation_score(clf, x, y, cv, scoring, sampler):
    '''
        This function computes the cross-validation score of a given 
        classifier using a choice of sampling function to mitigate 
        the class imbalance, and stratified k-fold sampling.
        
        The first five arguments are the same as 
        sklearn.model_selection.cross_val_score.
        
        - clf.predict_proba(x) returns class label probabilities
        - clf.fit(x,y) trains the model
        
        - x = data
        
        - y = labels
        
        - cv = the number of folds in the cross validation
        
        - scoring(classifier, x, y) returns a float
        
        The last argument is a choice of random sampler: an object 
        similar to the sampler objects available from the python 
        package imbalanced-learn. In particular, this 
        object needs to have the method:
        
        sampler.fit_sample(x,y)
        
        See https://contrib.scikit-learn.org/imbalanced-learn/
        for more details and examples of other sampling objects 
        available.  
    
    '''
    
    cv_score = 0.
    train_score = 0.
    test_score = 0.
    
    # stratified k-fold creates folds with the same ratio of positive 
    # and negative samples as the entire dataset.
    
    skf = model_selection.StratifiedKFold(n_splits=cv, random_state=0, shuffle=True)
    
    for train_idx, test_idx in skf.split(x,y):
        
        xfold_train_sampled, yfold_train_sampled = sampler.fit_sample(x.iloc[train_idx],y.iloc[train_idx])
        clf.fit(xfold_train_sampled, yfold_train_sampled)
        
        train_score = scoring(clf, xfold_train_sampled, yfold_train_sampled)
        test_score  = scoring(clf, x.iloc[test_idx], y.iloc[test_idx])
        
        print("Train: %.2f Test: %.2f"%(train_score,test_score))

        cv_score += test_score
        
    return cv_score/cv

# plot no skill and model roc curves
def plot_roc_curve(test_y, naive_probs, model_probs, no_skill_model_name):
    # plot naive skill roc curve
    fpr, tpr, _ = metrics.roc_curve(test_y, naive_probs)
    # get auc score
    auc_noskill =  metrics.roc_auc_score(test_y, naive_probs)
    plt.plot(fpr, tpr, linestyle='--', label='No Skill')
    # plot model roc curve
    fpr, tpr, _ = metrics.roc_curve(test_y, model_probs)
    # get auc score
    auc_modelskill =  metrics.roc_auc_score(test_y, model_probs)
    plt.plot(fpr, tpr, marker='.', label=no_skill_model_name)
    # axis labels
    plt.xlabel('False Positive Rate')
    plt.ylabel('True Positive Rate')
    # show the legend
    plt.legend()
    # show the title
    plt.title('No skill AUC={:.2f}, Model Skill AUC={:.2f}'.format(auc_noskill, auc_modelskill))
    # show the plot
    plt.show()    

def plot_pr_curve(test_y, naive_probs, model_probs, no_skill_model_name):
    # plot naive skill pr curve
    recall, precision, _ = metrics.precision_recall_curve(test_y, naive_probs)
    # get auc score
    auc_noskill =  metrics.average_precision_score(test_y, naive_probs,
                                                  average='micro')
    plt.plot(recall, precision, linestyle='--', label='No Skill')
    # plot model pr curve
    recall, precision, _ = metrics.precision_recall_curve(test_y, model_probs)
    auc_modelskill =  metrics.average_precision_score(test_y, model_probs,
                                                  average='micro')
    plt.plot(recall, precision, marker='.', label=no_skill_model_name)
    # axis labels
    plt.xlabel('Recall')
    plt.ylabel('Precision')
    # show the legend
    plt.legend()
    # show the title
    plt.title('No skill AUC={:.2f}, Model Skill AUC={:.2f}'.format(auc_noskill, auc_modelskill))
    # show the plot
    plt.show()
    
    
def imb_pipeline(clf, X, y, params, scoring, sampling):
    if sampling==True:
        model = Pipeline([
            ('sampling', RandomOverSampler(sampling_strategy=0.1)),
            ('classification', clf)
        ])
        print('Will sample on train data')
    else:
        model = Pipeline([
            ('classification', clf)
        ])
        print('Note - no sampling being done')
        
    gcv = model_selection.GridSearchCV(estimator=model, param_grid=params, cv=5, scoring=scoring, n_jobs=-1,
                       return_train_score=True)
    gcv.fit(X, y)

    return gcv

def sampling_flag(y, threshold):
    '''
    This function takes an nx1 shaped Series and compares the positive class ratio to a given threshold. 
    
    Returns True/False flag used in imb_pipeline 
    '''
    flag = False
    minority_ratio = (y.sum()/y.shape[0])
    if minority_ratio < threshold:
        flag = True
    return flag

# Get a list of all the MoAs to use for modelling
moas = list(y.columns)

drug = 'nfkb_inhibitor'

y_train_split[drug].value_counts()

lr_pipeline  = pipeline.Pipeline([('clf', linear_model.LogisticRegression(C=1.0,solver='sag',max_iter = 500,n_jobs=-1))])

ts = time.time()
lr_pipeline.fit(X_train_split, y_train_split[drug])
lr_pipeline_yhat = lr_pipeline.predict_proba(X_test_split)
lr_pipeline_pos_probs = lr_pipeline_yhat[:, 1]
# calculate roc auc
lr_roc_auc = metrics.roc_auc_score(y_test_split[drug], lr_pipeline_pos_probs)
print('Skill ROC AUC %.3f' % lr_roc_auc)
time.time() - ts

dummy = DummyClassifier(strategy='stratified')
dummy.fit(X_train_split, y_train_split[drug])
dummy_yhat = dummy.predict_proba(X_test_split)
dummy_pos_probs = dummy_yhat[:, 1]
# calculate roc auc
dummy_roc_auc = metrics.roc_auc_score(y_test_split[drug], dummy_pos_probs)
print('No Skill ROC AUC %.3f' % dummy_roc_auc)

plot_roc_curve(y_test_split[drug],dummy_pos_probs,lr_pipeline_pos_probs,'logistic')

plt.hist(lr_pipeline_pos_probs, bins=100)
plt.title('Probability Distribution for the Pos. Class [Test Set]')
plt.show()

lr_drug_report = metrics.classification_report(y_test_split[drug], (lr_pipeline_pos_probs>0.5).astype("int32"))
print(lr_drug_report)

metrics.plot_confusion_matrix(lr_pipeline, X_test_split, y_test_split[drug], cmap='Greens')
plt.show()

plot_pr_curve(y_test_split[drug],dummy_pos_probs,lr_pipeline_pos_probs,'logistic')

params = [{'classification__C': (0.005, 0.01, 0.05, 0.1, 0.5)},
          {'classification__n_estimators': (10, 20, 40), 'classification__min_samples_split': (5, 9, 12)}]

classifiers = [('Logistic Regression',
  linear_model.LogisticRegression(max_iter=500, solver='sag',
                     random_state=None,warm_start=False, n_jobs=None)),
 ('Random Forest Classifier',
  ensemble.RandomForestClassifier(verbose=0,
                             warm_start=False, n_jobs=None))]

ts = time.time()
drug_clfs = dict()
for moa in moas[:1]:
    moa = drug
    print('Working on {}'.format(moa))
    best_clf_score = dict()
    for param, classifier in zip(params, classifiers):
        print("Working on {}...".format(classifier[0]))
        clf = imb_pipeline(classifier[1], X_train_split, y_train_split[moa], param, scoring=pr_auc_score, 
                           sampling=sampling_flag(y_train_split[moa], 0.02)) 
        print("Best parameter for {} is {}".format(classifier[0], clf.best_params_))
        print("Best `AUPRC` for {} is {}".format(classifier[0], clf.best_score_))
        best_clf_score[clf.best_estimator_] = clf.best_score_
        print('-'*50)
        print('\n')
    best_estimator = max(best_clf_score, key=best_clf_score.get)
    drug_clfs[moa] = best_estimator

time.time()-ts

y_train_split['acetylcholine_receptor_antagonist'].sum()/y_train_split.shape[0]

ts = time.time()
drug_clfs = dict()
for moa in moas[:1]:
    moa = 'acetylcholine_receptor_antagonist'
    print('Working on {}'.format(moa))
    best_clf_score = dict()
    for param, classifier in zip(params, classifiers):
        print("Working on {}...".format(classifier[0]))
        clf = imb_pipeline(classifier[1], X_train_split, y_train_split[moa], param, scoring=pr_auc_score, 
                           sampling=sampling_flag(y_train_split[moa], 0.02)) 
        print("Best parameter for {} is {}".format(classifier[0], clf.best_params_))
        print("Best `AUPRC` for {} is {}".format(classifier[0], clf.best_score_))
        best_clf_score[clf.best_estimator_] = clf.best_score_
        print('-'*50)
        print('\n')
    best_estimator = max(best_clf_score, key=best_clf_score.get)
    drug_clfs[moa] = best_estimator

time.time()-ts

from keras.models import Sequential
from keras.layers import Dense, Dropout
from keras.optimizers import SGD, Nadam
from keras.metrics import AUC
from keras.utils import to_categorical
from keras.wrappers.scikit_learn import KerasClassifier 
from keras.constraints import maxnorm

from scipy.stats import uniform, randint

y_train_split.shape[1]

n_features = X_train_split.shape[1]
print(n_features)
output_num = y_train_split.shape[1]
print(output_num)

def create_model(learning_rate=0.001, kernel_initializer='uniform', 
                 activation ='relu', dropout_rate=0.0, weight_constraint=0,
                neurons=200):
    # create model
    model = Sequential()
    model.add(Dense(units=neurons, activation=activation, input_dim=n_features,
                   kernel_initializer = kernel_initializer))
    model.add(Dropout(rate=dropout_rate))
    model.add(Dense(output_num, activation='sigmoid', kernel_initializer = kernel_initializer))
    optimizer = Nadam(learning_rate=learning_rate)
    # Compile model
    model.compile(loss='binary_crossentropy', optimizer=optimizer)
    return model

history = KerasClassifier(build_fn=create_model).fit(X_train_split, y_train_split, 
                                                     validation_split = 0.15, epochs=15, 
                                                     batch_size=100, verbose=1,  use_multiprocessing=True)

loss = history.history['loss']
epochs = range(1, len(loss) + 1)

pr_auc_train = history.history['loss']
pr_auc_valid = history.history['val_loss']
plt.plot(epochs, pr_auc_train, 'b', label='loss')
plt.plot(epochs, pr_auc_valid, 'y', label='val loss')
plt.title('Training and validation - loss')
plt.xlabel('Epochs')
plt.ylabel('loss')
plt.legend()
plt.show()

model.evaluate(X_test_split, y_test_split)

# create model
model = KerasClassifier(build_fn=create_model, verbose=1, epochs=100, batch_size=60)

# grid search
batch_size = [40, 60, 80]
epochs = [100, 125, 150]
optimizer = ['SGD', 'RMSprop', 'Adagrad', 'Adadelta', 'Adam', 'Adamax', 'Nadam']
param_grid = dict(optimizer = optimizer,
                  #batch_size=batch_size, 
                  #epochs=epochs,
                  )
grid = model_selection.GridSearchCV(estimator=model, param_grid=param_grid, scoring = avg_precision_wrapper, 
                                    cv=3, return_train_score = True)
grid_result = grid.fit(X_train_split, y_train_split)

# summarize results
print("Best: %f using %s" % (grid_result.best_score_, grid_result.best_params_))
means = grid_result.cv_results_['mean_test_score']
stds = grid_result.cv_results_['std_test_score']
params = grid_result.cv_results_['params']
for mean, stdev, param in zip(means, stds, params):
    print("%f (%f) with: %r" % (mean, stdev, param))

# create model
model = KerasClassifier(build_fn=create_model, verbose=1)

# grid search
batch_size = [40, 60, 80]
epochs = [100, 125, 150]
learning_rate = [0.001, 0.01, 0.1, 0.2, 0.3]
param_grid = dict(learning_rate = learning_rate,
                  batch_size=batch_size, 
                  epochs=epochs,
                  )
grid = model_selection.GridSearchCV(estimator=model, param_grid=param_grid, scoring = avg_precision_wrapper, 
                                    cv=3, return_train_score = True)
grid_result = grid.fit(X_train_split, y_train_split)

# summarize results
print("Best: %f using %s" % (grid_result.best_score_, grid_result.best_params_))
means = grid_result.cv_results_['mean_test_score']
stds = grid_result.cv_results_['std_test_score']
params = grid_result.cv_results_['params']
for mean, stdev, param in zip(means, stds, params):
    print("%f (%f) with: %r" % (mean, stdev, param))

# create model
model = KerasClassifier(build_fn=create_model, verbose=0,
                       batch_size=80, epochs=125, learning_rate=0.001)

# Random search
kernel_initializer = ['uniform', 'lecun_uniform', 'normal', 'zero', 'glorot_normal', 'glorot_uniform', 'he_normal', 'he_uniform']
activation  = ['relu', 'tanh']
param_grid_dist = dict(kernel_initializer = kernel_initializer, activation=activation)
grid = model_selection.RandomizedSearchCV(estimator=model, param_distributions=param_grid_dist, scoring = avg_precision_wrapper, 
                                    cv=3, return_train_score = True, verbose=10)
grid_result = grid.fit(X_train_split, y_train_split)

# summarize results
print("Best: %f using %s" % (grid_result.best_score_, grid_result.best_params_))
means = grid_result.cv_results_['mean_test_score']
stds = grid_result.cv_results_['std_test_score']
params = grid_result.cv_results_['params']
for mean, stdev, param in zip(means, stds, params):
    print("%f (%f) with: %r" % (mean, stdev, param))

randint(1, 5).stats()

# create model
model = KerasClassifier(build_fn=create_model, verbose=0, learning_rate=0.001,
                       kernel_initializer='glorot_normal', activation='relu',
                       )

# random search
batch_size = [60, 80, 100]
epochs = [100, 125, 150]
neurons = [600, 800, 1000]
param_grid = dict(neurons = neurons, batch_size=batch_size, epochs = epochs)
grid = model_selection.GridSearchCV(estimator=model, param_grid=param_grid, scoring = avg_precision_wrapper, 
                                    cv=3, return_train_score = True, verbose=10)
grid_result = grid.fit(X_train_split, y_train_split)

# summarize results
print("Best: %f using %s" % (grid_result.best_score_, grid_result.best_params_))
means = grid_result.cv_results_['mean_test_score']
stds = grid_result.cv_results_['std_test_score']
params = grid_result.cv_results_['params']
for mean, stdev, param in zip(means, stds, params):
    print("%f (%f) with: %r" % (mean, stdev, param))

# create model
model = KerasClassifier(build_fn=create_model, verbose=0, learning_rate=0.001,
                       kernel_initializer='glorot_normal', activation='relu',
                       batch_size=60, epochs=125, neurons=800
                       )

# random search
weight_constraint = [1, 2, 3]
dropout_rate = [0.05, 0.1, 0.15]
param_grid = dict(dropout_rate = dropout_rate, weight_constraint=weight_constraint)
grid = model_selection.GridSearchCV(estimator=model, param_grid=param_grid, scoring = avg_precision_wrapper, 
                                    cv=3, return_train_score = True, verbose=10)
grid_result = grid.fit(X_train_split, y_train_split)

# summarize results
print("Best: %f using %s" % (grid_result.best_score_, grid_result.best_params_))
means = grid_result.cv_results_['mean_test_score']
stds = grid_result.cv_results_['std_test_score']
params = grid_result.cv_results_['params']
for mean, stdev, param in zip(means, stds, params):
    print("%f (%f) with: %r" % (mean, stdev, param))

# create model
model = KerasClassifier(build_fn=create_model, verbose=0, learning_rate=0.001,
                       kernel_initializer='glorot_normal', activation='relu',
                       batch_size=60, epochs=125, neurons=800, dropout_rate=0.15,
                        weight_constraint=1
                       )
history = model.fit(X_train_split, y_train_split, validation_split = 0.1, verbose=1)

model.model.evaluate(X_test_split, y_test_split)

loss = history.history['loss']
epochs = range(1, len(loss) + 1)

loss = history.history['loss']
val_loss = history.history['val_loss']
plt.plot(epochs, loss, 'b', label='loss')
plt.plot(epochs, val_loss, 'y', label='val_loss')
plt.title('Training and validation - cross-entropy loss')
plt.xlabel('Epochs')
plt.ylabel('loss')
plt.legend()
plt.show()

from skmultilearn.problem_transform import LabelPowerset

LabelPowerset(linear_model.LogisticRegression(max_iter=500,
                     random_state=None,warm_start=False, n_jobs=None))

train_split = pd.concat([X_train_split,y_train_split],axis=1)
train_split_sample = train_split.sample(random_state=0, frac=0.2)
X_train_split_sample = train_split_sample[X_train_split.columns]
y_train_split_sample = train_split_sample[y_train_split.columns]

y_train_split_sample['5-alpha_reductase_inhibitor'].value_counts()

params = [
    {
        'classifier': [ensemble.RandomForestClassifier(n_jobs=None)],
        'classifier__n_estimators': [100], 'classifier__min_samples_split': [5]
    },
]

ts = time.time()
gcv_lp = model_selection.GridSearchCV(LabelPowerset(), params, scoring=avg_precision_wrapper, cv=5,n_jobs=-1, verbose=1)
gcv_lp.fit(X_train_split, y_train_split)

time.time()-ts

gcv_lp.best_score_

train_probs = gcv_lp.predict_proba(X_train_split)

train_probs_df = pd.DataFrame(train_probs.toarray(), columns=moas)

train_probs_df[train_probs_df['5-alpha_reductase_inhibitor'] > 0.5]

gcv_lp.score(X_test_split, y_test_split)

lr_pipeline_LP  = pipeline.Pipeline([('scaler', MinMaxScaler()), ('clf', LabelPowerset(linear_model.LogisticRegression(C=1.0,solver='sag',max_iter = 1000,n_jobs=-1)))])
params = {'C':[1, 10]}
model_selection.GridSearchCV(lr_pipeline_LP, params, scoring=metrics.average_precision_score, cv=3)

probs = lr_pipeline_LP.predict_proba(X_encoded_sample.drop('sig_id',axis=1))

import scipy.sparse
probs_df = pd.DataFrame.sparse.from_spmatrix(probs, columns=y_sample.columns)

# For each class
precision = dict()
recall = dict()
average_precision = dict()
for col in probs_df.columns[3:4]:
    precision[col], recall[col], _ = metrics.precision_recall_curve(y_sample[col],
                                                        probs_df[col])
    average_precision[col] = metrics.average_precision_score(y_sample[col], probs_df[col])

# A "micro-average": quantifying score on all classes jointly
precision["micro"], recall["micro"], _ = metrics.precision_recall_curve(y_sample.values.ravel(),
    probs_df.values.ravel())
average_precision["micro"] = metrics.average_precision_score(np.array(y_sample), np.array(probs_df),
                                                     average="micro")
print('Average precision score, micro-averaged over all classes: {0:0.2f}'
      .format(average_precision["micro"]))

metrics.auc(recall["micro"], precision["micro"])

average_precision["micro"]

plt.step(recall['micro'], precision['micro'], where='post')

plt.xlabel('Recall')
plt.ylabel('Precision')
plt.ylim([0.0, 1.05])
plt.xlim([0.0, 1.0])
plt.title(
    'Average precision score, micro-averaged over all classes: AP={0:0.2f}'
    .format(average_precision["micro"]))