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1. dddMAPS dddMAPS Public

   Mutability adjusted proportion of singletons calculation using synonymous SNPs from the DDD unaffected parents.

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2. DDDNonCoding2017 DDDNonCoding2017 Public

   Code for paper published in March, 2017 analysing the role of de novo mutations in severe developmental disorders (part of the deciphering developmental disorders project).

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3. TFBS TFBS Public

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4. denovoTF denovoTF Public

   Calculating change in binding affinity for predicted TF binding sites as a result of de novo mutations in non-coding regions. Uses JASPAR database for TF binding prediction.

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5. wgcna_corr wgcna_corr Public

   Using Weighted Gene Coexpression Network Analysis (WGNCA) to analyze microarray data for correlations between gene modules (groups of genes with similar expression profiles) and phenotypes.

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6. DenovoSim DenovoSim Public

   Simulate de novo mutations using model based on trinucleotide mutation rate model introduced in Samocha et. al, 2014. Users can condition on number of patients in a study, and number of mutations o…

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