I don't like virtualenvwrapper, so I took some code from virtualenvwrapper.el just to get the virtualenv activated and deactivated and made a standalone emacs package.

(use-package venv
    :load-path "~/Downloads/venv.el")

Then use the commands virtualenv-activate and virtualenv-deactivate.

To activate the virtualenv currently used by Poetry run venv-from-poetry.

If you're looking for more features see these packages:

• pyvenv
• the original virtualenvwrapper.el