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EpiLaP - Epigenomic Label Predictor

Use machine learning on epigenomic data.

Setup

To install in dev/editable mode:

  • Clone the git
  • Create a virtual environment, activate it
  • In the root directory (setup.py), run "pip install -e ."
  • Install other requirements with pip (see requirements folder).

General

See input-format folder for examples of mandatory files.

usage: main.py [-h] [--offline] [--predict] [--model MODEL]
               category hyperparameters hdf5 chromsize metadata logdir

positional arguments:
  category         The metatada category to analyse.
  hyperparameters  A json file containing model hyperparameters.
  hdf5             A file with hdf5 filenames. Use absolute path!
  chromsize        A file with chrom sizes.
  metadata         A metadata JSON file.
  logdir           Directory for the output logs.

optional arguments:
  -h, --help       show this help message and exit
  --offline        Will log data offline instead of online. Currently cannot merge comet-ml offline
                   outputs.
  --predict        Enter prediction mode. Will use all data for the test set. Overwrites hparameter file
                   setting. Default mode is training mode.
  --model MODEL    Directory from which to load the desired model. Default is logdir.

Metadata handling and modifications

The Metadata class has an api to support modification of metadata as needed, like the select_category_subsets and remove_category_subsets methods. One can use them if they want to adjust label values on the fly, or perform additional filtering.

As soon as a label category exists in a dataset, any value is considered the label. Be it "", "--" or "NA".

If datasets containing differents keys is expected or possible, be sure to run remove_missing_labels on the relevant categories.

For additional information, refer to the documentation

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Use machine learning on epigenomic data

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