Supplementary material for Bocci, Kumar, Tripathi, Aguilar, Hanash, Levine and Onuchic, "Numb prevents a complete EMT by modulating Notch signalling"

To run the following code on your computer, you need: (i) Python (not older than 2.6) (ii) The following numerical packages: (ii-a) Numpy (https://www.numpy.org/) (ii-b) Matplotlib (https://matplotlib.org/) (ii-c) Scipy (https://www.scipy.org/) (ii-d) PyDSTool (https://www.ni.gsu.edu/~rclewley/PyDSTool/FrontPage.html)

The files are:

(1) functions.py - auxiliary functions (2) single_cell.py - methods for the single cell simulations (3) multi_cell.py - methods for the multi-cell simulations

single_cell.py contains the code for the single cell simulation, while multi_cell.py contains the code for tissue-level simulations. Both programs rely on auxiliary functions contained in functions.py, so functions.py must be in the same folder when compiling single_cell.py/multi_cell.py (otherwise, the path .../functions.py must be indicated).

To compile, run python single_cell.py (or python multi_cell.py) on your terminal after entering in your work directory.

For further questions about the code, please contact me (Federico Bocci - [email protected]).